Tecentriq Side Effects
Generic name: atezolizumab
Note: This document contains side effect information about atezolizumab. Some dosage forms listed on this page may not apply to the brand name Tecentriq.
Summary
Common side effects of Tecentriq include: herpes simplex encephalitis, infection, mycobacterium infection, retroperitoneal hemorrhage, sepsis, severe infection, urinary tract infection, colitis, diarrhea, and increased thyroid stimulating hormone level. Continue reading for a comprehensive list of adverse effects.
Applies to atezolizumab: parenteral injection.
Side effects include:
Single-agent atezolizumab (the active ingredient contained in Tecentriq) (≥20%): Fatigue or asthenia, nausea, cough, dyspnea, decreased appetite.
In combination with other antineoplastic agents in patients with NSCLC or SCLC (≥20%): Fatigue or asthenia, nausea, alopecia, constipation, diarrhea, decreased appetite.
In combination with albumin-bound paclitaxel in patients with triple-negative breast cancer (≥20%): Alopecia, peripheral neuropathy, fatigue, nausea, diarrhea, constipation, cough, headache, vomiting, decreased appetite; laboratory abnormalities occurring in ≥50% of patients include decreased concentrations of hemoglobin, leukocytes, neutrophils, and lymphocytes.
In combination with bevacizumab in patients with HCC (≥20%): Hypertension, fatigue, proteinuria.
In combination with cobimetinib and vemurafenib in patients with melanoma (≥20%): Rash, musculoskeletal pain, fatigue, hepatotoxicity, pyrexia, nausea, pruritus, edema, stomatitis, hypothyroidism, photosensitivity.
For Healthcare Professionals
Applies to atezolizumab: intravenous solution.
Cardiovascular
Common (1% to 10%): Venous thromboembolism[Ref]
Dermatologic
Very common (10% or more): Rash (15%), pruritus (13%)[Ref]
Endocrine
Frequency not reported: Immune-related thyroid disorders (e.g., hyperthyroidism, hypothyroidism)[Ref]
Gastrointestinal
Very common (10% or more): Nausea (25%), constipation (21%), diarrhea (18%), abdominal pain (17%), vomiting (17%)
Common (1% to 10%): Dehydration, intestinal obstruction[Ref]
General
The most common adverse reactions (greater than 20%) were fatigue, decreased appetite, nausea, urinary tract infection, pyrexia, and constipation. The most common Grade 3 to 4 adverse reactions (greater than 2%) were urinary tract infection, anemia, fatigue, dehydration, intestinal obstruction, urinary obstruction, hematuria, dyspnea, acute kidney injury, abdominal pain, venous thromboembolism, sepsis, and pneumonia.[Ref]
Genitourinary
Very common (10% or more): Urinary tract infection (22%)
Common (1% to 10%): Urinary obstruction[Ref]
Hematologic
Common (1% to 10%): Anemia, lymphopenia, increased alkaline phosphatase, increased alkaline phosphatase[Ref]
Hepatic
Common (1% to 10%): Acute kidney injury, liver enzyme increase, increased ALT, increased AST
Immunologic
Very common (10% or more): Immune related colitis (19.7%)
Common (1% to 10%): Immune related pneumonitis, immune related hepatitis, sepsis
Frequency not reported: Immune related endocrinopathies[Ref]
Local
Frequency not reported: Infusion related reactions[Ref]
Metabolic
Very common (10% or more): Decreased appetite (26%)
Common (1% to 10%): Hyponatremia, hyperglycemia, hypoalbuminemia[Ref]
Musculoskeletal
Very common (10% or more): Back/neck pain (15%), arthralgia (14%)[Ref]
Nervous system
Frequency not reported: Meningoencephalitis, myasthenic syndrome/myasthenia gravis, Guillain-Barre[Ref]
Ocular
Frequency not reported: Ocular inflammatory toxicity[Ref]
Other
Very common (10% or more): Fatigue (52%), pyrexia (21%), peripheral edema (18%)
Common (1% to 10%): Increased creatinine[Ref]
Psychiatric
Common (1% to 10%): Confusional state[Ref]
Renal
Common (1% to 10%): Hematuria[Ref]
Respiratory
Very common (10% or more): Dyspnea (16%), cough (14%)
Common (1% to 10%): Dyspnea, pneumonia[Ref]
Frequently asked questions
- What is the cost of Tecentriq?
- Is this a chemotherapy or immunotherapy drug?
- How effective is it?
- Does it cause hair loss?
- How is it administered?
- What type of cancer is Tecentriq used to treat?
More about Tecentriq (atezolizumab)
- Check interactions
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- Reviews (1)
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- Latest FDA alerts (2)
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)
- Breastfeeding
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Patient resources
Professional resources
Related treatment guides
References
1. Cerner Multum, Inc. UK Summary of Product Characteristics.
2. Product Information. Tecentriq (atezolizumab). Genentech. 2016.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.