Aspirin, caffeine, and dihydrocodeine (Oral)
AS-pir-in, KAF-een, dye-hye-droe-KOE-deen bye-TAR-trate
Addiction, Abuse, and Misuse:Aspirin/caffeine/dihydrocodeine bitartrate exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing aspirin/caffeine/dihydrocodeine bitartrate, and monitor all patients regularly for the development of these behaviors or conditions.Life-Threatening Respiratory Depression:Serious, life-threatening, or fatal respiratory depression may occur with use of aspirin/caffeine/dihydrocodeine bitartrate. Monitor for respiratory depression, especially during initiation of aspirin/caffeine/dihydrocodeine bitartrate or following a dose increase.Accidental Ingestion:Accidental ingestion of even one dose of aspirin/caffeine/dihydrocodeine bitartrate, especially by children, can result in a fatal overdose of aspirin/caffeine/dihydrocodeine bitartrate.Ultra-Rapid Metabolism of Codeine and Other Risk Factors for Life-Threatening Respiratory Depression in Children:Life-threatening respiratory depression and death have occurred in children who received codeine. Most of the reported cases occurred following tonsillectomy and/or adenoidectomy, and many of the children had evidence of being an ultra-rapid metabolizer of codeine due to a CYP2D6 polymorphism. Aspirin/caffeine/dihydrocodeine bitartrate is contraindicated in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and/or adenoidectomy. Avoid the use of aspirin/caffeine/dihydrocodeine bitartrate in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine.Neonatal Opioid Withdrawal Syndrome:Prolonged use of aspirin/caffeine/dihydrocodeine bitartrate during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.Interactions with Drug Affecting Cytochrome P450 Isoenzymes:The effects of concomitant use or discontinuation of CYP3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex. Use of CYP3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with aspirin/caffeine/dihydrocodeine bitartrate requires careful consideration of the effects on the parent drug, codeine, and the active metabolite, morphine.Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants:Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of aspirin/caffeine/dihydrocodeine bitartrate and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation .
Medically reviewed on June 7, 2018
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Opioid/Salicylate, Aspirin Combination
Pharmacologic Class: NSAID
Chemical Class: Salicylate, Aspirin
Uses For This Medicine
Aspirin, caffeine, and dihydrocodeine combination is used to relieve moderate to severe pain.
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce fever in patients. Caffeine is a CNS stimulant that is used together with pain relievers to increase their effect. It has also been used for migraine headaches. Dihydrocodeine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.
When dihydrocodeine is used for a long time or in large doses, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.
Aspirin, caffeine, and dihydrocodeine is available only with your doctor's prescription.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aspirin, caffeine, and dihydrocodeine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to aspirin, caffeine, and dihydrocodeine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Use of aspirin, caffeine, and dihydrocodeine combination is not recommended in children 12 years of age or younger.
Synalgos®-DC should not be used to relieve pain after surgery removal of tonsils or adenoids in children younger than 18 years of age. Severe breathing problems and deaths have been reported in some children who received codeine after tonsil or adenoid surgery.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aspirin, caffeine, and dihydrocodeine combination in the elderly. However, elderly patients are more likely to have age-related lung, liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving aspirin, caffeine, and dihydrocodeine combination in order to avoid potentially serious side effects.
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using aspirin, caffeine, and dihydrocodeine.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aspirin, caffeine, and dihydrocodeine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using aspirin, caffeine, and dihydrocodeine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Influenza Virus Vaccine, Live
Using aspirin, caffeine, and dihydrocodeine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abiraterone Acetate
- Alipogene Tiparvovec
- Alteplase, Recombinant
- Amtolmetin Guacil
- Chloral Hydrate
- Choline Salicylate
- Dabigatran Etexilate
- Eslicarbazepine Acetate
- Ethacrynic Acid
- Flufenamic Acid
- Mefenamic Acid
- Methylene Blue
- Morphine Sulfate Liposome
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Nitrous Oxide
- Opium Alkaloids
- Peginterferon Alfa-2b
- Pentosan Polysulfate Sodium
- Protein C
- Reteplase, Recombinant
- Salicylic Acid
- Sodium Oxybate
- Sodium Salicylate
- St John's Wort
- Tenofovir Disoproxil Fumarate
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolonium Chloride
- Varicella Virus Vaccine, Live
Using aspirin, caffeine, and dihydrocodeine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Enalapril Maleate
- Valproic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using aspirin, caffeine, and dihydrocodeine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aspirin, caffeine, and dihydrocodeine, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
Using aspirin, caffeine, and dihydrocodeine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aspirin, caffeine, and dihydrocodeine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of aspirin, caffeine, and dihydrocodeine. Make sure you tell your doctor if you have any other medical problems, especially:
- Alcohol abuse, or history of or
- Brain problems (eg, tumor, increased intracranial pressure), history of or
- Breathing or lung problems (eg, COPD, sleep apnea, respiratory depression) or
- Cor pulmonale (serious heart condition) or
- Depression, history of or
- Drug dependence, especially with narcotic abuse or dependence, or history of or
- Head injuries, history of or
- Hyperkalemia (high potassium levels in the blood) or
- Hypovolemia (low blood volume) or
- Mental health problems, history of or
- Obesity (overweight) or
- Weakened physical condition—Use with caution. May increase risk for more serious side effects.
- Bleeding problems or
- Hypotension (low blood pressure) or
- Pancreatitis (inflammation or swelling of the pancreas) or
- Peptic ulcer disease, active or history of or
- Seizures, history of—Use with caution. May make these conditions worse.
- Hemophilia (bleeding problem) or
- Reye's syndrome or
- Severe asthma, asthma with nasal polyps and runny nose, trouble breathing, or other lung problems or
- Stomach or bowel blockage (including paralytic ileus) or
- Surgery (eg, nasopharyngeal tonsils, tonsils)—Should not be used in patients with these conditions.
- Kidney disease or
- Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of This Medicine
Take aspirin, caffeine, and dihydrocodeine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of aspirin, caffeine, and dihydrocodeine is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.
Aspirin, caffeine, and dihydrocodeine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
Take aspirin, caffeine, and dihydrocodeine with food or a full glass of water to prevent stomach upset.
Aspirin, caffeine, and dihydrocodeine is taken only when needed, so there are no special instructions for a missed dose.
The dose of aspirin, caffeine, and dihydrocodeine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of aspirin, caffeine, and dihydrocodeine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (capsules):
- For moderate to moderately severe pain:
- Adults—Two capsules every 4 hours as needed.
- Children 13 years of age and older—Use and dose must be determined by your doctor.
- Children 12 years of age and younger—Use is not recommended.
- For moderate to moderately severe pain:
If you miss a dose of aspirin, caffeine, and dihydrocodeine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using This Medicine
It is very important that your doctor check your progress while you are using aspirin, caffeine, and dihydrocodeine, especially within the first 24 to 72 hours of treatment. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.
Do not use aspirin, caffeine, and dihydrocodeine if you are using or have used an MAO inhibitor (MAOI) such as isocarboxazid [Marplan®], linezolid [Zyvox®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]) within the past 14 days.
Check with your doctor before taking any of these medicines while you are using aspirin, caffeine, and dihydrocodeine. The use of alcohol or other medicines that affect the CNS with codeine may worsen the side effects of aspirin, caffeine, and dihydrocodeine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds, sedatives, tranquilizers, or sleeping medicines, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking aspirin, caffeine, and dihydrocodeine.
Aspirin, caffeine, and dihydrocodeine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help. Also, lying down for a while may relieve the dizziness or lightheadedness. If this problem continues or gets worse, check with your doctor right away.
Aspirin, caffeine, and dihydrocodeine may make you dizzy, drowsy, confused, or disoriented. Do not drive or do anything else that could be dangerous until you know how aspirin, caffeine, and dihydrocodeine affects you.
Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.
Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". Contact your doctor immediately if you experience extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine". As a result, there is too much morphine in the body and more side effects of morphine than usual. Children may be especially sensitive to this effect. Do not give aspirin, caffeine, and dihydrocodeine to:
- Children younger than 12 years of age.
- Children younger than 18 years of age who have had surgery removal of tonsils or adenoids.
- Children 12 to 18 years of age who have a high risk for breathing problems (eg, obstructive sleep apnea, obesity, lung disease).
If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to a morphine overdose in the nursing baby and cause very serious side effects.
For nursing mothers taking aspirin, caffeine, and dihydrocodeine:
- Talk to your doctor if you have any questions about taking codeine or about how aspirin, caffeine, and dihydrocodeine may affect your baby.
- Call your doctor if you become extremely tired and have difficulty caring for your baby.
- Your baby should generally nurse every 2 to 3 hours and should not sleep for more than 4 hours at a time.
- Check with your doctor, hospital emergency room, or local emergency services (eg, "call 9-1-1") right away if your baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, difficulty breathing, or limpness. These may be symptoms of an overdose and need immediate medical attention.
If you think you or someone else may have taken an overdose of aspirin, caffeine, and dihydrocodeine, get emergency help at once. Signs of an overdose include: dark urine, difficult or troubled breathing, irregular, fast or slow, or shallow breathing, nausea or vomiting, pain in the upper stomach, pale or blue lips, fingernails, or skin, pinpoint pupils of the eyes, or yellow eyes or skin.
Do not change your dose or suddenly stop using aspirin, caffeine, and dihydrocodeine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), hallucinations, stomach or muscle cramps, tremors, or unusual behavior.
Using aspirin, caffeine, and dihydrocodeine while you are pregnant may cause serious unwanted effects, including neonatal withdrawal syndrome in your newborn baby. Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using aspirin, caffeine, and dihydrocodeine.
Using too much of aspirin, caffeine, and dihydrocodeine may cause reduced infertility (unable to have children). Talk with your doctor before using aspirin, caffeine, and dihydrocodeine if you plan to have children.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
This Medicine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
- bleeding gums
- bloody or black, tarry stools
- bloody or cloudy urine
- blue lips and fingernails
- blurred vision
- chest pain or discomfort
- cold sweats
- continuing ringing or buzzing or other unexplained noise in the ears
- cool, pale skin
- coughing that sometimes produces a pink frothy sputum
- dark urine
- darkening of the skin
- difficult, fast, noisy breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast, pounding, or irregular heartbeat or pulse
- fast, slow, or irregular heartbeat
- flushed, dry skin
- fruit-like breath odor
- general tiredness and weakness
- greatly decreased frequency of urination or amount of urine
- headache, sudden and severe
- hearing loss
- increased hunger
- increased sweating
- increased thirst
- increased urination
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- loss of appetite
- loss of consciousness
- muscle cramps, spasms, pain, weakness, or stiffness
- muscle tremors
- numbness and tingling of the face, lips, hands, and feet
- overactive reflexes
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pinpoint red spots on the skin
- poor coordination
- rapid, deep breathing
- severe stomach pain
- skin rash
- slurred speech
- stomach pain, cramping, or burning
- sunken eyes
- swelling in the legs, feet, or ankles
- trembling or shaking
- trouble with breathing
- unexplained weight loss
- unusual bleeding or bruising
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- upper right abdominal pain
- vomiting of blood or material that looks like coffee grounds
- vomiting, severe or continuous
- weakness or heaviness of the legs
- wrinkled skin
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
- Extreme sleepiness
- irregular, fast or slow, or shallow breathing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- low body temperature
- weak or feeble pulse
- weight gain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: narcotic analgesic combinations
Other brands: Synalgos-DC