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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Loratadine-D 24 Hour, Sudafed Congestion, Claritin-D, Mucinex D, Zyrtec-D, SudoGest, Actifed, Allegra-D 24 Hour, Resperal-DM, Show all 1043 »Loratadine-D 12 Hour, Allegra-D 12 Hour, Sudafed 12-Hour, Claritin-D 24 Hour, Capmist DM, Aleve-D Sinus & Cold, Aprodine, Zyrtec-D 12 Hour, AllerClear D-24 Hour, Sinarest, Entex, Advil Cold and Sinus, Tusnel, Conex, Allerest Maximum Strength, Tylenol Cold, Virtussin DAC, Efidac, Bromphenex DM, Robitussin Allergy & Cough, Bromaline, Claritin-D 12 Hour, Cetiri D, Vanacof, Advil Allergy Sinus, Vicks Nyquil D Cold and Flu Nighttime Relief, Semprex-D, Guaifen DAC, Cheratussin DAC, Zutripro, Wal-Zyr D, Nucodine, Silfedrine, Disophrol, Carbofed DM Syrup, Dimetane DX, Dristan Sinus, Maxichlor PSE DM, Chlor-Trimeton Nasal Decongestant, Suphedrine, Clarinex-D 12 Hour, Allergy D-12, Robitussin Cough & Cold D, Aleve-D Sinus & Headache, Maxifed, Duomine, Brexin LA, Pseudodine C, Flutabs, Pseudoephedrine Plus, Deconamine, Hydron PCS, Suclor, Pseudo Max, Tekral, Neotuss D, Brofed, Q-Tapp, Aldex GS, Levall G, Clorfed, Pseudovent, J-Cof DHC, GP 500, Stahist, Coldcough Syrup, Entex T, Poly-Vent IR, Viravan-PDM, Congestac, Dicel DM, Guaivent (Ethex), Histex HC, Maxifed DM, Brometane DX, Chlorphedrin SR, Colfed-A, Hycofenix, Anaplex, Curaler, SudoGest Sinus & Allergy, Detussin, Kidcare Cough and Cold, Bromophed-DX, Stahist AD, BromTann/DM Tann/PSE Tann, Dimetapp DM, Allergy Relief D12, Panatuss PED, Chlo Tuss, Allergy Relief D, Despec DM, PanMist DM, Chlorafed HS Timecelles, Bromaline DM, Rezira, Triptifed, Desihist SA, Biotussin DAC, Tylenol Severe Cold & Flu Night Time, Allerfrin, Tylenol Allergy Sinus, Drixoral Allergy Sinus, Sinadrin Plus, Actifed Sinus Day and Night, Alka-Seltzer Cold and Sinus, Dixaphedrine, Acticon, Pseudoephedrine Sinus, Drexophed SR, Theraflu (pseudoephedrine) Daytime Severe Cold, Comtrex Cold and Flu Maximum Strength Tablet, Rescon, Theraflu Flu & Cough, Duraflu, M-End DMX, Benylin Multi-Symptom, Benadryl Children's Allergy And Sinus, Pediatex TDM, DiHydro-GP, Tavist NightTime Allergy, Welltuss EXP, Codar D, Actifed Allergy Day/Night, Nucofed, Uni-Cof Expectorant, Hydro-Tussin EXP, Zodryl DEC, Pancof EXP, Notuss-DC, EndaCof-DC, Pedia Relief Infant, Duotan PD, Benylin DM-D, Trikof-D, Relacon-DM NR, Despec Drops, Pseudo Cough, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Liquicough DM, KG-Fed, Maxifed DMX, Z-Cof 12DM, Pseudo DM GG, Balminil DM + Decongestant, Pseudo Max DMX, SudaTex-DM, Desgen DM (with pseudoephedrine), P-Tuss DM, Dexatrex D, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Decongestant Cold Formula, Tussin Pediatric Cold and Cough, Benadryl Allergy Sinus, Codafed, Respa SA, Nucofed Pediatric Expectorant, Phenylhistine Expectorant, Tussar SF, Poly-Tussin XP, Entuss-D, Hydrotussin HD, KG-Tuss HD, Medtuss HD, Spantuss HD, Vanacon, KG-Fed Pediatric Expectorant, Nucochem, Cycofed Pediatric Expectorant, Guiatussin DAC, Mytussin DAC, Guiatuss DAC, Guaiatussin DAC, Deconsal C Expectorant, Nucodine Expectorant, Su-Tuss HD Elixir, Tussafin Liquid, Nuco-Tuss Expectorant, Dihistine, Benaphen Plus, Vanex Expectorant, Lortuss LQ, Codafed Pediatric, Suttar-2, Neo AC, Allegra-D 12 Hour Allergy & Congestion, Allegra-D 24 Hour Allergy & Congestion, Suttar SF, Entuss-D JR, Decotuss-HD, Tussadur-HD, Gua PC, Tussend Expectorant, Novagest with Codeine, Guaifenesin DAC Liquid, Codahistine Expectorant, Detussin Expectorant, Tussgen Expectorant, SRC Expectorant, Nalex Expectorant, Deconamine CX, Cycofed, Ru-Tuss DM, Touro CC-LD, Poly-Vent DM, Pharmadrine, Drixoral Cold and Allergy, Drixomed, Dexaphen SA, 12 Hour Cold, Disobrom, Dexophed, Entre-Cough, Medent-DMI, C-Phed DPD Tann, Mardrops-DX, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Ambi 600/1000/30, Benylin DM-D-E, Drituss HD, Ambi 80/780/40, Tannate DMP-DEX, DuraTan Forte, Clarinex-D 24 Hour, Abatuss DMX, AllerDur, SuTan, Deltuss DP, Histatab D, DuraHist D, D-Hist D, Polaramine Expectorant, Tanafed DMX, TanaCof DM, Deltuss DMX, Entex Pac, Hexafed, Nalfrx, Lortuss DM, Tannate PD-DM, SuTan-DM, TanDur DM, Dur-Tann Forte, Bromatan Plus, Z-Cof 8DM, Deka, Trifed C, Tusnel Pediatric, ExeFen-DMX, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, Profen Forte DM, Profen II DM, Profen II DM Liquid, Tusnel-DM Pediatric Drops, ExeClear-DM, S-Pak DM, Tanafed DP, Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Ambifed-G DM, Medent DM, Tusnel Ped-C, Triafed & Codeine, Anatuss DM, Allerfrin with Codeine, Triacin C, Calmylin 4, Ambi 60/580/30, Ambifed DM, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Ambenyl-D, Pseudogest-DM, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Polyhist NC, Rhinosyn-X, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Hytussin Expectorant, Guaibid D, Hydro-Tuss XP, Sudatrate, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Advil Cold and Sinus Liqui-Gels, Advil Children's Cold, Clear-Atadine-D, Alavert D-12 Hour Allergy and Sinus, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour, AlleRx Dose Pack (AM Dose), Histussin D, Amdry-D, Extendryl PSE, Respivent-D, Allerx-D, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Quadra-Hist D, Nexafed Nasal Decongestant, nasofed, Suphedrin, ElixSure Congestion, Zymine HC, Liquituss HD, Allermed, Mucinex D Maximum Strength, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., ExeFen, Mucus Relief D, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, SymTan, Protuss-D, Procof D, Tussafin, Tussgen, P-V-Tussin, Hytussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Pancof HC, Children's Dimetapp Decongestant Infant, Novafed, Touro LA-LD, Tri-Sudo, Triposed, Allerphed, Triofed, Aphedrid, A-Phedrin, Actedril, Atridine, Atrofed, Atrogen, Hista-Tabs, LA Nasal Decongestant, Ridifed, Triphed, Genac, Vi-Sudo, Actagen, Altafed, Biofed-PE, Histafed, Triacin, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Triafed, Allercon, Cenafed, Sudodrin, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Sudafed Children's Nasal Decongestant, Decofed Liquid, Decofed, Kid Kare Drops, Myfedrine, Elixsure Decongestant, Pediatex TD, Unifed, Sudafed 24-Hour, Contac Cold, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Ed A-Hist PSE, Allerfrim, Zymine-D, Despec-SR, Pseudatex, Dynex HD, Guiatex II, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Respa-1st, Ambifed, Nasatab LA, Guiadrine II SR, Defen-LA, Decongest II, Desal II, Deco-D, Tenar PSE, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Hi Tex PSE, Eudal SR, Pseudocot-G, Guai Sudo, Touro LA, Entex HC, Pseudatex HC, Entex PSE, Nalex CR, Mardrops-EX, Zephrex LA, Zephrex, Pan-Mist LA, Medent-LDI, Despec-Tab, Guaimax-D, Anatuss LA, Fenex-PSE, Guaibid D Pediatric, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Cycofed Expectorant, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Versacaps, Guaivent PD, Guiatex PSE, Guaipax PSE, Medent, Guiatex II SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, We Mist LA, Med-RX, SudaTex-G, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudovent 400, Ambifed-G, Guaifenex PSE 80, Nasabid SR, Humibid GC, Iotex PSE, Robichem PE, Ami-Tex PSE, Pseudo-G/PSI, Mucus D, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, T-Tussin PE, Uni Tussin PE, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Degen II, Robafen PE, Respaire-30, Tusnel Pediatric Drops, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Robitussin Severe Congestion, KG-Fed Expectorant, Cordron-DM, Nucodine Pediatric, Bromfed SR, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Lodrane, LoHist PSB, Bromfed PD, Bidhist-D, M-END, Lodrane 12D, Dimetapp Elixir, Rynex PSE, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Shellcap, Drocon-CS, Sildec DM, Shellcap PD, Bromtapp-DM, Bromdex D, Neo DM Syrup, Dallergy DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Bromadine-DM, Anaplex DM, Brotapp-DM, Andehist DM NR Syrup, Bromaxefed DM RF Syrup, Carbodex DM Syrup, PSE Brom DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Allent, Lodrane LD, BroveX PSB DM, Comtrex Acute Head Cold, Re-Tann, Respi-Tann Pd, Carb Pseudo-Tan, Respi-Tann, Corzall, Allres Pd, Allres D, Pseudacarb, Zotex-D, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Dynatuss, J-TanD PD, Tussafed, Biodec DM, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Exall-D, LoHist-12D, Nalfed