Canagliflozin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Canagliflozin	Ozempic (semaglutide)	Metformin	Enter another drug to compare

Canagliflozin

Ozempic (semaglutide)

Metformin

Prescription only

Prescribed for Diabetic Kidney Disease, Cardiovascular Risk Reduction, Type 2 Diabetes. Canagliflozin may also be used for purposes not listed in this medication guide.

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

Prescription only

Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more

More about Canagliflozin

More about Ozempic (semaglutide)

More about Metformin

Ratings & Reviews

Canagliflozin has an average rating of 5.8 out of 10 from a total of 265 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 35% reported a negative effect.

Ozempic has an average rating of 6.7 out of 10 from a total of 1563 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 23% reported a negative effect.

Metformin has an average rating of 6.8 out of 10 from a total of 656 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 265 reviews

View all 1563 reviews

View all 656 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Yeast infection (29.8%)
Hair loss (9.4%)
Thirst (8.7%)
Frequent urination (7.9%)
Itching (6.4%)
Tiredness (6.0%)
Weight loss (4.5%)

View all Canagliflozin side effects

Nausea (33.3%)
Diarrhea (16.3%)
Constipation (15.7%)
Vomiting (12.3%)
Burping (8.7%)
Upset stomach (7.5%)
Headaches (7.4%)

View all Ozempic side effects

Diarrhea (25.6%)
Nausea (15.4%)
Upset stomach (9.8%)
Stomach pain (4.7%)
Gas (4.6%)
Headaches (4.4%)
Cramps (3.7%)

View all Metformin side effects

Drug Class

SGLT-2 inhibitors

GLP-1 Agonists (Incretin Mimetics)

Non-sulfonylureas

Generic Availability

N/A

No lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity	1.5 mL
Strength	2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per unit^*	$716.63
Cost^*	$1,074.94

View all Ozempic prices

Quantity	100 each
Strength	500 mg
Per unit^*	$0.15 - $0.24
Cost^*	$15.37 - $24.08

View all Metformin prices

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Dosage Forms

N/A

Subcutaneous solution

Oral solution
Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

13.1 hours

168 hours

4.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 391 drugs are known to interact with Canagliflozin:

4 major drug interactions (43 brand and generic names)
386 moderate drug interactions (1858 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 274 drugs are known to interact with Ozempic:

15 major drug interactions (34 brand and generic names)
258 moderate drug interactions (1455 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 378 drugs are known to interact with Metformin:

24 major drug interactions (129 brand and generic names)
345 moderate drug interactions (1799 brand and generic names)
9 minor drug interactions (35 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

Disease Interactions

First Approval Date

March 29, 2013

N/A

March 03, 1995

WADA Class View classifications

N/A

More Information

Patient Resources

Ozempic uses

Metformin uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Canagliflozin Alternatives Compared

See also:

Cozaar

Avapro

Ozempic

Accupril

Vasotec

Perindopril

Benazepril

Irbesartan

Captopril

Ramipril

Further information

Canagliflozin Alternatives Compared

See also:

Further information

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