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Tecentriq Side Effects

Generic Name: atezolizumab

Note: This page contains side effects data for the generic drug atezolizumab. It is possible that some of the dosage forms included below may not apply to the brand name Tecentriq.

For the Consumer

Applies to atezolizumab: intravenous solution

As well as its needed effects, atezolizumab (the active ingredient contained in Tecentriq) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking atezolizumab, check with your doctor or nurse immediately:

More common:
  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • constipation
  • cough or hoarseness
  • difficult, burning, or painful urination
  • fever or chills
  • frequent urge to urinate
  • general tiredness and weakness
  • loss of appetite
  • lower back or side pain
  • nausea or vomiting
  • pain
  • painful or difficult urination
  • rapid weight gain
  • stomach cramps
  • tenderness
  • tingling of the hands or feet
  • unusual weight gain or loss
  • watery or bloody diarrhea
Less common:
  • Chest pain
  • dark urine
  • depressed mood
  • dizziness
  • dry skin and hair
  • facial swelling
  • feeling cold
  • general feeling of discomfort or illness
  • hair loss
  • headache
  • hoarseness or husky voice
  • light-colored stools
  • muscle cramps and stiffness
  • nervousness
  • sensitivity to heat
  • skin rash
  • slowed heartbeat
  • sweating
  • thickening of bronchial secretions
  • trouble sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • weakness
  • yellow eyes and skin
Less common or rare:
  • Burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • confusion
  • difficulty with chewing, swallowing, or talking
  • double vision
  • drooping eyelids
  • drowsiness
  • headache
  • inability to move the arms and legs
  • irritability
  • muscle weakness
  • seizures
  • sensation of pins and needles
  • severe headache
  • severe tiredness
  • stabbing pain
  • stiff neck or back
  • sudden numbness and weakness in the arms and legs
Rare
  • Bloating
  • darkening of the skin
  • diarrhea
  • fainting
  • fast heartbeat
  • indigestion
  • pains in the stomach, side, or abdomen, possibly radiating to the back
Incidence not known:
  • Blurred vision
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • sweating

Minor Side Effects

Some atezolizumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Back or neck pain
  • itching skin
  • pain in the joints

For Healthcare Professionals

Applies to atezolizumab: intravenous solution

Cardiovascular

Common (1% to 10%): Venous thromboembolism[Ref]

Dermatologic

Very common (10% or more): Rash (15%), pruritus (13%)[Ref]

Endocrine

Frequency not reported: Immune-related thyroid disorders (e.g., hyperthyroidism, hypothyroidism)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (25%), constipation (21%), diarrhea (18%), abdominal pain (17%), vomiting (17%)
Common (1% to 10%): Dehydration, intestinal obstruction[Ref]

General

The most common adverse reactions (greater than 20%) were fatigue, decreased appetite, nausea, urinary tract infection, pyrexia, and constipation. The most common Grade 3 to 4 adverse reactions (greater than 2%) were urinary tract infection, anemia, fatigue, dehydration, intestinal obstruction, urinary obstruction, hematuria, dyspnea, acute kidney injury, abdominal pain, venous thromboembolism, sepsis, and pneumonia.[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection (22%)
Common (1% to 10%): Urinary obstruction[Ref]

Hematologic

Common (1% to 10%): Anemia, lymphopenia, increased alkaline phosphatase, increased alkaline phosphatase[Ref]

Hepatic

Common (1% to 10%): Acute kidney injury, liver enzyme increase, increased ALT, increased AST

Immunologic

Very common (10% or more): Immune related colitis (19.7%)
Common (1% to 10%): Immune related pneumonitis, immune related hepatitis, sepsis
Frequency not reported: Immune related endocrinopathies[Ref]

Local

Frequency not reported: Infusion related reactions[Ref]

Metabolic

Very common (10% or more): Decreased appetite (26%)
Common (1% to 10%): Hyponatremia, hyperglycemia, hypoalbuminemia[Ref]

Musculoskeletal

Very common (10% or more): Back/neck pain (15%), arthralgia (14%)[Ref]

Nervous system

Frequency not reported: Meningoencephalitis, myasthenic syndrome/myasthenia gravis, Guillain-Barré[Ref]

Ocular

Frequency not reported: Ocular inflammatory toxicity[Ref]

Other

Very common (10% or more): Fatigue (52%), pyrexia (21%), peripheral edema (18%)
Common (1% to 10%): Increased creatinine[Ref]

Psychiatric

Common (1% to 10%): Confusional state[Ref]

Renal

Common (1% to 10%): Hematuria[Ref]

Respiratory

Very common (10% or more): Dyspnea (16%), cough (14%)
Common (1% to 10%): Dyspnea, pneumonia[Ref]

References

1. "Product Information. Tecentriq (atezolizumab)." Genentech, South San Francisco, CA.

It is possible that some side effects of Tecentriq may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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