Comparing Hydroxyzine vs Trazodone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Hydroxyzine	Trazodone	Enter another drug to compare

Hydroxyzine

Trazodone

Prescription only

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

Prescription only

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

More about Hydroxyzine

More about Trazodone

Ratings & Reviews

Hydroxyzine has an average rating of 5.9 out of 10 from a total of 1408 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 35% reported a negative effect.

Trazodone has an average rating of 6.3 out of 10 from a total of 1438 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect.

View all 1408 reviews

View all 1438 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (21.9%)
Tiredness (10.5%)
Sleepy (6.3%)
Anxiety (5.6%)
Nausea (3.8%)
Dizziness (3.7%)
Dry mouth (3.1%)

View all Hydroxyzine side effects

Drowsiness (17.7%)
Headaches (9.5%)
Dizziness (8.6%)
Anxiety (5.9%)
Dry mouth (5.8%)
Tiredness (4.9%)
Insomnia (4.6%)

View all Trazodone side effects

Drug Class

Phenylpiperazine antidepressants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	4 tablet
Strength	hydrochloride 25 mg
Per unit^*	$2.74
Cost^*	$10.95

View all Hydroxyzine prices

Quantity	100 each
Strength	50 mg
Per unit^*	$0.20 - $0.21
Cost^*	$20.37 - $20.92

View all Trazodone prices

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Dosage Forms

Intramuscular solution
Oral capsule
Oral syrup
Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

7 hours

7.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 581 drugs are known to interact with Hydroxyzine:

93 major drug interactions (368 brand and generic names)
484 moderate drug interactions (1992 brand and generic names)
4 minor drug interactions (16 brand and generic names)

A total of 674 drugs are known to interact with Trazodone:

138 major drug interactions (504 brand and generic names)
521 moderate drug interactions (2174 brand and generic names)
15 minor drug interactions (71 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

April 12, 1956

December 24, 1981

WADA Class View classifications

N/A

More Information

Patient Resources

Trazodone uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Hydroxyzine vs Trazodone

See also:

Lexapro

Xanax

Xolair

Cymbalta

Paroxetine

Diazepam

Lorazepam

Venlafaxine

Buspirone

Alprazolam

Further information

Comparing Hydroxyzine vs Trazodone

See also:

Further information

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