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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Claritin-D, Sudafed Congestion, SudoGest, Mucinex D, Zyrtec-D, Virtussin DAC, Sudafed 12-Hour, Actifed, Resperal-DM, Show all 1037 »Vicks Nyquil D Cold and Flu Nighttime Relief, Entex, Allegra-D 24 Hour, Vicks Dayquil Daytime Cold/Flu, Cheratussin DAC, Wal-Zyr D, Allegra-D 12 Hour, Aprodine, Clarinex-D 24 Hour, Drixoral, Suphedrine, Claritin-D 24 Hour, Advil Cold and Sinus, Sinarest, Dimetapp Elixir, Rescon, Loratadine-D 24 Hour, Alka-Seltzer Cold and Sinus, Tusnel, Claritin-D 12 Hour, Stahist AD, Contac Cold, Vanacof, Conex, Theraflu Flu, Cold and Cough Powder, Singlet, Disophrol, Robitussin Allergy & Cough, Robitussin Cold Cough and Flu, Coldcough Syrup, Zyrtec-D 12 Hour, Tylenol Cold, Lodrane D, Sinus Relief, Suphedrin, Duraflu, Sudafed 24-Hour, Aleve-D Sinus & Cold, Zutripro, Zephrex, Allpanto-S, Panatuss PED, LoHist-12D, Brotapp, Lodrane, Tylenol Sinus Severe Congestion Daytime, Ornex, Brofed, Capmist DM, Hyphed, Semprex-D, Orlenta, Dimetapp DM, Benadryl Children's Allergy And Sinus, Silfedrine, NasOpen, Cycofed, Disobrom, 12 Hour Cold, Kolephrin, Bromaline DM, Bromadine-DM, Bromatane DX, Novahistine DMX, Decongest II, Dimetane DX, Q-Tapp DM, Guaivent (Ethex), Bromaline, Sinutab Non Drying, Deproist with Codeine, Bromhist-DM, Pseudox M, Profen II, Nacon, Q-Tapp, Alavert D-12 Hour Allergy and Sinus, Sildec, Touro CC, Robitussin Severe Congestion, Pseudovent, Guaifenex GP, Tusnel Pediatric Drops, Advil Cold and Sinus Liqui-Gels, Rezira, Hydro-Tussin EXP, Pancof, Chlo Tuss, Benadryl Allergy Sinus, Codimal, Notuss, M-END, Benylin DM-D, Tussend, Detuss, Nalex, Respaire-60 SR, Despec DM, Iosal II, Dristan Sinus, Anaplex, Allegra-D 12 Hour Allergy & Congestion, Endafed, Cetiri D, All Day Allergy-D, Bromhist Pediatric, Lortuss LQ, Robitussin Cough & Cold D, Mintex, Sudafed Children's Nasal Decongestant, Efidac, Elixsure Decongestant, Unifed, DuraHist D, Duomine, Seudotabs, Sinutab Regular Strength, Ephed Plus, Drexophed SR, Drixoral Decongestant Non-Drowsy, Nexafed, Phenylhistine DH Expectorant, Advil Allergy Sinus, Coldamine, Deltuss DMX, Phenylhistine DH, Tricode GF, Duralex, Deconamine, Sudafed Sinus Nighttime Plus Pain, Children's Dimetapp Decongestant Infant, Genaphed, Isophen-DF, Poly-Vent, Sinus & Cold D, Drixoral Non-Drowsy, Guaifenex PSE 85, Robitussin-DAC, Respa-AR, Stahist, Time-Hist, Triaminic-D Multi-Symptom Cold, Aleve-D Sinus & Headache, CPM-PSE DM Drops, Statuss Green, Flutabs, Clarinex-D 12 Hour, Notuss-NXD, Children's Nyquil, Cough Formula M Multi-Symptom, Pseudo GG TR, P-Tuss DM, Ambi 40 /400 /20, Dexatrex D, Drixoral Cough & Congestion Liquid Caps, Buckley's DM Decongestant, Relasin DM, Z-Cof DM, Pseudo Cough, Vicks 44D, Despec Drops, Pseudo DM GG, Trikof-D, Z-Cof 12DM, Relacon-DM NR, Maxifed DMX, SudaTex-DM, Pseudo Max DMX, Touro CC-LD, Liquicough DM, Desgen DM (with pseudoephedrine), Tussgen Expectorant, Deconamine CX, Poly-Tussin XP, Entuss-D, Hydrotussin HD, Nalex Expectorant, SRC Expectorant, Tussend Expectorant, Detussin Expectorant, Tusnel Pediatric, KG-Tuss HD, Medtuss HD, Drituss HD, Hydro-Tuss XP, Dynex HD, Hytussin