Lidocaine Side Effects
For the Consumer
Applies to lidocaine: intradermal powder
Along with its needed effects, lidocaine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking lidocaine:More common
- Flushing or redness of the skin
- itching skin
- small red or purple spots on the skin
- unusually warm skin
- Bruising, bleeding, burning, swelling, or pain at the application site
Some side effects of lidocaine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
For Healthcare Professionals
Applies to lidocaine: compounding powder, injectable solution, intravenous solution
Adverse reactions following administration of this drug are similar in nature to those observed with other amide local anesthetic agents. The most serious adverse reactions tend to be systemic in nature. In general, these adverse reactions are dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption, or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy, or diminished tolerance on the part of the patient.[Ref]
Frequency not reported: Bradycardia, hypotension, cardiovascular collapse, cardiac arrest, circulatory collapse, hypertension, arrhythmia, maternal hypotension, shock, tachycardia, ventricular fibrillation, heart block, myocardial depression, peripheral vasodilation[Ref]
Frequency not reported: Lightheadedness, headache, dizziness, drowsiness, cold/numbness, tremor, convulsions, unconsciousness, positional headache, peripheral nerve symptoms, spinal cord deficit, paresthesia, speech slurred, arachnoiditis, peripheral nerve injury, coma, paralysis of the lower extremities, cauda equina syndrome, Horner's syndrome, hemiparesis, circumoral paresthesia, nystagmus[Ref]
Frequency not reported: Vomiting, nausea, bowel control loss, swallowing difficult, numbness of tongue[Ref]
Frequency not reported: Nervousness, apprehension, euphoria, confusion, agitation, disorientation, psychosis, restlessness, excitement[Ref]
Frequency not reported: Methemoglobinemia[Ref]
Frequency not reported: Persistent anesthesia[Ref]
Frequency not reported: Blurred/doubled vision, diplopia, transient amaurosis, bilateral amaurosis[Ref]
1. Cerner Multum, Inc. "Australian Product Information." O 0
2. "Product Information. Lidocaine Hydrochloride, Injectable (lidocaine)." Hospira Inc, Lake Forest, IL.
3. "Product Information. Xylocaine (lidocaine)." Astra USA, Westborough, MA.
4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
5. MHRA. Medicines and Health Regulatory Agency "MHRA Drug Safety Update. Available from: URL: http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate."
Some side effects of lidocaine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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- Drug class: group I antiarrhythmics
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- Lidocaine Intradermal (Advanced Reading)
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