Comparing Amitriptyline vs Rizatriptan

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Amitriptyline	Rizatriptan	Enter another drug to compare

Amitriptyline

Rizatriptan

Prescription only

Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more

Prescription only

Prescribed for Migraine, Headache. Rizatriptan may also be used for purposes not listed in this medication guide.

More about Amitriptyline

More about Rizatriptan

Ratings & Reviews

Amitriptyline has an average rating of 7.6 out of 10 from a total of 1807 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect.

Rizatriptan has an average rating of 8.3 out of 10 from a total of 338 ratings on Drugs.com. 81% of reviewers reported a positive effect, while 12% reported a negative effect.

View all 1807 reviews

View all 338 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dry mouth (11.8%)
Drowsiness (11.8%)
Weight gain (8.0%)
Tiredness (5.8%)
Anxiety (4.5%)
Dizziness (4.4%)
Insomnia (4.4%)

View all Amitriptyline side effects

Drowsiness (11.8%)
Nausea (9.5%)
Tiredness (7.7%)
Dizziness (6.5%)
Sleepy (5.3%)
Pain (3.6%)
Anxiety (2.7%)

View all Rizatriptan side effects

Drug Class

Tricyclic antidepressants

Antimigraine agents

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	25 mg
Per unit^*	$0.38
Cost^*	$18.75

View all Amitriptyline prices

Quantity	12 each
Strength	10 mg
Per unit^*	$1.52 - $10.56
Cost^*	$18.19 - $126.67

View all Rizatriptan prices

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Dosage Forms

Oral tablet

Oral tablet
Oral tablet, disintegrating

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16 hours

6 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 717 drugs are known to interact with Amitriptyline:

144 major drug interactions (605 brand and generic names)
546 moderate drug interactions (2200 brand and generic names)
27 minor drug interactions (165 brand and generic names)

A total of 156 drugs are known to interact with Rizatriptan:

71 major drug interactions (292 brand and generic names)
29 moderate drug interactions (161 brand and generic names)
56 minor drug interactions (345 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using amitriptyline together with alcohol, this can alter the effects of... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

April 07, 1961

June 29, 1998

WADA Class View classifications

N/A

More Information

Patient Resources

Amitriptyline uses

Rizatriptan uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Amitriptyline vs Rizatriptan

See also:

Rexulti

Ubrelvy

Qulipta

Nurtec ODT

Paracetamol

Tylenol

Lexapro

Abilify

Zoloft

Seroquel

Further information

Comparing Amitriptyline vs Rizatriptan

See also:

Further information

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