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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Loratadine-D 24 Hour, Claritin-D, Zyrtec-D, Mucinex D, Virtussin DAC, SudoGest, Actifed, Sudafed 12-Hour, Show all 1038 »Allegra-D 24 Hour, Vicks Nyquil D Cold and Flu Nighttime Relief, Resperal-DM, Sinarest, Vicks Dayquil Daytime Cold/Flu, Advil Cold and Sinus, Loratadine-D 12 Hour, Vanacof, Cheratussin DAC, Wal-Zyr D, Entex, Sudafed 24-Hour, Suphedrine, Semprex-D, Conex, Allegra-D 12 Hour, Claritin-D 24 Hour, Aprodine, Robitussin Allergy & Cough, Rescon, Dristan Sinus, Mucinex D Maximum Strength, Tusnel, Alka-Seltzer Cold and Sinus, Tylenol Cold, Allegra-D 24 Hour Allergy & Congestion, Nexafed, Bromaline, Stahist AD, Zephrex, Alka-Seltzer Plus Flu/Body, Drixoral, Zutripro, Dimetapp Elixir, Nacon, Hycofenix, Coldcough Syrup, Coldamine, Dihydro-CP, Sinus Relief, Clarinex-D 12 Hour, Aleve-D Sinus & Cold, Sudafed 12 Hour Pressure+Pain, Dimetane DX, Alavert D-12 Hour Allergy and Sinus, Advil Cold and Sinus Liqui-Gels, Polyhist NC, Pseudo GG, Unifed, Silfedrine, Simplet, Pseudovent, Congestac, Allegra-D 12 Hour Allergy & Congestion, Cold Medicine Plus, Dimacol, Disophrol, Disobrom, Duraflu, Capmist DM, Neo AC, Up and Up All Day Allergy Relief D, Allergy Relief D, Cetiri D, Guaifenex PSE 80, Palgic DS, Deltuss DMX, Guaifen DAC, Rondamine, Pseudovent 400, Sudal SR, We Mist II LA, Panmist LA, Tusnel Pediatric Drops, Respaire-30, Lortuss EX, Robitussin-DAC, Coldmist Jr, Coldmist LA, Biclora-D, Carbiset, Coldec, Duomine, Acticon, Bromfenex, Histex SR, Shellcap, Lodrane, M-END, Suclor, Chlor-Trimeton Allergy Decongestant, Sildec, Brotapp, Dixaphedrine, Singlet, Pseudox M, Coldec D, Drixoral Cold and Allergy, Biodec DM, Dimaphen, Respi-Tann, Dynatuss, Guaifed, Dristan Cold Maximum Strength, Ambifed-G DM, Benadryl Allergy Sinus, Benadryl Children's Allergy And Sinus, Despec DM, Altarussin CF, Rezira, Brexin LA, Robitussin Cough & Cold D, Relacon-DM, Histinex PV, Hydron PCS, Duotan, Durafed, Deconamine, Clorfed, P-Tuss DM, Advil Allergy Sinus, Benylin Multi-Symptom, Decongestant Cold Formula, Vicks 44D, Multi Symptom Cough and Cold, Medent DM, M-End DMX, Medent-DMI, Mardrops-DX, Maxifed DM, Curaler, Pseudodine C, SuTan, Lortuss DM, Dicel, Klerist-D, Sudafed Cough Syrup, Dicel DM, Kidkare Cough/Cold, Triaminic-D Multi-Symptom Cold, Nalex Expectorant, Rescon-DM, Neotuss D, Benylin DM-D-E, Donatussin DM Syrup, NasOpen, Orlenta, Maldec, Allerfrin, Contac Cold, Sudafed Children's Nasal Decongestant, AllerClear D-24 Hour, Daytime Cold, Contact Cold and Sore Throat, Theraflu (pseudoephedrine) Daytime Severe Cold, Theraflu Flu, Cold and Cough Powder, Stahist, Tylenol Severe Cold & Flu Night Time, Amdry-D, Mesehist WC, Aleve-D Sinus & Headache, Bromophed-DX, Dimetapp DM, Triptifed, Histafed, Pseudoephedrine Sinus, Sinutab Ex-Strength, Sinus Maximum Strength, Sine-Off Maximum Strength, Tylenol Sinus Maximum Strength, Allerest Headache Strength, Sinutab Regular Strength, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Profen II DM Liquid, Syn-Rx DM, Sudodrin, Guaifenex DM RX, ExeFen-DMX, Aldex GS DM, Coldmist DM, Despec Drops, Pseudo Cough, Relasin DM, Relacon-DM