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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Sudafed Congestion, Claritin-D, Bromfed DM, Loratadine-D 24 Hour, Mucinex D, Zyrtec-D, Vicks Nyquil D Cold and Flu Nighttime Relief, Allegra-D 12 Hour, Sudafed 12-Hour, Vanacof, Show all 1042 »Allegra-D 24 Hour, Dimetapp DM, Claritin-D 24 Hour, Resperal-DM, Robitussin Allergy & Cough, Virtussin DAC, SudoGest, Aprodine, Bromaline, Entex, Loratadine-D 12 Hour, Capmist DM, Deconamine, Advil Cold and Sinus, Sinarest, Notuss, Conex, Tusnel, Sudafed 24-Hour, Cetiri D, Advil Allergy Sinus, Robitussin Cough & Cold D, Actifed, Claritin-D 12 Hour, Pseudovent, Cheratussin DAC, Silfedrine, Children's Nyquil, Suphedrine, Brotapp-DM, M-End DMX, Contac Cold, Aleve-D Sinus & Cold, Dimetapp Elixir, Lodrane, Mucinex D Maximum Strength, Zyrtec-D 12 Hour, Guaifen DAC, Sinutab Ex-Strength, Alavert D-12 Hour Allergy and Sinus, Robitussin Severe Congestion, Chlor-Trimeton Nasal Decongestant, Vicks Dayquil Daytime Cold/Flu (old formulation), Dexophed, Trinalin Repetabs, Benylin DM-D-E, Semprex-D, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Clarinex-D 24 Hour, Deconamine SR, Tylenol Cold, Creomulsion Cough/Cold/Allergy, Kidcare Cough and Cold, Rescon-DM, Brotapp, Stahist, Leader Allergy Relief D-24, Coldamine, M-End DM, Esocor P, Chlor-Trimeton Allergy Decongestant, Xiral SR, Fedahist, Clorfed, AllerClear D-24 Hour, Respivent-D, Allerest Maximum Strength, Rescon, Unit-Hist Drops, Brometane DX, Benylin Multi-Symptom, Despec Drops, Despec DM, Histussin D, Detussin, Sildec DM, Q-Tapp DM, Rezira, Andehist DM NR Syrup, Bromphenex DM, Bromophed-DX, Medent-DMI, Zutripro, Pseudacarb, JayCof-HC, Hydrocof-HC, Bromcomp HC, Dynahist ER, Dicel, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Benadryl Allergy Sinus, Bromplex DM, Entre-S, Neotuss D, Pseudo GG, Robitussin Cold Cough and Flu, Clarinex-D 12 Hour, Ed A-Hist PSE, Triposed, A-Phedrin, Atridine, Allerfrin, Triacin, Trisofed, Tripohist D, Notuss-NXD, Trifed C, Levall G, Sinufed, Drexophed SR, Mucus D, Zephrex, Nucodine, Congestac, Entex PSE, Actifed Cold & Sinus, Singlet, Chlo Tuss, Allergy Relief D, Wal-Zyr D, Theraflu Flu & Cough, Comtrex Cold and Flu Maximum Strength Tablet, Cough Formula M Multi-Symptom, Duraflu, Mescolor, Theraflu (pseudoephedrine) Daytime Severe Cold, Deconamine CX, Sudrine, Sudafed Children's Nasal Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, Children's Dimetapp Decongestant Infant, Suphedrin, Sinus Maximum Strength, Alka-Seltzer Cold and Sinus, Sinus Relief, Tylenol Sinus Maximum Strength, Nexafed Sinus Pressure + Pain, Nalex Expectorant, Carbic-D, Entuss-D, Severe Cold Multi-Symptom, Duomine, Dixaphedrine, Phenylhistine DH Expectorant, Bromatan Plus, Respa SA, Lortuss LQ, Liquicough DM, Ambi 40 /400 /20, Z-Cof DM, Relasin DM, ExeClear-DM, S-Pak DM, Poly-Tussin XP, Hydrotussin HD, Altarussin CF, KG-Tuss HD, Tekral, Medtuss HD, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Pseudo Cough, Z-Cof 12DM, Relacon-DM NR, Touro CC-LD, Tusnel Pediatric, Ambifed-G DM, Coldmist DM, Z-Cof DM(obs), Maxifed DMX, Allegra-D 12 Hour Allergy & Congestion, Trikof-D, Uni-Cof Expectorant, Detussin Expectorant, Allegra-D 24 Hour Allergy & Congestion, Benadryl Children's Allergy And Sinus, Tavist NightTime Allergy, Actifed Allergy Day/Night, DiHydro-GP, Hydro-Tussin EXP, Benaphen Plus, Pancof EXP, Welltuss EXP, Entuss-D JR, Tussend Expectorant, Tussadur-HD, Vanex Expectorant, Tussgen Expectorant, Viravan-PDM, Pseudo DM GG, Dexatrex D, Decotuss-HD, SRC Expectorant, Pseudo Max DMX, SudaTex-DM, Desgen DM (with pseudoephedrine), P-Tuss DM, Buckley's DM Decongestant, Pedia Relief Infant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Decongestant Cold Formula, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Pediatex TDM, Entre-Cough, Profen II DM Liquid, Drixoral Cold and Allergy, Triafed & Codeine, Pseudodine C, Deka, Desihist SA, Disobrom, Disophrol, Acticon, 12 Hour Cold, Dexaphen SA, Drixomed, Pharmadrine, Triacin C, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Dur-Tann Forte, TanDur DM, SuTan-DM, Tannate PD-DM, Deltuss DMX, Abatuss DMX, TanaCof DM, Tanafed DMX, Allerfrin with Codeine, Polyhist NC, D-Hist D, Guaifenesin DAC Liquid, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Biotussin