Afrin Alternatives Compared
| Afrin (oxymetazoline) | Pseudoephedrine | Phenylephrine |
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| Afrin (oxymetazoline) | Pseudoephedrine | Phenylephrine |
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Over-the-counter
Prescribed for Nasal Congestion. Afrin may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Pseudoephedrine effectively relieves nasal congestion and is found in several behind the counter combination cold and flu remedies. Photo ID must be produced to purchase it and pharmacies must keep... View more |
Prescription and OTC
Phenylephrine relieves congestion of the nasal passages and is found in many cold and flu remedies. There is some controversy over whether it works at the dosages usually found in over-the-counter... View more |
Related suggestions Nasal Congestion
Popular comparisons
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| More about Afrin (oxymetazoline) | More about Pseudoephedrine | More about Phenylephrine | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Afrin has an average rating of 3.5 out of 10 from a total of 134 ratings on Drugs.com. 22% of reviewers reported a positive effect, while 67% reported a negative effect. |
Pseudoephedrine has an average rating of 6.5 out of 10 from a total of 95 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 29% reported a negative effect. |
Phenylephrine has an average rating of 6.4 out of 10 from a total of 24 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 38% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Afrin side effects |
View all Pseudoephedrine side effects |
View all Phenylephrine side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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N/A |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Afrin prices |
View all Pseudoephedrine prices |
View all Phenylephrine prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other oxymetazoline brands include: 12 Hour Nasal, 12 Hour Nasal Decongestant Spray, Afrin Allergy Sinus Nasal Spray, Afrin NoDrip Allergy Sinus, Afrin NoDrip Extra Moisturizing, Afrin NoDrip Original, Afrin NoDrip Severe Congestion, Afrin NoDrip Sinus, Afrin Original, Afrin Severe Congestion, Afrin Sinus, Allerest 12 Hour Nasal Spray, CVS Health Sinus Relief, Dristan 12 Hour Nasal Spray, Duramist Plus, Four-Way Nasal Spray, Genasal, Giltuss Severe Sinus, Mucinex Sinus-Max Clear & Cool, Mucinex Sinus-Max Full Force, Mucinex Sinus-Max Moisture Smart, Nostrilla, Nostrilla 12 Hour, Rhinase D Moisturizing Nasal Decongestant, Todays Health Nasal Relief Extra Moisturizing, Vicks QlearQuil 12 Hour Nasal Decongestant Moisturizing Spray, Vicks Sinex 12-Hour Decongestant Nasal Spray, Vicks Sinex 12-Hour Decongestant UltraFine Mist, Vicks Sinex Moisturizing 12-Hour Decongestant UltraFine Mist, Vicks Sinex Severe Nasal Spray, Zicam Extreme Congestion Relief, Zicam Sinus Relief View more | 12 Hour Decongestant, 12 Hour Nasal Decongestant, Afrinol, Allermed, Cenafed, Children's Dimetapp Decongestant Infant, Chlor-Trimeton Nasal Decongestant, Contac Cold, Decofed, Decofed Liquid, Drixoral Decongestant Non-Drowsy, Efidac, Elixsure Decongestant, Entex, Genaphed, nasofed, Nexafed Nasal Decongestant, Novafed, Silfedrine, Sudafed 12-Hour, Sudafed 24-Hour, Sudafed Congestion, SudoGest, SudoGest 12 Hour, Suphedrin, Suphedrine, Zephrex-D View more | AH-Chew D, Biorphen, Congest Aid II, Contac-D, Despec-SF, Dimetapp Toddler's Drops Decongestant, Gilchew IR, Little Colds Decongestant, Nasal Decongestant PE, Nasop, Nasop12, Neo-Synephrine, Ricobid-D, Sudafed PE Children's Nasal Decongestant, Sudafed PE Congestion, Sudogest PE, Suphedrine PE, Vazculep View more | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
16 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 51 drugs are known to interact with Afrin:
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A total of 220 drugs are known to interact with Pseudoephedrine:
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A total of 201 drugs are known to interact with Phenylephrine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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N/A |
N/A |
December 20, 2012 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Professional Resources | ||||||||||||||||||||||||||
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N/A |
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Pseudoephedrine
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.