NR, Touro CC-LD, Z-Cof DM(obs), Tusnel Pediatric, Elixsure Decongestant, Suda-Tussin DM, Z-Cof DM, Seldane-D, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Daytime Liquicap, Tussin Cough and Cold, Comtrex Acute Head Cold, Profen II DM, Pseudogest-DM, Med-RX DM, Tussafed-LA, Drixoral Decongestant Non-Drowsy, Touro CC, Profen Forte DM, Viravan-P, SudoGest 12 Hour, Protuss DM, Kid Kare Drops, Superfed, Sudrine, Seudotabs, Actifed Allergy Day/Night, Chlor-Trimeton Nasal Decongestant, Afrinol, Hydro-Tussin EXP, Pancof EXP, Welltuss EXP, Decofed Liquid, Tavist NightTime Allergy, Respa SA, Cenafed, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Contac Cold and Flu Maximum Strength, Lortuss LQ, Tekral, Ridafed, Genaphed, Benaphen Plus, Uni-Cof Expectorant, DiHydro-GP, Dorcol Childrens Cough, Pseudo Max DMX, SudaTex-DM, Desgen DM (with pseudoephedrine), Pseudo DM GG, Trikof-D, Liquicough DM, Maxifed DMX, Z-Cof 12DM, Myfedrine, Decofed, Efidac, Benylin DM-D, Pedia Relief Infant, Viravan-PDM, Pediatex TDM, Balminil DM + Decongestant, Tussin Pediatric Cold and Cough, Dexatrex D, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Ambi 40 /400 /20, Ambenyl-D, 12 Hour Cold, Dexophed, Dexaphen SA, Drixomed, Pharmadrine, Desihist SA, Drexophed SR, Triacin, Biofed-PE, Altafed, Actagen, Vi-Sudo, Triphed, LA Nasal Decongestant, Ridifed, Hista-Tabs, TanDur DM, SuTan-DM, Tri-Sudo, Dur-Tann Forte, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Bromatan Plus, Ritifed, Actacin, Nucofed, Codar D, EndaCof-DC, Notuss-DC, KG-Fed, Zodryl DEC, Codafed Pediatric, Novagest with Codeine, Suttar SF, Codafed, Suttar-2, Cycofed, Nucodine, Deka, Clarinex-D 24 Hour, Zymine DXR, Pseudocot-T, Trisofed, Trip-PSE, Trifed C, Tripohist D, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Tannate PD-DM, Abatuss DMX, Poly-Vent DM, Entre-Cough, PanMist DM, Sudafed Cough, Balminil DM + Decongestant + Expectorant, Entex Pac, Z-Cof 8DM, Zymine-D, Allerfrim, Ed A-Hist PSE, Hist-PSE, TL-Dex DM, Ambi 600/1000/30, Anatuss DM, Z-COF 12, Tussadur-HD, Novahistine DMX, Ru-Tuss Expectorant, Novahistine DM Expectorant with Decongestant, Tenar DM, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Ambifed DM, Pediatex TD, Allercon, Atrofed, Atrogen, Duotan PD, Tanafed DP, AllerDur, Histatab D, DuraHist D, TanaCof DM, Tanafed DMX, Polaramine Expectorant, D-Hist D, Deltuss DP, Hexafed, Allerphed, Triposed, Triafed, Genac, Triofed, Aphedrid, Nalfrx, Atridine, Actedril, A-Phedrin, Rhinosyn-X, Entuss-D, Robitussin Severe Congestion, Sinutab Non Drying, Uni Tussin PE, Humibid GC, Med-RX, Sudafed Non Drying Sinus, S-Pack, Degen II, Robafen PE, Guaivent (Ethex), Altarussin PE, Nasabid SR, Panmist JR, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Profen II, ExeFen-IR, H 9600 SR, Pseudovent Ped, Guaifenex GP, Dynex, Venbid TR, Sinufed, Pseudo-G/PSI, Ami-Tex PSE, Mucus D, Zaptec PSE, Advil Children's Cold, Iotex PSE, Guaipax PSE, Comtrex Cold and Flu Maximum Strength Liquid, Hi Tex PSE, Guiatex PSE, Guai Sudo, Ru-Tuss DE, Guaifenex RX, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Q-Tussin PE, Mytussin PE, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Guiatex II SR, We Mist LA, Ambi 60/1000, Mucus Relief D, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, ExeFen, Ru-Tuss Jr., Maxifed-G, Liquituss HD, Maxifed, Pseudo GG TR, Protuss-D, Procof D, Histinex D, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Iotussin D Liquid, Hytussin, SymTan, Tussafin, Tussgen, P-V-Tussin, Nomuc-PE, Poly-Vent, Jr., Motrin Sinus Headache, Levall G, Motrin Childrens Cold, Motrin Cold and Flu, Sine-Aid IB, Ambifed-G, Pseudo Max, SudaTex-G, Coldmist, Drituss GP, Panmist-S, Motrin IB Sinus, Genacol Maximum Strength, Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Touro LA-LD, Pseudatex, Zymine HC, Histussin D, Detussin, Medent, Comtrex Cold and Flu Maximum Strength Tablet, Guaifenex PSE 120, Respivent-D, Allerx-D, Extendryl PSE, AlleRx Dose Pack (AM Dose), Sudatrate, Sinus & Cold D, Quadra-Hist D Pediatric, Childrens Tylenol Cold Plus Cough, nasofed, Comtrex Day and Night, Quadra-Hist D, Allergy Relief D 24 Hour, Allergy & Congestion Relief, Poly-Vent IR, Medent-LDI, Despec-Tab, Entex T, Pan-Mist LA, Zephrex LA, Leader Allergy Relief D-24, Entex PSE, Nalex CR, Mardrops-EX, Suphedrin, Drixoral Non-Drowsy, KG-Tuss HD, Hydrotussin HD, Novafed, Allermed, Children's Dimetapp Decongestant Infant, Pancof HC, Poly-Tussin XP, Detussin Expectorant, Tussgen Expectorant, SRC Expectorant, Deconamine CX, ElixSure Congestion, Medtuss HD, Hydro-Tuss XP, Dynex HD, Entex HC, Pseudatex HC, Drituss HD, Hytussin Expectorant, Spantuss HD, Vanacon, Su-Tuss HD Elixir, Tussafin Liquid, Guaimax-D, Anatuss LA, Guiadrine II, Demibid II, Iosal II, Respa-1st, Guiatex II, Guaifenex PSE 60, D-Feda II, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, Ambifed, Guiadrine II SR, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, GP 500, Tenar PSE, Defen-LA, Decongest II, Desal II, Deco-D, Tuss-LA, Sudal 60/500, Respaire-120 SR, G-Phed, Guaibid D, Nalex Jr, G-Phed- PD, Nasabid, Respaire-60 SR, Touro LA, Fenex-PSE, Nalex, Syn-Rx, Sinufed Timecelles, Versacaps, Pseudocot-G, Nasatab LA, Cough Formula M Multi-Symptom, Eudal SR, Clear-Atadine-D, Allergy Relief D12, Guaivent PD, Guaibid D Pediatric, Claritin-D 12 Hour, Guaifenesin DAC Liquid, Tussend Expectorant, Ambifed-G CDX, BroveX PSE, Lodrane D, BroveX PD, BroveX PSB, Bromhist Pediatric, B-Vex PD, Rynex PSE, Lodrane 12D, Brofed, LoHist PSB, Bromfed PD, Bromfed SR, Bidhist-D, Endafed, Touro A&H, Bromfenex PD, Pseubrom-PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Ultrabrom PD, Iofed PD, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Respahist, J-Tan D HC, SymTan A, Q-Tapp DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Histacol BD Drops, Allanhist PDX Drops, Bromhist-DM Drops, Bromplex DM, PSE Brom DM, Bromaxefed DM RF Syrup, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Brom Tann, ProHist DM, Visvex, Bromph HD, Bromcomp HC, Endacof HC, Brovex HC, Bromplex HD, Anaplex HD, Carbodex DM Syrup, P-Hist DM Drops, Sildec DM, J-Cof DHC, Drocon-CS, Lodrane Liquid, Nalfed, Pediatex-DM, Decahist-DM, Cordron-DM NR, Pseudo Carb DM, PSE Carbinoxamine DM, Mintex DM, Carbofed DM Drops, Carbaxef-DM, Maldec-DM, Rondamine DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, PSE Carb DM Drops, Carboxine DM, Pannaz S, Mintex HC, Pannaz, Biohist LA, Pediatex 12D, Carbodec, Histex HC, Tri-Vent HC, Carb PSE 12 DM, Carboxine 12 DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Tussafed, Cordron-DM, Di-Bromm, Unit-Hist Drops, Bromhist-NR, Brovex SR, LoHist-PD, Lodrane 24D, Unit-Tex 10/120 ER, AccuHist Pediatric, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, LoHist-12D, J-TanD PD, Zotex-D, Pseudacarb, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Allres D, Allres Pd, Re-Tann, Exall-D, Respi-Tann Pd, Carb Pseudo-Tan, Corzall, Bromtapp-DM, Andehist DM NR Syrup, Tusnel-A, Maxiflu DM, Theraflu Flu Cold & Cough, Comtrex Non-Drowsy, Day Time Multi Symptom, Contac Severe Cold and Flu Non Drowsy, Flutabs, Theraflu Max-D Severe Cold & Flu, Robitussin Cold Cough and Flu, All-Nite Multi-Symptom Cold/Flu Relief, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Balminil Cough and Flu Sugar Free, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, Benadryl Severe Allergy & Sinus Headache, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Severe Congestion Daytime, Tylenol Sinus Day/Night Convenience Pack, Sudafed Sinus Nighttime Plus Pain, Contac Day and Night Allergy, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Benadryl Cold, NyCair, Multi-Symptom Nighttime, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, Comtrex Allergy Sinus Night and Day, Sinarest Extra Strength, Sinutab Maximum Strength Caplets, Triaminicin, Allerest Sinus, Kolephrin, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Tricom, Comtrex Allergy Sinus, Codimal, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Drixoral Sinus, Drixoral Cold and Flu, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Drixoral Allergy Sinus, Sinadrin Plus, Maxiflu CD, Tavist Allergy/Sinus/Headache, Maxiflu CDX, Drixoral Cold/Flu, Complete Sinus Relief, Sudafed Triple Action, Suphedrin Sinus, BroveX PSE DM Tablets, PediaHist DM, BroveX PSE DM, PBM Allergy, Anaplex DMX, BroveX PSB DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, BromTann/DM Tann/PSE Tann, Bromdex D, Bromadine-DM, Brometane DX, Anaplex DM, Bromphenex DM, Brotapp-DM, Liquiphed DM, Myphetane DX Cough, Dallergy DM, Neo DM Syrup, Myphetane DX, Bromanate DX Cough, Bromatane DX, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Ephed Plus, Bayer Select Sinus Pain Formula, Dristan Cold Non-Drowsy, Contac Sinus, Suphedrin Plus, Genapap Sinus, Sinutab Maximum Strength Non Drowsy, Ornex, Allerest No Drowsiness, Ornex Maximum Strength, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Tavist Sinus, Phenapap, Sinarest Sinus, SymPak II, Dicel CD, M-End WC, Mar-cof BP, Rydex, Trinalin Repetabs, Sta-D, Actifed Cold and Sinus, Sinutab Maximum Strength, Ursinus, Ru-Tuss, Respa-AR, Carboxine 12D, Cydec, Histafed LA, Chlorafed, Aller-Chlor Decongestant, Sudogest Plus, Ryna Liquid, Neutrahist Drops, Clorfed II, Fedahist Gyrocaps, Cophene No 2, Pseudochlor, Anaplex, Anamine, Codimal-LA Half, Sudogest Cold & Allergy, Genaphed Plus, CP-Tannic, Dynahist-ER Pediatric, Histade, Mintex, Sudal-12, Re2+30, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, Hayfebrol Liquid, SudoGest Sinus & Allergy, Suphedrine Plus, Atrohist Pediatric Capsule, Allerest Maximum Strength, Rescon-Ed, Chlorafed Timecelles, Chlorafed HS Timecelles, Tanafed, Codimal-LA, Kronofed-A-Jr, Fedahist Timecaps, Dura-Tap/PD, Fedahist, Histalet, Biohist LA (old formulation), Chlor-Trimeton Decongestant, Deconamine SR, Novafed A, Duratuss DA, Chlorphedrin SR, Colfed-A, ND Clear, Kronofed-A, Chlordrine SR, Anamine TD, Time-Hist, Isophen-DF, Suphenamine-SR, Deconomed SR, D-Amine-SR, Pseudocot-C, Duralex, Rinade-BID, Pediox Chewable, C-Phed Tannate, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Nucodine Pediatric, Cycofed Expectorant, Nucodine Expectorant, KG-Fed Expectorant, Nucochem Pediatric Expectorant, Novadyne Expectorant, Dihistine Expectorant with Codeine, Decohistine Expectorant, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Deconsal C Expectorant, Guaiatussin DAC, Phenylhistine Expectorant, Biotussin DAC, Nuco-Tuss Expectorant, Nucochem, Gua PC, Dihistine, Tussar SF, Nucofed Pediatric Expectorant, Mytussin DAC, Guiatuss DAC, Guiatussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Co-Histine Expectorant, Deproist with Codeine, Qdall, Pseudoephedrine Plus, Dynahist ER, M-End Max D, Tusnel C, Theraflu Flu & Cough, Triaminic Softchews Cold and Allergy, LoHist-D, Sudal-12 Chewable, De-Congestine, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), Z-Tuss E, Tricode GF, Medent C, Ryna-CX, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Maxifed-G CDX, Maxifed-G CD, Ambifed CDX, Ambifed CD, Ambifed-G CD, Maxifed CD, Maxifed CDX, Histade CR, Histatab, Dihistine DH, Statuss Green, Tricode AR, Zodryl DAC, Decohistine DH, Phenylhistine DH, Notuss-NXD, Poly-Tussin D, Vanacof DX, Panatuss PED, Vanatab DX, Certuss-D, Clofera, Codehist DH, Phenylhistine DH Expectorant, Kidcare Cough and Cold, Creomulsion Pediatric, Children's Nyquil, Tanafed-DM, M-End DM, C-Phed DM, Creomulsion Cough/Cold/Allergy, Vicks 44M Pediatric, Co-Histine DH, Novadyne DH, Ryna-C, Codahistine-DH Elixir, Rhinosyn-DM, Panatuss PED Drops, Allpanto-S, Ex-Dec-TR, Dura-Ron, Coldec-TR, Andehist, Carboxine-PSE, Hydro-Tussin CBX, Carbic-D, Andec-TR, Andec, Palgic-DC, Mooredec, Cardec-S, Palgic-D, Cordron-D, Pediatex-D, KS Aller-Tec D-12, Allergy D-12, Zyrtec-D 12 Hour, All Day Allergy-D, Chlo Tuss, Co-Apap, Mintex PSE, Cordron-12 D, Cordron-D NR, Pseudo Carb, Carboxine-D, PSE Allergy, Atuss-12 DM, Atuss DS, AlleRx Dose Pack, Advil Children's Allergy Sinus, DryMax, DuraHist, RelCof DN PSE, Xiral SR, Atuss HS, Atuss HD, Hydrotuss HC, P-V-Tussin Syrup, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Dallergy PSE, Relcof PSE, Pseudo CM TR, Allergy DN, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Rhinaclear, AllePak, Hista-Vent PSE, Mescolor, PCM-LA, Amdry-C, Time-Hist QD, KG-Tussin, A-G Tussin, Duotan DM, Allres DS, T-Tanna DM, Pancof, Hydro-Tussin DHC, Tricof, Mesehist DM, Esocor P, Maxichlor PSE DM, Entre-S, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Uni-Cof, Z-Tuss 2, Hexatussin, Welltuss HC, Hyphed, Tussin-V, Q-V Tussin, Tussend, Pediatex HC, Notuss-Forte, Lemohist Plus, Notuss, Detuss, JayCof-HC, Codahistine Expectorant

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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