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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Claritin-D, Mucinex D, Zyrtec-D, Sudafed 12-Hour, Vicks Nyquil D Cold and Flu Nighttime Relief, Loratadine-D 24 Hour, Allegra-D 24 Hour, Allegra-D 12 Hour, Show all 1045 »SudoGest, Vanacof, Actifed, Loratadine-D 12 Hour, Aprodine, Entex, Advil Cold and Sinus, Tusnel, Sinarest, Claritin-D 24 Hour, Resperal-DM, Sudafed 24-Hour, Alka-Seltzer Cold and Sinus, Wal-Zyr D, Bromphenex DM, Conex, Cheratussin DAC, Tylenol Cold, Nucodine, Zyrtec-D 12 Hour, Aleve-D Sinus & Cold, Stahist AD, Sudafed Children's Nasal Decongestant, Capmist DM, Theraflu (pseudoephedrine) Daytime Severe Cold, Daytime Cold and Flu Relief, Duraflu, Lodrane, Maldec, Chlo Tuss, Dimaphen, Singlet, M-End DMX, Despec DM, Dorcol Childrens Cough, Robitussin Allergy & Cough, Brexin LA, Claritin-D 12 Hour, Dimetapp Elixir, Panatuss PED, Brofed, Advil Cold and Sinus Liqui-Gels, Robitussin Cough & Cold D, Stahist, Sinus Relief, NasOpen, Pseudoephedrine Sinus, Bromadine-DM, Dimetapp DM, Congestac, Contac Cold, Cold Medicine Plus, Simplet, Mucinex D Maximum Strength, Allegra-D 24 Hour Allergy & Congestion, Guaifenesin DAC Liquid, Pseudovent, Allerest Maximum Strength, Coldmist, Med-RX, Robitussin Severe Congestion, Anaplex, Deconamine, Drixoral Cold and Allergy, Actedril, Theraflu Flu & Cough, Bromaline, Clarinex-D 24 Hour, Childrens Tylenol Cold Plus Cough, Fedahist Timecaps, AccuHist DM Pediatric Drops, Rinade-BID, Children's Nyquil, CPM-PSE DM Drops, Kidkare Cough/Cold, Hydron PCS, Neotuss D, Histacol DM Pediatric Syrup, Benylin DM-D, Alavert D-12 Hour Allergy and Sinus, Dimetane DX, Sildec, Bromfed PD, Cough Formula M Multi-Symptom, Coldcough Syrup, Tricof, Corzall Plus, Semprex-D, KG-Fed, Suclor, Guaifenex PSE 120, Comtrex Cold and Flu Maximum Strength Tablet, Tavist-DA, Pancof EXP, Allegra-D 12 Hour Allergy & Congestion, Hycofenix, Pseudogest-DM, Allpanto-S, Dimacol, Robitussin CF, Poly-Vent DM, Klerist-D, Brotapp, Myphetane DX Cough, AllerClear D-24 Hour, Advil Allergy Sinus, Rescon, Ed A-Hist PSE, Benadryl Severe Allergy & Sinus Headache, Zaptec PSE, GP 500, Decongest II, Defen-LA, Pseudodine C, Cetiri D, All Day Allergy-D, Up and Up All Day Allergy Relief D, Maxiflu CD, Nalex, Entex T, Drixoral Allergy Sinus, Respaire-30, Clarinex-D 12 Hour, Virtussin DAC, Allerfrin, A-Phedrin, Guiatussin DAC, Contact Cold and Sore Throat, Vicks Dayquil Daytime Cold/Flu (old formulation), Allercon, NyCair, Acticon, All-Nite Multi-Symptom Cold/Flu Relief, Disophrol, Duomine, Deltuss DMX, Degen II, Tusnel Pediatric Drops, Biclora-D, Phenylhistine DH Expectorant, Aleve-D Sinus & Headache, Tricode AR, Sinutab Ex-Strength, Silfedrine, Children's Dimetapp Decongestant Infant, Nasabid SR, Chlor-Trimeton Nasal Decongestant, Tylenol Cold Severe Congestion Daytime, Allerest No Drowsiness, Profen Forte, Panmist JR, Maxifed, Nomuc-PE, ExeFen-IR, Pseudo Cough, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Liquicough DM, Maxifed DMX, Z-Cof 12DM, Trikof-D, Balminil DM + Decongestant, Pseudo DM GG, Buckley's DM Decongestant, Pseudo Max DMX, SudaTex-DM, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Decongestant Cold Formula, P-Tuss DM, Hydro-Tuss XP, Dexatrex D, Drituss HD, Tussin Pediatric Cold and Cough, Desgen DM (with pseudoephedrine), KG-Tuss HD, Pedia Relief Infant, Despec Drops, Vanacon, Tussadur-HD, Tussend Expectorant, Spantuss HD, Detussin Expectorant, Medtuss HD, Tussgen Expectorant, Tussafin Liquid, SRC Expectorant, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, Entuss-D, Hydrotussin HD, Su-Tuss HD Elixir, Vanex Expectorant, Viravan-PDM, Tavist NightTime Allergy, Pediatex TDM, DiHydro-GP, Uni-Cof Expectorant, Hydro-Tussin EXP, Welltuss EXP, Benylin Multi-Symptom, Benadryl Children's Allergy And Sinus, Decotuss-HD, Benadryl Allergy Sinus, Respa SA, Tekral, Benaphen Plus, Lortuss LQ, Hytussin Expectorant, Entuss-D JR, Actifed Allergy Day/Night, Tusnel Ped-C, Relacon-DM NR, D-Hist D, Bromatan Plus, Dur-Tann Forte, TanDur DM, SuTan-DM, Suttar SF, Tannate PD-DM, Abatuss DMX, TanaCof DM, Novagest with Codeine, Tanafed DMX, Polaramine Expectorant, DuraHist D, C-Phed DPD Tann, Histatab D, Duotan PD, Tanafed DP, AllerDur, SuTan, Deltuss DP, Hexafed, Nalfrx, Lortuss DM, Codahistine Expectorant, Gua PC, DuraTan Forte, Tannate DMP-DEX, Guaifen DAC, Deka, Codar