Comparing Mefenamic Acid vs Naproxen

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Mefenamic acid

Naproxen

Prescribed for Period Pain, Pain. mefenamic acid may also be used for purposes not listed in this medication guide.

Naproxen is effective for the short-term relief of pain and inflammation associated with arthritis, gout, menstruation, and tendonitis; however, like other NSAIDs, it has the potential to adversely... View more

Prescription only

Prescription and OTC

See the full naproxen side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 capsule
Dosage	250 mg
Per Unit^*	$5.61
Cost^*	$168.21

View all mefenamic acid prices

Quantity	4 tablet
Dosage	500 mg
Per Unit^*	$2.67
Cost^*	$10.69

View all naproxen prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral capsule

Oral capsule
Oral delayed release tablet
Oral suspension
Oral tablet
Oral tablet, extended release

Brand Names

N/A

Aflaxen, Aleve, All Day Pain Relief, All Day Relief, Anaprox, Anaprox-DS, Comfort Pac with Naproxen, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan, Naprosyn, Naproxen Sodium DS, Pamprin All Day Relief more

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

3.5 hours

18 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 359 drugs are known to interact with mefenamic acid:

90 major drug interactions (390 brand and generic names)
254 moderate drug interactions (1053 brand and generic names)
15 minor drug interactions (84 brand and generic names)

A total of 392 drugs are known to interact with naproxen:

92 major drug interactions (409 brand and generic names)
282 moderate drug interactions (1158 brand and generic names)
18 minor drug interactions (127 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using mefenamic acid together with alcohol. Do not drink alcohol while... View more

Ask your doctor before using naproxen together with alcohol. Do not drink alcohol while taking... View more

Disease Interactions

First Approval Date

March 28, 1967

March 11, 1976

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Patient resources

Advanced Reading

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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