Comparing Tizanidine vs Trazodone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tizanidine	Trazodone	Enter another drug to compare

Tizanidine

Trazodone

Prescription only

Tizanidine may be used to reduce muscle spasms but common side effects include sleepiness, a drop in blood pressure, and a dry mouth. The dosage of tizanidine should be tailored to each person and... View more

Prescription only

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

More about Tizanidine

More about Trazodone

Ratings & Reviews

Tizanidine has an average rating of 6.2 out of 10 from a total of 381 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect.

Trazodone has an average rating of 6.3 out of 10 from a total of 1433 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect.

View all 381 reviews

View all 1433 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (18.9%)
Dry mouth (9.2%)
Hallucinations (6.8%)
Dizziness (6.3%)
Tiredness (5.5%)
Vivid dreams (4.2%)
Headaches (3.7%)

View all Tizanidine side effects

Drowsiness (17.7%)
Headaches (9.6%)
Dizziness (8.7%)
Anxiety (5.9%)
Dry mouth (5.7%)
Tiredness (4.9%)
Insomnia (4.6%)

View all Trazodone side effects

Drug Class

Skeletal muscle relaxants

Phenylpiperazine antidepressants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	4 mg
Per unit^*	$0.61
Cost^*	$30.51

View all Tizanidine prices

Quantity	100 each
Strength	50 mg
Per unit^*	$0.20 - $0.21
Cost^*	$20.37 - $20.92

View all Trazodone prices

Get free Discount Card

Dosage Forms

Oral capsule
Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

2.5 hours

7.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 643 drugs are known to interact with Tizanidine:

242 major drug interactions (872 brand and generic names)
399 moderate drug interactions (1597 brand and generic names)
2 minor drug interactions (4 brand and generic names)

A total of 674 drugs are known to interact with Trazodone:

138 major drug interactions (503 brand and generic names)
521 moderate drug interactions (2174 brand and generic names)
15 minor drug interactions (71 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using tiZANidine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

November 27, 1996

December 24, 1981

WADA Class View classifications

N/A

More Information

Patient Resources

Tizanidine uses

Trazodone uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Tizanidine vs Trazodone

See also:

Flexeril

Robaxin

Ozempic

Valium

Zanaflex

Soma

Norflex

Lioresal

Skelaxin

Valtoco

Further information

Comparing Tizanidine vs Trazodone

See also:

Further information

Compare Drugs