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Generic name: bexagliflozin
Dosage form: tablets
Drug class: SGLT-2 inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 23, 2023.

What is Brenzavvy?

Brenzavvy is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

Brenzavvy belongs to the class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by reducing renal reabsorption of filtered glucose and lowering the renal threshold for glucose, thereby increasing urinary glucose excretion.

What is Brenzavvy used to treat?

Brenzavvy is used to treat type 2 diabetes.

Type 2 diabetes is a chronic disease characterized by high levels of sugar in the blood. It occurs when the body's cells resist the normal effect of insulin (a hormone produced by the pancreas), which is to drive glucose in the blood into the inside of the cells.

In people with insulin resistance, the pancreas responds to rising blood glucose levels by making extra insulin to maintain normal blood sugar levels. As the pancreas makes more and more insulin over time, it eventually cannot meet the demand, and blood glucose levels become elevated.

Brenzavvy works treat type 2 diabetes by lowering blood glucose levels.

Brenzavvy is not for people with type 1 diabetes. It may increase the risk of diabetic ketoacidosis in these people.

It is not known if Brenzavvy is safe and effective in children under 18 years of age.

Important information

Brenzavvy can cause serious side effects, including:

If you get any of these symptoms during treatment, if possible, check for ketones in your urine, even if your blood sugar is less than 250 mg/dL.

Call your healthcare provider right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot. Your healthcare provider may decide to stop your treatment for a while if you have these signs or symptoms. Talk to your healthcare provider about proper foot care.

Talk to your healthcare provider about what you can do to prevent dehydration including how much fluid you should drink on a daily basis.
Talk to your healthcare provider right away if you reduce the amount of food or liquid you drink, for example if you are sick or cannot eat, or start to lose liquids from your body, for example from vomiting or diarrhea.

Talk to your healthcare provider about what to do if you get symptoms of a yeast infection of the vagina or penis.
Your healthcare provider may suggest you use an over-the-counter antifungal medicine. Talk to your healthcare provider as soon as possible if you use an over-the counter antifungal medication and your symptoms do not go away.

Who should not take Brenzavvy?

You should not take Brenzavvy if you:

Before you take Brenzavvy

Before you take Brenzavvy, tell your healthcare provider about all of your medical conditions, including if you:

What other drugs will affect Brenzavvy?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Brenzavvy may affect the way other medicines work, and other medicines may affect how Brenzavvy works.

How should I take Brenzavvy?

Dosing information

Usual Adult Dose for Type 2 Diabetes

20 mg once daily, taken in the morning.

Use: adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Brenzavvy side effects

Brenzavvy may cause serious side effects, including:

The most common side effects include:

These are not all the possible side effect. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Brenzavvy?

Store Brenzavvy at room temperature between 68 °F to 77 °F (20 °C to 25 °C).

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Brenzavvy.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Brenzavvy?

Active ingredient: bexagliflozin
Inactive ingredients: colloidal silicon dioxide, glyceryl dibehenate, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene oxide, and poloxamer 188.
In addition, the film coating ingredient, Opadry II Blue 85F99153, contains the inactive ingredients FD&C Blue #1/Brilliant Blue FCF and FD&C Blue #2/Indigo Carmine, macrogol 3350, polyvinyl alcohol, talc, and titanium dioxide

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.