Skip to Content

Lidocaine Side Effects

For the Consumer

Applies to lidocaine: intradermal powder

In addition to its needed effects, some unwanted effects may be caused by lidocaine. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking lidocaine, check with your doctor or nurse immediately:

More common:
  • Flushing or redness of the skin
  • itching skin
  • small red or purple spots on the skin
  • unusually warm skin
Less common:
  • Bruising, bleeding, burning, swelling, or pain at the application site

Minor Side Effects

Some of the side effects that can occur with lidocaine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Nausea
  • vomiting

For Healthcare Professionals

Applies to lidocaine: compounding powder, injectable solution, intravenous solution

General

Adverse reactions following administration of this drug are similar in nature to those observed with other amide local anesthetic agents. The most serious adverse reactions tend to be systemic in nature. In general, these adverse reactions are dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption, or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy, or diminished tolerance on the part of the patient.[Ref]

Cardiovascular

Frequency not reported: Bradycardia, hypotension, cardiovascular collapse, cardiac arrest, circulatory collapse, hypertension, arrhythmia, maternal hypotension, shock, tachycardia, ventricular fibrillation, heart block, myocardial depression, peripheral vasodilation[Ref]

Nervous system

Frequency not reported: Lightheadedness, headache, dizziness, drowsiness, cold/numbness, tremor, convulsions, unconsciousness, positional headache, peripheral nerve symptoms, spinal cord deficit, paresthesia, speech slurred, arachnoiditis, peripheral nerve injury, coma, paralysis of the lower extremities, cauda equina syndrome, Horner's syndrome, hemiparesis, circumoral paresthesia, nystagmus[Ref]

Gastrointestinal

Frequency not reported: Vomiting, nausea, bowel control loss, swallowing difficult, numbness of tongue[Ref]

Psychiatric

Frequency not reported: Nervousness, apprehension, euphoria, confusion, agitation, disorientation, psychosis, restlessness, excitement[Ref]

Hematologic

Frequency not reported: Methemoglobinemia[Ref]

Dermatologic

Frequency not reported: Urticaria, cutaneous lesion, dermatitis, rash, angioedema, face edema[Ref]

Genitourinary

Frequency not reported: Bladder control loss, sexual function loss, perineal sensation loss, urinary retention[Ref]

Immunologic

Frequency not reported: Allergic reaction, anaphylaxis/anaphylactoid reaction[Ref]

Local

Frequency not reported: Persistent anesthesia[Ref]

Metabolic

Frequency not reported: Hypoglycemia[Ref]

Musculoskeletal

Frequency not reported: Twitching, backache, leg pain, buttock pain[Ref]

Ocular

Frequency not reported: Blurred/doubled vision, diplopia, transient amaurosis, bilateral amaurosis[Ref]

Other

Frequency not reported: Tinnitus, feeling hot, edema, shiver, total spinal block, hyperacusis, weakness, sphincter control loss[Ref]

Respiratory

Frequency not reported: Respiratory depression, respiratory arrest, dyspnea, bronchospasm, hypoventilation, apnea, respiratory inadequacy, respiratory failure, yawning[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Lidocaine Hydrochloride, Injectable (lidocaine)." Hospira Inc, Lake Forest, IL.

3. "Product Information. Xylocaine (lidocaine)." Astra USA, Westborough, MA.

4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

5. MHRA. Medicines and Health Regulatory Agency "MHRA Drug Safety Update. Available from: URL: http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate."

Not all side effects for lidocaine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide