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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Claritin-D, Sudafed Congestion, Bromfed DM, SudoGest, Mucinex D, Drixoral, Vicks Dayquil Daytime Cold/Flu, Zyrtec-D, Allegra-D 24 Hour, Actifed, Show all 1037 »Virtussin DAC, Claritin-D 24 Hour, Allegra-D 12 Hour, Sudafed 12-Hour, Resperal-DM, Theraflu Flu, Cold and Cough Powder, Vicks Nyquil D Cold and Flu Nighttime Relief, Entex, Semprex-D, Dimetapp Elixir, Cheratussin DAC, Advil Cold and Sinus, Wal-Zyr D, Sudafed Children's Nasal Decongestant, Claritin-D 12 Hour, Sudafed 24-Hour, Robitussin Cold Cough and Flu, Vanacof, Aprodine, Zyrtec-D 12 Hour, Conex, Sinutab Ex-Strength, Dristan Sinus, Capmist DM, Robitussin Allergy & Cough, Coldcough Syrup, Singlet, Alavert D-12 Hour Allergy and Sinus, Clarinex-D 12 Hour, Deconamine, Zutripro, Aleve-D Sinus & Cold, Rescon, Sinarest, Suphedrine, Panatuss PED, Advil Allergy Sinus, Clarinex-D 24 Hour, NasOpen, Lodrane D, Allpanto-S, Contac Cold, Loratadine-D 24 Hour, Alka-Seltzer Cold and Sinus, Brotapp, Tusnel, Dixaphedrine, Dexaphen SA, Pseudovent, Orlenta, Respaire-60 SR, Tylenol Sinus Severe Congestion Daytime, AllerClear D-24 Hour, 12 Hour Cold, Mooredec, Cardec-S, Maldec, Sinus Relief, Efidac, Drixoral Decongestant Non-Drowsy, LoHist-D, Nucodine Expectorant, Allermed, Duraflu, Tylenol Sinus Maximum Strength, Advil Cold and Sinus Liqui-Gels, Sinutab Maximum Strength Non Drowsy, Benadryl Cold, Hyphed, Bromadine-DM, M-END, Dimetapp DM, LoHist-12D, M-End DMX, Tusnel Pediatric Drops, AlleRx Dose Pack, Cough Formula M Multi-Symptom, Actedril, Despec DM, Brexin LA, Tylenol Cold, Duralex, Allegra-D 12 Hour Allergy & Congestion, Nucodine, Ambenyl-D, Stahist AD, Novahistine DMX, Brometane DX, Bromatane DX, Q-Tapp DM, Brotapp-DM, Pseudogest-DM, Tricode AR, Codahistine-DH Elixir, Hexatussin, Lemohist Plus, Rezira, Phenylhistine DH, Benylin DM-D, Maldec-DM, Benaphen Plus, Bromaline, Lodrane 24D, Endafed, Brofed, Benadryl Children's Allergy And Sinus, Allegra-D 24 Hour Allergy & Congestion, Poly-Tussin XP, Time-Hist, Pseudochlor, Isophen-DF, Tanafed, Histalet, Codar D, Pediatex-D, Decongestant Cold Formula, Su-Tuss HD Elixir, Allerest Maximum Strength, Sudogest Cold & Allergy, Coldec, Novafed A, CPM-PSE DM Drops, Guaifenex PSE 85, Seldane-D, Triofed, Theraflu (pseudoephedrine) Daytime Severe Cold, Contac Severe Cold and Flu Non Drowsy, Cetiri D, Deltuss DMX, Notuss-NXD, Mucinex D Maximum Strength, Poly-Vent, Drixoral Sinus, Codimal, Allerfrin, Disophrol, Zaptec PSE, Duomine, Drexophed SR, Kolephrin, Theraflu Max-D Severe Cold & Flu, Flutabs, Medent, Profen II, Guaifenex GP, Humibid GC, Comtrex Allergy Sinus Maximum Strength, Sudafed Sinus Nighttime Plus Pain, M-End DM, Suphedrin, Children's Dimetapp Decongestant Infant, Afrinol, Myfedrine, Silfedrine, Comtrex Cold and Flu Maximum Strength Tablet, Nalex, Stahist, Guaifed, Decongest II, Nexafed, SudoGest 12 Hour, Triaminic-D Multi-Symptom Cold, Ephed Plus, Ornex, Congestac, Polyhist NC, AllePak, Kidcare Cough and Cold, Deproist with Codeine, Allergy AM-PM Dose Pack, AccuHist PDX Drops, Chlo Tuss, Pedia Relief Infant, Pediatex TDM, Viravan-PDM, Balminil DM + Decongestant, Vicks 