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Apremilast Disease Interactions

There are 3 disease interactions with apremilast:


Apremilast (Includes Apremilast) ↔ Depression

Moderate Potential Hazard, Moderate plausibility

Applies to: Depression

Apremilast therapy has been associated with adverse reactions of depression. Therapy with apremilast should be administered cautiously in patients with a history of depression and/or suicidal thoughts or behavior. Patients, their caregivers, and families should be advised of the potential for emergence or worsening of depression, suicidal thoughts or other mood changes. The need for continued treatment with apremilast should be carefully weighed against the risks.


Apremilast (Includes Apremilast) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Increased apremilast systemic exposure has been observed in patients with severe renal impairment (CrCl < 30 mL/min). Therapy with apremilast should be administered cautiously in these patients. Initial dosage titration and maintenance dosage should be reduced in accordance with the product package labeling.


Apremilast (Includes Apremilast) ↔ Weight Loss

Moderate Potential Hazard, High plausibility

Applies to: Malnourished, Anorexia/Feeding Problems, Weight Loss/Failure to Thrive

Apremilast therapy has been associated with weight loss. During controlled clinical trials, weight reduction between 5% to 10% of body weight was reported in 10% of patients treated with apremilast compared to 3.3% of those receiving placebo. Weight change should be monitored during apremilast therapy, particularly in patients suffering from anorexia, malnutrition, or excessive weight loss. Physicians should evaluate patients for any unexplained or clinically significant weight loss, and discontinuation of apremilast should be considered if appropriate.

apremilast drug Interactions

There are 75 drug interactions with apremilast

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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