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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Claritin-D, Mucinex D, Loratadine-D 24 Hour, Vicks Nyquil D Cold and Flu Nighttime Relief, Allegra-D 12 Hour, Zyrtec-D, Sudafed 12-Hour, Advil Cold and Sinus, Show all 1044 »Aprodine, SudoGest, Conex, Loratadine-D 12 Hour, Entex, Capmist DM, Resperal-DM, Actifed, Vanacof, Allegra-D 24 Hour, Chlo Tuss, Tusnel, Coldcough Syrup, Robitussin Allergy & Cough, Claritin-D 24 Hour, Cheratussin DAC, Sinarest, Dimetapp Elixir, Guaifen DAC, Acticon, Daytime Cold and Flu Relief, Sudafed Children's Nasal Decongestant, Duraflu, Clarinex-D 12 Hour, Virtussin DAC, Alavert D-12 Hour Allergy and Sinus, AllerClear D-24 Hour, M-End DMX, Aleve-D Sinus & Cold, Zyrtec-D 12 Hour, Mucinex D Maximum Strength, Tylenol Cold, Cetiri D, Pseudo Cough, Robitussin Cough & Cold D, Phenylhistine DH, Phenylhistine DH Expectorant, Brotapp-DM, Theraflu (pseudoephedrine) Daytime Severe Cold, Vicks Dayquil Daytime Cold/Flu (old formulation), Brotapp, Nucodine, Stahist AD, Benaphen Plus, Claritin-D 12 Hour, Advil Allergy Sinus, Hydron PCS, Rescon, Semprex-D, Silfedrine, Pseudovent, Zephrex, Singlet, Entex PSE, DuraHist D, Children's Nyquil, Benadryl Allergy Sinus, SuTan, Robitussin Severe Congestion, Pseudodine C, Zutripro, Guaifenex PSE 120, Tusnel Pediatric Drops, Respaire-30, Decongest II, Robitussin CF, Pseudo DM GG, Pseudoephedrine Plus, LoHist-D, Mintex, Allerest Maximum Strength, SudoGest Sinus & Allergy, Brexin LA, Duralex, Clorfed, Deconamine SR, Deconamine, Relasin DM, PanMist DM, Despec DM, Protuss DM, Benylin DM-D-E, Theraflu Flu & Cough, Bromplex DM, Brometane DX, BromTann/DM Tann/PSE Tann, BroveX PSE DM Tablets, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Allegra-D 24 Hour Allergy & Congestion, Advil Cold and Sinus Liqui-Gels, Kolephrin, Vicks 44D, Cough Formula M Multi-Symptom, Contact Cold and Sore Throat, Bromfenex, Bromaline, Dimaphen, Lodrane 24D, Clofera, Hycofenix, Pseudo CM TR, Daytime Cold, Dixaphedrine, Codahistine-DH Elixir, Disophrol, Disobrom, Duomine, 12 Hour Allergy-D, Theraflu Max-D Severe Cold & Flu, Wal-Zyr D, Vanacof DX, Mescolor, Deltuss DMX, Lodrane D, Bromfed PD, Suphedrin, Maxifed, Panatuss PED, Nucofed Pediatric Expectorant, Allerfrin, Aphedrid, Triofed, Andehist, Sinutab Ex-Strength, Triaminicin, Nacon, Sinutab Maximum Strength, Pseudoephedrine Sinus, Ornex, Sinus Maximum Strength, Suphedrine, Cenafed, Contac Cold, Drixoral Decongestant Non-Drowsy, Relacon-DM, Ru-Tuss DM, SudaTex-DM, Aldex GS DM, Desgen DM (with pseudoephedrine), Altarussin CF, Pseudo Max DMX, Trikof-D, Z-Cof 12DM, Coldmist DM, Maxifed DMX, Liquicough DM, Ambi 40 /400 /20, Z-Cof DM, Despec Drops, Z-Cof DM(obs), Ambifed-G DM, Relacon-DM NR, Touro CC-LD, Tusnel Pediatric, Entuss-D, P-Tuss DM, Detussin Expectorant, Allegra-D 12 Hour Allergy & Congestion, Tussafin Liquid, Su-Tuss HD Elixir, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Tussadur-HD, Tussend Expectorant, Tussgen Expectorant, Lortuss LQ, SRC Expectorant, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, Vanacon, Spantuss HD, Medtuss HD, KG-Tuss HD, Hydrotussin HD, ExeClear-DM, Tekral, Dexatrex D, Pediatex TDM, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Decongestant Cold Formula, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Pedia Relief Infant, Viravan-PDM, DiHydro-GP, Respa SA, Uni-Cof Expectorant, Hydro-Tussin EXP, Pancof EXP, Welltuss EXP, Hytussin Expectorant, Benylin Multi-Symptom, Actifed Allergy Day/Night, Tavist NightTime Allergy, Benadryl Children's Allergy And Sinus, S-Pak DM, Ambi 600/1000/30, Profen II DM Liquid, Drixomed, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Clarinex-D 24 Hour, Deka, Drexophed SR, Desihist SA, Dexophed, 12 Hour Cold, Dexaphen SA, Drixoral Cold and Allergy, Polyhist NC, Pharmadrine, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Bromatan Plus, Dur-Tann Forte, TanDur DM, SuTan-DM, Tannate PD-DM, Abatuss DMX, Triacin C, Neo AC, Tanafed DMX, Codahistine Expectorant, Guiatussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Tussar SF, Biotussin DAC, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Nucochem, Dihistine, Gua PC, Guaifenesin DAC Liquid, Cycofed, Novagest with Codeine, Suttar SF, Codafed, Suttar-2, Codafed Pediatric, Zodryl DEC, Codar D, Nucofed, EndaCof-DC, Notuss-DC, KG-Fed, TanaCof DM, Polaramine Expectorant, ExeFen-DMX, Suda-Tussin DM, Donatussin DM Syrup, Anatuss DM, Ambenyl-D, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Pseudogest-DM, Novahistine DM Expectorant with Decongestant, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Med-RX DM, Tussafed-LA, Touro CC, Profen Forte DM, Profen II DM, Z-COF 12, Tenar DM, D-Hist D, Entre-Cough, Histatab D, Duotan PD, Tanafed DP, AllerDur, Deltuss DP, Hexafed, Nalfrx, Lortuss DM, Z-Cof 8DM, Entex Pac, Poly-Vent DM, Ambifed DM, Medent-DMI, Mardrops-DX, Maxifed DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Hydro-Tuss XP, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Drituss HD, G-Phed- PD, Dynex HD, Allergy & Congestion Relief, Histussin D, Zymine HC, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Advil Children's Cold, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Allergy Relief D 24 Hour, Liquituss HD, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Allerx-D, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain, Aleve-D Sinus & Headache, Quadra-Hist D Pediatric, Quadra-Hist D, Nexafed Nasal Decongestant, Detussin, SymTan, ElixSure Congestion, Ambi 80/780, Despec-SR, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., ExeFen, Mucus Relief D, Ambi 60/1000, Ambi 60/580, Aquatab D Dose Pack, Pancof HC, Protuss-D, Procof D, Rezira, Tussafin, Tussgen, P-V-Tussin, Hytussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, nasofed, Children's Dimetapp Decongestant Infant, Touro LA-LD, Triphed, Triafed, Triposed, Allerphed, A-Phedrin, Actedril, Atridine, Atrofed, Atrogen, Hista-Tabs, LA Nasal Decongestant, Ridifed, Tri-Sudo, Vi-Sudo, Allercon, Triptifed, Actagen, Altafed, Biofed-PE, Histafed, Triacin, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Genac, Pediatex TD, Allermed, Kid Kare Drops, Novafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Chlor-Trimeton Nasal Decongestant, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Myfedrine, Zymine-D, Sudodrin, Elixsure Decongestant, Unifed, Sudafed 24-Hour, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Ed A-Hist PSE, Allerfrim, Aldex GS, Pseudatex, Entex HC, Respa-1st, Eudal SR, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Guiatex II, Pseudocot-G, Ambifed, Guiadrine II SR, Defen-LA, Desal II, Deco-D, Tenar PSE, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Hi Tex PSE, Nasatab LA, Guaibid D Pediatric, Guai Sudo, Touro LA, Pseudatex HC, Nalex CR, Mardrops-EX, Zephrex LA, Congestac, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Despec-Tab, Entex T, Guaimax-D, Anatuss LA, Fenex-PSE, Guaivent PD, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Nalex Jr, Guiatuss DAC, Sinufed Timecelles, Versacaps, Guiatex PSE, Guaipax PSE, Medent, SudaTex-G, H 9600 SR, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, Coldmist, Panmist LA, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Ambifed-G, Levall G, Guaifenex PSE 80, Panmist JR, Nasabid SR, Iotex PSE, Robichem PE, Ami-Tex PSE, Pseudo-G/PSI, Mucus D, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, T-Tussin PE, Med-RX, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Uni Tussin PE, Humibid GC, Mytussin DAC, Dynatuss, Guaiatussin DAC, Bromfed SR, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Lodrane, LoHist PSB, Brofed, Bidhist-D, M-END, Lodrane 12D, Rynex PSE, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Shellcap, Allent, Shellcap PD, Drocon-CS, J-Cof DHC, Nalfed PD, Bromaline DM, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Bromadine-DM, Anaplex DM, Bromphenex DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Carbofed DM Syrup, Sildec DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Lodrane LD, Respahist, Dimetane DX, Maldec-DM, Allres Pd, Allres D, Pseudacarb, Zotex-D, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Cordron-DM, Comtrex Acute Head Cold, Tussafed, Biodec DM, Rondamine DM, Cydec-DM Syrup, Respi-Tann, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Corzall, Carb Pseudo-Tan, Iofed PD, Bromaxefed RF Syrup, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Sildec, Respi-Tann Pd, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, LoHist-PD, LoHist-12D, J-TanD PD, Exall-D, Re-Tann, Myphetane DX, Dallergy DM, Carb PSE 12 DM, Robitussin Cold Cough and Flu, Complete Sinus Relief, Sinadrin Plus, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Tylenol Cold Severe Congestion Daytime, Maxiflu CDX, Phlemgesic, Balminil Cough and Flu Sugar Free, Flutabs, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Alka-Seltzer Plus Flu/Body, Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, Drixoral Cold/Flu, Maxiflu CD, Daytime Non-Drowsy, Comtrex Nighttime Flu Therapy, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Allpanto-S, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Triaminic Flu, Cough & Fever, Comtrex Sinus and Nasal, Simplet, Tavist Allergy/Sinus/Headache, Tricom, Comtrex Allergy Sinus, Codimal, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Cold Medicine Plus, Actifed Cold & Sinus, Tylenol Cold Non-Drowsy Gelcaps, Severe Cold Multi-Symptom, Neo DM Syrup, Uni-Hist DM Pediatric Syrup, Ursinus, Stahist, Ru-Tuss, Respa-AR, Sta-D, Trinalin Repetabs, Dicel CD, SymPak II, M-End WC, Mar-cof BP, Rydex, Mesehist WC, AccuHist DM Pediatric Syrup, Sinarest Sinus, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Dimetapp DM, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, Bromdex D, Actifed Cold and Sinus, Nexafed Sinus Pressure + Pain, Benadryl Cold, Sudogest Sinus Maximum Strength, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Suphedrin Sinus, Ornex Maximum Strength, Allerest No Drowsiness, Benadryl Allergy Sinus Headache, Phenapap, Tavist Sinus, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Alka-Seltzer Cold and Sinus, Sinus Relief, Dristan Cold Non-Drowsy, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, Genapap Sinus, Suphedrin Plus, Carboxine 12 DM, PSE Allergy DM, Deconsal C Expectorant, Pseudochlor, Deconomed SR, Pseudocot-C, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Cophene No 2, Colfed-A, Anaplex, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Curaler, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, D-Amine-SR, Chlorphedrin SR, Ryna Liquid, Chlor-Trimeton Decongestant, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Allergy DN, Coldamine, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Histade CR, Duotan, Orlenta, Durafed, Biohist LA (old formulation), Novafed A, Duratuss DA, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Neutrahist Drops, Sudogest Cold & Allergy, Relcof PSE, Co-Histine Expectorant, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Decohistine Expectorant, Ambifed CDX, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Ambifed-G CD, Ambifed CD, Genaphed Plus, C-Phed Tannate, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Suclor, Re2+30, Sudal-12, Pediox Chewable, De-Congestine, Tricode GF, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), Triaminic Softchews Cold and Allergy, Qdall, Dynahist ER, M-End Max D, Dristan Cold Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Hista-Vent PSE, Dallergy PSE, Cordron-12 DM, Biclora-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, All Day Allergy-D, Allergy Relief D, Panatuss PED Drops, Cordron-D, Vanatab DX, Certuss-D, Poly-Tussin D, Notuss-NXD, Statuss Green, NasOpen, Dihistine DH, Tricode AR, Zodryl DAC, Decohistine DH, Codehist DH, Novadyne DH, Pediatex-D, Carboxine-PSE, Ryna-C, Carboxine 12D, Pediatex 12 DM, Tri-Vent HC, Histex HC, Mintex HC, Pannaz S, Pseudox M, Pannaz, Biohist LA, Coldec D, Coldec, Carbodec, Pediatex 12D, Carbiset, Hydro-Tussin CBX, Cydec, Palgic-DC, Andec, Mooredec, Rondamine, Cardec-S, Maldec, Palgic-D, Andec-TR, Carbic-D, Dura-Ron, Ex-Dec-TR, Coldec-TR, Co-Histine DH, Neotuss D, RelCof DN PSE, A-G Tussin, Notuss-Forte, Notuss, Detuss, Histinex PV, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, KG-Tussin, Z-Tuss 2, P-V-Tussin Syrup, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Children's Allergy Sinus, AlleRx Dose Pack, DryMax, DuraHist, Xiral SR, Lemohist Plus, Uni-Cof, Rhinosyn-DM, Maxichlor PSE DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Tanafed-DM, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Kidkare Cough/Cold, Dihydro-CP, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, Pancof, Tricof, Hydro-Tussin DHC, Tripohist D

Medically reviewed on Oct 31, 2018

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Breast Feeding

Lactation

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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