Comparing Diclofenac vs Lidocaine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diclofenac	Lidocaine	Enter another drug to compare

Diclofenac

Lidocaine

Prescription only

Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects compared with some other NSAIDs. Prescribed... View more

Prescription only

Lidocaine is used as a local or regional anesthetic to prevent pain signals from being transmitted to the brain during surgical, dental, and other procedures. Lidocaine antiarrhythmic is used in the... View more

More about Diclofenac

More about Lidocaine

Ratings & Reviews

Diclofenac has an average rating of 7.3 out of 10 from a total of 696 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 21% reported a negative effect.

Lidocaine has an average rating of 5.3 out of 10 from a total of 21 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 48% reported a negative effect.

View all 696 reviews

View all 21 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Upset stomach (4.9%)
Diarrhea (3.3%)
Nausea (3.3%)
Dizziness (2.9%)
Stomach pain (2.2%)
Drowsiness (2.0%)
Headaches (1.7%)

View all Diclofenac side effects

View all Lidocaine side effects

Drug Class

Nonsteroidal anti-inflammatory drugs

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	10 delayed release tablet
Strength	sodium 75 mg
Per unit^*	$1.53
Cost^*	$15.34

View all Diclofenac prices

Quantity	20 mL
Strength	1% preservative-free
Per unit^*	$0.70 - $0.78
Cost^*	$13.93 - $15.59

View all Lidocaine prices

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Dosage Forms

Oral capsule
Oral delayed release tablet
Oral powder for reconstitution
Oral tablet
Oral tablet, extended release

Injectable solution
Intravenous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1.8 hours

2 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 445 drugs are known to interact with Diclofenac:

97 major drug interactions (412 brand and generic names)
331 moderate drug interactions (1296 brand and generic names)
17 minor drug interactions (83 brand and generic names)

A total of 558 drugs are known to interact with Lidocaine:

37 major drug interactions (146 brand and generic names)
416 moderate drug interactions (2144 brand and generic names)
105 minor drug interactions (419 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using diclofenac together with alcohol. Do not drink alcohol while taking... View more

Grapefruit juice may increase the blood levels of lidocaine, which may increase the risk of side... View more

Disease Interactions

First Approval Date

July 28, 1988

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Diclofenac vs Lidocaine

See also:

Ubrelvy

Nurtec ODT

Qulipta

Taltz

Paracetamol

Tylenol

Cymbalta

Lyrica

Celebrex

Percocet

Further information

Comparing Diclofenac vs Lidocaine

See also:

Further information

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