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Lidocaine Patient Tips

Medically reviewed on Dec 13, 2017 by C. Fookes, BPharm.

How it works

  • Lidocaine may be used as a local anesthetic or in the treatment of arrhythmias.
  • Lidocaine works by blocking the influx of sodium ions into the membrane surrounding nerves. This prevents the initiation and conduction of impulses along the nerve, which results in an anesthetic effect.
  • Lidocaine belongs to the class of medicines known as class-1b antiarrhythmic drugs. It may also be called an anesthetic.


  • Lidocaine prevents the transmission of pain impulses and is used as a local anesthetic to numb specific areas of the body before minor surgical, dental, or other procedures. The effect of lidocaine is almost immediate.
  • May be combined with epinephrine which increases the intensity and duration of the anesthetic effect and constricts the blood vessels, reducing bleeding.
  • Lidocaine may also be used to produce regional anesthesia (a loss of sensation in a specific region of the body; for example, an arm or a leg or the entire pelvic region).
  • Lidocaine antiarrhythmic may be used in the emergency treatment of cardiac arrest, ventricular arrhythmias or other severe heart conditions.


If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Skin redness, itching, a rash, or a feeling of warmth may occur in the region where lidocaine has been administered subcutaneously when used for local anesthesia. Bruising, bleeding, swelling and pain at the injection site are less common.
  • Side effects may be more severe with lidocaine antiarrhythmic and include lightheadedness, drowsiness, nausea or vomiting, slow heartbeat, and low blood pressure. Drowsiness is usually a reflection of high blood levels of lidocaine.
  • Local anesthetics injected into the head or neck area may produce side effects similar to systemic toxicity including confusion, convulsions, and respiratory depression.
  • IM lidocaine may increase creatine phosphokinase levels which may compromise tests for this enzyme following an acute myocardial infarction.
  • May not be suitable for some people including those with respiratory disease, cardiovascular disease, liver or kidney disease, low blood pressure, epilepsy, myasthenia gravis or congestive heart failure.
  • May interact with some medications including beta-blockers, cimetidine, antiarrhythmics, and HIV agents.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Lidocaine is used as a local or regional anesthetic to prevent pain signals from being transmitted to the brain during surgical, dental, and other procedures. Lidocaine antiarrhythmic is used in the emergency treatment of certain heart conditions.


  • When administered as a local or regional anesthetic, lidocaine is effective almost immediately. Duration of effect is approximately 60 to 90 minutes.
  • When used for local or regional anesthesia, a temporary loss of sensation and a restriction in the ability to move the affected body area may occur.

Response and Effectiveness

  • Higher dosages or volumes of lidocaine will result in a shorter time to the onset of anesthesia, a longer duration of effect, a greater degree of muscle relaxation, and an increase in the spread of the anesthesia.
  • The duration of action of lidocaine may be prolonged in people with liver disease.


  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use lidocaine only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of this information. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Revision Date: 2017-12-13 01:37:33