PD, Nalfed, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Touro Allergy, LoHist-PD, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brotapp, Brovex SR, Dimaphen, Lodrane 24D, Anaplex DMX, PBM Allergy, Mintex DM, All-Nite Multi-Symptom Cold/Flu Relief, Tavist Allergy/Sinus/Headache, Maxiflu CD, Maxiflu CDX, Drixoral Cold/Flu, Complete Sinus Relief, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Multi-Symptom Nighttime, NyCair, Robitussin Cold Cough and Flu, Cold Medicine Plus, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Alka-Seltzer Plus Flu/Body, Vicks Dayquil Daytime Cold/Flu (old formulation), Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, Contact Cold and Sore Throat, Comtrex Sinus and Nasal, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Allpanto-S, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Comtrex Nighttime Flu Therapy, Sinutab Maximum Strength Caplets, Singlet, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, BroveX PSE DM, SymPak II, Suphedrin Plus, Phenapap, Nexafed Sinus Pressure + Pain, Sinarest Sinus, Sinutab Maximum Strength, Actifed Cold and Sinus, Ursinus, Ru-Tuss, Respa-AR, Sta-D, Trinalin Repetabs, Dicel CD, M-End WC, Tylenol Sinus Maximum Strength, Mar-cof BP, Rydex, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, Genapap Sinus, Sinutab Regular Strength, Tylenol Cold Non-Drowsy Gelcaps, Sudafed Triple Action, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Daytime Cold, Benadryl Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sinus Maximum Strength, Sine-Off Maximum Strength, Suphedrin Sinus, Ornex Maximum Strength, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Tavist Sinus, Ornex, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Sinus Relief, Dristan Cold Non-Drowsy, Contac Sinus, Pseudo Carb DM, PSE Carbinoxamine DM, Nuco-Tuss Pediatric Expectorant, ND Clear, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Orlenta, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, Chlordrine SR, Tanafed, Anamine TD, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Chlorafed, Codimal-LA, Fedahist, Chlor-Trimeton Allergy Decongestant, Allergy DN, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Pseudo CM TR, Histalet, Coldamine, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Deconamine SR, Novafed A, Duratuss DA, Histafed LA, Aller-Chlor Decongestant, AlleRx Dose Pack, Medent C, Z-Tuss E, Tricode GF, Ambifed CD, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Novahistine Expectorant, Lortuss EX, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Tusnel C, Dristan Cold Maximum Strength, Sudogest Plus, Mintex, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Re2+30, M-End Max D, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Qdall, Dynahist ER, DryMax, Advil Children's Allergy Sinus, PSE Carb DM Drops, Palgic DS, Coldec-TR, Andehist, Hydro-Tussin CBX, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, KS Aller-Tec D-12, Dura-Ron, Up and Up All Day Allergy Relief D, All Day Allergy-D, 12 Hour Allergy-D, Biclora-D, Panatuss PED Drops, Vanacof DX, Vanatab DX, Certuss-D, Clofera, Poly-Tussin D, Notuss-NXD, Statuss Green, Ex-Dec-TR, Carbic-D, Dihistine DH, Biohist LA, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Tri-Vent HC, Mintex HC, Pannaz S, Pseudox M, Nacon, Pannaz, Coldec D, Andec-TR, Coldec, Carbodec, Pediatex 12D, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Mooredec, Rondamine, Cardec-S, Maldec, Palgic-D, NasOpen, Tricode AR, Atuss HS, Pediatex HC, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Z-Tuss 2, Lemohist Plus, Notuss-Forte, Notuss, Detuss, Histinex PV, JayCof-HC, Tussend, T-Tanna DM, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Pedia Relief Cough-Cold, Duotan DM, Zodryl DAC, Children's Nyquil, Phenylhistine DH, Decohistine DH, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Rescon-DM, Allres DS, Tanafed-DM, C-Phed DM, M-End DM, Atuss-12 DM, Atuss DS, Entre-S, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Tripohist D

Medically reviewed on Jan 10, 2017

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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