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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Loratadine-D 24 Hour, Claritin-D, Mucinex D, Zyrtec-D, SudoGest, Loratadine-D 12 Hour, Aprodine, Virtussin DAC, Show all 1042 »Vicks Nyquil D Cold and Flu Nighttime Relief, Wal-Zyr D, Allegra-D 12 Hour, Sudafed 12-Hour, Advil Cold and Sinus, Stahist AD, Vanacof, Allegra-D 24 Hour, Actifed, Entex, Bromaline, Dimetapp DM, Sudafed 24-Hour, Vicks Dayquil Daytime Cold/Flu (old formulation), Cetiri D, AllerClear D-24 Hour, Resperal-DM, Tylenol Cold, Claritin-D 24 Hour, Cheratussin DAC, Stahist, Sinarest, Aleve-D Sinus & Cold, Tusnel, Clarinex-D 12 Hour, Sinutab Ex-Strength, Rondamine, Conex, Allerfrin, Capmist DM, Guaifen DAC, Mucus D, Robitussin Allergy & Cough, Carbic-D, M-End DMX, Disophrol, Chlo Tuss, Silfedrine, Bromphenex DM, Claritin-D 12 Hour, Mucinex D Maximum Strength, Zutripro, Suphedrine, nasofed, M-END, Lortuss DM, Clarinex-D 24 Hour, Brotapp, Dimetapp Elixir, Lodrane, Nucodine, Rescon, M-End DM, Children's Nyquil, Despec DM, Cenafed, Suphedrin, Corzall, Brotapp-DM, Zephrex, Dimaphen, Respaire-30, Pseudovent, Ornex, Sinus Relief, Pseudoephedrine Sinus, Unifed, Brofed, Nacon, Bromfenex, Coldec, Myfedrine, Entre-S, Bromadine-DM, Cold Medicine Plus, Alavert D-12 Hour Allergy and Sinus, Simplet, Allermed, Contac Cold, Guaifenex PSE 120, Duomine, Vanacon, Duraflu, Ambifed, Robitussin Cough & Cold D, Flutabs, Robitussin Severe Congestion, Rezira, Dixaphedrine, Trisofed, Trip-PSE, Maldec, Cardec-S, Carbodec, Allegra-D 12 Hour Allergy & Congestion, Respivent-D, Allegra-D 24 Hour Allergy & Congestion, Profen II, ExeFen, Hycofenix, Pseudatex HC, Afrinol, Maxifed, Decongest II, All Day Allergy-D, Comtrex Acute Head Cold, Rondamine DM, Tussafed, Chlor-Trimeton Nasal Decongestant, Endafed, Congestac, Lodrane D, 12 Hour Nasal Decongestant, Actacin, Allergy Relief D, Novafed A, Dexophed, Drixoral Cold and Allergy, Abatuss DMX, Cycofed, Guaifenesin DAC Liquid, Guiatussin DAC, Nucofed Expectorant, Medent, Chlor-Trimeton Allergy Decongestant, Codimal-LA Half, Kronofed-A, Duralex, Clorfed, Deconamine, Aquatab D Dose Pack, Benylin DM-D-E, Lemohist Plus, Coldcough Syrup, Dihydro-CP, Kidkare Cough/Cold, Ambifed DM, Tenar DM, SudaTex-DM, Phenylhistine DH Expectorant, Benaphen Plus, Phenylhistine DH, NasOpen, Genac, Poly-Vent, Levall G, Childrens Tylenol Cold Plus Cough, Sinadrin Plus, Dimetane DX, Theraflu Flu & Cough, Q-Tapp DM, Carbofed DM Syrup, Brometane DX, Theraflu (pseudoephedrine) Daytime Severe Cold, All-Nite Cold, Daytime Cold, Rydex, Ornex Maximum Strength, Allpanto-S, Singlet, Cough Formula M Multi-Symptom, Genacol Maximum Strength, Contac Day and Night Cold and Flu, Theraflu Flu Cold & Cough, Alka-Seltzer Plus Flu/Body, Tusnel-A, Maxiflu DM, Entuss-D JR, Myphetane DX, Decotuss-HD, Vanex Expectorant, Tussend