Metronidazole Topical Dosage
Medically reviewed by Drugs.com. Last updated on Aug 9, 2023.
Applies to the following strengths: 1%; 0.75%; 1.3%; 0.75% with cleanser
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Acne Rosacea
1% Topical Cream or Gel: Apply and rub in a thin film to entire affected area(s) once a day
0.75% Topical Cream, Gel, or Lotion: Apply and rub in a thin layer to entire affected area(s) twice a day (morning and evening)
Comments:
- Areas to be treated should be washed with a mild/gentle cleanser prior to application of this drug.
- Patients may use cosmetics after application of this drug.
- Topical lotion formulation: Patients should wait until dry (at least 5 minutes) to use cosmetics.
Uses:
- For 0.75% topical cream, gel, or lotion: For the topical treatment of inflammatory papules and pustules of rosacea
- For 1% topical cream: For the topical treatment of inflammatory lesions and erythema of rosacea
- For 1% topical gel: For the topical treatment of inflammatory lesions of rosacea
Usual Adult Dose for Bacterial Vaginosis
1.3% Vaginal Gel: Insert 1 applicatorful intravaginally once at bedtime.
0.75% Vaginal Gel: Insert 1 applicatorful intravaginally once a day (at bedtime) or twice a day for 5 days.
- Vandazole: Insert 1 applicatorful intravaginally once a day at bedtime for 5 days.
Use: For the treatment of bacterial vaginosis
- Vandazole: In nonpregnant women
Usual Pediatric Dose for Bacterial Vaginosis
1.3% Vaginal Gel:
- Females 12 years or older: Insert 1 applicatorful intravaginally once at bedtime.
Vandazole (0.75% Vaginal Gel):
- Postmenarchal females: Insert 1 applicatorful intravaginally once a day at bedtime for 5 days.
Use: For the treatment of bacterial vaginosis
- Vandazole: In nonpregnant women
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Comments:
- According to at least 1 manufacturer, the vaginal gel (0.75%) should be administered cautiously in patients with severe liver disease.
Precautions
CONTRAINDICATIONS:
Topical Formulations:
- History of hypersensitivity to the active component or any of the ingredients
Vaginal Formulations:
- History of hypersensitivity to the active component, any of the ingredients (including parabens), or other nitroimidazole derivatives
- Concomitant use of disulfiram or use within 2 weeks of disulfiram
- Consumption of alcohol/ethanol or propylene glycol during and for at least 24 hours (1.3% vaginal gel) or for at least 3 days (Vandazole [0.75% vaginal gel]) after therapy
Topical formulations: Safety and efficacy have not been established in patients younger than 18 years.
Vaginal formulations: Safety and efficacy of the 1.3% vaginal gel have not been established in patients younger than 12 years; safety and efficacy of Vandazole (0.75% vaginal gel) have not been established in premenarchal females.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Topical formulations: For topical use only; not for oral, ophthalmic, or intravaginal use.
- Vaginal formulations: For intravaginal use only; not for ophthalmic, dermal, or oral use.
Storage requirements:
- Store at controlled room temperature 20C to 25C (68F to 77F).
- For 0.75% topical cream, 0.75% topical lotion, and vaginal gel: Protect from freezing.
- For Vandazole (0.75% vaginal gel): Avoid exposure to extreme heat or cold.
- For 1.3% vaginal gel: Do not refrigerate.
Patient advice (topical formulations):
- Use this product as directed by physician.
- For external use only
- Avoid contact with the eyes.
- Report any side effects to physician.
- For 0.75% topical formulations: If local irritation occurs, use the product less often or discontinue use.
- For 1% topical formulations: If local irritation occurs, discontinue use.
Patient advice (vaginal formulations):
- Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
- Do not consume alcohol or products containing ethanol or propylene glycol during therapy and for at least 3 days (Vandazole [0.75% vaginal gel]) or for at least 24 hours (1.3% gel) after treatment.
- Do not engage in vaginal intercourse or use other vaginal products (e.g., tampons, douches) during therapy with the 0.75% vaginal gel or after the single administration of the 1.3% vaginal gel.
- Discontinue use and contact healthcare provider if vaginal irritation occurs.
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- During pregnancy
- Drug class: topical anti-rosacea agents
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Patient resources
- Metronidazole topical drug information
- Metronidazole vaginal
- Metronidazole Cream, Gel, and Lotion
- Metronidazole Vaginal Gel
Other brands
MetroGel, MetroGel-Vaginal, Vandazole, MetroCream, ... +6 more
Professional resources
- MetroNIDAZOLE (Topical) monograph
- Metronidazole Cream (FDA)
- Metronidazole Gel (FDA)
- Metronidazole Lotion (FDA)
- Metronidazole Vaginal Gel (FDA)
Other brands
MetroGel, MetroGel-Vaginal, Vandazole, MetroCream, ... +4 more
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.