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Metronidazole Topical Dosage

Applies to the following strength(s): 1% ; 0.75% ; 0.75% with cleanser ; 1.3%

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Acne Rosacea

Metronidazole topical 1% gel or cream: Apply a thin film to the affected area once a day.
Metronidazole topical 0.75% gel, cream, or lotion: Apply a thin film to the affected area twice a day.

Usual Adult Dose for Bacterial Vaginosis

Insert one applicatorful of metronidazole topical 0.75% vaginal gel intravaginally once (at bedtime) or twice a day for 5 consecutive days.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Gel, cream, lotion: Data not available
Vaginal gel: The manufacturer recommends caution when administering this drug to patients with severe hepatic disease.

Dose Adjustments

The duration of topical therapy is 4 to 10 weeks depending on the nature and severity of the condition.


Patients should be advised to use metronidazole topical less frequently or discontinue use if a reaction suggesting local irritation occurs.

Convulsive seizures and peripheral neuropathy have been reported in patients receiving oral or IV metronidazole. If abnormal neurologic signs appear, metronidazole topical vaginal gel should be discontinued at once. The use of metronidazole topical 1% gel should be reevaluated at once if abnormal neurologic signs appear. Metronidazole topical should be used with caution in patients with central nervous system diseases.

Metronidazole topical should be used with caution in patients with evidence of, or history of blood dyscrasia.

Although disulfiram-like reactions have not been reported in patients receiving vaginal metronidazole, the manufacturer recommends that alcohol be avoided. Metronidazole topical vaginal gel should not be used in patients who have taken disulfiram within the last 2 weeks.

Safety and efficacy have not been established in pediatric patients (less than 18 years of age).


Data not available

Other Comments

Metronidazole topical may cause eye irritation if applied too close to the eyes. Contact with the eyes should be avoided.

Topical areas to be treated should be washed with a mild cleanser prior to application.

The manufacturer recommends avoidance of vaginal intercourse during treatment with metronidazole topical vaginal gel.