44D, Pseudo DM GG, Trikof-D, Pseudo Max DMX, SudaTex-DM, Desgen DM (with pseudoephedrine), Z-Cof 12DM, Dexatrex D, DiHydro-GP, P-Tuss DM, Drixoral Cough & Congestion Liquid Caps, Buckley's DM Decongestant, Tussin Pediatric Cold and Cough, Hydrotussin HD, KG-Tuss HD, Medtuss HD, Spantuss HD, Maxifed DMX, Entuss-D, SRC Expectorant, Nalex Expectorant, Deconamine CX, Vanacon, Tussafin Liquid, Entex HC, Pseudatex HC, Hycofenix, Dynex HD, Hydro-Tuss XP, Hytussin Expectorant, Drituss HD, Tussgen Expectorant, Detussin Expectorant, Tavist NightTime Allergy, Benadryl Allergy Sinus, Respa SA, Actifed Allergy Day/Night, Benylin Multi-Symptom, Hydro-Tussin EXP, Pancof EXP, Welltuss EXP, Tekral, Lortuss LQ, Vanex Expectorant, Tussadur-HD, Tussend Expectorant, Decotuss-HD, Entuss-D JR, Contac Cold and Flu Maximum Strength, Childrens Tylenol Cold Plus Cough, Uni-Cof Expectorant, Suda-Tussin DM, D-Hist D, Polaramine Expectorant, DuraHist D, Histatab D, Duotan PD, Tanafed DMX, TanaCof DM, TanDur DM, Dur-Tann Forte, SuTan-DM, Tannate PD-DM, Abatuss DMX, Tanafed DP, AllerDur, Poly-Vent DM, Entre-Cough, Medent-DMI, Mardrops-DX, Maxifed DM, Entex Pac, Z-Cof 8DM, Deltuss DP, SuTan, Hexafed, Nalfrx, Lortuss DM, Bromatan Plus, DuraTan Forte, Neo AC, Cycofed, Triacin C, Allerfrin with Codeine, Triafed & Codeine, KG-Fed, Notuss-DC, Codafed Pediatric, Suttar-2, Zodryl DEC, Nucofed, EndaCof-DC, Trifed C, Pseudodine C, Drixoral Cold and Allergy, Drixomed, Pharmadrine, Tannate DMP-DEX, C-Phed DPD Tann, Acticon, Disobrom, Deka, Theraflu Flu & Cough, Desihist SA, Dexophed, PanMist DM, Sudafed Cough, Profen II DM Liquid, ExeFen-DMX, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Profen II DM, Profen Forte DM, Med-RX DM, Protuss DM, Tussafed-LA, Touro CC, Robitussin Cough & Cold D, Aldex GS DM, Relacon-DM, Pseudo Cough, Despec Drops, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Relacon-DM NR, Touro CC-LD, Altarussin CF, Coldmist DM, Z-Cof DM(obs), Ambifed-G DM, Tusnel Pediatric, Tussin Cough and Cold, Multi Symptom Cough and Cold, Ambifed DM, Ambi 60/580/30, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Calmylin 4, Ambi 80/780/40, Balminil DM + Decongestant + Expectorant, Sudafed Cough Syrup, TL-Dex DM, Ambi 600/1000/30, Benylin DM-D-E, Donatussin DM Syrup, Anatuss DM, Tusnel Ped-C, Genacol Maximum Strength, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Guaifenex DM RX, Syn-Rx DM, Dimacol, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Liquicough DM, Guaibid D Pediatric, Motrin Childrens Cold, Motrin Cold and Flu, Motrin Sinus Headache, Advil Children's Cold, Comtrex Cold and Flu Maximum Strength Liquid, Sine-Aid IB, Motrin IB Sinus, Liquituss HD, SymTan, Detussin, Histussin D, Zymine HC, Comtrex Day and Night, Clear-Atadine-D, Respivent-D, Extendryl PSE, Allerx-D, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain, Amdry-D, AlleRx Dose Pack (AM Dose), Leader Allergy Relief D-24, Allergy Relief D12, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudatrate, Pancof HC, ColdCough HCM, Pseudo GG TR, Maxifed, Ru-Tuss Jr., ExeFen, Mucus Relief D, Maxifed-G, Nomuc-PE, Touro LA-LD, Pseudatex, Aldex GS, Despec-SR, Poly-Vent, Jr., Ambi 60/1000, Ambi 60/580, Iotussin