Skip to main content
Print

Klonopin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Klonopin Onfi Epidiolex
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Klonopin (clonazepam) Onfi (clobazam) Epidiolex (cannabidiol)
Prescription only

Klonopin may be used in the treatment of panic disorder and certain types of seizure disorder. Sedation is the most common side effect and it can cause both physical and psychological dependence... View more

Prescription only

Prescribed for Lennox-Gastaut Syndrome. Onfi may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Lennox-Gastaut Syndrome, Dravet Syndrome, Tuberous Sclerosis Complex. Epidiolex may also be used for purposes not listed in this medication guide.

More about Klonopin (clonazepam) More about Onfi (clobazam) More about Epidiolex (cannabidiol)
Generic Status

Lower-cost generic is available

Lower-cost generic is available

No lower-cost generic available
Ratings & Reviews

Klonopin has an average rating of 8.5 out of 10 from a total of 743 ratings on Drugs.com. 83% of reviewers reported a positive effect, while 10% reported a negative effect.

Onfi has an average rating of 5.7 out of 10 from a total of 12 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 33% reported a negative effect.

Epidiolex has an average rating of 3.7 out of 10 from a total of 3 ratings on Drugs.com. 0% of reviewers reported a positive effect, while 67% reported a negative effect.

View all 743 reviews

View all 12 reviews

View all 3 reviews

Drug Class
Side Effects

See also: Klonopin side effects in more detail.

See also: Onfi side effects in more detail.

See also: Epidiolex side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 100 tablet
Dosage 0.5 mg
Per Unit* $2.78
Cost* $278.23

View all Klonopin prices and generic prices

Quantity 100 tablet
Dosage 10 mg
Per Unit* $29.03
Cost* $2,903.16

View all Onfi prices and generic prices

Quantity 60 mL
Dosage 100 mg/mL
Per Unit* $16.69
Cost* $1,001.43

View all Epidiolex prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Oral tablet
  • Oral suspension
  • Oral tablet
  • Oral liquid
Brand Names

N/A

 Other clobazam brands include: Sympazan

N/A
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

40 hours

82 hours

61 hours
CSA Schedule ** View glossary of terms
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 515 drugs are known to interact with Klonopin:

  • 29 major drug interactions (153 brand and generic names)
  • 454 moderate drug interactions (1668 brand and generic names)
  • 32 minor drug interactions (208 brand and generic names)

A total of 508 drugs are known to interact with Onfi:

  • 32 major drug interactions (163 brand and generic names)
  • 442 moderate drug interactions (1704 brand and generic names)
  • 34 minor drug interactions (220 brand and generic names)

A total of 585 drugs are known to interact with Epidiolex:

  • 15 major drug interactions (68 brand and generic names)
  • 517 moderate drug interactions (2268 brand and generic names)
  • 53 minor drug interactions (177 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Using clonazePAM together with alcohol can increase nervous system side effects such as dizziness... View more
  • Alcohol can increase the nervous system side effects of cloBAZam such as dizziness, drowsiness, and... View more
  • Food may affect the absorption and blood levels of cannabidiol. To avoid significant fluctuations... View more
  • Using cannabidiol together with alcohol may increase side effects such as dizziness, drowsiness... View more
Disease Interactions
First Approval Date

June 04, 1975

October 21, 2011

June 25, 2018
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Compare Drugs

To view a report comparing 3 (or more) medications, please sign in or create an account.

Create an account Sign In