Comparing Methotrexate vs Pembrolizumab
| Methotrexate | Pembrolizumab |
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| Methotrexate | Pembrolizumab |
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Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prescribed for Endometrial Cancer, Breast Cancer, Cervical Cancer, Colorectal Cancer, Biliary Tract Tumor, Esophageal Carcinoma, Gastric Cancer, Head and Neck Cancer, Hepatocellular Carcinoma... View more |
Related suggestions Breast Cancer
Colorectal Cancer
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| More about Methotrexate | More about Pembrolizumab | ||||||||
| Generic Status | |||||||||
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No lower-cost generic available |
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| Ratings & Reviews | |||||||||
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Methotrexate has an average rating of 6.6 out of 10 from a total of 328 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 23% reported a negative effect. |
Pembrolizumab has an average rating of 4.2 out of 10 from a total of 213 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 59% reported a negative effect. |
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| Drug Class | |||||||||
| Side Effects | |||||||||
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See also: methotrexate side effects in more detail. |
See also: pembrolizumab side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||
View all methotrexate prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Form(s) Available | |||||||||
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N/A |
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| Brand Names | |||||||||
| Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | Keytruda | ||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
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15 hours |
624 hours |
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| CSA Schedule ** View glossary of terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 680 drugs are known to interact with methotrexate:
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A total of 19 drugs are known to interact with pembrolizumab:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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December 07, 1953 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.