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Farxiga

Generic Name: dapagliflozin (DAP a gli FLOE zin)
Brand Names: Farxiga

Medically reviewed by Sanjai Sinha, MD. Last updated on Jun 2, 2020.

What is Farxiga?

Farxiga (dapagliflozin) is an oral diabetes medicine that helps control blood sugar levels. Dapagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

Farxiga is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Farxiga is used to lower the risk of needing to be in the hospital for heart failure in adults with type 2 diabetes who also have heart disease.

Farxiga is also used to lower the risk of needing to be in the hospital for heart failure in adults who have heart failure when the heart is weak and cannot pump enough blood to the rest of the body.

Farxiga is not for treating type 1 diabetes.

Important Information

You should not use Farxiga if you have diabetic ketoacidosis, severe kidney disease, or if you are on dialysis.

Taking Farxiga can make you dehydrated, which could cause you to feel weak or dizzy (especially when you stand up).

Farxiga can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

Some people taking this medicine have had bladder cancer, but it is not clear if dapagliflozin was the actual cause.

Before taking this medicine

You should not use Farxiga if you are allergic to dapagliflozin, or if you have:

  • severe kidney disease (or if you are on dialysis); or

  • diabetic ketoacidosis (call your doctor for treatment).

To make sure Farxiga is safe for you, tell your doctor if you have ever had:

  • liver or kidney disease;

  • bladder infections or other urination problems;

  • low blood pressure;

  • problems with your pancreas, including surgery;

  • if you are dehydrated;

  • if you drink alcohol often; or

  • if you are on a low salt diet.

Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.

You should not use Farxiga during the second or third trimester of pregnancy.

You should not breast-feed while using this medicine.

Farxiga is not approved for use by anyone younger than 18 years old.

How should I take Farxiga?

Take Farxiga exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may take Farxiga with or without food.

Call your doctor if you are sick with vomiting or diarrhea, if you consume less food or fluid than usual, or if you are sweating more than usual.

Your blood sugar will need to be checked often, and you may also need to test the level of ketones your urine. Farxiga can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have ketones in the urine.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. You may need to stop taking Farxiga for at least 3 days before a surgery. Ask your doctor before changing your dose or medication schedule.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.

Farxiga is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

Farxiga dosing information

Usual Adult Dose for Diabetes Type 2:

To improve glycemic control:
Initial dose: 5 mg orally once a day
-May increase to 10 mg orally once a day for additional glycemic control if lower dose has been tolerated
Maximum dose: 10 mg/day

To reduce the risk of hospitalization for heart failure: 10 mg orally once a day

Comments:
-Correct volume depletion prior to initiating therapy.
-If used in combination with insulin or an insulin secretagogue, a lower dose of insulin or the insulin secretagogue should be considered to reduce the risk of hypoglycemia.

Uses:
-As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.
-To reduce the risk of hospitalization for heart failure in patients with type 2 diabetes mellitus and established cardiovascular disease (CVD) or multiple cardiovascular (CV) risk factors.

Usual Adult Dose for Heart Failure with Reduced Ejection Fraction:

10 mg orally once a day

Comments:
-Correct volume depletion prior to initiating therapy.
-This drug is not recommended for patients with type 1 diabetes mellitus.

Use: To reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure (NYHA class II-IV) with reduced ejection fraction.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Farxiga?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Farxiga side effects

Get emergency medical help if you have signs of an allergic reaction to Farxiga: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Call your doctor at once if you have:

  • little or no urination;

  • dehydration symptoms - dizziness, weakness, feeling light-headed (like you might pass out);

  • kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

  • ketoacidosis (too much acid in the blood) - nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or

  • signs of a bladder infection - pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back.

Side effects may be more likely to occur in older adults.

Common Farxiga side effects include:

  • genital yeast infection;

  • urinating more than usual; or

  • sore throat and runny or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Farxiga?

Tell your doctor about all your other medicines, especially:

  • insulin or other oral diabetes medicines; or

  • a diuretic or "water pill."

This list is not complete. Other drugs may interact with dapagliflozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Farxiga only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Related questions

Farxiga may lead to modest weight loss, even though it's not a weight loss drug. Clinical studies showed people taking Farxiga alone, at either 5 mg or 10 mg daily, lost about 6 pounds over 24 weeks. Read more

Taking the drug Farxiga may lead to constipation in some people. The good news is that it doesn't seem to happen often. In studies, only around 2% of people taking Farxiga developed constipation, compared to 1.5% of people taking a placebo. Read more

Farxiga may cause acute kidney injury. Signs to watch out for include urinating less or swelling in you legs or feet. Before starting Farxiga your doctor will determine if you are at increased risk for acute kidney injury. Read more

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