Azulfidine Alternatives Compared
| Azulfidine | Simponi | Methotrexate |
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| Azulfidine (sulfasalazine) | Simponi (golimumab) | Methotrexate |
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Prescription only
Prescribed for Juvenile Rheumatoid Arthritis, Lymphocytic Colitis, Inflammatory Bowel Disease, Rheumatoid Arthritis, Ulcerative Colitis, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance... View more |
Prescription only
Prescribed for Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis, Spondyloarthritis, Ulcerative Colitis. Simponi may also be used for purposes not listed in this medication guide. |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Related suggestions Rheumatoid Arthritis
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| More about Azulfidine (sulfasalazine) | More about Simponi (golimumab) | More about Methotrexate | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Azulfidine has an average rating of 5.3 out of 10 from a total of 3 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 33% reported a negative effect. |
Simponi has an average rating of 6.2 out of 10 from a total of 110 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 31% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 327 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 23% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Common side effects include:
See also: Azulfidine side effects in more detail. |
Common side effects include:
See also: Simponi side effects in more detail. |
Commonly reported side effects include:
See also: methotrexate side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Azulfidine prices and generic prices |
View all Simponi prices |
View all methotrexate prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other sulfasalazine brands include: Azulfidine EN-tabs | Other golimumab brands include: Simponi Aria | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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10 hours |
336 hours |
15 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 250 drugs are known to interact with Azulfidine:
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A total of 455 drugs are known to interact with Simponi:
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A total of 668 drugs are known to interact with methotrexate:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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June 20, 1950 |
April 24, 2009 |
December 07, 1953 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.