Skip to Content

Dapagliflozin Dosage

Applies to the following strength(s): 5 mg ; 10 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Diabetes Type 2

Initial dose: 5 mg orally once a day
Maximum dose: May increase to 10 mg orally once a day in patients tolerating therapy with 5 mg/day and requiring additional glycemic control

-If used in combination with insulin or an insulin secretagogue, a lower dose of insulin or the insulin secretagogue should be considered to reduce the risk of hypoglycemia.

Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Renal Dose Adjustments

Mild renal impairment (eGFR 60 mL/min/1.73 m2 or greater): No adjustment recommended
Moderate renal impairment (eGFR 30 to less than 60 mL/min/1.73 m2:): Not recommended
Severe renal impairment (eGFR is less than 30 mL/min/1.73 m2): Use is contraindicated

Liver Dose Adjustments

-Mild or Moderate: No adjustment recommended.
-Severe: Use caution as the safety and efficacy has not been specifically studied.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.



Other Comments

Administration advice:
-Take in the morning, with or without food

-Correct volume depletion prior to initiating treatment
-Not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis

-Assess fluid status prior to initiation and monitor for signs and symptoms of volume depletion during therapy.
-Verify renal function at baseline, and monitor periodically during therapy.
-Monitor for signs and symptoms of acute kidney injury.
-Monitor for LDL-C per standard of care.
-Evaluate for the presence of acidosis, including ketoacidosis in symptomatic patients, even if blood sugar is below 250 mg/dL.

Patient advice:
-This drug will cause the urine to test positive for glucose.
-Ensure adequate fluid intake to avoid adverse reactions related to volume depletion such as orthostatic hypotension.
-Seek medical advice during periods of stress as medical management of diabetes may change.
-Inform patients that genital mycotic infections, urinary tract infections, and hypersensitivity reactions may occur; patients should be instructed to contact their health care professional.
-Patients experiencing symptoms of ketoacidosis such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue, or sleepiness should be instructed to seek immediate medical attention.
-Patients should be instructed to seek medical attention promptly for signs and symptoms of acute kidney injury such as decreased urine, swelling in the legs or feet.