Dapagliflozin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Dapagliflozin	Metformin	Ozempic (semaglutide)	Enter another drug to compare

Dapagliflozin

Metformin

Ozempic (semaglutide)

Prescription only

Prescribed for Heart Failure, Chronic Kidney Disease, Type 2 Diabetes. Dapagliflozin may also be used for purposes not listed in this medication guide.

Prescription only

Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

More about Dapagliflozin

More about Metformin

More about Ozempic (semaglutide)

Ratings & Reviews

Dapagliflozin has an average rating of 4.7 out of 10 from a total of 199 ratings on Drugs.com. 27% of reviewers reported a positive effect, while 46% reported a negative effect.

Metformin has an average rating of 6.8 out of 10 from a total of 660 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 19% reported a negative effect.

Ozempic has an average rating of 6.6 out of 10 from a total of 1582 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 23% reported a negative effect.

View all 199 reviews

View all 660 reviews

View all 1582 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Yeast infection (21.6%)
Frequent urination (10.6%)
Hair loss (9.0%)
Headaches (7.5%)
Urinary tract infection (7.5%)
Dehydration (7.0%)
Dizziness (7.0%)

View all Dapagliflozin side effects

Diarrhea (25.6%)
Nausea (15.3%)
Upset stomach (9.8%)
Stomach pain (4.7%)
Gas (4.5%)
Headaches (4.4%)
Cramps (3.6%)

View all Metformin side effects

Nausea (33.4%)
Diarrhea (16.3%)
Constipation (15.7%)
Vomiting (12.3%)
Burping (8.8%)
Upset stomach (7.5%)
Headaches (7.4%)

View all Ozempic side effects

Drug Class

SGLT-2 inhibitors

Non-sulfonylureas

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet
Strength	5 mg
Per unit^*	$15.75
Cost^*	$472.43

View all Dapagliflozin prices

Quantity	100 each
Strength	500 mg
Per unit^*	$0.10 - $0.11
Cost^*	$10.00 - $10.79

View all Metformin prices

Quantity	1.5 mL
Strength	2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per unit^*	$654.89
Cost^*	$982.34

View all Ozempic prices

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Dosage Forms

Oral tablet

Oral solution
Oral tablet
Oral tablet, extended release

Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12.9 hours

4.5 hours

168 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 375 drugs are known to interact with Dapagliflozin:

3 major drug interactions (12 brand and generic names)
366 moderate drug interactions (1803 brand and generic names)
6 minor drug interactions (23 brand and generic names)

A total of 380 drugs are known to interact with Metformin:

25 major drug interactions (131 brand and generic names)
346 moderate drug interactions (1806 brand and generic names)
9 minor drug interactions (35 brand and generic names)

A total of 275 drugs are known to interact with Ozempic:

16 major drug interactions (36 brand and generic names)
258 moderate drug interactions (1457 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

January 08, 2014

March 03, 1995

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Dapagliflozin uses

Metformin uses

Ozempic uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Dapagliflozin Alternatives Compared

See also:

Trulicity

Lantus

Entyvio

Tresiba

Levemir

Victoza

Basaglar

Novolog

Soliqua

Toujeo SoloStar

Further information

Dapagliflozin Alternatives Compared

See also:

Further information

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