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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Claritin-D, Bromfed DM, Sudafed Congestion, SudoGest, Mucinex D, Zyrtec-D, Virtussin DAC, Sudafed 12-Hour, Actifed, Vicks Dayquil Daytime Cold/Flu, Show all 1037 »Allegra-D 24 Hour, Allegra-D 12 Hour, Entex, Cheratussin DAC, Claritin-D 24 Hour, Resperal-DM, Vicks Nyquil D Cold and Flu Nighttime Relief, Aprodine, Wal-Zyr D, Dimetapp Elixir, Rescon, Suphedrine, Theraflu Flu, Cold and Cough Powder, Drixoral, Singlet, Advil Cold and Sinus, Robitussin Allergy & Cough, Claritin-D 12 Hour, Semprex-D, Lodrane D, Robitussin Cold Cough and Flu, Allpanto-S, Tylenol Cold, Vanacof, Stahist AD, Aleve-D Sinus & Cold, Coldcough Syrup, Panatuss PED, Zyrtec-D 12 Hour, Deconamine, Conex, Sinarest, Suphedrin, Loratadine-D 24 Hour, Dristan Sinus, Tusnel, Dexaphen SA, Disophrol, Sinus Relief, Clarinex-D 24 Hour, Contac Cold, Sudafed 24-Hour, Sudafed Children's Nasal Decongestant, Pseudovent, LoHist-12D, 12 Hour Cold, Brotapp, Dimetapp DM, Dixaphedrine, Tylenol Sinus Severe Congestion Daytime, Nexafed, NasOpen, Advil Allergy Sinus, Zutripro, Ornex, LoHist-D, Alka-Seltzer Cold and Sinus, Brexin LA, Orlenta, Hyphed, Actedril, Cough Formula M Multi-Symptom, Allegra-D 12 Hour Allergy & Congestion, Triaminic-D Multi-Symptom Cold, CPM-PSE DM Drops, Stahist, Sinus & Cold D, Coldec, Pseudox M, Children's Nyquil, M-End DM, AccuHist PDX Drops, Advil Cold and Sinus Liqui-Gels, Brofed, Endafed, M-END, Benylin DM-D, Detuss, Mintex, Time-Hist, Allergy AM-PM Dose Pack, Tanafed, Duralex, Isophen-DF, Lemohist Plus, Rezira, Bromadine-DM, Brometane DX, Bromatane DX, Alavert D-12 Hour Allergy and Sinus, Q-Tapp DM, Capmist DM, Hydro-Tussin EXP, Benadryl Children's Allergy And Sinus, Despec DM, Novahistine DMX, AllerClear D-24 Hour, Respa-AR, Drexophed SR, Tricode GF, Guaifed, Sinutab Ex-Strength, Duomine, Disobrom, Decongest II, Notuss-NXD, Iosal II, Phenylhistine DH, Comtrex Allergy Sinus Maximum Strength, Guaifenex GP, Duraflu, Flutabs, Cetiri D, Pseudo GG TR, M-End DMX, Allerfrin, Nalex, Poly-Vent, Deproist with Codeine, Tusnel Pediatric Drops, Sudafed Sinus Nighttime Plus Pain, Seudotabs, Sinutab Non Drying, Profen II, Sinutab Regular Strength, Genaphed, Children's Dimetapp Decongestant Infant, Silfedrine, Humibid GC, Robitussin Severe Congestion, Drixoral Non-Drowsy, Ephed Plus, Efidac, Guaifenex PSE 85, Kolephrin, Polyhist NC, Deltuss DMX, Medent, Codimal, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, Zephrex, Trikof-D, SudaTex-DM, Desgen DM (with pseudoephedrine), P-Tuss DM, Pseudo Max DMX, Pseudo DM GG, Z-Cof 12DM, Liquicough DM, Maxifed DMX, Tussafin Liquid, Ambifed-G DM, Tusnel Pediatric, Touro CC-LD, Z-Cof DM(obs), Altarussin CF, Relacon-DM, Coldmist DM, Relacon-DM NR, Despec Drops, Vanacon, Spantuss HD, Su-Tuss HD Elixir, Z-Cof DM, Pseudo Cough, Relasin DM, Ambi 40 /400 /20, Pediatex TDM, Comtrex Cold and Flu Maximum Strength Liquid, Entuss-D, Poly-Tussin XP, Deconamine CX, Genacol Maximum Strength, Lortuss LQ, Respa SA, Tekral, Benaphen Plus, Nalex Expectorant, SRC Expectorant, Aldex GS DM, Vanex Expectorant, Tussadur-HD, Decotuss-HD, Entuss-D JR, Tussgen Expectorant, Allegra-D 24 Hour Allergy & Congestion, Detussin Expectorant, Hydrotussin HD, KG-Tuss HD, Balminil DM + Decongestant, Pedia Relief Infant, Viravan-PDM, Tussin Pediatric Cold and Cough, Decongestant Cold Formula, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Tussend Expectorant, Medtuss HD, Actifed Allergy Day/Night, Tavist NightTime Allergy, Benadryl Allergy Sinus, Benylin Multi-Symptom, Welltuss EXP, DiHydro-GP, Uni-Cof Expectorant, Pancof EXP, Dexatrex D, Ambifed DM, Pharmadrine, Drixoral Cold and Allergy, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Drixomed, Acticon, Clarinex-D 12 Hour, Pseudodine C, Deka, Desihist SA, Dexophed, Bromatan Plus, Dur-Tann Forte, DuraHist D, D-Hist D, Histatab D, Duotan PD, Tanafed DP, Polaramine Expectorant, Tanafed DMX, SuTan-DM, TanDur DM, Tannate PD-DM, Abatuss DMX, TanaCof DM, Trifed C, Triafed & Codeine, Guaifenesin DAC Liquid, Codahistine Expectorant, Novagest with Codeine, Suttar SF, Codafed, Gua PC, Dihistine, Phenylhistine Expectorant, Biotussin DAC, Nuco-Tuss Expectorant, Nucochem, Guaifen DAC, Suttar-2, Codafed Pediatric, Nucodine, Cycofed, Neo AC, Triacin C, Allerfrin with Codeine, KG-Fed, Notuss-DC, Zodryl DEC, Codar D, Nucofed, EndaCof-DC, AllerDur, SuTan, Pseudogest-DM, Suda-Tussin DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Guaifenex DM RX, Syn-Rx DM, Dimacol, Ambenyl-D, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Daytime Liquicap, Multi Symptom Cough and Cold, ExeFen-DMX, Profen II DM, Profen II DM Liquid, ExeClear-DM, S-Pak DM, Profen Forte DM, Robitussin Cough & Cold D, Protuss DM, Tussin Cough and Cold, Med-RX DM, Tussafed-LA, Touro CC, Anatuss DM, Donatussin DM Syrup, Medent-DMI, Poly-Vent DM, Mardrops-DX, Maxifed DM, PanMist DM, Entre-Cough, Entex Pac, Hexafed, Deltuss DP, Nalfrx, Lortuss DM, Z-Cof 8DM, Sudafed Cough, Sudafed Cough Syrup, Hytussin Expectorant, Ambi 60/580/30, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Calmylin 4, Ambi 80/780/40, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Ambi 600/1000/30, Benylin DM-D-E, Ru-Tuss DM, G-Phed, Motrin IB Sinus, Zymine HC, Sine-Aid IB, Motrin Cold and Flu, Motrin Sinus Headache, Motrin Childrens Cold, Histussin D, Detussin, ColdCough HCM, H-C Tussive D, Pancof HC, SymTan, Liquituss HD, Advil Children's Cold, Comtrex Day and Night, Extendryl PSE, Amdry-D, Respivent-D, Allerx-D, Sudafed 12 Hour Pressure+Pain, AlleRx Dose Pack (AM Dose), Sudatrate, Allergy Relief D12, Clear-Atadine-D, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Entuss-D Liquid, Histinex D, Poly-Vent, Jr., Despec-SR, Nomuc-PE, Maxifed-G, Ru-Tuss Jr., Maxifed, Aldex GS, Touro LA-LD, Ambifed-G, Pseudovent 400, Levall G, Guaifenex PSE 80, Pseudatex, ExeFen, Mucus Relief D, Tussgen, Tussafin, P-V-Tussin, Hytussin, Iotussin D Liquid, Procof D, Protuss-D, Ambi 60/580, Ambi 60/1000, Ambi 80/780, Mucinex D Maximum Strength, Aquatab D Dose Pack, Aleve-D Sinus & Headache, Quadra-Hist D Pediatric, Hista-Tabs, Atrogen, LA Nasal Decongestant, Ridifed, Triphed, Tri-Sudo, Atrofed, Atridine, Allerphed, Triposed, Triofed, Aphedrid, A-Phedrin, Vi-Sudo, Triptifed, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Altafed, Actagen, Biofed-PE, Histafed, Triacin, Triafed, Genac, Superfed, Sudrine, Chlor-Trimeton Nasal Decongestant, Afrinol, Decofed Liquid, Ridafed, Cenafed, nasofed, Quadra-Hist D, ElixSure Congestion, Allermed, Novafed, Decofed, Kid Kare Drops, Allerfrim, Ed A-Hist PSE, Zymine-D, Pediatex TD, Allercon, Hist-PSE, Dristan Cold Maximum Strength, Sudodrin, Myfedrine, SudoGest 12 Hour, Viravan-P, Seldane-D, Pseudo Max, Sudal SR, Tuss-LA, Sudal 60/500, Stamoist E, V-Dec-M, Deconsal LA, Duratuss GP (old formulation), Eudal SR, Nasatab LA, Versacaps, Sinufed Timecelles, Guaivent PD, Guaibid D Pediatric, Pseudocot-G, D-Feda II, Guaifenex PSE 60, Deco-D, Desal II, Tenar PSE, GP 500, Guaifed-PSE, Defen-LA, Guiadrine II SR, Guiadrine II, Demibid II, Respa-1st, Guiatex II, Ambifed, G-Phed- PD, Nalex Jr, Mardrops-EX, Nalex CR, Zephrex LA, Congestac, Pan-Mist LA, Entex PSE, Comtrex Cold and Flu Maximum Strength Tablet, Dynex HD, Hydro-Tuss XP, Entex HC, Pseudatex HC, Hycofenix, Poly-Vent IR, Medent-LDI, Nasabid, Respaire-60 SR, Tussar SF, Respaire-120 SR, Guaibid D, Syn-Rx, Fenex-PSE, Entex T, Despec-Tab, Guaimax-D, Anatuss LA, Touro LA, Abletex-PSE, Guiadrine PSE 120, Panmist JR, Panmist LA, H 9600 SR, Pseudovent Ped, ExeFen-IR, Dynex, Nasabid SR, Med-RX, Altarussin PE, Respaire-30, S-Pack, Sudafed Non Drying Sinus, Uni Tussin PE, Profen Forte, Durasal II, Panmist-S, We Mist II LA, Pseudo GG, Coldmist LA, Coldmist Jr, Drituss GP, Coldmist, Guiadrine PSE, Miraphen PSE, Guiatex II SR, We Mist LA, SudaTex-G, Guaivent (Ethex), Robafen PE, Pseudo-G/PSI, Ami-Tex PSE, Mucus D, Zaptec PSE, Ru-Tuss DE, Iotex PSE, Guaipax PSE, Guaifenex PSE 120, Guai-Vent/PSE, Hi Tex PSE, Guiatex PSE, Guai Sudo, Guaifenex RX, Guaitab, Tussin PE, Tusscidin PE, Sinufed, Venbid TR, Degen II, T-Tussin PE, Robichem PE, Guiatuss PE, Biotuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Drituss HD, Ambifed CDX, BroveX PSB, BroveX PD, B-Vex PD, Bromhist Pediatric, Shellcap, Touro A&H, BroveX PSE, Rynex PSE, Bromfed PD, LoHist PSB, Bromfed SR, Bidhist-D, Lodrane 12D, Allent, Shellcap PD, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Bromfenex, Pseubrom-PD, Nalfed PD, Lodrane LD, Respahist, Iofed PD, Ultrabrom PD, Lodrane, J-Tan D HC, Pediahist DM Drops, Bromhist-DM Drops, Bromph DM, Uni-Hist PDX Drops, Histacol BD Drops, Allanhist PDX Drops, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromaxefed DM RF Syrup, Bromtapp-DM, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Brom Tann, ProHist DM, Visvex, Bromph HD, Bromcomp HC, Endacof HC, SymTan A, Brovex HC, Bromplex HD, Anaplex HD, Carbodex DM Syrup, P-Hist DM Drops, Sildec DM, J-Cof DHC, Drocon-CS, Lodrane Liquid, Nalfed, Cydec-DM Drops, Dura-Ron DM, Carbaxef-DM, Carbofed DM Drops, Pediatex-DM, Decahist-DM, Cydec-DM Syrup, Maldec-DM, Dynatuss, Cordron-DM, Tussafed, Biodec DM, Rondamine DM, Cordron-DM NR, Pseudo Carb DM, Pediatex 12 DM, Cordron-12 DM, Tri-Vent HC, Histex HC, Pannaz S, Mintex HC, PSE Allergy DM, Carb PSE 12 DM, PSE Carbinoxamine DM, Mintex DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carbodex DM Drops, Andehist DM NR, Unit-Tex 10/120 ER, AccuHist Pediatric, Unit-Hist Drops, Di-Bromm, Brovex SR, Bromhist-NR, Bromhist