SGLT-2 inhibitors

Other names: gliflozins, sodium-glucose cotransporter-2 inhibitors

What are SGLT-2 inhibitors

SGLT-2 inhibitor is an abbreviation for sodium-glucose cotransporter-2 inhibitors. SGLT-2 inhibitors are a class of medicine used to lower high blood glucose levels in people with type 2 diabetes. They may also be called gliflozins. Available agents are canagliflozin, dapagliflozin, and empagliflozin.

SGLT-2 inhibitors inhibit SGLT-2 proteins located in the renal tubules of the kidneys which are responsible for reabsorbing glucose back into the blood. As a result, more glucose is excreted in the urine. SGLT-2 inhibitors have been shown to be effective at lowering hemoglobin A1c levels, improving weight loss and lowering blood pressure. They carry a low risk of hypoglycemia (low blood sugar levels). They are usually well tolerated.

SGLT-2 inhibitors may be used in the treatment of type 2 diabetes and act independently of beta-cell function in the pancreas.

List of SGLT-2 inhibitors:

Drug Name ( View by: Brand | Generic )	Reviews	Ratings
Invokana (Pro, More...) generic name: canagliflozin	194 reviews		6.5
Jardiance (Pro, More...) generic name: empagliflozin	44 reviews		6.5
Farxiga (Pro, More...) generic name: dapagliflozin	53 reviews		5.2