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Atezolizumab

Generic name: atezolizumab
Brand name: Tecentriq
Dosage form: intravenous (infusion) injection
Drug class: Anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 4, 2023.

What is atezolizumab?

Atezolizumab is a type of immunotherapy drug that helps the body's immune system to track down and fight cancer. It is a monoclonal antibody that works by blocking a protein called programmed death-ligand 1 (PD-L1). It is part of a group of drugs called immune checkpoint inhibitors, which help to extend the amount of time a person can live with cancer or life without their cancer getting worse.

Atezolizumab. was first approved by the US Food and Drug Administration (FDA) in 2016.

What is atezolizumab used for?

Atezolizumab is a prescription medicine used to treat adults with:

It is not known if atezolizumab is safe and effective in children.

Important information

Atezolizumab is a medicine that may treat certain cancers by working with your immune system. Atezolizumab can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.

Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:

Getting medical treatment right away may help keep these problems from becoming more serious.

Your healthcare provider will check you for these problems during your treatment with atezolizumab. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with atezolizumab if you have severe side effects.

What should I tell my doctor before receiving atezolizumab?

Before receiving atezolizumab, tell your healthcare provider about all of your medical conditions, including if you:

How should I receive atezolizumab?

What happens if I miss a dose?

If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.

Dosing information

What are the side effects of atezolizumab?

Atezolizumab can cause serious side effects, including:

The most common side effects of atezolizumab when used alone include:

The most common side effects of atezolizumab when used in lung cancer with other anti-cancer medicines include:

The most common side effects of atezolizumab when used in hepatocellular carcinoma with bevacizumab include:

The most common side effects of atezolizumab when used in melanoma with cobimetinib and vemurafenib include:

Atezolizumab may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of atezolizumab.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Pregnancy and breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant. atezolizumab can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with atezolizumab.

Females who are able to become pregnant:

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if atezolizumab passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of atezolizumab.

Storage

Store atezolizumab vials under refrigeration at 2°C to 8°C (36°F to 46°F) in original carton to protect from light. Do not freeze. Do not shake.

What are the ingredients in atezolizumab?

Active ingredient: atezolizumab

Inactive ingredients: glacial acetic acid, L-histidine, polysorbate 20 and sucrose

Atezolizumab is manufactured by Genentech, Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080-4990 USA, under the brandname Tecentiq.

Popular FAQ

Tecentriq treatment costs around $14,540 per month depending on the dosage schedule (every 2, 3 or 4 weeks). Doses in children 2 years and older with alveolar soft part sarcoma (ASPS) are weight-based but could cost up to $10,380 every 3 weeks at the maximum dose. Continue reading

Atezolizumab (brand name: Tecentriq) is a type of immunotherapy drug called an “immune checkpoint inhibitor”. It helps to stimulate the body’s immune system to fight certain types cancer, including lung, liver and skin cancer. Continue reading

Atezolizumab (Tecentriq) is approved to treat several different types of cancer. Cancer treatment is always individualized for each patient. It’s effectiveness and your length of response will depend upon your diagnosis, previous treatments, and other medical conditions, among other factors. Continue reading

Hair loss (alopecia) is listed as a common side effect with atezolizumab (Tecentriq) when used with certain other cancer treatments. Hair loss was not reported as a side effect when used as a single agent for urothelial (bladder) cancer treatment (but Tecentriq is no longer FDA-approved to be used in bladder cancer). Continue reading

Atezolizumab (Tecentriq) is given by a slow intravenous (IV) infusion into your vein, usually once every 2, 3 or 4 weeks. Your initial infusion typically lasts for 60 minutes, and infusions after this may be reduced to 30 minutes, based on your tolerability. Continue reading

Tecentriq (atezolizumab) is an immune checkpoint inhibitor used to treat non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), heptatocellular (liver) carcinoma (HCC), melanoma (skin cancer), and alveolar soft part sarcoma (ASPS), a rare soft tissue tumor. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.