Pediatric Drops, Q-Tapp, Andehist NR Syrup, Touro Allergy, Bromaline, Bromaxefed RF Syrup, Sildec, Dimaphen, Lodrane 24D, Allres Pd, Corzall, Allres D, Pseudacarb, Corzall Plus, Zotex-D, Respi-Tann, Carb Pseudo-Tan, J-TanD PD, LoHist-PD, Exall-D, Re-Tann, Respi-Tann Pd, Andehist DM NR Syrup, Brotapp-DM, Co-Apap, Tusnel-A, Theraflu Flu Cold & Cough, Alka-Seltzer Plus Flu/Body, Contac Severe Cold and Flu Non Drowsy, Comtrex Non-Drowsy, Maxiflu DM, Theraflu Max-D Severe Cold & Flu, All-Nite Multi-Symptom Cold/Flu Relief, NyCair, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Balminil Cough and Flu Sugar Free, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Benadryl Cold, Daytime Cold, Contac Day and Night Allergy, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Severe Cold Multi-Symptom, Theraflu (pseudoephedrine) Daytime Severe Cold, Day Relief Cold and Flu, Contact Cold and Sore Throat, Tylenol Cold Non-Drowsy Gelcaps, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Multi-Symptom Nighttime, Tylenol Severe Cold & Flu Night Time, Comtrex Allergy Sinus Night and Day, Tylenol Allergy Sinus, Allerest Headache Strength, Sinarest Extra Strength, Sinutab Maximum Strength Caplets, Triaminicin, Allerest Sinus, Comtrex Allergy Sinus, Comtrex Sinus and Nasal, Triaminic Flu, Cough & Fever, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Allergy Sinus Maximum Strength, Cold Medicine Plus, Drixoral Cold and Flu, Drixoral Allergy Sinus, Drixoral Sinus, Hexaflu, All-Nite Cold, Contac Day and Night Cold and Flu, Sinadrin Plus, Complete Sinus Relief, Tavist Allergy/Sinus/Headache, Actifed Cold & Sinus, Maxiflu CD, Maxiflu CDX, Drixoral Cold/Flu, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, EndaCof PD Drops, Theraflu Flu & Cough, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM, BroveX PSE DM Tablets, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Mesehist WC, Rydex, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, PBM Allergy, BroveX PSB DM, Myphetane DX Cough, Bromanate DX Cough, Bromophed-DX, Liquiphed DM, Bromphenex DM, Anaplex DM, Myphetane DX, Dimetane DX, BromTann/DM Tann/PSE Tann, Anaplex DMX, Bromdex D, Neo DM Syrup, Dallergy DM, Mar-cof BP, M-End WC, Sinutab Maximum Strength Non Drowsy, Tavist Sinus, Bayer Select Sinus Pain Formula, Dristan Cold Non-Drowsy, Sine-Off Maximum Strength, Contac Sinus, Benadryl Allergy Sinus Headache, Sudogest Sinus Maximum Strength, Sinus Maximum Strength, Sudafed Triple Action, Suphedrin Sinus, Ornex Maximum Strength, Allerest No Drowsiness, Tylenol Sinus Maximum Strength, Genapap Sinus, Sta-D, Ru-Tuss, Trinalin Repetabs, Dicel CD, SymPak II, Ursinus, Actifed Cold and Sinus, Phenapap, Suphedrin Plus, Pseudoephedrine Sinus, Sinarest Sinus, Sinutab Maximum Strength, Nacon, Pannaz, Klerist-D, Anamine, Codimal-LA Half, Fedahist Gyrocaps, Curaler, Clorfed II, Anaplex, Cophene No 2, Anamine TD, Chlordrine SR, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Chlorafed, Histafed LA, Hayfebrol Liquid, SudoGest Sinus & Allergy, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Allerest Maximum Strength, Genaphed Plus, Sudogest Cold & Allergy, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, ND