DAC, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Nucochem, Dihistine, Gua PC, Codahistine Expectorant, Novagest with Codeine, Neo AC, Suttar SF, Codafed, Suttar-2, Codafed Pediatric, Zodryl DEC, Codar D, Nucofed, EndaCof-DC, Notuss-DC, KG-Fed, Cycofed, Polaramine Expectorant, DuraHist D, ExeFen-DMX, Pseudogest-DM, Anatuss DM, Ambenyl-D, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Tusnel Ped-C, Z-COF 12, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, Profen Forte DM, Profen II DM, Donatussin DM Syrup, Novahistine DM Expectorant with Decongestant, Histatab D, Poly-Vent DM, Duotan PD, Tanafed DP, AllerDur, SuTan, Deltuss DP, Hexafed, Nalfrx, Lortuss DM, Z-Cof 8DM, Entex Pac, Vanacon, Mardrops-DX, Tenar DM, Maxifed DM, PanMist DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Ambi 600/1000/30, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Ambifed DM, Spantuss HD, Guaibid D Pediatric, Su-Tuss HD Elixir, Zymine HC, Tussgen, P-V-Tussin, Hytussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Pancof HC, SymTan, Liquituss HD, Motrin Cold and Flu, Procof D, Motrin Childrens Cold, Motrin Sinus Headache, Advil Cold and Sinus Liqui-Gels, Advil Children's Cold, Clear-Atadine-D, Allergy Relief D12, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Tussafin, Protuss-D, Allerx-D, Despec-SR, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Ambifed-G, Guaifenex PSE 80, Medent, Pseudatex, Touro LA-LD, Aldex GS, Guaifenex PSE 85, Aquatab D Dose Pack, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Maxifed, Pseudo GG TR, Ru-Tuss Jr., ExeFen, Mucus Relief D, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Extendryl PSE, Sinus & Cold D, We Mist II LA, LA Nasal Decongestant, Pediatex TD, Allercon, Genac, Triafed, Allerphed, Triofed, Aphedrid, Actedril, Atrofed, Atrogen, Hista-Tabs, Ridifed, Allerfrim, Tri-Sudo, Triphed, Vi-Sudo, Triptifed, Actagen, Altafed, Biofed-PE, Histafed, Ritifed, Actacin, Pseudocot-T, Zymine DXR, Zymine-D, Hist-PSE, Sudafed 12 Hour Pressure+Pain, Seudotabs, Aleve-D Sinus & Headache, Quadra-Hist D Pediatric, Quadra-Hist D, Nexafed Nasal Decongestant, nasofed, ElixSure Congestion, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Superfed, Seldane-D, Afrinol, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Panmist-S, Drituss GP, Tussafin Liquid, Duratuss GP (old formulation), Sinufed Timecelles, Versacaps, Guaivent PD, Guiatussin DAC, Pseudocot-G, Nasatab LA, Eudal SR, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Deconsal LA, Nalex Jr, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Respa-1st, Guiatex II, Ambifed, Guiadrine II SR, Defen-LA, Decongest II, G-Phed- PD, Guaifed, Deco-D, Poly-Vent IR, Hytussin Expectorant, Drituss HD, Hydro-Tuss XP, Dynex HD, Entex HC, Pseudatex HC, Hycofenix, Nalex CR, Mardrops-EX, Zephrex LA, Pan-Mist LA, Medent-LDI, Guaibid D, Despec-Tab, Entex T, Guaimax-D, Anatuss LA, Touro LA, Fenex-PSE, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Desal II, Tenar PSE, Coldmist, Panmist JR, Respaire-30, Tusnel Pediatric Drops, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Uni Tussin PE, Humibid GC, Med-RX, Nasabid SR, Panmist LA, H 9600 SR, Robafen PE, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, SudaTex-G, Guaivent (Ethex), Degen II, GP 500, Pseudo-G/PSI, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Zaptec PSE, Venbid TR, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Cycofed Pediatric Expectorant, Cordron-DM, Mytussin DAC, BroveX PSE, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, LoHist PSB, Brofed, Bromfed PD, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, Lodrane D, BroveX PD, Bromph HD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Visvex, Bromplex HD, Pseubrom-PD, Uni-Hist DM Pediatric Drops, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Bromadine-DM, Anaplex DM, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Bromhist-DM Drops, Anaplex HD, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, J-Cof DHC, M-END, Drocon-CS, Ultrabrom PD, Bromfenex, Dallergy DM, Dura-Ron DM, Allres D, Zotex-D, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Comtrex Acute Head Cold, Dynatuss, Tussafed, Biodec DM, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Cydec-DM Drops, Corzall, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, Allres Pd, Respi-Tann, Bromfenex PD, Bromhist Pediatric Drops, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Q-Tapp, AccuHist Pediatric, Carb Pseudo-Tan, Unit-Tex 10/120 ER, Di-Bromm, Bromhist-NR, Brovex SR, Dimaphen, Lodrane 24D, LoHist-PD, LoHist-12D, J-TanD PD, Exall-D, Re-Tann, Respi-Tann Pd, Dimetane DX, Neo DM Syrup, Cordron-12 DM, All-Nite Multi-Symptom Cold/Flu Relief, Drixoral Cold/Flu, Complete Sinus Relief, Sinadrin Plus, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, NyCair, Tylenol Cold Severe Congestion Daytime, Maxiflu CD, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Flutabs, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Alka-Seltzer Plus Flu/Body, Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Maxiflu CDX, Tavist Allergy/Sinus/Headache, Day Relief Cold and Flu, Simplet, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Allpanto-S, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Triaminic Flu, Cough & Fever, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tricom, Cold Medicine Plus, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Contact Cold and Sore Throat, Tylenol Cold Non-Drowsy Gelcaps, Bromdex D, Uni-Hist DM Pediatric Syrup, Sinutab Maximum Strength, Actifed Cold and Sinus, Ursinus, Ru-Tuss, Respa-AR, Sta-D, Dicel CD, SymPak II, M-End WC, Mar-cof BP, Rydex, Mesehist WC, AccuHist DM Pediatric Syrup, Pseudoephedrine Sinus, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Sinarest Sinus, Phenapap, Daytime Cold and Flu Relief, Suphedrin Sinus, Daytime Non-Drowsy, Daytime Cold, Benadryl Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Ornex Maximum Strength, Suphedrin Plus, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Tavist Sinus, Ornex, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Dristan Cold Non-Drowsy, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Genapap Sinus, PSE Allergy DM, Pediatex 12 DM, Guiatuss DAC, Anamine, Isophen-DF, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Klerist-D, Rinade-BID, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Curaler, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Suphenamine-SR, Duralex, Hayfebrol Liquid, Novafed A, Rhinaclear, Allergy DN, Pseudo CM TR, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Duratuss DA, Pseudocot-C, Histalet, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, SudoGest Sinus & Allergy, Suphedrine Plus, Time-Hist QD, Dihistine Expectorant with Codeine, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant, Ambifed-G CDX, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Maxifed CD, Ambifed-G CD, Atrohist Pediatric Capsule, Sudal-12 Chewable, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Suclor, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Tannate, Ambifed CDX, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Qdall, M-End Max D, Dristan Cold Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Tricode GF, Ambifed CD, AllePak, Amdry-C, Tri-Vent HC, Biclora-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, All Day Allergy-D, 12 Hour Allergy-D, Panatuss PED Drops, Cordron-D, Panatuss PED, Vanacof DX, Vanatab DX, Certuss-D, Clofera, Poly-Tussin D, Statuss Green, NasOpen, Stahist AD, Dihistine DH, Tricode AR, Zodryl DAC, Pediatex-D, Carboxine-PSE, Decohistine DH, Carbiset, Histex HC, Mintex HC, Pannaz S, Pseudox M, Nacon, Pannaz, Biohist LA, Coldec D, Coldec, Carbodec, Pediatex 12D, Carboxine 12D, Cydec, Hydro-Tussin CBX, Palgic-DC, Andec, Mooredec, Rondamine, Cardec-S, Maldec, Palgic-D, Andec-TR, Dura-Ron, Ex-Dec-TR, Coldec-TR, Andehist, Phenylhistine DH, Codehist DH, PCM-LA, Hydrotuss HC, Detuss, Histinex PV, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydron PCS, Lemohist Plus, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Children's Allergy Sinus, AlleRx Dose Pack, DryMax, DuraHist, RelCof DN PSE, Dallergy PSE, Relcof PSE, Hista-Vent PSE, Notuss-Forte, Z-Tuss 2, Novadyne DH, Kidkare Cough/Cold, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Pediatric, Tanafed-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Atuss DS, Maxichlor PSE DM, Neutrahist PDX Drops, Coldcough Syrup, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Trip-PSE

Medically reviewed on January 10, 2017.

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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