Skip to Content

Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Claritin-D, Sudafed Congestion, Loratadine-D 24 Hour, Mucinex D, Sudafed 12-Hour, Aprodine, SudoGest, Actifed, Zyrtec-D, Show all 1042 »Loratadine-D 12 Hour, Virtussin DAC, Cheratussin DAC, Vanacof, Bromaline, Allegra-D 12 Hour, Allegra-D 24 Hour, Claritin-D 24 Hour, Resperal-DM, AllerClear D-24 Hour, Entex, Advil Cold and Sinus, Vicks Nyquil D Cold and Flu Nighttime Relief, Zyrtec-D 12 Hour, Wal-Zyr D, Tusnel, Disophrol, Cetiri D, Robitussin Cold Cough and Flu, Rondamine, Robitussin Allergy & Cough, Silfedrine, Qdall, Stahist AD, Dimetapp DM, Advil Allergy Sinus, Suphedrine, Zephrex, Phenylhistine DH Expectorant, Tylenol Cold, Bromphenex DM, Sudafed 24-Hour, Unifed, Sudafed Children's Nasal Decongestant, Pseudovent, Mucus D, Chlo Tuss, Aleve-D Sinus & Cold, Stahist, Singlet, Bromadine-DM, Carbic-D, Hycofenix, Zutripro, Bromfenex, Lodrane, Dimetapp Elixir, Sinufed, Hista-Vent PSE, Coldamine, Exall-D, Sinus Relief, Decongest II, Nucodine, Pseudoephedrine Plus, Brotapp, Triacin C, SuTan, Robitussin Severe Congestion, Triaminic-D Multi-Symptom Cold, Semprex-D, Claritin-D 12 Hour, Lortuss DM, Drexophed SR, Pseudogest-DM, Robitussin Cough & Cold D, Chlor-Trimeton Nasal Decongestant, Allegra-D 12 Hour Allergy & Congestion, Dimetane DX, Brotapp-DM, Dristan Sinus, Cenafed, M-End DMX, Afrinol, SudoGest 12 Hour, Tricode AR, Drixoral Sinus, Guaifenesin DAC Liquid, Allpanto-S, Entex PSE, Clarinex-D 24 Hour, Aphedrid, Clofera, Disobrom, Panatuss PED, Conex, Duomine, Pannaz, Biodec DM, Nacon, Hydro-Tussin CBX, Histussin D, Phenylhistine DH, CPM-PSE DM Drops, Neutrahist PDX Drops, Children's Nyquil, Creomulsion Cough/Cold/Allergy, NasOpen, Touro CC, Capmist DM, Poly-Vent DM, Bromph DM, Bromhist-DM Drops, Defen-LA, Histinex PV, Hydrocof-HC, Benylin Multi-Symptom, Bromfenex PD, BroveX PD, Brofed, Triacin, Atrofed, Atridine, Dicel, Suclor, Histade, Clarinex-D 12 Hour, Chlorafed, Nalex Expectorant, Anamine, Anamine TD, Isophen-DF, Chlor-Trimeton Decongestant, Histade CR, Dixaphedrine, Lortuss LQ, 12 Hour Cold, Bromophed-DX, NyCair, Lodrane 24D, Carbofed DM Syrup, Decohistine DH, Lortuss EX, Actifed Cold and Sinus, Tenar PSE, Decongestant Cold Formula, Nasatab LA, Rescon, Severe Cold Multi-Symptom, Respaire-120 SR, Entex T, Congestac, Daytime Cold, Tusnel C, Theraflu Flu, Cold and Cough Powder, Respi-Tann, 12 Hour Allergy-D, Neo AC, Polyhist NC, Allergy Relief D, Pseudoephedrine Sinus, Alka-Seltzer Cold and Sinus, Ornex, Drixoral Decongestant Non-Drowsy, Contac Cold, Sudodrin, Genaphed, Children's Dimetapp Decongestant Infant, Contact Cold and Sore Throat, Guaifenex PSE 120, Alka-Seltzer Plus Flu/Body, Sinutab Ex-Strength, Acticon, Mucus Relief D, Nomuc-PE, Advil Cold and Sinus Liqui-Gels, Guaifen DAC, Guiatussin DAC, Deproist with Codeine, Medent, Zaptec PSE, Leader Allergy Relief D-24, Kolephrin, Dimaphen, Trinalin Repetabs, Sinarest, Cold Medicine Plus, Tricode GF, Hi Tex PSE, Tussin Pediatric Cold and Cough, DiHydro-GP, Pediatex TDM, Dexatrex D, Viravan-PDM, Buckley's DM Decongestant, Balminil DM + Decongestant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Pedia Relief Infant, Desgen DM (with pseudoephedrine), Benylin DM-D, P-Tuss DM, Tussgen Expectorant, Uni-Cof Expectorant, Medtuss HD, SRC Expectorant, Deconamine CX, Poly-Tussin XP, Entuss-D, Hydrotussin HD, KG-Tuss HD, Tussafin Liquid, Suttar-2, Su-Tuss HD Elixir, Pseudo Max DMX, Spantuss HD, Vanacon, Codafed, Suttar SF, Novagest with Codeine, Detussin Expectorant, Tussend Expectorant, Hydro-Tussin EXP, Respa SA, Pancof EXP, Welltuss EXP, Actifed Allergy Day/Night, Tavist NightTime Allergy, Benadryl Children's Allergy And Sinus, Benadryl Allergy Sinus, Tekral, Tussadur-HD, Benaphen Plus, Zodryl DEC, Codafed Pediatric, Allegra-D 24 Hour Allergy & Congestion, Entuss-D JR, Decotuss-HD, Vanex Expectorant, SudaTex-DM, Tussafed-LA, Pseudo DM GG, Nucofed, Duotan PD, Tanafed DP, AllerDur, Deltuss DP, Cycofed, Hexafed, Nalfrx, KG-Fed, Notuss-DC, EndaCof-DC, Z-Cof 8DM, DuraHist D, Entex Pac, Entre-Cough, Medent-DMI, Mardrops-DX, Maxifed DM, PanMist DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Histatab D, D-Hist D, Benylin DM-D-E, Trifed C, Deka, Desihist SA, Dexophed, Dexaphen SA, Drixomed, Pseudodine C, Drixoral Cold and Allergy, Pharmadrine, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Polaramine Expectorant, Bromatan Plus, Dur-Tann Forte, TanDur DM, Triafed & Codeine, Allerfrin with Codeine, SuTan-DM, Tannate PD-DM, Deltuss DMX, Abatuss DMX, TanaCof DM, Tanafed DMX, Ambi 600/1000/30, Ambi 80/780/40, Trikof-D, Tusnel Pediatric, Profen II DM Liquid, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Ambifed-G DM, Touro CC-LD, Codar D, Relacon-DM NR, Despec Drops, Despec DM, Pseudo Cough, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Liquicough DM, Maxifed DMX, Z-Cof 12DM, ExeFen-DMX, Profen II DM, Calmylin 4, Rhinosyn-X, Ambi 60/580/30, Ambifed DM, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Dorcol Childrens Cough, Profen Forte DM, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Ambenyl-D, Nalex Jr, Hytussin Expectorant, Advil Children's Cold, ColdCough HCM, Pancof HC, SymTan, Liquituss HD, Detussin, Zymine HC, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Clear-Atadine-D, Entuss-D Liquid, Alavert D-12 Hour Allergy and Sinus, Allergy Relief D12, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Allerx-D, Sinus & Cold D, H-C Tussive D, Histinex D, Aleve-D Sinus & Headache, ExeFen, Pseudatex, Touro LA-LD, Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Maxifed-G, Maxifed, Pseudo GG TR, Ru-Tuss Jr., Ambi 60/1000, Iotussin D Liquid, Ambi 60/580, Ambi 80/780, Mucinex D Maximum Strength, Aquatab D Dose Pack, Protuss-D, Procof D, Rezira, Tussafin, Tussgen, P-V-Tussin, Hytussin, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Levall G, Vi-Sudo, Triposed, Allerphed, Triofed, A-Phedrin, Actedril, Atrogen, Hista-Tabs, LA Nasal Decongestant, Ridifed, Tri-Sudo, Triphed, Triptifed, Genac, Actagen, Allerfrin, Altafed, Biofed-PE, Histafed, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Triafed, Allercon, Quadra-Hist D, Efidac, Nexafed Nasal Decongestant, nasofed, Suphedrin, ElixSure Congestion, Allermed, Novafed, Ridafed, Seudotabs, Sudrine, Superfed, Decofed Liquid, Decofed, Pediatex TD, Kid Kare Drops, Myfedrine, Elixsure Decongestant, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Ed A-Hist PSE, Allerfrim, Zymine-D, Guaifenex PSE 80, Ambifed-G, Drituss HD, Demibid II, Guaibid D Pediatric, Pseudocot-G, Eudal SR, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Guiadrine II, Versacaps, Iosal II, Respa-1st, Guiatex II, Ambifed, Guiadrine II SR, Desal II, Deco-D, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guaivent PD, Sinufed Timecelles, Guiatex PSE, Despec-Tab, Hydro-Tuss XP, Dynex HD, Entex HC, Pseudatex HC, Carbodex DM Drops, Nalex CR, Mardrops-EX, Zephrex LA, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Guaimax-D, G-Phed- PD, Anatuss LA, Touro LA, Fenex-PSE, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Guaibid D, Guaifed, Gua PC, Guai-Vent/PSE, Guai Sudo, Pseudovent 400, Guiadrine PSE, Panmist LA, Panmist JR, H 9600 SR, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiatex II SR, Med-RX, We Mist LA, SudaTex-G, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Nasabid SR, Humibid GC, Guaipax PSE, Robichem PE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, T-Tussin PE, Uni Tussin PE, Tusscidin PE, Tussin PE, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Respaire-30, Tusnel Pediatric Drops, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Codahistine Expectorant, Comtrex Acute Head Cold, Dihistine, Bidhist-D, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, LoHist PSB, Bromfed PD, Bromfed SR, Lodrane 12D, Drocon-CS, Rynex PSE, Lodrane D, BroveX PSE, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Anaplex HD, M-END, Respahist, PSE Brom DM, Dallergy DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Brometane DX, Anaplex DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, Bromaline DM, J-Cof DHC, Uni-Hist DM Pediatric Drops, Bromplex DM, Pediahist DM Drops, Q-Tapp DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, Nalfed PD, Iofed PD, Bromdex D, Carbaxef-DM, Zotex-D, Corzall Plus, Andehist DM NR, Cordron-DM, Dynatuss, Tussafed, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Carbofed DM Drops, Allres D, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, Pseudacarb, Allres Pd, Ultrabrom PD, Q-Tapp, Pseubrom-PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Bromhist Pediatric Drops, Corzall, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, LoHist-PD, LoHist-12D, J-TanD PD, Re-Tann, Respi-Tann Pd, Carb Pseudo-Tan, Neo DM Syrup, BromTann/DM Tann/PSE Tann, Tri-Vent HC, All-Nite Multi-Symptom Cold/Flu Relief, Maxiflu CDX, Drixoral Cold/Flu, Complete Sinus Relief, Sinadrin Plus, Drixoral Allergy Sinus, Drixoral Cold and Flu, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, Tylenol Cold Severe Congestion Daytime, Tavist Allergy/Sinus/Headache, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Flutabs, Duraflu, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Vicks Dayquil Daytime Cold/Flu (old formulation), Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Maxiflu CD, Actifed Cold & Sinus, Day Relief Cold and Flu, Comtrex Sinus and Nasal, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Comtrex Nighttime Flu Therapy, Allergy Sinus Maximum Strength, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Non-Drowsy Super Strength Contac Complete, Tylenol Cold Non-Drowsy Gelcaps, Anaplex DMX, Rydex, Nexafed Sinus Pressure + Pain, Sinarest Sinus, Sinutab Maximum Strength, Ursinus, Ru-Tuss, Respa-AR, Sta-D, Dicel CD, SymPak II, M-End WC, Mar-cof BP, Mesehist WC, Suphedrin Plus, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Phenapap, Genapap Sinus, Daytime Cold and Flu Relief, Sinus Maximum Strength, Daytime Non-Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Benadryl Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Suphedrin Sinus, Tylenol Sinus Maximum Strength, Ornex Maximum Strength, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Tavist Sinus, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Dristan Cold Non-Drowsy, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Pediatex 12 DM, Histex HC, Nucochem, Curaler, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Histafed LA, ND Clear, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Allerest Maximum Strength, Chlordrine SR, Kronofed-A, Tavist-DA, Tanafed, VisRx Dose Pack, Histatab, Duotan, Durafed, Biohist LA (old formulation), Deconamine, Deconamine SR, Novafed A, Duratuss DA, Clorfed, Histalet, Fedahist, Chlorafed HS Timecelles, Suphenamine-SR, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Chlor-Trimeton Allergy Decongestant SR, Dynahist-ER Pediatric, ScopoHist, Cycofed Expectorant, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, KG-Fed Expectorant, Nucofed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Biotussin DAC, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Tussar-2, Novahistine Expectorant, CP-Tannic, Dynahist ER, Mintex, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, M-End Max D, Medent C, Dristan Cold Maximum Strength, Z-Tuss E, Ambifed CD, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Allergy AM-PM Dose Pack, Pseudo CM TR, Mintex HC, Notuss-NXD, Palgic DS, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, All Day Allergy-D, Biclora-D, Panatuss PED Drops, Vanacof DX, Vanatab DX, Certuss-D, Poly-Tussin D, Statuss Green, PSE Allergy, Dihistine DH, Zodryl DAC, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Neotuss D, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Pediatric, Kidcare Cough and Cold, Mintex PSE, Carboxine-D, Tanafed-DM, Mooredec, Pannaz S, Pseudox M, Biohist LA, Coldec D, Coldec, Carbodec, Pediatex 12D, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Cardec-S, Pseudo Carb, Maldec, Palgic-D, Andec-TR, Dura-Ron, Ex-Dec-TR, Coldec-TR, Andehist, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Rescon-DM, C-Phed DM, Allergy DN, Advil Children's Allergy Sinus, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, AlleRx Dose Pack, Hexatussin, DryMax, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Hyphed, Welltuss HC, M-End DM, Pedia Relief Cough-Cold, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, AccuHist PDX Drops, Esocor P, Mesehist DM, Allres DS, Duotan DM, T-Tanna DM, Pancof, Tussend, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Coldcough Syrup, Z-Tuss 2, Lemohist Plus, Notuss-Forte, Notuss, Detuss, JayCof-HC, Pediatex HC, Tripohist D

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20170110

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide