Comparing Bupropion vs Hydroxyzine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Bupropion	Hydroxyzine	Enter another drug to compare

Bupropion

Hydroxyzine

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Prescription only

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

More about Bupropion

More about Hydroxyzine

Ratings & Reviews

Bupropion has an average rating of 7.0 out of 10 from a total of 2903 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect.

Hydroxyzine has an average rating of 5.9 out of 10 from a total of 1406 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 35% reported a negative effect.

View all 2903 reviews

View all 1406 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (16.4%)
Insomnia (11.5%)
Headaches (7.2%)
Sexual dysfunction (6.3%)
Irritability (6.2%)
Depression (5.6%)
Loss of appetite (5.6%)

View all Bupropion side effects

Drowsiness (21.8%)
Tiredness (10.5%)
Sleepy (6.3%)
Anxiety (5.6%)
Nausea (3.8%)
Dizziness (3.7%)
Dry mouth (3.1%)

View all Hydroxyzine side effects

Drug Class

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 each
Strength	150 mg/24 hours
Per unit^*	$1.55
Cost^*	$46.43

View all Bupropion prices

Quantity	4 tablet
Strength	hydrochloride 25 mg
Per unit^*	$2.74
Cost^*	$10.95

View all Hydroxyzine prices

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Dosage Forms

Oral tablet
Oral tablet, extended release

Intramuscular solution
Oral capsule
Oral syrup
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

30 hours

7 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 559 drugs are known to interact with Bupropion:

218 major drug interactions (951 brand and generic names)
336 moderate drug interactions (1873 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 581 drugs are known to interact with Hydroxyzine:

93 major drug interactions (368 brand and generic names)
484 moderate drug interactions (1992 brand and generic names)
4 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 30, 1985

April 12, 1956

WADA Class View classifications

N/A

More Information

Patient Resources

Bupropion uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Bupropion vs Hydroxyzine

See also:

Vraylar

Lexapro

Rexulti

Abilify

Zoloft

Seroquel

Prozac

Cymbalta

Wellbutrin

Zyprexa

Further information

Comparing Bupropion vs Hydroxyzine

See also:

Further information

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