Naloxone and pentazocine
Generic Name: naloxone and pentazocine (oral) (nal OX one and pen TAZ oh seen)
Brand Name: Talwin NX
What is naloxone and pentazocine?
Naloxone and pentazocine is a combination medicine used to treat moderate to severe pain. Naloxone is included in this medication to prevent the misuse of the narcotic ingredient.
Naloxone and pentazocine may also be used for purposes not listed in this medication guide.
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Before taking this medicine
You should not use naloxone and pentazocine if you are allergic to naloxone or pentazocine.
Tell your doctor if you have ever had:
breathing problems, sleep apnea;
drug or alcohol addiction, or mental illness;
liver or kidney disease;
a blockage in your stomach or intestines;
heart disease or a heart attack;
problems with your gallbladder, pancreas, or thyroid;
Addison's disease or other adrenal gland disorder;
porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); or
if you have recently received other narcotic pain medicine or methadone.
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with naloxone and pentazocine and cause a serious condition called serotonin syndrome.
If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.
If you breastfeed while taking this medicine, tell your doctor if your baby is very drowsy or has breathing problems.
Naloxone and pentazocine is not approved for use by anyone younger than 12 years old.
How should I take naloxone and pentazocine?
Follow the directions on your prescription label and read all medication guides. Never use naloxone and pentazocine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Naloxone and pentazocine is usually taken as 1 or 2 tablets every 3 to 4 hours. Follow your doctor's instructions. Do not take more than 12 tablets in a 24-hour period.
If you are using any other narcotic pain medicine, the pain-relieving effects of the narcotic may be reversed while you are also taking naloxone and pentazocine.
Never crush or break a naloxone and pentazocine pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death.
You should not stop using this medicine suddenly. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.
Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
What happens if I miss a dose?
Since naloxone and pentazocine is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.
Do not take more than 12 tablets in a 24-hour period.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A pentazocine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include anxiety, nightmares, hallucinations, slow breathing, fast heart rate, severe dizziness, vomiting, numbness or tingling, fainting, or seizure (convulsions).
What should I avoid while taking naloxone and pentazocine?
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid driving or operating machinery until you know how naloxone and pentazocine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Avoid smoking, which can make this medication less effective in relieving your pain.
Naloxone and pentazocine side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
slow heartbeats, weak or shallow breathing, breathing that stops during sleep;
confusion, hallucinations, unusual thoughts or behavior;
severe weakness or drowsiness;
a light-headed feeling, like you might pass out;
low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Serious side effects may be more likely in older adults and those who are malnourished or debilitated.
Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Common side effects may include:
nausea, vomiting; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect naloxone and pentazocine?
Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
other narcotic medications--opioid pain medicine or prescription cough medicine;
drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or
drugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting.
This list is not complete. Other drugs may affect naloxone and pentazocine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 7.01.
More about naloxone / pentazocine
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 25 Reviews
- Drug class: narcotic analgesic combinations
Other brands: Talwin Nx