Emsam Alternatives Compared
| Emsam | Trintellix | Vraylar |
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| Emsam (selegiline) | Trintellix (vortioxetine) | Vraylar (cariprazine) |
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Prescription only
Prescribed for Depression, Major Depressive Disorder. Emsam may also be used for purposes not listed in this medication guide. |
Prescription only
Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more |
Prescription only
Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more |
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| More about Emsam (selegiline) | More about Trintellix (vortioxetine) | More about Vraylar (cariprazine) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Emsam has an average rating of 7.6 out of 10 from a total of 50 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 14% reported a negative effect. |
Trintellix has an average rating of 6.0 out of 10 from a total of 1108 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 33% reported a negative effect. |
Vraylar has an average rating of 5.8 out of 10 from a total of 483 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 36% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Emsam side effects in more detail. |
See also: Trintellix side effects in more detail. |
See also: Vraylar side effects in more detail. |
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| Generic Availability | ||||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Emsam prices |
View all Trintellix prices |
View all Vraylar prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other selegiline brands include: Atapryl, Eldepryl, Zelapar |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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84 hours |
66 hours |
504 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 515 drugs are known to interact with Emsam:
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A total of 352 drugs are known to interact with Trintellix:
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A total of 569 drugs are known to interact with Vraylar:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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February 27, 2006 |
September 30, 2013 |
September 17, 2015 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.