Narcotic analgesic combinations are products that contain a narcotic analgesic with one or more other analgesics, such as acetaminophen, aspirin, or ibuprofen. They should only be used to treat moderate-to-severe pain when other less potent analgesics are not effective.
Narcotic analgesics (also called opiates, opioid analgesics, or narcotics) relieve acute and chronic severe pain by binding to opioid receptors. Most narcotic analgesics act on the mu opioid receptor and are very effective at relieving pain; however, they also activate reward pathways meaning that narcotic analgesics have a tendency to cause addiction, dependence, and tolerance (where increasing dosages are needed to provide the same pain-relieving effect).
Different narcotic analgesic combinations have different potencies and side effects, based on the ingredients they contain.
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