Expectorant, Detussin Expectorant, Tussgen Expectorant, SRC Expectorant, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, Entuss-D, Hydrotussin HD, KG-Tuss HD, Tussadur-HD, Lortuss LQ, Comtrex Non-Drowsy, DiHydro-GP, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Vicks 44D, Decongestant Cold Formula, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Pedia Relief Infant, Viravan-PDM, Pediatex TDM, Uni-Cof Expectorant, Tekral, Hydro-Tussin EXP, Pancof EXP, Welltuss EXP, Contac Severe Cold and Flu Non Drowsy, Benylin Multi-Symptom, Actifed Allergy Day/Night, Tavist NightTime Allergy, Benadryl Children's Allergy And Sinus, Benadryl Allergy Sinus, Respa SA, Medtuss HD, Drituss HD, Spantuss HD, G-Phed, Medent-LDI, Despec-Tab, Entex T, Guaimax-D, Anatuss LA, Touro LA, Fenex-PSE, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, Respaire-120 SR, Pan-Mist LA, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Versacaps, Guaivent PD, Guaibid D Pediatric, Pseudocot-G, Nasatab LA, Eudal SR, Poly-Vent IR, Zephrex LA, Su-Tuss HD Elixir, All-Nite Multi-Symptom Cold/Flu Relief, Tussafin Liquid, Hytussin Expectorant, P-Tuss DM, Hydro-Tuss XP, Dynex HD, Entex HC, Theraflu Max-D Severe Cold & Flu, Balminil Cough and Flu Sugar Free, Phlemgesic, Tylenol Cold Severe Congestion Daytime, Robitussin Cold Cough and Flu, NyCair, Mardrops-EX, Multi-Symptom Nighttime, Tylenol Severe Cold & Flu Night Time, Hexaflu, Andehist DM NR, Drixoral Sinus, Drixoral Cold and Flu, Drixoral Allergy Sinus, Complete Sinus Relief, Drixoral Cold/Flu, Entex PSE, Nalex CR, Dexatrex D, Z-Cof 12DM, Desgen DM (with pseudoephedrine), Non-Drowsy Super Strength Contac Complete, Deltuss DP, Hexafed, Nalfrx, Benadryl Cold, Severe Cold Multi-Symptom, Daytime Non-Drowsy, Daytime Cold and Flu Relief, Tylenol Cold Non-Drowsy Gelcaps, Day Relief Cold and Flu, Contact Cold and Sore Throat, Day Time Multi Symptom, AllerDur, Z-Cof 8DM, Entex Pac, Entre-Cough, Poly-Vent DM, Medent-DMI, Mardrops-DX, Maxifed DM, PanMist DM, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, SuTan, Tanafed DP, Ambi 600/1000/30, Bromatan Plus, Desihist SA, Disobrom, Acticon, 12 Hour Cold, Dexaphen SA, Drixomed, Pharmadrine, Sudafed Sinus Nighttime Plus Pain, Tannate DMP-DEX, C-Phed DPD Tann, DuraTan Forte, Dur-Tann Forte, Duotan PD, TanDur DM, SuTan-DM, Tannate PD-DM, Deltuss DMX, TanaCof DM, Tanafed DMX, Polaramine Expectorant, D-Hist D, DuraHist D, Histatab D, Contac Day and Night Allergy, TL-Dex DM, Ambi 80/780/40, Pseudo Max DMX, Tusnel Pediatric, Profen II DM Liquid, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, Z-Cof DM(obs), Ambifed-G DM, Touro CC-LD, Profen II DM, Relacon-DM NR, Despec Drops, Pseudo Cough, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Liquicough DM, Maxifed DMX, Tuss-LA, Trikof-D, Pseudo DM GG, ExeFen-DMX, Profen Forte DM, Calmylin 4, