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Aspirin / caffeine / dihydrocodeine Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 21, 2023.

Applies to aspirin / caffeine / dihydrocodeine: oral capsule.

Warning

Oral route (Capsule)

Respiratory depression and death have been reported in children following tonsillectomy or adenoidectomy. These children had evidence of being ultra-rapid metabolizers due to a CYP2D6 polymorphism.

Serious side effects

Along with its needed effects, aspirin/caffeine/dihydrocodeine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aspirin/caffeine/dihydrocodeine:

Incidence not known

Other side effects

Some side effects of aspirin / caffeine / dihydrocodeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to aspirin / caffeine / dihydrocodeine: oral capsule.

General

The most frequently expected adverse reactions based on the individual components include lightheadedness, dizziness, drowsiness, sedation, nausea, vomiting, constipation, pruritus and skin reactions.[Ref]

Gastrointestinal

Dihydrocodeine:

Frequency not reported: Nausea, vomiting, constipation, abdominal pain, diarrhea, dry mouth, indigestion, spasm of biliary tract

Caffeine:

Frequency not reported: Diarrhea, nausea, stomach pain, vomiting[Ref]

Hypersensitivity

Dihydrocodeine:

Frequency not reported: Anaphylactoid reactions, hypersensitivity reactions[Ref]

Respiratory

Dihydrocodeine:

Frequency not reported: Respiratory depression, cough suppression[Ref]

Psychiatric

Dihydrocodeine:

Frequency not reported: Confusion, physical and psychological dependence, hallucinations vivid dreams

Caffeine:

Frequency not reported: Anxiety, anxiety neurosis, excitement, insomnia, irritability, restlessness, tenseness[Ref]

Dermatologic

Dihydrocodeine:

Frequency not reported: Sweating, pruritus, skin reactions

Caffeine:

Frequency not reported: Urticaria[Ref]

Cardiovascular

Dihydrocodeine:

Frequency not reported: Orthostatic hypotension

Caffeine:

Frequency not reported: Extrasystoles, palpitations, tachycardia[Ref]

Endocrine

Chronic opioid use may influence the hypothalamic-pituitary-gonadal axis and lead to androgen deficiency; however, the causal role of opioids is unknown due to the lack of studies into the many medical, physical, lifestyle, and psychological stressors that influence gonadal hormone levels.[Ref]

Opioids:

Frequency not reported: Adrenal insufficiency, androgen deficiency[Ref]

Genitourinary

Dihydrocodeine:

Frequency not reported: Urinary retention[Ref]

Metabolic

Dihydrocodeine:

Frequency not reported: Anorexia[Ref]

Nervous system

Dihydrocodeine:

Rare (less than 0.1%): Narcosis

Frequency not reported: Lightheadedness, dizziness, drowsiness, sedation, headache

Caffeine:

Frequency not reported: Headaches, lightheadedness, tremor

Opioids:

Frequency not reported: Serotonin syndrome[Ref]

Ocular

Dihydrocodeine:

Frequency not reported: Miosis

Caffeine:

Frequency not reported: Scintillating scotoma[Ref]

Other

Dihydrocodeine:

Frequency not reported: Fatigue

Caffeine:

Frequency not reported: Tinnitus[Ref]

Renal

Dihydrocodeine:

Rare (less than 0.1%): Acute renal failure

Frequency not reported: Granulomatous interstitial nephritis

Caffeine:

Frequency not reported: Diuresis[Ref]

References

1. Product Information. Trezix (acetaminophen/caffeine/dihydrocodeine). WraSer Pharmaceuticals. 2016.

2. Product Information. Synalgos-DC (aspirin / caffeine / dihydrocodeine). Sun Pharmaceutical Industries. 2022.

3. US Food and Drug Administration. Opioid Pain Medicines: Drug Safety Communication - New Safety Warnings Added to Prescription Opioid Medications. http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm491715.htm 2016.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.