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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Loratadine-D 24 Hour, Bromfed DM, Sudafed Congestion, Claritin-D, SudoGest, Mucinex D, Virtussin DAC, Loratadine-D 12 Hour, Aprodine, Actifed, Show all 1040 »Zyrtec-D, Allegra-D 24 Hour, Sudafed 12-Hour, Advil Cold and Sinus, Vicks Dayquil Daytime Cold/Flu, Conex, Resperal-DM, Vicks Nyquil D Cold and Flu Nighttime Relief, Tylenol Sinus Severe Congestion Daytime, Claritin-D 24 Hour, Entex, Wal-Zyr D, Robitussin Allergy & Cough, Allegra-D 12 Hour, Cheratussin DAC, Tusnel, Sinarest, Rondamine, Suphedrine, Semprex-D, Dimetapp Elixir, Despec DM, Capmist DM, AllerClear D-24 Hour, Tylenol Cold, Claritin-D 12 Hour, Sudafed 24-Hour, Bromfenex, Deconamine, Singlet, Sinus Relief, Stahist, Stahist AD, Andec, Decongestant Cold Formula, Pseudoephedrine Sinus, Clarinex-D 24 Hour, Abatuss DMX, Actifed Allergy Day/Night, Cetiri D, Allergy D-12, Zyrtec-D 12 Hour, Bromphenex DM, Brotapp-DM, Coldec, Vanacof, NasOpen, Suclor, Pseudoephedrine Plus, Deconamine SR, Advil Allergy Sinus, Coldcough Syrup, Nucodine, SuTan, Robitussin Cold Cough and Flu, Robitussin Severe Congestion, Guaifenex PSE 120, Drixoral Decongestant Non-Drowsy, Children's Dimetapp Decongestant Infant, Respivent-D, Aleve-D Sinus & Cold, Silfedrine, Decongest II, Sinutab Ex-Strength, Mucinex D Maximum Strength, Maxifed, Codehist DH, Dristan Sinus, All Day Allergy-D, Theraflu Flu, Cold and Cough Powder, Allpanto-S, Advil Cold and Sinus Liqui-Gels, Creomulsion Cough/Cold/Allergy, Aldex GS, Notuss, Tussend, A-G Tussin, Profen Forte, Zutripro, Pancof, Ambifed-G, Alavert D-12 Hour Allergy and Sinus, Trisofed, Unifed, Ridafed, AccuHist Pediatric, Dimaphen, Carbodex DM Drops, Pannaz, Dynatuss, Bromaline, Coldec D, Mooredec, Maldec, Carbic-D, Aphedrid, Hydron PCS, Ultrabrom, Lodrane, Histex HC, Pseudo CM TR, Drixoral Cold and Allergy, Deltuss DMX, M-END, Benylin DM-D-E, Acticon, Disophrol, Iosal II, Zephrex, Disobrom, Anatuss DM, Dimacol, Hydro-Tussin EXP, Benaphen Plus, Benadryl Children's Allergy And Sinus, Pediatex TDM, Tussin Pediatric Cold and Cough, Robitussin Cough & Cold D, Tussend Expectorant, Dexatrex D, Tenar PSE, Guai-Vent/PSE, Humibid GC, Durafed, Anaplex, Allerest Maximum Strength, H 9600 SR, Pseudovent, Mescolor, Benadryl Allergy Sinus, Pseudovent Ped, Dicel, Tusnel Pediatric Drops, Trifed C, Pseudodine C, Biotuss PE, Codar D, Respaire-30, Robitussin-DAC, Ryna-CX, Guaifen DAC, ExeFen-IR, Guiatussin DAC, Contact Cold and Sore Throat, Anaplex DM, Sinutab Regular Strength, Ornex, Brometane DX, Bromophed-DX, Drixoral Cold/Flu, Dimetapp DM, BroveX PSE DM Tablets, Dimetane DX, Actifed Cold and Sinus, Theraflu (pseudoephedrine) Daytime Severe Cold, Tusnel-A, Duraflu, Flutabs, Entuss-D JR, Tussafin Liquid, Su-Tuss HD Elixir, Vanacon, Detussin Expectorant, Decotuss-HD, Vanex Expectorant, Tussadur-HD, Spantuss HD, Hytussin Expectorant, SRC Expectorant, Medtuss HD, KG-Tuss HD, Entuss-D, Poly-Tussin XP, Tylenol Cold Severe Congestion Daytime, Hydrotussin HD, Nalex Expectorant, Deconamine CX, Tussgen Expectorant, Respa SA, Alka-Seltzer Plus Flu/Body, Viravan-PDM, Theraflu Flu Cold & Cough, DiHydro-GP, Uni-Cof Expectorant, Pedia Relief Infant, Benylin DM-D, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Balminil DM + Decongestant, Pancof EXP, Welltuss EXP, Lortuss LQ, Balminil Cough and Flu Sugar Free, Phlemgesic, Allegra-D 12 Hour Allergy & Congestion, Tekral, Drituss HD, Maxiflu DM, Theraflu Max-D Severe Cold & Flu, Benylin Multi-Symptom, Tavist NightTime Allergy, Allegra-D 24 Hour Allergy & Congestion, Hycofenix, Nalex, Fenex-PSE, Syn-Rx, Respaire-60 SR, Nasabid, Touro LA, Anatuss LA, Medent-LDI, Poly-Vent IR, Despec-Tab, Entex T, Guaimax-D, G-Phed, Respaire-120 SR, Guaibid D Pediatric, Guaivent PD, Pseudocot-G, Nasatab LA, Eudal SR, Versacaps, Sinufed Timecelles, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Pan-Mist LA, Congestac, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, All-Nite Cold, Contac Day and Night Cold and Flu, Hexaflu, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Entex HC, Dynex HD, Pseudatex HC, Comtrex Non-Drowsy, Comtrex Day and Night, Drixoral Sinus, Drixoral Cold and Flu, Entex PSE, Actifed Cold & Sinus, Nalex CR, Mardrops-EX, Zephrex LA, Tavist Allergy/Sinus/Headache, Maxiflu CD, Drixoral Allergy Sinus, Sinadrin Plus, Complete Sinus Relief, Maxiflu CDX, Hydro-Tuss XP, Day Time Multi Symptom, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Tylenol Cold Non-Drowsy Gelcaps, Day Relief Cold and Flu, Z-Cof 8DM, Non-Drowsy Super Strength Contac Complete, Severe Cold Multi-Symptom, Daytime Cold, Rescon, Deltuss DP, Hexafed, Nalfrx, Lortuss DM, Entex Pac, Entre-Cough, TL-Dex DM, Balminil DM + Decongestant + Expectorant, Ambi 600/1000/30, Ambi 80/780/40, Calmylin 4, Sudafed Cough Syrup, Sudafed Cough, Medent-DMI, Poly-Vent DM, Mardrops-DX, Maxifed DM, PanMist DM, AllerDur, Tanafed DP, Sudafed Sinus Nighttime Plus Pain, Dixaphedrine, Contac Day and Night Allergy, Tannate DMP-DEX, C-Phed DPD Tann, Pharmadrine, Drixomed, Duomine, Desihist SA, Dexophed, 12 Hour Cold, Dexaphen SA, DuraTan Forte, Bromatan Plus, DuraHist D, D-Hist D, Histatab D, Benadryl Cold, Duotan PD, Polaramine Expectorant, Tanafed DMX, TanDur DM, Dur-Tann Forte, SuTan-DM, Tannate PD-DM, TanaCof DM, Ambi 60/580/30, Ambifed DM, Tusnel Pediatric, Ambifed-G DM, Touro CC-LD, Relacon-DM NR, Despec Drops, Z-Cof DM(obs), Altarussin CF, Ru-Tuss DM, S-Pak DM, Aldex GS DM, Relacon-DM, Coldmist DM, Pseudo Cough, Relasin DM, SudaTex-DM, Pseudo Max DMX, Desgen DM (with pseudoephedrine), P-Tuss DM, Sudal 60/500, Pseudo DM GG, Trikof-D, Ambi 40 /400 /20, Z-Cof DM, Liquicough DM, Maxifed DMX, Z-Cof 12DM, ExeClear-DM, Profen II DM Liquid, Dorcol Childrens Cough, Rhinosyn-X, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Ru-Tuss Expectorant, Novahistine DMX, Novahistine DM Expectorant with Decongestant, Tenar DM, Z-COF 12, Donatussin DM Syrup, Ambenyl-D, Pseudogest-DM, Tusnel Ped-C, Touro CC, Tussafed-LA, Profen Forte DM, Profen II DM, ExeFen-DMX, Med-RX DM, Protuss DM, Medent DM, Tusnel-DM Pediatric Drops, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Contac Severe Cold and Flu Non Drowsy, Duratuss GP (old formulation), Comtrex Nighttime Flu Therapy, Simplet, Comtrex Sinus and Nasal, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Tricom, Dristan Cold Maximum Strength, Aleve-D Sinus & Headache, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Quadra-Hist D, Comtrex Allergy Sinus, Theracaps Multi-Symptom Cough & Cold Reliever, Co-Apap, Seudotabs, Genaphed, Sudrine, Superfed, Chlor-Trimeton Nasal Decongestant, Cenafed, Novafed, nasofed, Theraflu Flu & Cough, Suphedrin, ElixSure Congestion, Allermed, Sinus & Cold D, Codimal, Triaminicin, Advil Children's Cold, Sinarest Extra Strength, Allerest Headache Strength, Comtrex Allergy Sinus Night and Day, Motrin Sinus Headache, Motrin Childrens Cold, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, AlleRx Dose Pack (AM Dose), Sudatrate, Amdry-D, Extendryl PSE, Allerx-D, Kolephrin, Allergy Relief D 24 Hour, Clear-Atadine-D, Allerest Sinus, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Afrinol, Sudafed Children's Nasal Decongestant, LA Nasal Decongestant, Hista-Tabs, Ridifed, Tri-Sudo, Triphed, Atrogen, Atrofed, Triofed, Allerphed, A-Phedrin, Actedril, Atridine, Vi-Sudo, Triptifed, Pseudocot-T, Actacin, Zymine DXR, Trip-PSE, Tripohist D, Ritifed, Triacin, Allerfrin, Actagen, Altafed, Biofed-PE, Histafed, Triposed, Triafed, SudoGest 12 Hour, Contac Cold, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Nexafed, Elixsure Decongestant, Sudodrin, Efidac, Decofed Liquid, Decofed, Kid Kare Drops, Myfedrine, Viravan-P, Seldane-D, Zymine-D, Allerfrim, Pediatex TD, Allercon, Genac, Ed A-Hist PSE, Hist-PSE, Contac Cold and Flu Maximum Strength, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Cold Medicine Plus, Zymine HC, Robichem PE, Q-Tussin PE, T-Tussin PE, Tusscidin PE, Tussin PE, Mytussin PE, Mastussin PE, Ru-Tuss DE, Zaptec PSE, Guaifenex RX, Guaitab, Guiatuss PE, Sinufed, Venbid TR, Med-RX, Uni Tussin PE, Nasabid SR, Panmist LA, Panmist JR, Sinutab Non Drying, Sudafed Non Drying Sinus, Robafen PE, Degen II, Guaivent (Ethex), Altarussin PE, S-Pack, Mucus D, Pseudo-G/PSI, Respa-1st, Guiadrine II, Guiatex II, Ambifed, Guiadrine II SR, Demibid II, Guaifenex PSE 60, V-Dec-M, Stamoist E, Drexophed SR, Deconsal LA, D-Feda II, Defen-LA, Desal II, Guai Sudo, Guiatex PSE, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Hi Tex PSE, Guiadrine PSE 120, Deco-D, GP 500, Guaifed-PSE, Abletex-PSE, Guaifenex GP, Dynex, Aquatab D Dose Pack, Ambi 80/780, Protuss-D, Procof D, Rezira, Ambi 60/580, Ambi 60/1000, Pseudo GG TR, Maxifed-G, Ru-Tuss Jr., ExeFen, Mucus Relief D, Tussafin, Tussgen, SymTan, Pancof HC, Liquituss HD, Detussin, Histussin D, ColdCough HCM, H-C Tussive D, Hytussin, P-V-Tussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, Nomuc-PE, Poly-Vent, Jr., Drituss GP, Coldmist, We Mist II LA, Panmist-S, Pseudo GG, SudaTex-G, We Mist LA, Durasal II, Profen II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, Coldmist LA, Coldmist Jr, Touro LA-LD, Pseudatex, Despec-SR, Guaifenex PSE 85, Poly-Vent, Medent, Guaifenex PSE 80, Sudal SR, Pseudo Max, Pseudovent 400, Levall G, Tuss-LA, Tylenol Sinus Day/Night Convenience Pack, Palgic-D, Cardec-S, Andec-TR, Dura-Ron, Ex-Dec-TR, Palgic-DC, Cydec, Carbodec, Biohist LA, Pediatex 12D, Carboxine 12D, Carbiset, Coldec-TR, Andehist, PSE Allergy, Carboxine-D, Mintex PSE, Palgic DS, Bromhist-DM, Pseudo Carb, Cordron-12 D, Carboxine-PSE, Hydro-Tussin CBX, Cordron-D, Pediatex-D, Cordron-D NR, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Cordron-DM NR, Pediatex-DM, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, Decahist-DM, Carbofed DM Drops, Cydec-DM Syrup, Maldec-DM, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, PSE Carb DM Drops, Carboxine DM, Pannaz S, Mintex HC, Pseudox M, Nacon, Cough Formula M Multi-Symptom, Tri-Vent HC, Pediatex 12 DM, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Vicks 44M Pediatric, Rhinosyn-DM, Creomulsion Pediatric, Kidcare Cough and Cold, Children's Nyquil, Sta-D, Neotuss D, Novadyne DH, Phenylhistine DH Expectorant, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Rescon-DM, Tanafed-DM, Neutrahist PDX Drops, Kidkare Cough/Cold, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Maxichlor PSE DM, Entre-S, M-End DM, C-Phed DM, Atuss-12 DM, Dicel DM, Atuss DS, Decohistine DH, Phenylhistine DH, Chlo Tuss, Biclora-D, M-End WC, Panatuss PED Drops, Panatuss PED, Allergy Relief D, 12 Hour Allergy-D, Rydex, Mesehist WC, Mar-cof BP, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, Vanacof DX, Vanatab DX, Trinalin Repetabs, Dicel CD, Dihistine DH, Tricode AR, Zodryl DAC, SymPak II, Statuss Green, Certuss-D, Clofera, Poly-Tussin D, Notuss-NXD, Rondamine DM, Biodec DM, Brovex HC, Endacof HC, SymTan A, J-Tan D HC, Bromdex D, Bromcomp HC, Visvex, Drocon-CS, Neo DM Syrup, Anaplex HD, Bromplex HD, Bromph HD, BromTann/DM Tann/PSE Tann, Anaplex DMX, Bidhist-D, Bromfed SR, Lodrane 12D, Rynex PSE, Lodrane D, Bromfed PD, Brofed, PBM Allergy, BroveX PSB DM, BroveX PSE DM, PediaHist DM, LoHist PSB, J-Cof DHC, Sildec DM, Bromaxefed DM RF Syrup, Bromtapp-DM, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Andehist DM NR Syrup, Bromadine-DM, Bromanate DX Cough, Myphetane DX, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Brom Tann, Histacol BD Drops, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Allanhist PDX Drops, Uni-Hist PDX Drops, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, BroveX PSE, BroveX PD, LoHist-12D, LoHist-PD, J-TanD PD, Exall-D, Re-Tann, Lodrane 24D, Brovex SR, Unit-Hist Drops, Unit-Tex 10/120 ER, Di-Bromm, Bromhist-NR, Brotapp, Respi-Tann Pd, Carb Pseudo-Tan, EndaCof PD Drops, AccuHist DM Pediatric Drops, Andehist DM NR, Cordron-DM, Tussafed, Corzall Plus, Zotex-D, Corzall, Respi-Tann, Allres Pd, Allres D, Pseudacarb, Bromhist Pediatric Drops, Q-Tapp, Lodrane LD, Shellcap PD, Nalfed PD, Respahist, Iofed PD, Allent, Shellcap, B-Vex PD, BroveX PSB, Bromhist Pediatric, Endafed, Touro A&H, Ultrabrom PD, Pseubrom-PD, Touro Allergy, Nalfed, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Lodrane Liquid, Pseubrom, Bromfenex PD, Histex SR, M-Hist TD, Iofed, Mesehist DM, Triaminic-D Multi-Symptom Cold, Lortuss EX, Ornex Maximum Strength, Tusnel C, Z-Tuss E, Tricode GF, Comtrex Cold and Flu Maximum Strength Tablet, Allerest No Drowsiness, M-End Max D, Dynahist ER, Comtrex Acute Head Cold, Benadryl Allergy Sinus Headache, Sudogest Sinus Maximum Strength, Ambifed CD, Ambifed CDX, Nucofed Expectorant, Novahistine Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Medent C, Maxifed-G CDX, Ambifed-G CDX, Ambifed-G CD, Maxifed CD, Maxifed CDX, Maxifed-G CD, Qdall, Triaminic Softchews Cold and Allergy, Atrohist Pediatric Capsule, Suphedrine Plus, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, Hayfebrol Liquid, SudoGest Sinus & Allergy, Neutrahist Drops, Sudogest Plus, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, CP-Tannic, Histade, Sudal-12 Tannate, Sudal-12 Chewable, SudaHist, AccuHist Drops (old formulation), LoHist-D, De-Congestine, C-Phed Tannate, Mintex, Re2+30, Sudal-12, Pediox Chewable, Decohistine Expectorant, Dihistine Expectorant with Codeine, Nucofed, Sinus Maximum Strength, EndaCof-DC, Notuss-DC, KG-Fed, Suphedrin Sinus, Zodryl DEC, Suttar SF, Novagest with Codeine, Codafed, Suttar-2, Codafed Pediatric, Cycofed, Neo AC, Dallergy DM, M-End DMX, Tylenol Sinus NightTime, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Deka, Clarinex-D 12 Hour, Triacin C, Polyhist NC, Allerfrin with Codeine, Triafed & Codeine, Sudafed Triple Action, Guaifenesin DAC Liquid, Codahistine Expectorant, Cycofed Expectorant, Nucodine Pediatric, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Phenhist Expectorant, Dihistine Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Guaiatussin DAC, Guiatuss DAC, Nuco-Tuss Expectorant, Phenylhistine Expectorant, Nucochem, Dihistine, Gua PC, Biotussin DAC, Tussar SF, Mytussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant, AlleRx Dose Pack, Advil Children's Allergy Sinus, Genapap Sinus, Tylenol Sinus Maximum Strength, DryMax, Suphedrin Plus, Atuss HS, Hydrocof-HC, Hydrotuss HC, Cordron-HC, Cordron-HC NR, Atuss HD, DuraHist, Xiral SR, Rhinaclear, AllePak, Allergy DN, Coldamine, ScopoHist, Time-Hist QD, Amdry-C, Dallergy PSE, RelCof DN PSE, Relcof PSE, Hista-Vent PSE, PCM-LA, P-V-Tussin Syrup, KG-Tussin, Uni-Cof, Dihydro-CP, Z-Tuss 2, Lemohist Plus, Ursinus, Hydro-Tussin DHC, Tricof, Duotan DM, Allres DS, T-Tanna DM, Respa-AR, Ru-Tuss, Sinutab Maximum Strength, Sinarest Sinus, Hexatussin, Welltuss HC, Hyphed, Tussin-V, Q-V Tussin, Pediatex HC, JayCof-HC, Phenapap, Notuss-Forte, Detuss, Histinex PV, Allergy AM-PM Dose Pack, VisRx Dose Pack, ND Clear, Kronofed-A, Chlordrine SR, Anamine TD, Time-Hist, Isophen-DF, Suphenamine-SR, Deconomed SR, D-Amine-SR, Pseudocot-C, Duralex, Rinade-BID, Chlorafed Timecelles, Brexin LA, Clorfed II, Fedahist Gyrocaps, Curaler, Chlorafed, Histafed LA, Codimal-LA Half, Klerist-D, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Colfed-A, Chlorphedrin SR, Tavist Sinus, Sinutab Maximum Strength Non Drowsy, Histade CR, Chlor-Trimeton Decongestant, Duotan, Bayer Select Sinus Pain Formula, Ephed Plus, Sine-Off Maximum Strength, Histatab, Contac Sinus, Dristan Cold Non-Drowsy, Alka-Seltzer Cold and Sinus, Biohist LA (old formulation), Novafed A, Kronofed-A-Jr, Codimal-LA, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorafed HS Timecelles, Tanafed, Duratuss DA, Clorfed, Histalet, Fedahist, Tylenol Allergy Complete NightTime

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20170110

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