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Tecentriq Side Effects

Generic Name: atezolizumab

Note: This document contains side effect information about atezolizumab. Some of the dosage forms listed on this page may not apply to the brand name Tecentriq.

In Summary

Common side effects of Tecentriq include: herpes simplex encephalitis, infection, mycobacterium infection, retroperitoneal hemorrhage, sepsis, severe infection, urinary tract infection, colitis, diarrhea, and increased thyroid stimulating hormone level. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to atezolizumab: intravenous solution

Side effects requiring immediate medical attention

Along with its needed effects, atezolizumab (the active ingredient contained in Tecentriq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking atezolizumab:

More common

  • Black, tarry stools
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chills
  • constipation
  • cough
  • difficult, burning, or painful urination
  • difficulty in breathing
  • dizziness
  • ear congestion
  • fever
  • frequent urge to urinate
  • general feeling of tiredness and weakness
  • headache
  • hoarseness
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • muscle aches
  • nausea
  • nervousness
  • nosebleed
  • pain
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stomach cramps
  • stuffy or runny nose
  • tenderness
  • tingling of the hands or feet
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • watery or bloody diarrhea

Less common

  • Anxiety
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • chest pain
  • confusion
  • dark urine
  • decreased urine
  • depressed mood
  • difficulty with chewing, swallowing, or talking
  • double vision
  • drooping eyelids
  • drowsiness
  • dry skin and hair
  • facial swelling
  • feeling cold
  • general feeling of discomfort or illness
  • inability to move the arms and legs
  • irritability
  • light-colored stools
  • lightheadedness
  • muscle cramp, stiffness, or weakness
  • numbness in the hands, feet, or lips
  • rapid, shallow breathing
  • seizures
  • sensation of pins and needles
  • sensitivity to heat
  • severe headache
  • severe tiredness
  • skin rash
  • stabbing pain
  • stiff neck or back
  • sudden numbness and weakness in the arms and legs
  • sweating
  • thickening of bronchial secretions
  • tightness in the chest
  • trouble sleeping
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Rare

  • Blistering, peeling, or loosening of the skin
  • darkening of the skin
  • diarrhea
  • fainting
  • hives, itching
  • indigestion
  • joint or muscle pain
  • joint stiffness or swelling
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet

Incidence not known

  • Flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased urination
  • sweating

Side effects not requiring immediate medical attention

Some side effects of atezolizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back, neck, arm, or leg pain
  • difficulty in moving
  • loss of or change in taste
  • thinning of the hair or hair loss
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to atezolizumab: intravenous solution

Cardiovascular

Common (1% to 10%): Venous thromboembolism[Ref]

Dermatologic

Very common (10% or more): Rash (15%), pruritus (13%)[Ref]

Endocrine

Frequency not reported: Immune-related thyroid disorders (e.g., hyperthyroidism, hypothyroidism)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (25%), constipation (21%), diarrhea (18%), abdominal pain (17%), vomiting (17%)

Common (1% to 10%): Dehydration, intestinal obstruction[Ref]

General

The most common adverse reactions (greater than 20%) were fatigue, decreased appetite, nausea, urinary tract infection, pyrexia, and constipation. The most common Grade 3 to 4 adverse reactions (greater than 2%) were urinary tract infection, anemia, fatigue, dehydration, intestinal obstruction, urinary obstruction, hematuria, dyspnea, acute kidney injury, abdominal pain, venous thromboembolism, sepsis, and pneumonia.[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection (22%)

Common (1% to 10%): Urinary obstruction[Ref]

Hematologic

Common (1% to 10%): Anemia, lymphopenia, increased alkaline phosphatase, increased alkaline phosphatase[Ref]

Hepatic

Common (1% to 10%): Acute kidney injury, liver enzyme increase, increased ALT, increased AST

Immunologic

Very common (10% or more): Immune related colitis (19.7%)

Common (1% to 10%): Immune related pneumonitis, immune related hepatitis, sepsis

Frequency not reported: Immune related endocrinopathies[Ref]

Local

Frequency not reported: Infusion related reactions[Ref]

Metabolic

Very common (10% or more): Decreased appetite (26%)

Common (1% to 10%): Hyponatremia, hyperglycemia, hypoalbuminemia[Ref]

Musculoskeletal

Very common (10% or more): Back/neck pain (15%), arthralgia (14%)[Ref]

Nervous system

Frequency not reported: Meningoencephalitis, myasthenic syndrome/myasthenia gravis, Guillain-Barre[Ref]

Ocular

Frequency not reported: Ocular inflammatory toxicity[Ref]

Other

Very common (10% or more): Fatigue (52%), pyrexia (21%), peripheral edema (18%)

Common (1% to 10%): Increased creatinine[Ref]

Psychiatric

Common (1% to 10%): Confusional state[Ref]

Renal

Common (1% to 10%): Hematuria[Ref]

Respiratory

Very common (10% or more): Dyspnea (16%), cough (14%)

Common (1% to 10%): Dyspnea, pneumonia[Ref]

References

1. "Product Information. Tecentriq (atezolizumab)." Genentech, South San Francisco, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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