Expectorant, Tussafin Liquid, Spantuss HD, Vanacon, Su-Tuss HD Elixir, Tussadur-HD, Vanex Expectorant, DiHydro-GP, Uni-Cof Expectorant, Pancof EXP, Welltuss EXP, Pediatex TDM, Viravan-PDM, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Pedia Relief Infant, Benylin Multi-Symptom, Actifed Allergy Day/Night, Allegra-D 24 Hour Allergy & Congestion, Entuss-D JR, Decotuss-HD, Comtrex Cold and Flu Maximum Strength Liquid, Benaphen Plus, Tavist NightTime Allergy, Respa SA, Tekral, Decongestant Cold Formula, Ambenyl-D, C-Phed DPD Tann, Tannate DMP-DEX, DuraTan Forte, Bromatan Plus, Dur-Tann Forte, Dixaphedrine, Pharmadrine, Acticon, Dexophed, Dexaphen SA, Drixomed, Drixoral Cold and Allergy, TanDur DM, SuTan-DM, Tanafed DP, Duotan PD, AllerDur, SuTan, Deltuss DP, Histatab D, D-Hist D, Abatuss DMX, Tannate PD-DM, TanaCof DM, Tanafed DMX, Polaramine Expectorant, Desihist SA, M-End DMX, Codafed, Suttar SF, Suttar-2, Codafed Pediatric, Zodryl DEC, Novagest with Codeine, Guaifenesin DAC Liquid, Guaifen DAC, Nucochem, Dihistine, Gua PC, Codahistine Expectorant, Codar D, Nucofed, Triafed & Codeine, Allerfrin with Codeine, Trifed C, Pseudodine C, Deka, Triacin C, Polyhist NC, Notuss-DC, EndaCof-DC, KG-Fed, Nucodine, Neo AC, Hexafed, Nalfrx, Daytime Liquicap, Medent DM, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Tusnel-DM Pediatric Drops, Tusnel Ped-C, Syn-Rx DM, Dorcol Childrens Cough, Guaifenex DM RX, Suda-Tussin DM, Pseudogest-DM, Med-RX DM, Tussafed-LA, Relacon-DM, Aldex GS DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Ru-Tuss DM, S-Pak DM, Profen II DM, Profen Forte DM, ExeFen-DMX, Profen II DM Liquid, ExeClear-DM, Rhinosyn-X, Ru-Tuss Expectorant, PanMist DM, Maxifed DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, Mardrops-DX, Medent-DMI, Z-Cof 8DM, Lortuss DM, Entex Pac, Entre-Cough, Poly-Vent DM, TL-Dex DM, Ambi 600/1000/30, Donatussin DM Syrup, Z-COF 12, Anatuss DM, Entex HC, Dimacol, Novahistine DM Expectorant with Decongestant, Tenar DM, Ambi 80/780/40, Benylin DM-D-E, Calmylin 4, Ambi 60/580/30, Ambifed DM, Ambifed-G DM, G-Phed- PD, Motrin Cold and Flu, Sine-Aid IB, Motrin Childrens Cold, Motrin Sinus Headache, Comtrex Day and Night, Advil Children's Cold, Motrin IB Sinus, Zymine HC, SymTan, Pancof HC, Liquituss HD, Detussin, Histussin D, Clear-Atadine-D, Allergy Relief D12, Respivent-D, Extendryl PSE, Allerx-D, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Amdry-D, AlleRx Dose Pack (AM Dose), Allergy & Congestion Relief, Leader Allergy Relief D-24, Allergy Relief D 24 Hour, AllerClear D-24 Hour, Sudatrate, ColdCough HCM, H-C Tussive D, Maxifed, Maxifed-G, Ru-Tuss Jr., ExeFen, Mucus Relief D, Nomuc-PE, Poly-Vent, Jr., Pseudatex, Medent, Touro LA-LD, Aldex GS, Despec-SR, Ambi 60/1000, Ambi 60/580, Hytussin, P-V-Tussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, Tussgen, Tussafin, Mucinex D Maximum Strength, Ambi 80/780, Aquatab D Dose Pack, Protuss-D, Procof D, Quadra-Hist D, nasofed, LA Nasal Decongestant, Hista-Tabs, Ridifed, Tri-Sudo, Vi-Sudo, Triphed, Atrogen, Atrofed, Aphedrid, Triofed, A-Phedrin, Actedril, Atridine, Triptifed, Actagen, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Altafed, Allerfrin, Biofed-PE, Histafed, Triacin, Allerphed, Triposed, Afrinol, Chlor-Trimeton Nasal Decongestant, Decofed Liquid, Decofed, Kid Kare Drops, Superfed, Sudrine, Allermed, ElixSure Congestion, Novafed, Cenafed, Ridafed, Myfedrine, Sudodrin, Pediatex TD, Zymine-D, Allercon, Genac, Triafed, Allerfrim, Ed A-Hist PSE, Viravan-P, SudoGest 12 Hour, Seldane-D, Dristan Cold Maximum Strength, Hist-PSE, Guaifenex PSE 80, Levall G, Deconsal LA, Duratuss GP (old formulation), D-Feda II, Guaifenex PSE 60, Guiadrine II, Demibid II, V-Dec-M, Stamoist E, Nasatab LA, Pseudocot-G, Eudal SR, Sudal 60/500, Tuss-LA, Respa-1st, Guiatex II, Abletex-PSE, Guaifed-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, GP 500, Tenar PSE, Guiadrine II SR, Ambifed, Defen-LA, Desal II, Deco-D, Guaibid D Pediatric, Guaivent PD, Poly-Vent IR, Pan-Mist LA, Medent-LDI, Despec-Tab, Entex T, Congestac, Zephrex LA, Comtrex Cold and Flu Maximum Strength Tablet, Hycofenix, Entex PSE, Nalex CR, Mardrops-EX, Guaimax-D, Anatuss LA, Nalex Jr, Guaifed, Nuco-Tuss Expectorant, Sinufed Timecelles, Versacaps, Guaibid D, Respaire-120 SR, Fenex-PSE, Touro LA, Syn-Rx, Nasabid, G-Phed, Hi Tex PSE, Guiatex PSE, ExeFen-IR, Dynex, Profen Forte, Durasal II, Guiadrine PSE, Miraphen PSE, Pseudovent Ped, H 9600 SR, Med-RX, Humibid GC, Nasabid SR, Panmist LA, Panmist JR, Guiatex II SR, We Mist LA, Sudal SR, Coldmist Jr, Pseudo Max, Pseudovent 400, Ambifed-G, Coldmist LA, Pseudo GG, Coldmist, SudaTex-G, Drituss GP, We Mist II LA, Panmist-S, Uni Tussin PE, Sudafed Non Drying Sinus, Guaifenex RX, Ru-Tuss DE, Guaitab, Biotuss PE, Guiatuss PE, Zaptec PSE, Mucus D, Guaipax PSE, Guai Sudo, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Mastussin PE, Mytussin PE, Robafen PE, Degen II, Respaire-30, Altarussin PE, S-Pack, Venbid TR, Sinufed, Robichem PE, Q-Tussin PE, T-Tussin PE, Tusscidin PE, Tussin PE, Pseudatex HC, Ambifed CD, BroveX PD, BroveX PSE, BroveX PSB, B-Vex PD, Shellcap, Touro A&H, Rynex PSE, Lodrane 12D, LoHist PSB, J-Tan D HC, Bromfed PD, Bromfed SR, Bidhist-D, Allent, Shellcap PD, Histex SR, Bromfenex PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Bromfenex, Pseubrom-PD, Nalfed PD, Lodrane LD, Respahist, Iofed PD, Ultrabrom PD, SymTan A, Brovex HC, Bromplex DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Uni-Hist PDX Drops, Bromph DM, Carbofed DM Syrup, PSE Brom DM, Brotapp-DM, Bromphenex DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, Allanhist PDX Drops, Histacol BD Drops, Bromplex HD, Anaplex HD, Bromph HD, Visvex, Endacof HC, Bromcomp HC, Drocon-CS, J-Cof DHC, ProHist DM, Brom Tann, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, Lodrane Liquid, Nalfed, Carbofed DM Drops, Carbaxef-DM, Decahist-DM, Pediatex-DM, Pseudo Carb DM, Cordron-DM NR, Cydec-DM Drops, Dura-Ron DM, Biodec DM, Tussafed, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Mintex DM, PSE Carbinoxamine DM, Histex HC, Tri-Vent HC, Mintex HC, Pannaz S, Biohist LA, Pannaz, Pediatex 12 DM, Cordron-12 DM, Carboxine DM, PSE Carb DM Drops, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Dynatuss, Cordron-DM, Bromhist-NR, Di-Bromm, Brovex SR, Dimaphen, LoHist-PD, Lodrane 24D, Unit-Hist Drops, Unit-Tex 10/120 ER, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Bromhist Pediatric Drops, AccuHist Pediatric, J-TanD PD, Exall-D, Zotex-D, Pseudacarb, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Allres D, Allres Pd, Respi-Tann Pd, Re-Tann, Carb Pseudo-Tan, Respi-Tann, Corzall, Anaplex DM, Brometane DX, Theraflu Max-D Severe Cold & Flu, Balminil Cough and Flu Sugar Free, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Co-Apap, Phlemgesic, Tylenol Cold Severe Congestion Daytime, Tylenol Severe Cold & Flu Night Time, All-Nite Cold, Multi-Symptom Nighttime, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Alka-Seltzer Plus Flu/Body, Comtrex Non-Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Daytime Cold, Contac Day and Night Allergy, Benadryl Cold, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Day Time Multi Symptom, Contac Severe Cold and Flu Non Drowsy, Non-Drowsy Super Strength Contac Complete, Contact Cold and Sore Throat, Day Relief Cold and Flu, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Contac Day and Night Cold and Flu, Comtrex Allergy Sinus Maximum Strength, Sinutab Ex-Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Triaminicin, Sinarest Extra Strength, Tylenol Allergy Sinus, Allerest Sinus, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Simplet, Tricom, Comtrex Allergy Sinus, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Drixoral Allergy Sinus, Sinadrin Plus, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Complete Sinus Relief, Drixoral Cold/Flu, Actifed Cold & Sinus, Cold Medicine Plus, Tavist Allergy/Sinus/Headache, Maxiflu CD, Maxiflu CDX, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Theraflu Flu & Cough, Contac Cold and Flu Maximum Strength, AccuHist DM Pediatric Drops, EndaCof PD Drops, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, M-End WC, SymPak II, Mar-cof BP, Rydex, Mesehist WC, PediaHist DM, BroveX PSE DM Tablets, Myphetane DX, Dallergy DM, Bromanate DX Cough, Myphetane DX Cough, Liquiphed DM, Bromophed-DX, Neo DM Syrup, Bromdex D, PBM Allergy, BroveX PSE DM, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Dicel CD, Trinalin Repetabs, Sudogest Sinus Maximum Strength, Allerest No Drowsiness, Benadryl Allergy Sinus Headache, Tavist Sinus, Bayer Select Sinus Pain Formula, Sinutab Maximum Strength Non Drowsy, Ornex Maximum Strength, Suphedrin Sinus, Tylenol Sinus NightTime, Actifed Sinus Day and Night, Tylenol Sinus Day/Night Convenience Pack, Sudafed Triple Action, Sinus Maximum Strength, Dristan Cold Non-Drowsy, Contac Sinus, Actifed Cold and Sinus, Sinutab Maximum Strength, Ursinus, Ru-Tuss, Sta-D, Sinarest Sinus, Pseudoephedrine Sinus, Tylenol Sinus Maximum Strength, Sine-Off Maximum Strength, Genapap Sinus, Suphedrin Plus, Phenapap, Coldec D, Coldec, Curaler, Clorfed II, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, Fedahist Gyrocaps, Codimal-LA Half, Pseudochlor, Rescon-Ed, Cophene No 2, Anamine, Klerist-D, Sudogest Plus, Neutrahist Drops, Chlor-Trimeton Allergy Decongestant SR, Allerest Maximum Strength, Tavist-DA, Dynahist-ER Pediatric, Histade, CP-Tannic, Atrohist Pediatric Capsule, Suphedrine Plus, Sudogest Cold & Allergy, Ryna Liquid, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Brexin LA, Chlorafed Timecelles, Clorfed, Duratuss DA, Histalet, Fedahist, Chlorafed HS Timecelles, Tanafed, Novafed A, Deconamine SR, Chlor-Trimeton Decongestant, Histade CR, Duotan, Durafed, Biohist LA (old formulation), Codimal-LA, Kronofed-A-Jr, Suphenamine-SR, Rinade-BID, Kronofed-A, ND Clear, Anamine TD, Chlordrine SR, Pseudocot-C, Deconomed SR, Fedahist Timecaps, Dura-Tap/PD, Chlorphedrin SR, Colfed-A, D-Amine-SR, Suclor, Re2+30, Phenhist Expectorant, Dihistine Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Expectorant, Nucochem Pediatric Expectorant, Dihistine Expectorant with Codeine, Decohistine Expectorant, Novahistine Expectorant, Medent C, Nucofed Expectorant, Tussar-2, Co-Histine Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Pediatric Expectorant, Guiatussin DAC, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Biotussin DAC, Tussar SF, Mytussin DAC, Guiatuss DAC, KG-Fed Expectorant, Cycofed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Ryna-CX, Maxifed-G CDX, AccuHist Drops (old formulation), SudaHist, LoHist-D, Triaminic Softchews Cold and Allergy, Qdall, Pseudoephedrine Plus, Sudal-12 Tannate, Dicel, Pediox Chewable, Sudal-12, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dynahist ER, M-End Max D, Ambifed-G CDX, Ambifed-G CD, Maxifed CD, Maxifed CDX, Maxifed-G CD, Ambifed CDX, Triaminic Flu, Cough & Fever, Comtrex Acute Head Cold, Genacol Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Histatab, VisRx Dose Pack, Vanatab DX, Vanacof DX, Certuss-D, Clofera, Dihistine DH, Poly-Tussin D, Panatuss PED Drops, Biclora-D, Allergy D-12, Childrens Tylenol Cold Plus Cough, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, Allergy Relief D, Tricode AR, Zodryl DAC, Vicks 44M Pediatric, Rhinosyn-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Rescon-DM, Kidcare Cough and Cold, Neotuss D, Codahistine-DH Elixir, Codehist DH, Decohistine DH, Novadyne DH, Co-Histine DH, Ryna-C, Palgic DS, Mintex PSE, Rondamine, Mooredec, Cardec-S, Maldec, Andec-TR, Palgic-D, Andec, Palgic-DC, Pediatex 12D, Carbodec, Carboxine 12D, Carbiset, Cydec, Carbic-D, Dura-Ron, Cordron-12 D, Cordron-D NR, Pseudo Carb, Carboxine-D, PSE Allergy, Pediatex-D, Cordron-D, Coldec-TR, Ex-Dec-TR, Andehist, Hydro-Tussin CBX, Carboxine-PSE, Tanafed-DM, C-Phed DM, Atuss HS, Atuss HD, Advil Children's Allergy Sinus, AlleRx Dose Pack, DuraHist, DryMax, Cordron-HC NR, Cordron-HC, P-V-Tussin Syrup, KG-Tussin, Hydrotuss HC, Hydron PCS, Hydrocof-HC, Xiral SR, RelCof DN PSE, Rhinaclear, AllePak, Allergy DN, Pseudo CM TR, Allergy AM-PM Dose Pack, ScopoHist, Time-Hist QD, Amdry-C, Relcof PSE, Dallergy PSE, Mescolor, Hista-Vent PSE, PCM-LA, A-G Tussin, Q-V Tussin, AccuHist PDX Drops, Neutrahist PDX Drops, Esocor P, Mesehist DM, Duotan DM, Allres DS, Kidkare Cough/Cold, Maxichlor PSE DM, Atuss-12 DM, M-End DM, Dicel DM, Atuss DS, Entre-S, T-Tanna DM, Tricof, Pediatex HC, JayCof-HC, Welltuss HC, Hexatussin, Tussin-V, Histinex PV, Notuss-Forte, Dihydro-CP, Hydro-Tussin DHC, Uni-Cof, Z-Tuss 2, Lemohist Plus, Phenylhistine Expectorant

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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