D, Nucofed, EndaCof-DC, Notuss-DC, Cycofed, Neo AC, Polyhist NC, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Zodryl DEC, Dixaphedrine, Codafed Pediatric, Suttar-2, Codafed, Drexophed SR, Desihist SA, Dexophed, Disobrom, 12 Hour Cold, Dexaphen SA, Drixomed, Pharmadrine, Dihistine, Nucochem, Touro CC-LD, Profen II DM, Suda-Tussin DM, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, Profen Forte DM, ExeFen-DMX, Syn-Rx DM, Profen II DM Liquid, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Ambifed-G DM, Tusnel Pediatric, Guaifenex DM RX, Rhinosyn-X, Nuco-Tuss Expectorant, Balminil DM + Decongestant + Expectorant, Phenylhistine Expectorant, Biotussin DAC, Z-Cof 8DM, Entex Pac, Entre-Cough, Medent-DMI, Mardrops-DX, Maxifed DM, PanMist DM, Sudafed Cough, Sudafed Cough Syrup, TL-Dex DM, Ru-Tuss Expectorant, Ambi 600/1000/30, Benylin DM-D-E, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Ambenyl-D, Novahistine DMX, Ambifed DM, Guaibid D, Dynex HD, Sudatrate, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Advil Children's Cold, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour, AlleRx Dose Pack (AM Dose), Zymine HC, Amdry-D, Extendryl PSE, Respivent-D, Allerx-D, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Quadra-Hist D, Nexafed Nasal Decongestant, nasofed, Suphedrin, Dristan Sinus, Histussin D, ElixSure Congestion, Procof D, Poly-Vent, Jr., Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., ExeFen, Mucus Relief D, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, Protuss-D, Rezira, Detussin, Tussafin, Tussgen, P-V-Tussin, Hytussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Pancof HC, SymTan, Liquituss HD, Suphedrine, Allermed, Guaifenex PSE 85, Vi-Sudo, Allerphed, Triofed, Aphedrid, Atridine, Atrofed, Atrogen, Hista-Tabs, LA Nasal Decongestant, Ridifed, Tri-Sudo, Triphed, Triptifed, Triafed, Actagen, Altafed, Biofed-PE, Histafed, Triacin, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Triposed, Genac, Novafed, Kid Kare Drops, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Myfedrine, Pediatex TD, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Allerfrim, Zymine-D, Poly-Vent, Despec-SR, Entex HC, Guiadrine II, Nasatab LA, Eudal SR, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Iosal II, Guaibid D Pediatric, Respa-1st, Guiatex II, Ambifed, Guiadrine II SR, Desal II, Deco-D, Tenar PSE, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Pseudocot-G, Guaivent PD, Guiatex PSE, Guaimax-D, Pseudatex HC, Dynatuss, Entex PSE, Nalex CR, Mardrops-EX, Zephrex LA, Zephrex, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Despec-Tab, Anatuss LA, Versacaps, Touro LA, Fenex-PSE, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Nucofed Pediatric Expectorant, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Hi Tex PSE, Guai Sudo, Aldex GS, Panmist-S, Guaifenex GP, Dynex, Profen II, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, SudaTex-G, Drituss GP, We Mist II LA, Pseudo GG, H 9600 SR, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Ambifed-G, Levall G, Guaifenex PSE 80, Medent, Pseudatex, Touro LA-LD, Pseudovent Ped, Panmist LA, Guaipax PSE, Q-Tussin PE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Mucus D, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Robichem PE, Humibid GC, T-Tussin PE, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Robafen PE, Guaivent (Ethex), Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Uni Tussin PE, Tussar SF, Comtrex Acute Head Cold, KG-Fed Pediatric Expectorant, Bromhist Pediatric, SymTan A, J-Tan D HC, LoHist PSB, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Endafed, Endacof HC, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Bromfenex PD, Brovex HC, Bromcomp HC, M-Hist TD, Uni-Hist PDX Drops, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Allanhist PDX Drops, Visvex, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, J-Cof DHC, M-END, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Histex SR, Ultrabrom, Anaplex DM, Cordron-DM NR, Cordron-DM, Tussafed, Biodec DM, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Pseudo Carb DM, Andehist DM NR, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Tri-Vent HC, Histex HC, Mintex HC, Carbodex DM Drops, Zotex-D, Iofed, Bromhist-NR, Pseubrom, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Brovex SR, Pseudacarb, Lodrane 