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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Loratadine-D 24 Hour, Bromfed DM, Sudafed Congestion, Claritin-D, Mucinex D, Zyrtec-D, Tusnel, SudoGest, Sudafed 12-Hour, Advil Cold and Sinus, Show all 1043 »Robitussin Allergy & Cough, Actifed, Allegra-D 12 Hour, Aprodine, Loratadine-D 12 Hour, Claritin-D 24 Hour, Resperal-DM, Despec DM, Conex, Vicks Nyquil D Cold and Flu Nighttime Relief, Aleve-D Sinus & Cold, Suphedrine, Vanacof, Chlo Tuss, Entex, Allegra-D 24 Hour, Guaifen DAC, Cheratussin DAC, Sinarest, Singlet, Tylenol Cold, Allercon, Bromaline, Drixoral Cold and Allergy, Virtussin DAC, nasofed, Claritin-D 12 Hour, Anaplex, Tussin PE, Tusnel Pediatric Drops, Maxifed, Mucinex D Maximum Strength, Deltuss DMX, Allergy D-12, Dristan Sinus, NasOpen, Duomine, Disobrom, Disophrol, Cold Medicine Plus, Chlor-Trimeton Nasal Decongestant, Flutabs, Chlor-Trimeton Allergy Decongestant, Allerest Maximum Strength, Dimetapp DM, All Day Allergy-D, Cetiri D, Robitussin Cough & Cold D, Carbic-D, Childrens Tylenol Cold Plus Cough, Sudafed 24-Hour, Allerfrin, Chlorphedrin SR, Corzall, Motrin IB Sinus, Coldcough Syrup, Dimacol, Levall G, Decongest II, Allegra-D 24 Hour Allergy & Congestion, Respaire-120 SR, Capmist DM, Nexafed Sinus Pressure + Pain, Allpanto-S, Comtrex Day and Night, Fenex-PSE, Lortuss DM, Dicel, Deconamine, Esocor P, Benadryl Allergy Sinus, Bromph DM, AllerClear D-24 Hour, Andehist DM NR Syrup, Dimetane DX, Zutripro, Children's Nyquil, Corzall Plus, Silfedrine, Triacin, Tussafin Liquid, Vicks Dayquil Daytime Cold/Flu (old formulation), Alka-Seltzer Plus Flu/Body, Phenylhistine Expectorant, Brotapp, Novafed, Xiral SR, Lodrane D, Lodrane, Clarinex-D 12 Hour, Kolephrin, Duraflu, Tylenol Allergy Sinus, Bromfed PD, Sinutab Ex-Strength, Actifed Cold & Sinus, Dimetapp Elixir, Genac, Atrogen, Clarinex-D 24 Hour, Actedril, Dixaphedrine, Genaphed, Ridafed, Sudafed Children's Nasal Decongestant, Unifed, Contac Cold, Nalex Expectorant, Stahist AD, Benadryl Severe Allergy & Sinus Headache, Zyrtec-D 12 Hour, Simplet, Wal-Zyr D, Deka, Maldec, Coldec D, Advil Allergy Sinus, Z-Cof 12DM, Touro CC, Z-Cof DM, Trikof-D, Ambi 40 /400 /20, Liquicough DM, Pseudo DM GG, Maxifed DMX, Profen Forte DM, Despec Drops, Relasin DM, Ambifed-G DM, SudaTex-DM, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Tusnel Pediatric, Pseudo Cough, Touro CC-LD, Relacon-DM NR, S-Pak DM, ExeClear-DM, Profen II DM Liquid, ExeFen-DMX, Profen II DM, Pseudo Max DMX, Medtuss HD, Desgen DM (with pseudoephedrine), Tussend Expectorant, Benaphen Plus, Lortuss LQ, Med-RX DM, Allegra-D 12 Hour Allergy & Congestion, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Tussadur-HD, Detussin Expectorant, Respa SA, Tussgen Expectorant, SRC Expectorant, Deconamine CX, Vanacon, Poly-Tussin XP, Spantuss HD, Entuss-D, Hydrotussin HD, KG-Tuss HD, Tekral, Benadryl Children's Allergy And Sinus, P-Tuss DM, Hytussin Expectorant, Dexatrex D, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Decongestant Cold Formula, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Pedia Relief Infant, Viravan-PDM, Tavist NightTime Allergy, Su-Tuss HD Elixir, Pediatex TDM, DiHydro-GP, Uni-Cof Expectorant, Hydro-Tussin EXP, Pancof EXP, Welltuss EXP, Benylin Multi-Symptom, Actifed Allergy Day/Night, Tussafed-LA, Maxifed DM, Protuss DM, M-End DMX, Notuss-DC, KG-Fed, Cycofed, Nucodine, Neo AC, Polyhist NC, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Pseudodine C, Drexophed SR, Nucofed, Desihist SA, Dexophed, Acticon, 12 Hour Cold, Dexaphen SA, Drixomed, Pharmadrine, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Bromatan Plus, EndaCof-DC, Codar D, TanDur DM, Tussar SF, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Guiatussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Biotussin DAC, Zodryl DEC, Nuco-Tuss Expectorant, Nucochem, Dihistine, Gua PC, Codahistine Expectorant, Guaifenesin DAC Liquid, Novagest with Codeine, Suttar SF, Codafed, Suttar-2, Codafed Pediatric, Dur-Tann Forte, SuTan-DM, Tussin Cough and Cold, Novahistine DMX, Benylin DM-D-E, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Ambifed DM, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Ambenyl-D, Ru-Tuss Expectorant, TL-Dex DM, Rhinosyn-X, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Pseudogest-DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Ambi 600/1000/30, Balminil DM + Decongestant + Expectorant, Tannate PD-DM, Deltuss DP, Abatuss DMX, TanaCof DM, Tanafed DMX, Polaramine Expectorant, D-Hist D, DuraHist D, Histatab D, Duotan PD, Tanafed DP, AllerDur, SuTan, Rescon, Sudafed Cough Syrup, Hexafed, Nalfrx, Z-Cof 8DM, Entex Pac, Entre-Cough, Poly-Vent DM, Medent-DMI, Mardrops-DX, Hydro-Tuss XP, PanMist DM, Sudafed Cough, Drituss HD, Sinufed Timecelles, Dynex HD, Advil Cold and Sinus Liqui-Gels, ColdCough HCM, Pancof HC, SymTan, Liquituss HD, Detussin, Histussin D, Zymine HC, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Advil Children's Cold, Entuss-D Liquid, Clear-Atadine-D, Alavert D-12 Hour Allergy and Sinus, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Allerx-D, H-C Tussive D, Histinex D, Sudafed 12 Hour Pressure+Pain, Ru-Tuss Jr., Guaifenex PSE 80, Medent, Pseudatex, Touro LA-LD, Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Pseudo GG TR, ExeFen, Iotussin D Liquid, Mucus Relief D, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, Protuss-D, Procof D, Rezira, Tussafin, Tussgen, P-V-Tussin, Hytussin, Sinus & Cold D, Aleve-D Sinus & Headache, Pseudovent 400, Tri-Sudo, Triafed, Triposed, Allerphed, Triofed, Aphedrid, A-Phedrin, Atridine, Atrofed, Hista-Tabs, LA Nasal Decongestant, Ridifed, Triphed, Zymine-D, Vi-Sudo, Triptifed, Actagen, Altafed, Biofed-PE, Histafed, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Pediatex TD, Allerfrim, Quadra-Hist D Pediatric, Decofed Liquid, Quadra-Hist D, Nexafed Nasal Decongestant, Suphedrin, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Cenafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Efidac, Ed A-Hist PSE, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Ambifed-G, Pseudo Max, Entex HC, Guiadrine II, Nasatab LA, Eudal SR, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Iosal II, Guaibid D Pediatric, Respa-1st, Guiatex II, Ambifed, Guiadrine II SR, Defen-LA, Desal II, Deco-D, Tenar PSE, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Pseudocot-G, Guaivent PD, Guaifenex PSE 120, Entex T, Pseudatex HC, Hycofenix, Entex PSE, Nalex CR, Mardrops-EX, Zephrex LA, Congestac, Zephrex, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Despec-Tab, Guaimax-D, Versacaps, Anatuss LA, Touro LA, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Nuco-Tuss Pediatric Expectorant, Guai-Vent/PSE, Hi Tex PSE, Sudal SR, Profen Forte, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Durasal II, Robitussin Severe Congestion, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, SudaTex-G, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Uni Tussin PE, Sinutab Non Drying, Guiatex PSE, Mastussin PE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Mucus D, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mytussin PE, Sudafed Non Drying Sinus, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Sinufed, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Respaire-30, Altarussin PE, S-Pack, Nucodine Pediatric, Cordron-DM, Nucochem Expectorant, Brofed, M-END, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, LoHist PSB, Bromfed SR, Sildec DM, Bidhist-D, Lodrane 12D, Rynex PSE, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Shellcap, Allent, J-Cof DHC, Carbodex DM Syrup, Lodrane LD, Bromtapp-DM, Dallergy DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Brometane DX, Bromadine-DM, Anaplex DM, Bromphenex DM, Brotapp-DM, Bromaxefed DM RF Syrup, P-Hist DM Drops, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, Shellcap PD, Nalfed PD, Bromdex D, Biodec DM, Respi-Tann Pd, Carb Pseudo-Tan, Respi-Tann, Allres Pd, Allres D, Pseudacarb, Zotex-D, Andehist DM NR, Carbodex DM Drops, Comtrex Acute Head Cold, Dynatuss, Tussafed, Rondamine DM, Exall-D, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, Re-Tann, J-TanD PD, Respahist, Touro Allergy, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Andehist NR Syrup, LoHist-12D, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, Dimaphen, Lodrane 24D, LoHist-PD, Neo DM Syrup, BromTann/DM Tann/PSE Tann, Carboxine DM, Balminil Cough and Flu Sugar Free, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Robitussin Cold Cough and Flu, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Theraflu Max-D Severe Cold & Flu, Sinadrin Plus, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Contact Cold and Sore Throat, Day Relief Cold and Flu, Tylenol Cold Non-Drowsy Gelcaps, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Drixoral Allergy Sinus, Complete Sinus Relief, Severe Cold Multi-Symptom, Comtrex Nighttime Flu Therapy, Theraflu Flu, Cold and Cough Powder, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Comtrex Sinus and Nasal, Tricom, Drixoral Cold/Flu, Comtrex Allergy Sinus, Codimal, Allerest Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Tavist Allergy/Sinus/Headache, Maxiflu CD, Maxiflu CDX, Theraflu (pseudoephedrine) Daytime Severe Cold, Daytime Cold, Anaplex DMX, Mar-cof BP, Sinutab Maximum Strength, Actifed Cold and Sinus, Semprex-D, Ursinus, Stahist, Ru-Tuss, Respa-AR, Sta-D, Trinalin Repetabs, Dicel CD, SymPak II, M-End WC, Rydex, Pseudoephedrine Sinus, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Sinarest Sinus, Phenapap, Benadryl Cold, Sudogest Sinus Maximum Strength, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Sinus Maximum Strength, Suphedrin Sinus, Ornex Maximum Strength, Allerest No Drowsiness, Benadryl Allergy Sinus Headache, Suphedrin Plus, Tavist Sinus, Ornex, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Alka-Seltzer Cold and Sinus, Sinus Relief, Dristan Cold Non-Drowsy, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, Genapap Sinus, PSE Carb DM Drops, Carboxine 12 DM, Nucochem Pediatric Expectorant, ND Clear, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, Chlordrine SR, Codimal-LA, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Kronofed-A-Jr, Chlorafed HS Timecelles, Chlorafed, ScopoHist, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Allergy DN, Pseudo CM TR, Coldamine, Allergy AM-PM Dose Pack, Tanafed, VisRx Dose Pack, Histatab, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Deconamine SR, Novafed A, Duratuss DA, Clorfed, Histalet, Fedahist, Curaler, Histafed LA, DuraHist, Maxifed-G CDX, Dristan Cold Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Tricode GF, Ambifed CD, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Maxifed-G CD, Robitussin-DAC, Dynahist ER, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, M-End Max D, Qdall, Aller-Chlor Decongestant, CP-Tannic, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, Histade, Pseudoephedrine Plus, Mintex, Suclor, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, RelCof DN PSE, DryMax, Carb PSE 12 DM, Biclora-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, 12 Hour Allergy-D, Allergy Relief D, Panatuss PED Drops, Carboxine-PSE, Panatuss PED, Vanacof DX, Vanatab DX, Certuss-D, Clofera, Poly-Tussin D, Notuss-NXD, Statuss Green, Dihistine DH, Tricode AR, Zodryl DAC, Phenylhistine DH, Cordron-D, Hydro-Tussin CBX, Codehist DH, Carbodec, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Tri-Vent HC, Histex HC, Mintex HC, Pannaz S, Pseudox M, Nacon, Pannaz, Biohist LA, Coldec, Pediatex 12D, Andehist, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Mooredec, Rondamine, Cardec-S, Palgic-D, Andec-TR, Dura-Ron, Ex-Dec-TR, Coldec-TR, Decohistine DH, Phenylhistine DH Expectorant, AlleRx Dose Pack, Hexatussin, Dihydro-CP, Uni-Cof, Z-Tuss 2, Lemohist Plus, Notuss-Forte, Notuss, Detuss, Histinex PV, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hyphed, Tricof, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Children's Allergy Sinus, Hydro-Tussin DHC, Pancof, Novadyne DH, M-End DM, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Neotuss D, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Tanafed-DM, C-Phed DM, Atuss-12 DM, Pedia Relief Cough-Cold, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Tripohist D

Medically reviewed on January 10, 2017

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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