Comparing Apremilast vs Methotrexate
Apremilast | Methotrexate |
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Apremilast | Methotrexate |
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Prescription only
Apremilast is a PDE4 inhibitor that may be used to treat plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s Disease. It has been associated with severe diarrhea, nausea, a... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
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More about Apremilast | More about Methotrexate | ||||||||
Ratings & Reviews | |||||||||
Apremilast has an average rating of 5.2 out of 10 from a total of 467 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 40% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 335 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
Generic Availability | |||||||||
N/A |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Methotrexate prices |
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Dosage Forms Available | |||||||||
N/A |
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Brand Names | |||||||||
Otezla | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
9 hours |
15 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 103 drugs are known to interact with Apremilast:
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A total of 709 drugs are known to interact with Methotrexate:
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Alcohol/Food/Lifestyle Interactions | |||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||
First Approval Date | |||||||||
March 21, 2014 |
December 07, 1953 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.