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SGLT-2 inhibitors

Other names: gliflozins, sodium-glucose cotransporter-2 inhibitors

What are SGLT-2 inhibitors

SGLT-2 inhibitor is an abbreviation for sodium-glucose cotransporter-2 inhibitors. SGLT-2 inhibitors are a class of medicine used to lower high blood glucose levels in people with type 2 diabetes. They may also be called gliflozins. Available agents are canagliflozin, dapagliflozin, and empagliflozin.

SGLT-2 inhibitors inhibit SGLT-2 proteins located in the renal tubules of the kidneys which are responsible for reabsorbing glucose back into the blood. As a result, more glucose is excreted in the urine. SGLT-2 inhibitors have been shown to be effective at lowering hemoglobin A1c levels, improving weight loss and lowering blood pressure. They carry a low risk of hypoglycemia (low blood sugar levels). They are usually well tolerated.

SGLT-2 inhibitors may be used in the treatment of type 2 diabetes and act independently of beta-cell function in the pancreas.

List of SGLT-2 inhibitors:

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Drug NameView by: Brand | Generic Reviews Avg. Ratings
Jardiance (Pro, More...)
generic name: empagliflozin
56 reviews
Invokana (Pro, More...)
generic name: canagliflozin
211 reviews
Farxiga (Pro, More...)
generic name: dapagliflozin
57 reviews

See also...

Medical conditions associated with SGLT-2 inhibitors: