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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Loratadine-D 24 Hour, Bromfed DM, Claritin-D, Sudafed Congestion, Zyrtec-D, Mucinex D, Vicks Dayquil Daytime Cold/Flu, Allegra-D 24 Hour, Advil Cold and Sinus, SudoGest, Show all 1039 »Virtussin DAC, Sudafed 12-Hour, Loratadine-D 12 Hour, Vicks Nyquil D Cold and Flu Nighttime Relief, Aprodine, Allegra-D 12 Hour, Entex, Actifed, Sinarest, Resperal-DM, Semprex-D, Conex, Alavert D-12 Hour Allergy and Sinus, Vanacof, Wal-Zyr D, Cheratussin DAC, Dimetapp Elixir, Claritin-D 24 Hour, Tusnel, Suphedrine, Alka-Seltzer Cold and Sinus, Cetiri D, M-End DMX, Drixoral, AllerClear D-24 Hour, Sudafed 24-Hour, Mucinex D Maximum Strength, Decongestant Cold Formula, Robitussin-DAC, Stahist, Disophrol, Tylenol Cold, Robitussin Cold Cough and Flu, Pseudo GG, Bromaline, Brotapp-DM, Bromph DM, Hydron PCS, Alka-Seltzer Plus Flu/Body, Rondamine, Phenapap, Simplet, BromTann/DM Tann/PSE Tann, Orlenta, Dimetapp DM, Deconamine, Dicel DM, Coldec, Mucus D, Guaifen DAC, Advil Cold and Sinus Liqui-Gels, Cold Medicine Plus, Contac Cold, Shellcap, Brotapp, Dimacol, Zutripro, Dihydro-CP, Duomine, Acticon, Hydrocof-HC, Chlo Tuss, Nexafed, Coldcough Syrup, Singlet, Clarinex-D 12 Hour, Silfedrine, Afrinol, Advil Allergy Sinus, Amdry-D, Relacon-DM, Despec DM, Respivent-D, Clear-Atadine-D, Dimetane DX, Maldec, Bromtapp-DM, Bromaline DM, Respi-Tann, Histacol BD Drops, Sinutab Ex-Strength, Clorfed, Bromph HD, Visvex, Welltuss HC, Rezira, Allegra-D 12 Hour Allergy & Congestion, Pseudoephedrine Plus, Stahist AD, Benadryl Children's Allergy And Sinus, Sildec, Q-Tapp, Bromfenex, Lodrane, Benadryl Allergy Sinus, Cordron-DM, SudaHist, Nalex Expectorant, Pseudox M, Robitussin Cough & Cold D, Nacon, Durafed, Coldec D, Duotan, Fedahist, Rinade-BID, Chlorafed, Hycofenix, Curaler, Klerist-D, Brexin LA, Cophene No 2, Mooredec, Theraflu Flu, Cold and Cough Powder, Pseudovent 400, Guaifenex PSE 80, Poly-Vent, Duraflu, Coldmist Jr, Dixaphedrine, Biclora-D, Phenylhistine DH, Up and Up All Day Allergy Relief D, Codehist DH, Aleve-D Sinus & Cold, Guaifenex PSE 60, Actedril, Daytime Cold, Deltuss DMX, Abatuss DMX, Dexaphen SA, Panatuss PED Drops, Respaire-30, Tusnel Pediatric Drops, Pseudovent, Sinufed, Guaifenex PSE 120, Notuss-DC, NasOpen, Neo AC, Polyhist NC, Panatuss PED, Clarinex-D 24 Hour, Coldmist LA, Profen Forte, Trifed C, Pseudodine C, Nasatab LA, Phenylhistine DH Expectorant, Sudafed Cough Syrup, Coldamine, Capmist DM, Comtrex Acute Head Cold, Sudafed Children's Nasal Decongestant, Versacaps, Mardrops-DX, Unifed, Dimaphen, Ru-Tuss, Drixoral Decongestant Non-Drowsy, DuraHist, Sinutab Regular Strength, Pseudoephedrine Sinus, Hexafed, Triaminic-D Multi-Symptom Cold, Sinus & Cold D, Congestac, Zephrex, Sine-Off Maximum Strength, Multi Symptom Cough and Cold, Sinus Relief, Tusnel C, Ephed Plus, Ornex, Sinus Maximum Strength, Balminil DM + Decongestant, Benylin DM-D, Tussin Pediatric Cold and Cough, Viravan-PDM, Drixoral Cough & Congestion Liquid Caps, Pedia Relief Infant, Buckley's DM Decongestant, Dexatrex D, Vicks 44D, Pediatex TDM, Pancof EXP, Hydro-Tussin EXP, Uni-Cof Expectorant, DiHydro-GP, Welltuss EXP, Su-Tuss HD Elixir, KG-Tuss HD, Medtuss HD, Spantuss HD, Hydrotussin HD, Entuss-D, Deconamine CX, Poly-Tussin XP, Vanacon, Tussafin Liquid, Entex HC, Pseudatex HC, Allpanto-S, Dynex HD, Hydro-Tuss XP, Hytussin Expectorant, Drituss HD, SRC Expectorant, Tussgen Expectorant, Benaphen Plus, Lortuss LQ, Theracaps Multi-Symptom Cough & Cold Reliever, Tekral, Respa SA, Actifed Allergy Day/Night, Tavist NightTime Allergy, Co-Apap, Allegra-D 24 Hour Allergy & Congestion, Tussend Expectorant, Detussin Expectorant, Tussadur-HD, Vanex Expectorant, Entuss-D JR, Decotuss-HD, Benylin Multi-Symptom, Profen Forte DM, AllerDur, Tanafed DP, SuTan, Deltuss DP, Rescon, Duotan PD, Histatab D, Tanafed DMX, TanaCof DM, Polaramine Expectorant, D-Hist D, DuraHist D, Nalfrx, Lortuss DM, Balminil DM + Decongestant + Expectorant, Sudafed Cough, TL-Dex DM, Ambi 600/1000/30, Benylin DM-D-E, PanMist DM, Maxifed DM, Entex Pac, Z-Cof 8DM, Entre-Cough, Poly-Vent DM, Medent-DMI, Tannate PD-DM, SuTan-DM, Triafed & Codeine, Allerfrin with Codeine, Deka, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Drexophed SR, Triacin C, Nucodine, Nucofed, Codar D, EndaCof-DC, KG-Fed, Cycofed, Desihist SA, Dexophed, DuraTan Forte, C-Phed DPD Tann, Bromatan Plus, Dur-Tann Forte, TanDur DM, Tannate DMP-DEX, Pharmadrine, Disobrom, 12 Hour Cold, Drixomed, Drixoral Cold and Allergy, Ambi 80/780/40, Calmylin 4, Ambifed-G DM, Z-Cof DM(obs), Tusnel Pediatric, Touro CC-LD, Relacon-DM NR, Altarussin CF, Coldmist DM, ExeClear-DM, Profen II DM Liquid, S-Pak DM, Ru-Tuss DM, Aldex GS DM, Despec Drops, Pseudo Cough, Pseudo DM GG, Trikof-D, Pseudo Max DMX, SudaTex-DM, Desgen DM (with pseudoephedrine), Z-Cof 12DM, Maxifed DMX, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Liquicough DM, ExeFen-DMX, Profen II DM, Novahistine DMX, Ambenyl-D, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Anatuss DM, Donatussin DM Syrup, Ambifed DM, Ambi 60/580/30, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Syn-Rx DM, Guaifenex DM RX, Protuss DM, Tussin Cough and Cold, Med-RX DM, Tussafed-LA, Touro CC, Daytime Liquicap, Medent DM, Suda-Tussin DM, Pseudogest-DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, P-Tuss DM, G-Phed- PD, Allergy Relief D12, Comtrex Cold and Flu Maximum Strength Liquid, Claritin-D 12 Hour, Leader Allergy Relief D-24, Allergy Relief D 24 Hour, Allergy & Congestion Relief, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Motrin Childrens Cold, Motrin Cold and Flu, Motrin Sinus Headache, Advil Children's Cold, Contac Cold and Flu Maximum Strength, Sudatrate, AlleRx Dose Pack (AM Dose), Comtrex Day and Night, Cough Formula M Multi-Symptom, nasofed, Suphedrin, Drixoral Non-Drowsy, Comtrex Cold and Flu Maximum Strength Tablet, Quadra-Hist D, Allerx-D, Extendryl PSE, Sudafed 12 Hour Pressure+Pain, Aleve-D Sinus & Headache, Quadra-Hist D Pediatric, Sine-Aid IB, Motrin IB Sinus, Protuss-D, Aquatab D Dose Pack, Procof D, Tussafin, P-V-Tussin, Tussgen, Ambi 80/780, Ambi 60/580, Ru-Tuss Jr., Pseudo GG TR, ExeFen, Mucus Relief D, Ambi 60/1000, Hytussin, Iotussin D Liquid, Histussin D, Detussin, Zymine HC, Theraflu Flu & Cough, Dristan Sinus, Liquituss HD, SymTan, Entuss-D Liquid, Histinex D, H-C Tussive D, ColdCough HCM, Pancof HC, ElixSure Congestion, Children's Dimetapp Decongestant Infant, LA Nasal Decongestant, Hista-Tabs, Ridifed, Tri-Sudo, Vi-Sudo, Triphed, Atrogen, Atrofed, Triofed, Allerphed, Aphedrid, A-Phedrin, Atridine, Triptifed, Actagen, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Altafed, Allerfrin, Biofed-PE, Histafed, Triacin, Triposed, Triafed, Chlor-Trimeton Nasal Decongestant, Superfed, Decofed Liquid, Efidac, Kid Kare Drops, Decofed, Sudrine, Seudotabs, Novafed, Allermed, Cenafed, Genaphed, Ridafed, Myfedrine, Sudodrin, Zymine-D, Allerfrim, Pediatex TD, Allercon, Genac, Ed A-Hist PSE, Hist-PSE, SudoGest 12 Hour, Elixsure Decongestant, Viravan-P, Seldane-D, Dristan Cold Maximum Strength, Maxifed, Maxifed-G, Respa-1st, Iosal II, Guiatex II, Ambifed, Defen-LA, Guiadrine II SR, Guiadrine II, Demibid II, V-Dec-M, Stamoist E, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Decongest II, Desal II, Guiatex PSE, Hi Tex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Guai-Vent/PSE, Guiadrine PSE 120, Tenar PSE, Deco-D, GP 500, Guaifed-PSE, Abletex-PSE, Tuss-LA, Sudal 60/500, Guaimax-D, Entex T, Anatuss LA, Touro LA, Nalex, Fenex-PSE, Despec-Tab, Medent-LDI, Mardrops-EX, Nalex CR, Zephrex LA, Pan-Mist LA, Poly-Vent IR, Syn-Rx, Respaire-60 SR, Guaivent PD, Sinufed Timecelles, Guaibid D Pediatric, Pseudocot-G, Eudal SR, Zodryl DEC, Nalex Jr, G-Phed, Nasabid, Respaire-120 SR, Guaibid D, Guaifed, Ami-Tex PSE, Pseudo-G/PSI, Guiatex II SR, Guiadrine PSE, We Mist LA, SudaTex-G, Drituss GP, Coldmist, Miraphen PSE, Durasal II, Guaifenex GP, Pseudovent Ped, Dynex, ExeFen-IR, Profen II, We Mist II LA, Panmist-S, Despec-SR, Aldex GS, Guaifenex PSE 85, Poly-Vent, Jr., Nomuc-PE, Touro LA-LD, Pseudatex, Pseudo Max, Sudal SR, Ambifed-G, Levall G, Medent, H 9600 SR, Panmist JR, Q-Tussin PE, Mytussin PE, Robichem PE, T-Tussin PE, Tussin PE, Tusscidin PE, Mastussin PE, Guiatuss PE, Ru-Tuss DE, Zaptec PSE, Guaifenex RX, Guaitab, Biotuss PE, Venbid TR, Degen II, Humibid GC, Uni Tussin PE, Med-RX, Nasabid SR, Panmist LA, Robitussin Severe Congestion, Sinutab Non Drying, Guaivent (Ethex), Robafen PE, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Entex PSE, Maxifed-G CD, Touro A&H, Endafed, Allent, Shellcap PD, Nalfed PD, Lodrane LD, Bromhist Pediatric, B-Vex PD, Lodrane D, Rynex PSE, BroveX PSE, BroveX PD, BroveX PSB, Respahist, Iofed PD, Lodrane Liquid, Pseubrom, Nalfed, Touro Allergy, Andehist NR Syrup, Iofed, Ultrabrom, Pseubrom-PD, Ultrabrom PD, Bromfenex PD, Histex SR, M-Hist TD, Lodrane 12D, Bidhist-D, Brom Tann, Allanhist PDX Drops, ProHist DM, P-Hist DM Drops, Sildec DM, Carbodex DM Syrup, Robitussin Allergy & Cough, Uni-Hist PDX Drops, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, J-Cof DHC, M-END, LoHist PSB, J-Tan D HC, Brofed, Bromfed PD, Bromfed SR, SymTan A, Brovex HC, Anaplex HD, Drocon-CS, Bromplex HD, Bromcomp HC, Endacof HC, Bromaxefed RF Syrup, Bromhist Pediatric Drops, PSE Carbinoxamine DM, Mintex DM, PSE Carb DM Drops, Carboxine DM, Carb PSE 12 DM, Carboxine 12 DM, Pseudo Carb DM, Cordron-DM NR, Carbaxef-DM, Cydec-DM Drops, Carbofed DM Drops, Decahist-DM, Pediatex-DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12D, Carbodec, Carboxine 12D, Carbiset, Cydec, Biohist LA, Pannaz, Tri-Vent HC, Pediatex 12 DM, Histex HC, Mintex HC, Pannaz S, Dura-Ron DM, Cydec-DM Syrup, LoHist-12D, LoHist-PD, J-TanD PD, Exall-D, Respi-Tann Pd, Re-Tann, Lodrane 24D, Brovex SR, Unit-Tex 10/120 ER, AccuHist Pediatric, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Carb Pseudo-Tan, Corzall, Tussafed, Dynatuss, Biodec DM, Rondamine DM, Maldec-DM, Carbodex DM Drops, Andehist DM NR, Allres D, Allres Pd, Pseudacarb, Zotex-D, Corzall Plus, Carbofed DM Syrup, PSE Brom DM, Comtrex Non-Drowsy, Theraflu Flu Cold & Cough, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Contact Cold and Sore Throat, Non-Drowsy Super Strength Contac Complete, Tricom, Tusnel-A, Balminil Cough and Flu Sugar Free, Phlemgesic, Theraflu Max-D Severe Cold & Flu, Flutabs, Maxiflu DM, Day Relief Cold and Flu, Tylenol Cold Non-Drowsy Gelcaps, Benadryl Severe Allergy & Sinus Headache, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Sudafed Sinus Nighttime Plus Pain, Contac Day and Night Allergy, Daytime Non-Drowsy, Daytime Cold and Flu Relief, Theraflu (pseudoephedrine) Daytime Severe Cold, Severe Cold Multi-Symptom, Benadryl Cold, Tylenol Cold Severe Congestion Daytime, All-Nite Multi-Symptom Cold/Flu Relief, Sinutab Maximum Strength Caplets, Triaminicin, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Maxiflu CD, Tavist Allergy/Sinus/Headache, Sinarest Extra Strength, Allerest Headache Strength, Allerest Sinus, Kolephrin, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Maxiflu CDX, Drixoral Cold/Flu, All-Nite Cold, Comtrex Allergy Sinus, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, NyCair, Contac Day and Night Cold and Flu, Hexaflu, Sinadrin Plus, Complete Sinus Relief, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, BroveX PSE DM, BroveX PSE DM Tablets, PBM Allergy, BroveX PSB DM, Bromdex D, Anaplex DMX, PediaHist DM, AccuHist DM Pediatric Drops, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Comtrex Sinus and Nasal, EndaCof PD Drops, Neo DM Syrup, Dallergy DM, Anaplex DM, Bromadine-DM, Bromphenex DM, Andehist DM NR Syrup, Bromaxefed DM RF Syrup, Brometane DX, Liquiphed DM, Bromanate DX Cough, Myphetane DX, Bromatane DX, Myphetane DX Cough, Bromophed-DX, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Dristan Cold Non-Drowsy, Bayer Select Sinus Pain Formula, Contac Sinus, Tylenol Sinus Maximum Strength, Suphedrin Plus, Genapap Sinus, Sinutab Maximum Strength Non Drowsy, Tavist Sinus, Ornex Maximum Strength, Suphedrin Sinus, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Sinarest Sinus, Sinutab Maximum Strength, M-End WC, SymPak II, Mar-cof BP, Rydex, Mesehist WC, Dicel CD, Trinalin Repetabs, Comtrex Nighttime Flu Therapy, Actifed Cold and Sinus, Ursinus, Respa-AR, Sta-D, Palgic-DC, Andec, Suphedrine Plus, Hayfebrol Liquid, Atrohist Pediatric Capsule, Allerest Maximum Strength, Tavist-DA, Chlor-Trimeton Allergy Decongestant SR, SudoGest Sinus & Allergy, Genaphed Plus, Sudogest Plus, Aller-Chlor Decongestant, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Dynahist-ER Pediatric, CP-Tannic, Sudal-12 Chewable, De-Congestine, Dicel, Sudal-12 Tannate, AccuHist Drops (old formulation), C-Phed Tannate, Pediox Chewable, Mintex, Histade, Suclor, Re2+30, Sudal-12, Chlor-Trimeton Allergy Decongestant, Histafed LA, D-Amine-SR, Colfed-A, Deconomed SR, Pseudocot-C, Suphenamine-SR, Duralex, Chlorphedrin SR, Fedahist Timecaps, Chlorafed HS Timecelles, Tanafed, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Isophen-DF, Kronofed-A, Anamine, Anaplex, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Pseudochlor, Rescon-Ed, Chlordrine SR, ND Clear, Anamine TD, Time-Hist, Chlorafed Timecelles, LoHist-D, Triaminic Softchews Cold and Allergy, Guiatuss DAC, Guaiatussin DAC, Mytussin DAC, Guiatussin DAC, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Deconsal C Expectorant, Nucodine Expectorant, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Novagest with Codeine, Guaifenesin DAC Liquid, Suttar SF, Codafed, Suttar-2, Codahistine Expectorant, Gua PC, Phenylhistine Expectorant, Biotussin DAC, Nuco-Tuss Expectorant, Nucochem, Dihistine, Nucochem Pediatric Expectorant, Novadyne Expectorant, Ambifed CDX, Ambifed CD, Ambifed-G CD, Ambifed-G CDX, Maxifed CDX, Maxifed CD, Tricode GF, Z-Tuss E, Dynahist ER, Qdall, M-End Max D, Triaminic Flu, Cough & Fever, Lortuss EX, Codimal, Maxifed-G CDX, Dihistine Expectorant with Codeine, Decohistine Expectorant, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Co-Histine Expectorant, Deproist with Codeine, Medent C, Ryna-CX, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Histalet, Duratuss DA, Ryna-C, Co-Histine DH, Codahistine-DH Elixir, Neotuss D, Vicks 44M Pediatric, Rhinosyn-DM, Novadyne DH, Decohistine DH, Statuss Green, Notuss-NXD, Dihistine DH, Tricode AR, Zodryl DAC, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Entre-S, Atuss DS, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, Atuss-12 DM, M-End DM, Children's Nyquil, Kidcare Cough and Cold, Rescon-DM, Tanafed-DM, C-Phed DM, Poly-Tussin D, Clofera, Hydro-Tussin CBX, Andehist, Carboxine-PSE, Cordron-D, Cordron-D NR, Pediatex-D, Coldec-TR, Ex-Dec-TR, Palgic-D, Cardec-S, Andec-TR, Carbic-D, Dura-Ron, Cordron-12 D, Pseudo Carb, Allergy Relief D, All Day Allergy-D, Vanacof DX, Vanatab DX, Certuss-D, Zyrtec-D 12 Hour, KS Aller-Tec D-12, PSE Allergy, Carboxine-D, Mintex PSE, Palgic DS, Allergy D-12, AccuHist PDX Drops, CPM-PSE DM Drops, Relcof PSE, Dallergy PSE, Mescolor, Hista-Vent PSE, Amdry-C, PCM-LA, RelCof DN PSE, Xiral SR, Atuss HS, Atuss HD, Advil Children's Allergy Sinus, AlleRx Dose Pack, DryMax, Time-Hist QD, AllePak, Chlor-Trimeton Decongestant, Histade CR, Biohist LA (old formulation), Deconamine SR, Novafed A, Histatab, VisRx Dose Pack, Allergy DN, Rhinaclear, Pseudo CM TR, ScopoHist, Allergy AM-PM Dose Pack, Cordron-HC NR, Cordron-HC, Uni-Cof, Hydro-Tussin DHC, Z-Tuss 2, Lemohist Plus, Notuss-Forte, Tricof, Pancof, Mesehist DM, Esocor P, Allres DS, Duotan DM, T-Tanna DM, Notuss, Detuss, A-G Tussin, Q-V Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Tussin-V, Hyphed, JayCof-HC, Histinex PV, Pediatex HC, Tussend, Hexatussin, Codafed Pediatric

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20170110

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