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SGLT-2 inhibitors

Medically reviewed by Carmen Pope, BPharm. Last updated on May 30, 2023.

Other names: sodium-glucose cotransporter-2 inhibitors

What are SGLT-2 inhibitors?

SGLT-2 inhibitor is an abbreviation for sodium-glucose cotransporter-2 inhibitors. SGLT-2 inhibitors are a class of medicine used to lower high blood glucose levels in people with type 2 diabetes. They may also be called gliflozins.

SGLT-2 inhibitors inhibit SGLT-2 proteins located in the renal tubules of the kidneys which are responsible for reabsorbing glucose back into the blood. As a result, more glucose is excreted in the urine. SGLT-2 inhibitors have been shown to be effective at lowering hemoglobin A1c levels, improving weight loss and lowering blood pressure. They carry a low risk of hypoglycemia (low blood sugar levels).

They are usually well tolerated. SGLT-2 inhibitors may be used in the treatment of type 2 diabetes and act independently of beta-cell function in the pancreas.

List of SGLT-2 inhibitors

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Jardiance (Pro)
Generic name: empagliflozin
5.3
 302 reviews
Invokana (Pro)
Generic name: canagliflozin
6.0
 257 reviews
Farxiga (Pro)
Generic name: dapagliflozin
4.6
 146 reviews
Steglatro (Pro)
Generic name: ertugliflozin
6.0
 11 reviews
Brenzavvy
Generic name: bexagliflozin 		No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions associated with SGLT-2 inhibitors:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer