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Pazopanib

Generic Name: pazopanib (paz OH pa nib)
Brand Name: Votrient

Medically reviewed by Drugs.com on Jul 22, 2020 – Written by Cerner Multum

What is pazopanib?

Pazopanib is used to treat advanced renal cell carcinoma (kidney cancer).

Pazopanib is also used to treat soft tissue sarcoma (a tumor that can develop in or around muscles, tendons, joints, organs, or blood vessels). Pazopanib is usually given after other cancer medications have been tried without successful treatment of soft tissue sarcoma.

Pazopanib may also be used for purposes not listed in this medication guide.

Important Information

Pazopanib can cause severe or life-threatening liver problems. You will need frequent blood tests to check your liver function.

Call your doctor at once if you have: nausea, vomiting, upper stomach pain, loss of appetite, tiredness, easy bruising, dark urine, or jaundice (yellowing of the skin or eyes).

Before taking this medicine

Tell your doctor if you have ever had:

  • liver disease;

  • heart disease, heart rhythm disorder, long QT syndrome;

  • high blood pressure;

  • a blood clot or stroke;

  • a thyroid disorder;

  • headaches, seizures, or vision problems;

  • a perforation (a hole or tear) in your stomach or intestines;

  • a fistula (an abnormal passageway) within your stomach or intestines;

  • stomach or intestinal bleeding; or

  • a surgery within the past 7 days.

You may need to have a negative pregnancy test before starting this treatment.

Do not use pazopanib if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using pazopanib and for at least 2 weeks after your last dose.

If you are a man whose sex partner is pregnant or could become pregnant, use condoms while taking pazopanib, and for at least 2 weeks after your last dose. You should use condoms even if you have had a vasectomy.

You should not breastfeed while you are using pazopanib, and for at least 2 weeks after your last dose.

How should I take pazopanib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take pazopanib on an empty stomach, at least 1 hour before or 2 hours after a meal.

Swallow the tablet whole and do not crush, chew, or break it.

Pazopanib can cause severe or life-threatening infections, liver problems, or high blood pressure. You will need frequent medical tests.

If you need surgery, tell the surgeon ahead of time that you are using pazopanib. You may need to stop using the medicine for at least 7 days before your surgery.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking pazopanib?

Grapefruit may interact with pazopanib and lead to unwanted side effects. Avoid the use of grapefruit products.

Ask your doctor before using an antacid. Do not take an antacid within several hours before or after taking pazopanib. Avoid taking stomach acid reducers (Axid, Nexium, Pepcid, Prevacid, Prilosec, Protonix, Tagamet, Zantac, Zegerid) while taking pazopanib.

Pazopanib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor or get emergency medical help if you have signs of dangerously high blood pressure: severe chest pain, severe headache, blurred vision, pounding in your neck or ears, anxiety, shortness of breath, or feeling like you might pass out.

Call your doctor at once if you have:

  • headache, confusion, change in mental status, vision changes, seizure;

  • sudden chest pain, wheezing, dry cough;

  • unusual bleeding or bruising;

  • any wound or surgical incision that will not heal;

  • fast or pounding heartbeats, fluttering in your chest, and sudden dizziness (like you might pass out);

  • heart problems--swelling, rapid weight gain, feeling short of breath;

  • liver problems--nausea, vomiting, upper stomach pain, loss of appetite, tiredness, dark urine, or jaundice (yellowing of the skin or eyes).

  • signs of infection--fever, runny nose, sore throat, body aches, skin sores, pain or burning when you urinate;

  • signs of stomach bleeding--stomach pain or swelling, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • signs of a stroke or blood clot--sudden numbness or weakness, severe headache, slurred speech, vision problems, chest pain, sudden shortness of breath, pain or cold feeling in an arm or leg; or

  • signs of tumor cell breakdown--tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.

Liver problems may be more likely in adults older than 65.

Common side effects may include:

  • nausea, vomiting, diarrhea, stomach pain;

  • loss of appetite, weight loss;

  • trouble breathing;

  • tumor pain, bone pain, muscle pain;

  • headache, feeling tired;

  • changes in hair or skin color; or

  • changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pazopanib dosing information

Usual Adult Dose for Renal Cell Carcinoma:

800 mg orally once a day without food, at least 1 hour before or 2 hours after a meal

Comments:
-Limitation of Use: The efficacy of the drug for adipocytic soft tissue sarcoma or gastrointestinal stromal tumors has not been demonstrated.
-Dose should not exceed 800 mg.
-Swallow tablets whole with water; do not break or crush due to potential for increased rate of absorption which may affect systemic exposure.
-Do not take missed dose if less than 12 hours until the next dose.
-Avoid grapefruit or grapefruit juice as it may increase plasma concentration of the drug.
-There is no specific antidote for overdosage of the drug. Treatment should consist of general supportive measures.

Uses: Advanced renal cell carcinoma (RCC), advanced soft tissue sarcoma (STS) with prior chemotherapy

Usual Adult Dose for Soft Tissue Sarcoma:

800 mg orally once a day without food, at least 1 hour before or 2 hours after a meal

Comments:
-Limitation of Use: The efficacy of the drug for adipocytic soft tissue sarcoma or gastrointestinal stromal tumors has not been demonstrated.
-Dose should not exceed 800 mg.
-Swallow tablets whole with water; do not break or crush due to potential for increased rate of absorption which may affect systemic exposure.
-Do not take missed dose if less than 12 hours until the next dose.
-Avoid grapefruit or grapefruit juice as it may increase plasma concentration of the drug.
-There is no specific antidote for overdosage of the drug. Treatment should consist of general supportive measures.

Uses: Advanced renal cell carcinoma (RCC), advanced soft tissue sarcoma (STS) with prior chemotherapy

What other drugs will affect pazopanib?

Tell your doctor about all your other medicines, especially:

  • an antibiotic;

  • an antidepressant;

  • cholesterol medicine that contains simvastatin (Zocor, Vytorin, Juvisync, Simcor);

  • heart rhythm medication;

  • HIV or AIDS medications; or

  • stomach acid reducers such as Nexium, Prilosec, Tagamet, and others.

This list is not complete. Other drugs may affect pazopanib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.