Sertraline Alternatives Compared
| Sertraline | Rexulti (brexpiprazole) | Bupropion |
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| Sertraline | Rexulti (brexpiprazole) | Bupropion |
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Prescription only
Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Headaches, nausea, diarrhea, weight loss, insomnia, tremors, and sexual dysfunction are the... View more |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Sertraline | More about Rexulti (brexpiprazole) | More about Bupropion | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Sertraline has an average rating of 7.3 out of 10 from a total of 4568 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
Rexulti has an average rating of 6.6 out of 10 from a total of 492 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 25% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2904 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Sertraline side effects |
View all Rexulti side effects |
View all Bupropion side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Sertraline prices |
View all Rexulti prices |
View all Bupropion prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Zoloft |
N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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66 hours |
91 hours |
30 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 673 drugs are known to interact with Sertraline:
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A total of 600 drugs are known to interact with Rexulti:
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A total of 559 drugs are known to interact with Bupropion:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 30, 1991 |
July 10, 2015 |
December 30, 1985 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Vraylar
Vraylar is a once a day antipsychotic medication used to treat mental health or mood disorders ...
Lexapro
Lexapro is used to treat anxiety and major depressive disorder. Learn about side effects ...
Rexulti
Rexulti (brexpiprazole) is a prescription antipsychotic medication used in the treatment of major ...
Abilify
Abilify is an antipsychotic medicine used to treat the symptoms of schizophrenia and bipolar ...
Zoloft
Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic ...
Seroquel
Seroquel is used to treat the symptoms of schizophrenia, bipolar disorder and major depressive ...
Xanax
Xanax (alprazolam) is a benzodiazepine medication used to treat anxiety and panic disorders ...
Prozac
Prozac (fluoxetine) is an SSRI antidepressant used to treat depression, OCD, panic disorder ...
Cymbalta
Cymbalta (duloxetine) is used to treat major depressive disorder, general anxiety disorder and ...
Wellbutrin
Wellbutrin (bupropion) is used to treat major depressive disorder and seasonal affective disorder ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.