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Invokana Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Invokana Mounjaro Metformin
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Invokana (canagliflozin) Mounjaro (tirzepatide) Metformin
Prescription only

Invokana is effective at lowering blood glucose levels in people with type 2 diabetes. It also reduces the risk of future cardiovascular events (such as a heart attack or stroke) and kidney disease... View more

Prescription only

Prescribed for Diabetes - Type 2. Mounjaro may also be used for purposes not listed in this medication guide.

Prescription only

Metformin improves how the body responds to insulin and it is effective for the treatment of type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side... View more

More about Invokana (canagliflozin) More about Mounjaro (tirzepatide) More about Metformin
Generic Status

No lower-cost generic available

No lower-cost generic available

Lower-cost generic is available
Ratings & Reviews

Invokana has an average rating of 5.8 out of 10 from a total of 257 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 35% reported a negative effect.

Mounjaro has an average rating of 6.3 out of 10 from a total of 102 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 32% reported a negative effect.

Metformin has an average rating of 6.9 out of 10 from a total of 626 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 257 reviews

View all 102 reviews

View all 626 reviews

Drug Class
Side Effects

Common side effects include:

  • vulvovaginal candidiasis
  • vaginal infection
  • vulvitis
  • vulvovaginitis
  • mean glomerular filtration rate decreased

See also: Invokana side effects in more detail.

See also: Mounjaro side effects in more detail.

Commonly reported side effects include:

  • lactic acidosis
  • diarrhea
  • nausea
  • nausea and vomiting
  • vomiting
  • flatulence

See also: metformin side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 30 tablet
Dosage 100 mg
Per Unit* $21.33
Cost* $639.78

View all Invokana prices

Quantity 2 mL
Dosage 2.5 mg/0.5 mL
Per Unit* $543.38
Cost* $1,086.76

View all Mounjaro prices

Quantity 100 each
Dosage 500 mg
Per Unit* $0.16 - $0.22
Cost* $16.02 - $22.18

View all metformin prices

Get free Discount Card

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Dosage Form(s) Available
  • Oral tablet
  • Subcutaneous solution
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
Brand Names

N/A

N/A

 Glumetza, Riomet, Riomet ER
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

13.1 hours

120 hours

4.5 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
Drug Interactions

A total of 364 drugs are known to interact with Invokana:

  • 2 major drug interactions (34 brand and generic names)
  • 341 moderate drug interactions (1514 brand and generic names)
  • 21 minor drug interactions (263 brand and generic names)

A total of 247 drugs are known to interact with Mounjaro:

  • 2 major drug interactions (5 brand and generic names)
  • 224 moderate drug interactions (1144 brand and generic names)
  • 21 minor drug interactions (263 brand and generic names)

A total of 356 drugs are known to interact with metformin:

  • 19 major drug interactions (111 brand and generic names)
  • 308 moderate drug interactions (1478 brand and generic names)
  • 29 minor drug interactions (287 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more
  • Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more
  • MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more
Disease Interactions
First Approval Date

March 29, 2013

N/A

March 03, 1995
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources

N/A
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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