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Farxiga

Generic name: dapagliflozin (DAP a gli FLOE zin)
Brand name: Farxiga
Drug class: SGLT-2 inhibitors

Medically reviewed by Sanjai Sinha, MD. Last updated on Aug 6, 2021.

What is Farxiga?

Farxiga (dapagliflozin) is an oral diabetes medicine that helps control blood sugar levels. Dapagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

Farxiga is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Farxiga is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.

Farxiga is also used to lower the risk of needing to be in the hospital for heart failure in adults with type 2 diabetes who also have heart disease.

Farxiga is also used to lower the risk of further worsening of kidney disease, end-stage kidney disease (ESKD), death due to cardiovascular disease, and hospitalization for heart failure in adults with chronic kidney disease.

Warnings

You should not use Farxiga if you have diabetic ketoacidosis, severe kidney disease, or if you are on dialysis.

Taking Farxiga can make you dehydrated, which could cause you to feel weak or dizzy (especially when you stand up).

Farxiga can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

Some people taking this medicine have had bladder cancer, but it is not clear if dapagliflozin was the actual cause.

Before taking this medicine

You should not use Farxiga if you are allergic to dapagliflozin, or if you have:

  • severe kidney disease (or if you are on dialysis); or

  • diabetic ketoacidosis (call your doctor for treatment).

To make sure Farxiga is safe for you, tell your doctor if you have:

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

You should not use dapagliflozin during the second or third trimester of pregnancy.

You should not breastfeed while using this medicine.

Farxiga is not approved for use by anyone younger than 18 years old.

How should I take Farxiga?

Take Farxiga exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may take Farxiga with or without food.

You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea, or if you eat or drink less than usual.

Low blood sugar (hypoglycemia) can make you feel very hungry, dizzy, irritable, or shaky. To quickly treat hypoglycemia, eat or drink hard candy, crackers, raisins, fruit juice, or non-diet soda. Your doctor may prescribe glucagon injection in case of severe hypoglycemia.

Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.

Tell your doctor if you have frequent symptoms of high blood sugar (hyperglycemia) such as increased thirst or urination. Ask your doctor before changing your dose or medication schedule.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Farxiga.

Your treatment may also include diet, exercise, weight control, and special medical care.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Farxiga?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Farxiga side effects

Get emergency medical help if you have signs of an allergic reaction to Farxiga: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Call your doctor at once if you have:

  • little or no urination;

  • dehydration symptoms - dizziness, weakness, feeling light-headed (like you might pass out);

  • kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

  • ketoacidosis (too much acid in the blood) - nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or

  • signs of a bladder infection - pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back.

Side effects may be more likely to occur in older adults.

Common Farxiga side effects may include:

  • genital yeast infection;

  • urinating more than usual; or

  • sore throat and runny or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Farxiga?

Tell your doctor about all your other medicines, especially:

  • insulin or other oral diabetes medicines; or

  • a diuretic or "water pill."

This list is not complete. Other drugs may interact with dapagliflozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Farxiga (dapagliflozin) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is used for the treatment of type 2 diabetes, heart failure and chronic kidney disease (CKD). It starts working after just one dose, but it may take a week for Farxiga to take full effect. Continue reading

Farxiga may lead to modest weight loss, even though it's not a weight loss drug. Clinical studies showed people taking Farxiga alone, at either 5 mg or 10 mg daily, lost about 6 pounds over 24 weeks. Continue reading

Farxiga (dapagliflozin) is used to treat certain adults with type 2 diabetes mellitus, heart failure and chronic kidney disease.

Farxiga is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It also works by reducing the increased activity of the sympathetic nervous system that contributes to the progression of heart failure and the increased intraglomerular pressure that contributes to CKD. Continue reading

Farxiga (dapagliflozin) may cause acute kidney injury. Signs to watch out for include urinating less or swelling in you legs or feet. Before starting Farxiga your doctor will determine if you are at increased risk for acute kidney injury. Continue reading

More FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Farxiga only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.