Comparing Amitriptyline vs Sertraline
Amitriptyline | Sertraline |
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Amitriptyline | Sertraline |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Headaches, nausea, diarrhea, weight loss, insomnia, tremors, and sexual dysfunction are the... View more |
Related suggestions Depression
Anxiety and Stress
Post Traumatic Stress Disorder
Vulvodynia
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More about Amitriptyline | More about Sertraline | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Amitriptyline has an average rating of 7.6 out of 10 from a total of 1768 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect. |
Sertraline has an average rating of 7.3 out of 10 from a total of 4433 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 18% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: amitriptyline side effects in more detail. |
See also: sertraline side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all amitriptyline prices |
View all sertraline prices |
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Dosage Form(s) Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
N/A |
Zoloft | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
16 hours |
66 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 705 drugs are known to interact with amitriptyline:
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A total of 656 drugs are known to interact with sertraline:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
April 07, 1961 |
December 30, 1991 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.