D Liquid, Hytussin, Histinex D, Entuss-D Liquid, H-C Tussive D, P-V-Tussin, Tussgen, Aquatab D Dose Pack, Ambi 80/780, Protuss-D, Procof D, Tussafin, Aleve-D Sinus & Headache, Quadra-Hist D Pediatric, LA Nasal Decongestant, Hista-Tabs, Ridifed, Tri-Sudo, Triphed, Atrogen, Atrofed, Allerphed, Triposed, Aphedrid, A-Phedrin, Atridine, Vi-Sudo, Triptifed, Pseudocot-T, Trisofed, Zymine DXR, Trip-PSE, Tripohist D, Actacin, Ritifed, Altafed, Actagen, Biofed-PE, Histafed, Triacin, Triafed, Genac, Seudotabs, Ridafed, Sudrine, Superfed, Chlor-Trimeton Nasal Decongestant, Genaphed, Cenafed, nasofed, Quadra-Hist D, Drixoral Non-Drowsy, ElixSure Congestion, Novafed, Decofed Liquid, Decofed, Allerfrim, Ed A-Hist PSE, Zymine-D, Pediatex TD, Allercon, Hist-PSE, Dristan Cold Maximum Strength, Sudodrin, Kid Kare Drops, Elixsure Decongestant, Unifed, Viravan-P, Guaifenex PSE 80, Levall G, Guiadrine II, Demibid II, Iosal II, Respa-1st, Guiatex II, Guaifenex PSE 60, D-Feda II, Stamoist E, Tuss-LA, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, Ambifed, Guiadrine II SR, Guai-Vent/PSE, Guiadrine PSE 120, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Abletex-PSE, Guaifed-PSE, Desal II, Defen-LA, Deco-D, Tenar PSE, GP 500, Sudal 60/500, Eudal SR, Entex T, Despec-Tab, Guaimax-D, Anatuss LA, Touro LA, Medent-LDI, Poly-Vent IR, Mardrops-EX, Nalex CR, Zephrex LA, Zephrex, Pan-Mist LA, Fenex-PSE, Syn-Rx, Guaivent PD, Versacaps, Codafed, Pseudocot-G, Nasatab LA, Sinufed Timecelles, G-Phed- PD, G-Phed, Nasabid, Respaire-120 SR, Guaibid D, Nalex Jr, Guai Sudo, Guaipax PSE, Profen Forte, ExeFen-IR, Durasal II, Miraphen PSE, Guiadrine PSE, Dynex, Pseudovent Ped, Nasabid SR, Med-RX, Panmist LA, Panmist JR, H 9600 SR, Guiatex II SR, We Mist LA, Sudal SR, Coldmist Jr, Pseudo Max, Pseudovent 400, Ambifed-G, Coldmist LA, Pseudo GG, Coldmist, SudaTex-G, Drituss GP, We Mist II LA, Panmist-S, Uni Tussin PE, Robitussin Severe Congestion, Guiatuss PE, Biotuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Guaitab, Guaifenex RX, Ami-Tex PSE, Iotex PSE, Pseudo-G/PSI, Mucus D, Ru-Tuss DE, Robichem PE, T-Tussin PE, Altarussin PE, Respaire-30, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Guaivent (Ethex), Robafen PE, Tussin PE, Tusscidin PE, Sinufed, Venbid TR, Degen II, Entex PSE, Ambifed-G CDX, Shellcap, Touro A&H, Allent, Shellcap PD, Nalfed PD, Lodrane LD, Bromhist Pediatric, B-Vex PD, Rynex PSE, Lodrane 12D, BroveX PSE, BroveX PD, BroveX PSB, Respahist, Iofed PD, Pseubrom, Iofed, Lodrane Liquid, Nalfed, Andehist NR Syrup, Touro Allergy, Ultrabrom, M-Hist TD, Pseubrom-PD, Ultrabrom PD, Bromfenex, Bromfenex PD, Histex SR, Bidhist-D, Bromfed SR, ProHist DM, Brom Tann, P-Hist DM Drops, Carbodex DM Syrup, J-Cof DHC, Sildec DM, Histacol BD Drops, Allanhist PDX Drops, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Drocon-CS, Anaplex HD, Triaminic Flu, Cough & Fever, J-Tan D HC, Lodrane, LoHist PSB, Bromfed PD, SymTan A, Brovex HC, Bromph HD, Bromplex HD, Visvex, Bromcomp HC, Endacof HC, Bromaxefed RF Syrup, Sildec, Pseudo Carb DM, Cordron-DM NR, Mintex DM, PSE Carbinoxamine DM, Carboxine DM, PSE Carb DM Drops, Pediatex-DM, Decahist-DM, Dura-Ron DM, Cydec-DM