24D, LoHist-PD, LoHist-12D, J-TanD PD, Exall-D, Re-Tann, Respi-Tann Pd, Carb Pseudo-Tan, Respi-Tann, Corzall, Allres Pd, Allres D, Brotapp-DM, Brometane DX, Pseudox M, Maxiflu DM, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, Robitussin Cold Cough and Flu, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Flutabs, Tusnel-A, Complete Sinus Relief, Theraflu Flu Cold & Cough, Alka-Seltzer Plus Flu/Body, Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, Tylenol Cold Non-Drowsy Gelcaps, Daytime Non-Drowsy, Severe Cold Multi-Symptom, Daytime Cold, Benadryl Cold, Sinadrin Plus, Drixoral Cold/Flu, Sudafed Sinus Nighttime Plus Pain, Comtrex Allergy Sinus, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Tricom, Codimal, Maxiflu CDX, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Tavist Allergy/Sinus/Headache, Contac Day and Night Allergy, Tylenol Allergy Complete NightTime, Liquiphed DM, PediaHist DM, Trinalin Repetabs, Dicel CD, SymPak II, M-End WC, Mar-cof BP, Rydex, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, EndaCof PD Drops, BroveX PSE DM Tablets, Respa-AR, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Neo DM Syrup, Dallergy DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Bromophed-DX, Sta-D, Ru-Tuss, Actifed Sinus Day and Night, Bayer Select Sinus Pain Formula, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Sinus Maximum Strength, Suphedrin Sinus, Ornex Maximum Strength, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Tavist Sinus, Ornex, Sinutab Maximum Strength Non Drowsy, Ephed Plus, Ursinus, Dristan Cold Non-Drowsy, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, Genapap Sinus, Suphedrin Plus, Phenapap, Nexafed Sinus Pressure + Pain, Sinarest Sinus, Sinutab Maximum Strength, Actifed Cold and Sinus, Pannaz S, Nacon, Cycofed Pediatric Expectorant, Clorfed II, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Codimal-LA Half, Fedahist Gyrocaps, Curaler, Suphenamine-SR, Chlorafed, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Suphedrine Plus, Isophen-DF, Duralex, Chlor-Trimeton Allergy Decongestant SR, Duratuss DA, Coldamine, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Deconamine SR, Novafed A, Clorfed, Pseudocot-C, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Atrohist Pediatric Capsule, Dynahist-ER Pediatric, Allergy DN, Phenhist Expectorant, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Halotussin DAC, Maxifed CDX, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Maxifed-G CD, Maxifed CD, CP-Tannic, LoHist-D, Histade, Mintex, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), Triaminic Softchews Cold and Allergy, Ambifed-G CDX, Pseudoephedrine Plus, Qdall, Dynahist ER, M-End Max D, Dristan Cold Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Tricode GF, Ambifed CD, Ambifed CDX, Ambifed-G CD, Pseudo CM TR, Rhinaclear, Pannaz, Notuss-NXD, Palgic DS, Allergy D-12, KS Aller-Tec D-12, 12 Hour Allergy-D, Allergy Relief D, Panatuss PED Drops, Vanacof DX, Vanatab DX, Certuss-D, Clofera, Ninjacof-D, Poly-Tussin D, Statuss Green, PSE Allergy, Dihistine DH, Zodryl DAC, Phenylhistine DH, Decohistine DH, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Mintex PSE, Carboxine-D, Kidcare Cough and Cold, Cardec-S, Biohist LA, Coldec D, Coldec, Carbodec, Pediatex 12D, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Mooredec, Rondamine, Palgic-D, Pseudo Carb, Andec-TR, Carbic-D, Dura-Ron, Ex-Dec-TR, Coldec-TR, Andehist, Hydro-Tussin CBX, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Creomulsion Pediatric, Rescon-DM, AllePak, Atuss HS, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Advil Children's Allergy Sinus, Tussend, AlleRx Dose Pack, DryMax, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, Welltuss HC, Pediatex HC, Tanafed-DM, Allres DS, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, Esocor P, Mesehist DM, Triaminic-D Multi-Symptom Cold, Duotan DM, JayCof-HC, T-Tanna DM, Pedia Relief Cough-Cold, Pancof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Z-Tuss 2, Lemohist Plus, Zutripro, Notuss-Forte, Notuss, Detuss, Histinex PV, Tripohist D

Medically reviewed by Drugs.com. Last updated on Dec 5, 2018.

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Breast Feeding

Lactation

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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