Skip to Content

Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Claritin-D, Allegra-D 12 Hour, Mucinex D, Zyrtec-D, Sudafed 12-Hour, Allegra-D 24 Hour, SudoGest, Theraflu Flu & Cough, Show all 1046 »Advil Cold and Sinus, Aleve-D Sinus & Cold, Claritin-D 24 Hour, Robitussin Cough & Cold D, Robitussin Allergy & Cough, Actifed, Capmist DM, Tylenol Cold, Conex, Comtrex Cold and Flu Maximum Strength Tablet, Vanacof, Aprodine, Coldcough Syrup, Resperal-DM, Semprex-D, Wal-Zyr D, Tusnel, Loratadine-D 24 Hour, Virtussin DAC, Maldec, Zyrtec-D 12 Hour, Dimetapp Elixir, Duraflu, Zephrex, Sinarest, Duomine, Dristan Cold Non-Drowsy, Vicks Dayquil Daytime Cold/Flu (old formulation), Pseudoephedrine Sinus, Rescon, Abatuss DMX, M-End DMX, Chlo Tuss, Clarinex-D 12 Hour, Advil Allergy Sinus, Cetiri D, LoHist-D, Sudafed 24-Hour, Ambifed CD, Childrens Tylenol Cold Plus Cough, Bromaline, Unifed, Singlet, Sudafed Children's Nasal Decongestant, Aleve-D Sinus & Headache, AllerClear D-24 Hour, Claritin-D 12 Hour, Rynex PSE, Pseudovent, Mucinex D Maximum Strength, Brotapp, Nacon, Clorfed, Mooredec, Dimetapp DM, Allergy Relief D, CPM-PSE DM Drops, Dimetane DX, Dristan Cold Maximum Strength, Bromfed SR, Rhinosyn-DM, Bromophed-DX, Brometane DX, Bromphenex DM, Isophen-DF, Dimaphen, Phenylhistine DH Expectorant, Brofed, Stahist AD, Kronofed-A-Jr, Entex, Curaler, Motrin IB Sinus, Desal II, Sinufed, Tusnel Pediatric Drops, Robitussin Severe Congestion, Profen Forte, Mucus Relief D, Allerfrin, Motrin Childrens Cold, Touro LA, Hista-Tabs, Genac, Loratadine-D 12 Hour, Allergy & Congestion Relief, Sudafed 12 Hour Pressure+Pain, Genaphed, nasofed, Decongest II, Entex PSE, Aller-Chlor Decongestant, Deltuss DMX, Dicel, Biotussin DAC, Cheratussin DAC, Nucochem, Clarinex-D 24 Hour, Disophrol, Tannate DMP-DEX, D-Hist D, Trisofed, SymPak II, Robitussin CF, Benylin DM-D-E, Relacon-DM, Trikof-D, Benylin Multi-Symptom, Actifed Allergy Day/Night, 12 Hour Cold, Maxifed, Cough Formula M Multi-Symptom, Sinus Relief, Sinutab Maximum Strength, Daytime Cold, Ursinus, Stahist, Daytime Cold and Flu Relief, Contact Cold and Sore Throat, NyCair, Vicks Nyquil D Cold and Flu Nighttime Relief, Benadryl Cold, Sinus Maximum Strength, Flutabs, Benadryl Severe Allergy & Sinus Headache, Maxiflu CD, Comtrex Day and Night, Benadryl Children's Allergy And Sinus, Respa SA, Tavist NightTime Allergy, Tekral, Benaphen Plus, Benadryl Allergy Sinus, Dicel CD, Lortuss LQ, Allegra-D 12 Hour Allergy & Congestion, All-Nite Cold, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Tussadur-HD, Tussend Expectorant, Detussin Expectorant, Tussgen Expectorant, SRC Expectorant, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, Allegra-D 24 Hour Allergy & Congestion, Uni-Cof Expectorant, Tylenol Severe Cold & Flu Night Time, Drixoral Cough & Congestion Liquid Caps, Ambi 40 /400 /20, Liquicough DM, Maxifed DMX, Z-Cof 12DM, Pseudo DM GG, Pseudo Max DMX, SudaTex-DM, Desgen DM (with pseudoephedrine), P-Tuss DM, Dexatrex D, Buckley's DM Decongestant, Vicks 44D, Welltuss EXP, Decongestant Cold Formula, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Pedia Relief Infant, Viravan-PDM, Pediatex TDM, DiHydro-GP, Hydrotussin HD, Hydro-Tussin EXP, Pancof EXP, Entuss-D, Hytussin Expectorant, KG-Tuss HD, Respaire-60 SR, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Despec-Tab, Entex T, Guaimax-D, Anatuss LA, Fenex-PSE, Nalex, Syn-Rx, Nasabid, Zephrex LA, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Versacaps, Guaivent PD, Guaibid D Pediatric, Pseudocot-G, Congestac, Mardrops-EX, Medtuss HD, Contac Day and Night Cold and Flu, Spantuss HD, Vanacon, Su-Tuss HD Elixir, Tussafin Liquid, Relasin DM, Drituss HD, Hydro-Tuss XP, Dynex HD, Entex HC, Pseudatex HC, Hycofenix, Hexaflu, Nalex CR, Drixoral Sinus, Drixoral Cold and Flu, Drixoral Allergy Sinus, Sinadrin Plus, Complete Sinus Relief, Drixoral Cold/Flu, Maxiflu CDX, Tavist Allergy/Sinus/Headache, Actifed Cold & Sinus, Tussafed, Cold Medicine Plus, Z-Cof DM, Touro CC-LD, Pseudo Cough, AllerDur, SuTan-DM, Tannate PD-DM, TanaCof DM, Tanafed DMX, Polaramine Expectorant, Maxiflu DM, DuraHist D, Histatab D, Theraflu Max-D Severe Cold & Flu, Duotan PD, Tanafed DP, SuTan, Dur-Tann Forte, Deltuss DP, Hexafed, Nalfrx, Lortuss DM, Balminil Cough and Flu Sugar Free, Phlemgesic, Tylenol Cold Severe Congestion Daytime, Robitussin Cold Cough and Flu, All-Nite Multi-Symptom Cold/Flu Relief, Multi-Symptom Nighttime, Z-Cof 8DM, TanDur DM, Bromatan Plus, Entre-Cough, Alka-Seltzer Plus Flu/Body, Polyhist NC, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Pseudodine C, Non-Drowsy Super Strength Contac Complete, Day Time Multi Symptom, Deka, Contac Severe Cold and Flu Non Drowsy, Comtrex Non-Drowsy, Theraflu Flu Cold & Cough, DuraTan Forte, Drexophed SR, Desihist SA, Dexophed, Disobrom, Acticon, Dexaphen SA, Drixomed, Drixoral Cold and Allergy, Pharmadrine, Dixaphedrine, Tusnel-A, C-Phed DPD Tann, Entex Pac, Poly-Vent DM, Despec DM, Profen II DM Liquid, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, Profen Forte DM, Profen II DM, ExeFen-DMX, ExeClear-DM, Tusnel Ped-C, S-Pak DM, Ru-Tuss DM, Aldex GS DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Ambifed-G DM, Tusnel Pediatric, Eudal SR, Relacon-DM NR, Despec Drops, Tusnel-DM Pediatric Drops, Pseudogest-DM, Medent-DMI, Ambifed DM, Mardrops-DX, Maxifed DM, PanMist DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Ambi 600/1000/30, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Tenar DM, Suda-Tussin DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Ambenyl-D, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Nasatab LA, Duratuss GP (old formulation), Sudal 60/500, Triaminic Flu, Cough & Fever, Allerx-D, Kolephrin, Codimal, Comtrex Allergy Sinus, Sinus & Cold D, Quadra-Hist D Pediatric, Quadra-Hist D, Tricom, Simplet, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Extendryl PSE, Theracaps Multi-Symptom Cough & Cold Reliever, Co-Apap, Allpanto-S, Nexafed Nasal Decongestant, Silfedrine, Suphedrin, Suphedrine, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Respivent-D, Amdry-D, Ridafed, Advil Children's Cold, Detussin, Histussin D, Zymine HC, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Triaminicin, Dristan Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Sinus Headache, Advil Cold and Sinus Liqui-Gels, Sinarest Extra Strength, AlleRx Dose Pack (AM Dose), Allerest Headache Strength, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, Sinutab Ex-Strength, Tylenol Allergy Sinus, Allerest Sinus, Clear-Atadine-D, Alavert D-12 Hour Allergy and Sinus, Allergy Relief D12, Leader Allergy Relief D-24, Allergy Relief D 24 Hour, Sudatrate, Cenafed, Seudotabs, SymTan, Tri-Sudo, Triposed, Allerphed, Triofed, Aphedrid, A-Phedrin, Actedril, Atridine, Atrofed, Atrogen, LA Nasal Decongestant, Ridifed, Triphed, Allercon, Vi-Sudo, Triptifed, Actagen, Altafed, Biofed-PE, Histafed, Triacin, Ritifed, Actacin, Pseudocot-T, Zymine DXR, Trip-PSE, Triafed, Pediatex TD, Sudrine, Contac Cold, Superfed, Chlor-Trimeton Nasal Decongestant, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Drixoral Decongestant Non-Drowsy, Zymine-D, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Contac Cold and Flu Maximum Strength, Genacol Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Theraflu Flu, Cold and Cough Powder, Hist-PSE, Ed A-Hist PSE, Allerfrim, Liquituss HD, Pancof HC, Tuss-LA, T-Tussin PE, Mucus D, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Robichem PE, Tusscidin PE, Ami-Tex PSE, Tussin PE, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Respaire-30, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Uni Tussin PE, Pseudo-G/PSI, Iotex PSE, Med-RX, Ambifed, Stamoist E, V-Dec-M, Nucodine, Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Respa-1st, Guiatex II, Guiadrine II SR, Guaipax PSE, Defen-LA, Deco-D, Tenar PSE, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Guai Sudo, Humibid GC, Nasabid SR, ColdCough HCM, Ambi 60/580, Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., ExeFen, Ambi 60/1000, Ambi 80/780, Pseudatex, Aquatab D Dose Pack, Protuss-D, Procof D, Rezira, Tussafin, Tussgen, P-V-Tussin, Hytussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, H-C Tussive D, Touro LA-LD, Medent, Panmist LA, We Mist LA, Panmist JR, H 9600 SR, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, SudaTex-G, Guaifenex PSE 80, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Ambifed-G, Levall G, Neo AC, Nucofed, Cycofed, PSE Allergy DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, Cordron-12 DM, Cydec-DM Drops, Pediatex 12 DM, Tri-Vent HC, Histex HC, Mintex HC, Bayer Select Sinus Pain Formula, Pannaz S, Pseudox M, Pannaz, Sinutab Maximum Strength Non Drowsy, Ornex, Biohist LA, Carbaxef-DM, Dura-Ron DM, Coldec, Corzall, Bromhist-NR, Brovex SR, Lodrane 24D, LoHist-PD, LoHist-12D, J-TanD PD, Exall-D, Re-Tann, Respi-Tann Pd, Carb Pseudo-Tan, Respi-Tann, Allres Pd, Cydec-DM Syrup, Allres D, Pseudacarb, Zotex-D, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Cordron-DM, Dynatuss, Ephed Plus, Biodec DM, Rondamine DM, Maldec-DM, Coldec D, Carbodec, Unit-Hist Drops, Vanatab DX, Ornex Maximum Strength, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, All Day Allergy-D, 12 Hour Allergy-D, Biclora-D, Suphedrin Sinus, Panatuss PED Drops, Panatuss PED, Vanacof DX, Certuss-D, Sudogest Sinus Maximum Strength, Rondec-D, Clofera, Ninjacof-D, Poly-Tussin D, Notuss-NXD, Statuss Green, NasOpen, Dihistine DH, Tricode AR, Zodryl DAC, Phenylhistine DH, Decohistine DH, Allerest No Drowsiness, Benadryl Allergy Sinus Headache, Pediatex 12D, Ex-Dec-TR, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Rondamine, Cardec-S, Palgic-D, Andec-TR, Carbic-D, Dura-Ron, Coldec-TR, Tavist Sinus, Andehist, Hydro-Tussin CBX, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, Di-Bromm, Unit-Tex 10/120 ER, Novadyne DH, Carbofed DM Syrup, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Bromadine-DM, Anaplex DM, Brotapp-DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Uni-Hist DM Pediatric Drops, Myphetane DX, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Bromanate DX Cough, Dallergy DM, Sildec DM, Ru-Tuss, M-End WC, Mar-cof BP, Rydex, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Sta-D, Respa-AR, Actifed Cold and Sinus, Neo DM Syrup, Sinarest Sinus, Nexafed Sinus Pressure + Pain, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Carbodex DM Syrup, J-Cof DHC, AccuHist Pediatric, Bromfenex PD, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Histex SR, Bromhist Pediatric, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, Endafed, B-Vex PD, M-END, Suphedrin Plus, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Phenapap, Genapap Sinus, BroveX PSB, Tylenol Sinus Maximum Strength, Sinutab Regular Strength, Sine-Off Maximum Strength, Contac Sinus, Lodrane, LoHist PSB, Bromfed PD, Bidhist-D, Lodrane 12D, Lodrane D, BroveX PSE, BroveX PD, Codehist DH, Co-Histine DH, KG-Fed, SudaHist, CP-Tannic, Histade, Mintex, Suclor, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, AccuHist Drops (old formulation), Tavist-DA, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, Dynahist ER, M-End Max D, Theraflu (pseudoephedrine) Daytime Severe Cold, Comtrex Acute Head Cold, Daytime Non-Drowsy, Tylenol Cold Non-Drowsy Gelcaps, Day Relief Cold and Flu, Lortuss EX, Dynahist-ER Pediatric, Chlor-Trimeton Allergy Decongestant SR, Z-Tuss E, Fedahist Gyrocaps, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Anamine, Klerist-D, Codimal-LA Half, Clorfed II, Allerest Maximum Strength, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Tusnel C, Tricode GF, ND Clear, Gua PC, Guiatuss DAC, Mytussin DAC, Guiatussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Guaifen DAC, Dihistine, Codahistine Expectorant, Deconsal C Expectorant, Novagest with Codeine, Suttar SF, Codafed, Suttar-2, Codafed Pediatric, Coditussin DAC, Guaifenesin DAC, Zodryl DEC, Codar D, Trinalin Repetabs, EndaCof-DC, Notuss-DC, Guaiatussin DAC, Nucodine Expectorant, Ambifed CDX, Tussar-2, Ambifed-G CD, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Deproist with Codeine, KG-Fed Expectorant, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, Chlordrine SR, Kronofed-A, Ryna-C, Histinex PV, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Z-Tuss 2, Lemohist Plus, Zutripro, Notuss-Forte, Notuss, Detuss, JayCof-HC, Pedia Relief Cough-Cold, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Tylenol Sinus Day/Night Convenience Pack, T-Tanna DM, Hydrocof-HC, C-Phed DM, Codahistine-DH Elixir, Neotuss D, Sudafed Triple Action, Tylenol Sinus Severe Congestion Daytime, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Children's Nyquil, Rescon-DM, Tanafed-DM, M-End DM, Duotan DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Hydron PCS, Cordron-HC, Suphenamine-SR, Fedahist, Severe Cold Multi-Symptom, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Deconamine, Deconamine SR, Novafed A, Duratuss DA, Histalet, Tanafed, Sudafed Sinus Nighttime Plus Pain, Chlorafed HS Timecelles, Codimal-LA, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Contac Day and Night Allergy, Tylenol Allergy Complete NightTime, Cordron-HC NR, Mescolor, Atuss HD, Atuss HS, Tylenol Sinus NightTime, Advil Children's Allergy Sinus, AlleRx Dose Pack, DryMax, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Relcof PSE, Hista-Vent PSE, Actifed Sinus Day and Night, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Allergy DN, Pseudo CM TR, Coldamine, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Tripohist D

Medically reviewed by Drugs.com. Last updated on Mar 15, 2020.

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Breast Feeding

Lactation

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.