Clear, Kronofed-A, Durafed, Duotan, Biohist LA (old formulation), Deconamine SR, Duratuss DA, Novafed A, Chlor-Trimeton Decongestant, Histade CR, Coldamine, Pseudo CM TR, ScopoHist, VisRx Dose Pack, Histatab, Clorfed, Histalet, D-Amine-SR, Colfed-A, Deconomed SR, Pseudocot-C, Suphenamine-SR, Rinade-BID, Chlorphedrin SR, Fedahist Timecaps, Chlorafed HS Timecelles, Fedahist, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Tavist-DA, Dynahist-ER Pediatric, Decohistine Expectorant, Co-Histine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Halotussin DAC, Phenhist Expectorant, Tussar-2, Nucofed Expectorant, Robitussin-DAC, Maxifed-G CDX, Ryna-CX, Medent C, Novahistine Expectorant, Novadyne Expectorant, Nucochem Pediatric Expectorant, Guiatuss DAC, Guaiatussin DAC, Mytussin DAC, Guiatussin DAC, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Deconsal C Expectorant, Nucodine Expectorant, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Maxifed-G CD, Maxifed CDX, Sudal-12 Chewable, De-Congestine, Dicel, Sudal-12 Tannate, AccuHist Drops (old formulation), SudaHist, C-Phed Tannate, Pediox Chewable, Histade, CP-Tannic, Suclor, Re2+30, Sudal-12, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Ambifed CD, Z-Tuss E, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Ambifed-G CD, Maxifed CD, Ambifed-G CDX, Tusnel C, Lortuss EX, Dynahist ER, Qdall, M-End Max D, Childrens Tylenol Cold Plus Cough, Comtrex Acute Head Cold, Allergy DN, Rhinaclear, Chlo Tuss, Biclora-D, Panatuss PED Drops, Vanacof DX, Certuss-D, Vanatab DX, Allergy Relief D, All Day Allergy-D, Contac Cold and Flu Maximum Strength, Palgic DS, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, Clofera, Poly-Tussin D, Co-Histine DH, Novadyne DH, Ryna-C, Codahistine-DH Elixir, Rhinosyn-DM, Neotuss D, Phenylhistine DH Expectorant, Codehist DH, Dihistine DH, Statuss Green, Tricode AR, Zodryl DAC, Decohistine DH, Mintex PSE, PSE Allergy, Andec, Palgic-DC, Mooredec, Rondamine, Maldec, Cardec-S, Cydec, Carbiset, Coldec D, Biohist LA, Carbodec, Pediatex 12D, Carboxine 12D, Palgic-D, Andec-TR, Pediatex-D, Cordron-D, Cordron-D NR, Cordron-12 D, Carboxine-D, Pseudo Carb, Carboxine-PSE, Hydro-Tussin CBX, Dura-Ron, Carbic-D, Ex-Dec-TR, Coldec-TR, Andehist, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Hydron PCS, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Atuss HD, Cordron-HC NR, P-V-Tussin Syrup, KG-Tussin, Hexatussin, Welltuss HC, Tussin-V, Q-V Tussin, A-G Tussin, Atuss HS, Advil Children's Allergy Sinus, Hista-Vent PSE, Mescolor, PCM-LA, Amdry-C, AllePak, Time-Hist QD, Relcof PSE, Dallergy PSE, DryMax, AlleRx Dose Pack, DuraHist, Xiral SR, RelCof DN PSE, Tussend, Pediatex HC, Entre-S, Atuss DS, Maxichlor PSE DM, Kidkare Cough/Cold, Esocor P, Neutrahist PDX Drops, Dicel DM, Atuss-12 DM, Kidcare Cough and Cold, Creomulsion Pediatric, Rescon-DM, Tanafed-DM, C-Phed DM, Mesehist DM, Allres DS, Notuss-Forte, Z-Tuss 2, Notuss, Histinex PV, JayCof-HC, Uni-Cof, Dihydro-CP, T-Tanna DM, Duotan DM, Pancof, Tricof, Hydro-Tussin DHC, Nucofed Pediatric Expectorant

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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