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Oxymetazoline use while Breastfeeding

Medically reviewed by Last updated on Jan 5, 2022.

Drugs containing Oxymetazoline: Afrin, Upneeq, Afrin Original, Rhofade, Vicks Sinex 12-Hour Decongestant Nasal Spray, Zicam Extreme Congestion Relief, Zicam Sinus Relief, Mucinex Sinus-Max Full Force, Afrin Sinus, Genasal, Show all 47 »Vicks Sinex Severe Nasal Spray, Nostrilla, Visine L.R. Long Lasting Redness Relief, Dristan 12 Hour Nasal Spray, Afrin Severe Congestion, Mucinex Sinus-Max Clear & Cool, Duration, OcuClear, Mucinex Sinus-Max Pressure, Pain & Cough and Sinus-Max Clear & Cool Nasal Spray, Oxymeta-12, Oxyfrin, NRS Nasal, Four-Way Nasal Spray, Neo-Synephrine 12 Hour, Vicks Sinex 12-Hour Decongestant UltraFine Mist, Vicks Sinex Moisturizing 12-Hour Decongestant UltraFine Mist, Mucinex Sinus-Max Moisture Smart, Sudafed OM Sinus Cold, Sudafed OM Sinus Congestion, Vicks QlearQuil 12 Hour Nasal Decongestant Moisturizing Spray, Nostrilla 12 Hour, Todays Health Nasal Relief Extra Moisturizing, Afrin NoDrip Original, Afrin NoDrip Severe Congestion, Afrin NoDrip Extra Moisturizing, Afrin NoDrip Sinus, 12 Hour Nasal Decongestant Spray, Afrin NoDrip Allergy Sinus, Afrin Allergy Sinus Nasal Spray, Giltuss Severe Sinus, NTZ Long Acting Nasal, Allerest 12 Hour Nasal Spray, Duramist Plus, CVS Health Sinus Relief, Sinarest Nasal, 12 Hour Nasal, Kovanaze

Oxymetazoline Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although no information exists on the use of oxymetazoline specifically during breastfeeding, very little should reach the infant through breastmilk because of the local administration and limited absorption into the maternal bloodstream. It is recommended over oral systemic decongestants such as pseudoephedrine during breastfeeding.[1] Topical use on the face is unlikely to present a risk to the nursing infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Anderson PO. Decongestants and milk production. J Hum Lact 2000;16:294. Letter. PMID: 11155604. [PubMed: 11155604]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Adrenergic alpha-Agonists


Nasal Decongestants

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Further information

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