Comparing Bupropion vs Lithium

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Bupropion	Lithium	Enter another drug to compare

Bupropion

Lithium

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Prescription only

Lithium may be used to treat manic episodes associated with bipolar I disorder; however, there is a fine line between too much and too little, and ongoing monitoring is needed to prevent lithium... View more

More about Bupropion

More about Lithium

Ratings & Reviews

Bupropion has an average rating of 7.0 out of 10 from a total of 2904 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect.

Lithium has an average rating of 7.3 out of 10 from a total of 493 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 20% reported a negative effect.

View all 2904 reviews

View all 493 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (16.4%)
Insomnia (11.5%)
Headaches (7.2%)
Sexual dysfunction (6.3%)
Irritability (6.2%)
Depression (5.6%)
Loss of appetite (5.6%)

View all Bupropion side effects

Tremors (13.0%)
Weight gain (10.1%)
Thirst (8.7%)
Nausea (6.3%)
Depression (5.9%)
Anxiety (5.3%)
Hair loss (3.7%)

View all Lithium side effects

Drug Class

Antimanic agents

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 each
Strength	150 mg/24 hours
Per unit^*	$1.55
Cost^*	$46.43

View all Bupropion prices

Quantity	100 each
Strength	300 mg
Per unit^*	$0.22
Cost^*	$22.35

View all Lithium prices

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Dosage Forms

Oral tablet
Oral tablet, extended release

Oral capsule
Oral syrup
Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

30 hours

29 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Drug Interactions

A total of 559 drugs are known to interact with Bupropion:

218 major drug interactions (951 brand and generic names)
336 moderate drug interactions (1874 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 723 drugs are known to interact with Lithium:

185 major drug interactions (708 brand and generic names)
501 moderate drug interactions (2103 brand and generic names)
37 minor drug interactions (261 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Alcohol can increase the nervous system side effects of lithium such as dizziness, drowsiness, and... View more

Disease Interactions

First Approval Date

December 30, 1985

April 06, 1970

WADA Class View classifications

N/A

More Information

Patient Resources

Bupropion uses

Lithium uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Bupropion vs Lithium

See also:

Vraylar

Lexapro

Rexulti

Zoloft

Abilify

Seroquel

Prozac

Cymbalta

Wellbutrin

Zyprexa

Further information

Comparing Bupropion vs Lithium

See also:

Further information

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