Syrup, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Carboxine 12 DM, Carb PSE 12 DM, Nacon, Pseudox M, Pannaz, Biohist LA, Coldec D, Pannaz S, Mintex HC, Cordron-12 DM, PSE Allergy DM, Pediatex 12 DM, Tri-Vent HC, Histex HC, Rondamine DM, Biodec DM, Dimaphen, Brovex SR, LoHist-PD, J-TanD PD, Re-Tann, Exall-D, Bromhist-NR, Di-Bromm, Bromhist Pediatric Drops, Q-Tapp, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Respi-Tann Pd, Carb Pseudo-Tan, Carbodex DM Drops, Andehist DM NR, Cordron-DM, Dynatuss, Tussafed, Corzall Plus, Zotex-D, Corzall, Respi-Tann, Allres Pd, Allres D, Pseudacarb, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Comtrex Non-Drowsy, Alka-Seltzer Plus Flu/Body, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, Contact Cold and Sore Throat, Theraflu Flu Cold & Cough, Tusnel-A, Tylenol Cold Severe Congestion Daytime, All-Nite Multi-Symptom Cold/Flu Relief, Phlemgesic, Balminil Cough and Flu Sugar Free, Maxiflu DM, Tylenol Cold Non-Drowsy Gelcaps, Daytime Cold and Flu Relief, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus NightTime, Sudafed Triple Action, Sinus Maximum Strength, Suphedrin Sinus, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Severe Cold Multi-Symptom, Daytime Non-Drowsy, Daytime Cold, Contac Day and Night Allergy, Tylenol Allergy Complete NightTime, NyCair, Multi-Symptom Nighttime, Allerest Headache Strength, Comtrex Allergy Sinus Night and Day, Sinarest Extra Strength, Triaminicin, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Tylenol Allergy Sinus, Allerest Sinus, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Simplet, Tricom, Comtrex Allergy Sinus, Cold Medicine Plus, Actifed Cold & Sinus, Hexaflu, Drixoral Cold and Flu, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Drixoral Allergy Sinus, Sinadrin Plus, Maxiflu CD, Tavist Allergy/Sinus/Headache, Maxiflu CDX, Drixoral Cold/Flu, Complete Sinus Relief, Ornex Maximum Strength, Allerest No Drowsiness, BroveX PSB DM, PBM Allergy, Anaplex DMX, BromTann/DM Tann/PSE Tann, Neo DM Syrup, Bromdex D, BroveX PSE DM, BroveX PSE DM Tablets, Histacol DM Pediatric Syrup, Pediahist DM Syrup, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, Dallergy DM, Dimetane DX, Bromtapp-DM, Andehist DM NR Syrup, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Bromphenex DM, Anaplex DM, Bromanate DX Cough, Myphetane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Bromhist-DM, AccuHist DM Pediatric Syrup, Genapap Sinus, Sinutab Regular Strength, Suphedrin Plus, Phenapap, Sinarest Sinus, Pseudoephedrine Sinus, Sine-Off Maximum Strength, Contac Sinus, Benadryl Allergy Sinus Headache, Sudogest Sinus Maximum Strength, Tavist Sinus, Bayer Select Sinus Pain Formula, Dristan Cold Non-Drowsy, Sinutab Maximum Strength, Actifed Cold and Sinus, Mar-cof BP, M-End WC, Rydex, Mesehist WC, Uni-Hist DM Pediatric Syrup, SymPak II, Dicel CD, Ru-Tuss, Ursinus, Respa-AR, Sta-D, Trinalin Repetabs, Carbodec, Pediatex 12D, Genaphed Plus, Ryna Liquid, SudoGest Sinus & Allergy, Hayfebrol Liquid, Atrohist Pediatric Capsule, Suphedrine Plus, Neutrahist Drops, Sudogest Plus, Chlorafed, Curaler, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, C-Phed Tannate, Pediox Chewable, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, Dicel, Sudal-12, Re2+30, CP-Tannic, Dynahist-ER Pediatric, Histade, Mintex, Suclor, Clorfed II, Fedahist Gyrocaps, Fedahist Timecaps, Dura-Tap/PD, Chlorphedrin SR, Colfed-A, Deconomed SR, D-Amine-SR, Kronofed-A-Jr, Codimal-LA, Duratuss DA, Deconamine SR, Clorfed, Fedahist, Chlorafed HS Timecelles, Pseudocot-C, Rinade-BID, Anaplex, Cophene No 2, Anamine, Klerist-D, Codimal-LA Half, Rescon-Ed, Chlorafed Timecelles, Kronofed-A, Suphenamine-SR, ND Clear, Chlordrine SR, Anamine TD, SudaHist, AccuHist Drops (old formulation), Deconsal C Expectorant, KG-Fed Expectorant, Guaiatussin DAC, Guiatuss DAC, Guiatussin DAC, Mytussin DAC, Cycofed Expectorant, Nucodine Pediatric, Novadyne Expectorant, Halotussin DAC, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Gua PC, Dihistine, Codahistine Expectorant, Guaifenesin DAC Liquid, Novagest with Codeine, Guaifen DAC, Nucochem, Tussar SF, Nucofed Pediatric Expectorant, Biotussin DAC, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Phenhist Expectorant, Dihistine Expectorant, Tusnel C, Lortuss EX, Z-Tuss E, Tricode GF, Ambifed CDX, Ambifed CD, Comtrex Acute Head Cold, Co-Apap, Pseudoephedrine Plus, Triaminic Softchews Cold and Allergy, Qdall, Dynahist ER, M-End Max D, Ambifed-G CD, Maxifed CD, Tussar-2, Nucofed Expectorant, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Novahistine Expectorant, Medent C, Maxifed-G CD, Maxifed CDX, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Biohist LA (old formulation), Durafed, Dihistine DH, Statuss Green, Zodryl DAC, Decohistine DH, Phenylhistine DH Expectorant, Codehist DH, Poly-Tussin D, Clofera, Panatuss PED Drops, Biclora-D, Vanacof DX, Vanatab DX, Certuss-D, Novadyne DH, Co-Histine DH, Tanafed-DM, Rescon-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Children's Nyquil, Creomulsion Pediatric, Neotuss D, Ryna-C, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Allergy Relief D, All Day Allergy-D, Carbic-D, Andec-TR, Dura-Ron, Ex-Dec-TR, Andehist, Coldec-TR, Palgic-D, Rondamine, Carbiset, Carboxine 12D, Cydec, Palgic-DC, Andec, Hydro-Tussin CBX, Carboxine-PSE, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Palgic DS, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, Mintex PSE, PSE Allergy, Cordron-D NR, Cordron-D, Cordron-12 D, Pseudo Carb, Carboxine-D, Atuss DS, Entre-S, Xiral SR, DuraHist, RelCof DN PSE, Dallergy PSE, Mescolor, Relcof PSE, DryMax, Advil Children's Allergy Sinus, Cordron-HC, Hydrocof-HC, Cordron-HC NR, Atuss HD, Atuss HS, Hista-Vent PSE, PCM-LA, Histatab, VisRx Dose Pack, Histade CR, Chlor-Trimeton Decongestant, Duotan, ScopoHist, Coldamine, Time-Hist QD, Amdry-C, Rhinaclear, Allergy DN, Pseudo CM TR, Hydron PCS, Hydrotuss HC, Pancof, T-Tanna DM, Tricof, Hydro-Tussin DHC, Uni-Cof, Dihydro-CP, Duotan DM, Allres DS, Kidkare Cough/Cold, Maxichlor PSE DM, Neutrahist PDX Drops, Esocor P, Mesehist DM, Z-Tuss 2, Notuss-Forte, Q-V Tussin, Tussin-V, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Welltuss HC, Tussend, Detuss, Notuss, Histinex PV, JayCof-HC, Pediatex HC, Suttar SF

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20141202

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