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Metronidazole Topical Dosage

Medically reviewed by Last updated on Aug 10, 2018.

Applies to the following strengths: 1%; 0.75%; 1.3%; 0.75% with cleanser

Usual Adult Dose for Acne Rosacea

1% Topical Cream or Gel: Apply and rub in a thin film to the affected area(s) once a day

0.75% Topical Cream, Gel, or Lotion: Apply and rub in a thin layer to affected area(s) twice a day in the morning and evening

-A gentle cleaner should be used prior to application.
-Cosmetics may be applied following application.

Use: For the topical treatment of inflammatory lesions and erythema of rosacea

Usual Adult Dose for Bacterial Vaginosis

1.3% Vaginal Gel: Insert 1 applicatorful intravaginally once at bedtime

0.75% Vaginal Gel: Insert 1 applicatorful intravaginally once or twice a day for 5 days; once a day dosing should be administered at bedtime

Use: For the treatment of bacterial vaginosis in non-pregnant women

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Mild to moderate liver dysfunction: Data not available
Severe liver dysfunction: Use with caution.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:
-Topical 0.75% and 1% formulations: For topical use only; not for oral, ophthalmic, or intravaginal use.
-Vaginal 0.75% and 1.3% formulations: For intravaginal use only; not for ophthalmic, dermal, or oral use.

Storage requirements:
-Vaginal gel: Protect from freezing; do not refrigerate; protect from extreme heat.

Patient advice:
-A gentle cleanser should be used prior to application of topical products for rosacea; cosmetics may be applied following application.
-Avoid use of alcohol during therapy and for at least 24 hours (1.3% gel) or 3 days after discontinuing treatment.
-Avoid sexual intercourse and use of other vaginal products (e.g., tampons or douches) following the single administration of the vaginal gel.
-Discontinue use and contact your physician if vaginal irritation occurs.
-Consult the Patient Instructions for Use for proper administration techniques.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.