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Tecentriq

Generic Name: atezolizumab (A te zoe LIZ ue mab)
Brand Names: Tecentriq

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 5, 2020.

What is Tecentriq?

Tecentriq (atezolizumab) is a monoclonal antibody that affects the actions of the body's immune system. Atezolizumab strengthens your immune system to help your body fight against tumor cells.

Tecentriq is used to treat adults with:

Tecentriq is used when the cancer has spread to other parts of the body (metastatic), or cannot be removed by surgery.

Your doctor may perform a biopsy to test your cancer for a protein called "PD-L1," or a specific genetic marker (an abnormal "EGFR" or "ALK" or "BRAF" gene).

Tecentriq is sometimes given after other cancer treatments have not worked or have stopped working. Tecentriq may be given in combination with chemotherapy medicines.

Important Information

Tecentriq affects your immune system and may cause it to attack normal healthy tissues or organs, leading to serious or life-threatening medical problems.

Call your doctor at once if you have new or worsening symptoms such as: chest pain, cough, breathing problems, stomach pain, vomiting, changes in appetite or weight, increased thirst or urination, headaches, neck stiffness, vision problems, tiredness, mood changes, muscle weakness, bleeding or bruising, bloody or tarry stools, dark urine, or yellowing of the skin or eyes.

Before taking this medicine

You should not use Tecentriq if you are allergic to atezolizumab.

To make sure Tecentriq is safe for you, tell your doctor if you have:

You may need to have a negative pregnancy test before starting this treatment.

Do not use Tecentriq if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 5 months after your last dose.

Tecentriq may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because atezolizumab can harm an unborn baby.

You should not breastfeed while using atezolizumab and for at least 5 months after your last dose.

How is Tecentriq given?

Tecentriq is given as an infusion into a vein, usually once every 2 or 4 weeks. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take up to 60 minutes to complete.

You may be given other medications to help treat certain serious side effects. Keep using these medicines for as long as your doctor has prescribed.

Tecentriq helps your immune system fight against tumor cells, but your immune system may attack normal healthy tissues or organs. When this happens, you may develop serious or life-threatening medical problems. You will need frequent medical tests.

Your doctor will determine how long to treat you with this medicine.

Tecentriq Dosing Information

Usual Adult Dose of Tecentriq for Non-Small Cell Lung Cancer:

1200 mg IV over 60 minutes every 3 weeks until disease progression or unacceptable toxicity

Comments:
-If the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes.
-Do not administer this drug as an IV push or bolus.

Uses:
-Urothelial Carcinoma: For the treatment of patients with locally advanced or metastatic urothelial carcinoma who are not eligible for cisplatin-containing chemotherapy and whose tumors express PD-L1 (PD-L1 stained tumor-infiltrating immune cells [IC] covering 5% or greater of the tumor area), OR are not eligible for any platinum-containing chemotherapy regardless of level of tumor PD-L1 expression, OR have disease progression during or following any platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant chemotherapy
-Metastatic Non-Small Cell Lung Cancer: For the treatment of patients with metastatic non-small cell lung cancer (NSCLC) who have disease progression during or following platinum-containing chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving this drug

Usual Adult Dose of Tecentriq for Urothelial Carcinoma:

1200 mg IV over 60 minutes every 3 weeks until disease progression or unacceptable toxicity

Comments:
-If the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes.
-Do not administer this drug as an IV push or bolus.

Uses:
-Urothelial Carcinoma: For the treatment of patients with locally advanced or metastatic urothelial carcinoma who are not eligible for cisplatin-containing chemotherapy and whose tumors express PD-L1 (PD-L1 stained tumor-infiltrating immune cells [IC] covering 5% or greater of the tumor area), OR are not eligible for any platinum-containing chemotherapy regardless of level of tumor PD-L1 expression, OR have disease progression during or following any platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant chemotherapy
-Metastatic Non-Small Cell Lung Cancer: For the treatment of patients with metastatic non-small cell lung cancer (NSCLC) who have disease progression during or following platinum-containing chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving this drug

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Tecentriq injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Tecentriq?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Tecentriq side effects

Get emergency medical help if you have signs of an allergic reaction to Tecentriq (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, chilled or feverish, itchy, tingly, or have neck or back pain, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

  • new or worsening cough, shortness of breath;

  • chest pain, irregular heartbeats;

  • swelling in your ankles;

  • severe stomach pain, nausea, vomiting, diarrhea, bloody or tarry stools;

  • liver problems - right-sided upper stomach pain, loss of appetite, drowsiness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);

  • nervous system problems - neck stiffness, increased sensitivity to light, confusion, severe muscle weakness, numbness or tingling in your hands or feet, vision problems, eye pain or redness;

  • signs of infection - fever, flu symptoms, cough, back pain, painful or frequent urination; or

  • signs of a hormonal disorder - frequent or unusual headaches, dizziness, feeling very tired, mood or behavior changes, hoarse or deepened voice, increased hunger or thirst, increased urination, constipation, hair loss, feeling cold, weight gain, or weight loss.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Tecentriq side effects may include:

  • nausea, vomiting, loss of appetite;

  • diarrhea, constipation;

  • headache, tiredness, weakness;

  • cough, feeling short of breath;

  • numbness or tingling in your hands or feet;

  • infections; or

  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tecentriq?

Other drugs may interact with atezolizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tecentriq only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Related questions

Atezolizumab (Tecentriq) is given by a slow intravenous (IV) infusion into your vein, usually once every 2, 3 or 4 weeks. Your initial infusion typically lasts for 60 minutes, and infusions after this may be reduced to 30 minutes, based on your tolerability. Read more

Atezolizumab (Tecentriq) is approved to treat several different types of cancer. Cancer treatment is always individualized for each patient. It’s effectiveness and your length of response will depend upon your diagnosis, previous treatments, and other medical conditions, among other factors. Read more

Atezolizumab (brand name: Tecentriq) is a type of immunotherapy drug called an “immune checkpoint inhibitor”. It helps to stimulate the body’s immune system to fight certain types cancer, including lung, liver and skin cancer. Read more

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