Brenzavvy Side Effects
Generic name: bexagliflozin
Medically reviewed by Drugs.com. Last updated on Jan 25, 2025.
Note: This document provides detailed information about Brenzavvy.
Applies to bexagliflozin: oral tablet Side Effects associated with bexagliflozin. Some dosage forms listed on this page may not apply specifically to the brand name Brenzavvy.
Applies to bexagliflozin: oral tablet.
Precautions
It is very important that your doctor check your progress at regular visits, especially during the first few weeks that you take this medicine. Blood and urine tests may be needed to check for unwanted effects.
Using this medicine during the second and later part of a pregnancy can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away.
Dizziness, lightheadedness, or fainting may occur with this medicine. This is more common if you have kidney disease, low blood pressure, or if you are taking a diuretic (water pill). Drinking plenty of fluids each day may help. Drink plenty of water during exercise or in hot weather. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This may cause you to lose too much water.
Diabetic ketoacidosis (high ketones and acid in the blood) may occur while you are using this medicine. This can be life-threatening and requires immediate medical attention. Your doctor may give you insulin, fluid, and carbohydrate replacement to treat this condition. Tell your doctor right away if you have nausea, vomiting, trouble breathing, increased thirst or urination.
Check with your doctor right away if you have bloody urine, decrease in how much or how often you urinate, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.
This medicine may increase your risk of having urinary tract infections, including pyelonephritis or urosepsis. Check with your doctor right away if you have bladder pain, bloody or cloudy urine, difficult, burning, or painful urination, or lower back or side pain.
This medicine may increase your risk of having lower leg or toe amputation (leg removal surgery). Check with your doctor right away if you have pain, tenderness, sores or ulcers, or infections on your leg or foot.
This medicine may cause hypoglycemia (low blood sugar). This is more common when this medicine is taken together with other diabetes medicines (eg, insulin, glipizide, or glyburide). Low blood sugar must be treated before it causes you to pass out (unconsciousness). People feel different symptoms of low blood sugar. It is important that you learn which symptoms you usually have so you can treat it quickly. Some symptoms of low blood sugar include: behavior changes that are similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty with thinking, drowsiness, excessive hunger, a fast heartbeat, headaches that continue, nausea, shakiness, slurred speech, or unusual tiredness or weakness. Talk to your doctor about how to treat low blood sugar.
Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your diabetes medicine, overeat or do not follow your diet plan, have a fever or infection, or do not exercise as much as usual. Some symptoms of high blood sugar include blurred vision, drowsiness, dry mouth, flushed and dry skin, a fruit-like breath odor, increased frequency and amount of urination, ketones in the urine, loss of appetite, nausea or vomiting, rapid and deep breathing, tiredness, or unusual thirst. If symptoms of high blood sugar occur, check your blood sugar level and call your doctor for instructions.
This medicine may cause vaginal yeast infections in women and yeast infections of the penis in men. This is more common in patients who have a history of genital yeast infections or in men who are not circumcised. Women may have a vaginal discharge, itching, or odor. Men may have redness, itching, swelling, or pain around the penis, or a discharge with a strong odor from the penis. Check with your doctor right away if you have any of these symptoms.
This medicine may cause a rare but serious bacterial infection, called necrotizing fasciitis of the perineum or Fournier's gangrene, which can cause damage to the tissue under the skin in the area between and around the anus and genitals (perineum). Fournier's gangrene may lead to hospitalization, multiple surgeries, or death. Check with your doctor right away if you have fever, unusual tiredness or weakness, or pain, tenderness, redness, or swelling of the area between and around your anus and genitals.
Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine 3 days before you have surgery or other procedures that require fasting. This medicine may also affect the results of certain medical tests (eg, urine glucose tests may not be accurate).
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Brenzavvy
Along with its needed effects, bexagliflozin (the active ingredient contained in Brenzavvy) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking bexagliflozin:
More common side effects
- bladder pain
- bloody or cloudy urine
- difficult, burning, or painful urination
- frequent urination
- increased urge to urinate during the night
- increased volume of pale, dilute urine
- itching of the vagina or genitals
- lower back or side pain
- thick, white vaginal discharge with mild or no odor
- trouble in holding or releasing urine
- walking to urinate at night
Less common side effects
- anxiety
- blurred vision
- chills
- cold sweats
- coma
- confusion
- cool, pale skin
- depression
- dizziness, faintness, or lightheadedness when getting up suddenly from lying or sitting position
- dry mouth
- fast heartbeat
- feeling of constant movement of self or surroundings
- foul smelling discharge from the penis
- headache
- increase in heart rate
- increased hunger
- itching in genital or other skin areas
- nausea
- nervousness
- nightmares
- pain in the skin around the penis
- rapid breathing
- rash of the penis
- redness, itching, or swelling of the penis
- scaling
- seizures
- sensation of spinning
- shakiness
- slurred speech
- sunken eyes
- thirst
- unusual tiredness or weakness
- wrinkled skin
Incidence not known
- agitation
- flushed, dry skin
- fruit-like breath odor
- hostility
- irritability
- lethargy
- loss of consciousness
- muscle twitching
- pain, tenderness, redness, or swelling of the area between the anus and genitals
- stomach pain
- stupor
- sweating
- swelling of the face, ankles, or hands
- trouble breathing
- unexplained weight loss
- vomiting
Other side effects of Brenzavvy
Some side effects of bexagliflozin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- blistering, crusting, irritation, itching, or reddening of the skin
- cracked, dry, or scaly skin
For healthcare professionals
Applies to bexagliflozin: oral tablet.
General adverse events
Most common adverse reactions with an incidence of 5% or greater were female genital mycotic infection, urinary tract infection and increased urination.[Ref]
Dermatologic
- Common (1% to 10%): Rash and dermatitis[Ref]
Gastrointestinal
- Common (1% to 10%): Thirst[Ref]
Genitourinary
- Common (1% to 10%): Female genital mycotic infection, male genital mycotic infection, vaginal pruritus[Ref]
Metabolic
- Common (1% to 10%): Hypoglycemia, volume depletion[Ref]
Other
- Common (1% to 10%): Amputation, sepsis[Ref]
Renal
- Common (1% to 10%): Increased urination, urinary tract infection[Ref]
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References
1. (2023) "Product Information. Brenzavvy (bexagliflozin)." TheracosBio, LLC
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Brenzavvy side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.