Comparing Doxycycline vs Metronidazole Topical

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxycycline Remove Doxycycline from your drug comparison	Metronidazole topical Remove Metronidazole topical from your drug comparison	Add another drug to compare

Doxycycline

Metronidazole topical

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight nor in pregnant women in the last half of... View more

Prescribed for Rosacea, Perioral Dermatitis, Bacterial Vaginitis. May also be prescribed off label for Balanoposthitis.

Prescription only

Ratings & Reviews

View all 1506 reviews

View all 292 reviews

Drug Class

Side Effects

See the full doxycycline side effects document.

See the full metronidazole topical side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	10 capsule
Dosage	hyclate 100 mg
Per Unit^*	$2.33
Cost^*	$23.30

View all doxycycline prices

Quantity	55 gram(s)
Dosage	1%
Per Unit^*	$2.64
Cost^*	$145.38

View all metronidazole topical prices

Get free Discount Card

Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Injectable powder for injection
Oral capsule
Oral delayed release capsule
Oral delayed release tablet
Oral powder for reconstitution
Oral tablet

Topical cream
Topical gel
Topical lotion
Vaginal gel with applicator

Brand Names

Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more MetroCream, MetroGel, MetroGel-Vaginal, MetroLotion, Noritate, Nuvessa, Rosaclear, Rosadan, Vandazole View more

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

23 hours

N/A

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full Pregnancy Warnings document.

Category B No proven risk in humans

See the full Pregnancy Warnings document.

Drug Interactions

A total of 191 drugs are known to interact with doxycycline:

13 major drug interactions (38 brand and generic names)
148 moderate drug interactions (1824 brand and generic names)
30 minor drug interactions (123 brand and generic names)

A total of 8 drugs are known to interact with metronidazole topical:

1 major drug interactions (2 brand and generic names)
7 moderate drug interactions (26 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Consumption of alcoholic beverages or products containing alcohol or propylene glycol during... View more

Disease Interactions

First Approval Date

December 05, 1967

November 22, 1988

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer