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Oxymetazoline use while Breastfeeding

Medically reviewed by Last updated on Oct 2, 2022.

Drugs containing Oxymetazoline: Afrin, Rhofade, Upneeq, Afrin Original, Afrin Sinus, Vicks Sinex 12-Hour Decongestant Nasal Spray, Afrin NoDrip Sinus, Afrin Severe Congestion, Mucinex Sinus-Max Full Force, Vicks Sinex Severe Nasal Spray, Show all 48 »Genasal, Four-Way Nasal Spray, Nostrilla, Zicam Sinus Relief, Vicks Sinex Moisturizing 12-Hour Decongestant UltraFine Mist, Dristan 12 Hour Nasal Spray, Afrin Allergy Sinus Nasal Spray, Mucinex Sinus-Max Clear & Cool, Visine L.R. Long Lasting Redness Relief, Mucinex Sinus-Max Pressure, Pain & Cough and Sinus-Max Clear & Cool Nasal Spray, Oxymeta-12, Oxyfrin, NRS Nasal, Zicam Extreme Congestion Relief, Neo-Synephrine 12 Hour, Vicks Sinex 12-Hour Decongestant UltraFine Mist, Mucinex Sinus-Max Moisture Smart, Sudafed OM Sinus Cold, Sudafed OM Sinus Congestion, Vicks QlearQuil 12 Hour Nasal Decongestant Moisturizing Spray, Nostrilla 12 Hour, Todays Health Nasal Relief Extra Moisturizing, Afrin NoDrip Original, Afrin NoDrip Severe Congestion, Afrin NoDrip Extra Moisturizing, 12 Hour Nasal Decongestant Spray, Afrin NoDrip Allergy Sinus, Rhinase D Moisturizing Nasal Decongestant, Giltuss Severe Sinus, NTZ Long Acting Nasal, Allerest 12 Hour Nasal Spray, Duramist Plus, CVS Health Sinus Relief, Duration, Sinarest Nasal, 12 Hour Nasal, OcuClear, Kovanaze

Oxymetazoline Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although no information exists on the use of oxymetazoline specifically during breastfeeding, very little should reach the infant through breastmilk because of the local administration and limited absorption into the maternal bloodstream. It is recommended over oral systemic decongestants such as pseudoephedrine during breastfeeding.[1] Topical use on the face is unlikely to present a risk to the nursing infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Anderson PO. Decongestants and milk production. J Hum Lact 2000;16:294. Letter. PMID: 11155604. [PubMed: 11155604]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Adrenergic alpha-Agonists


Nasal Decongestants

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Further information

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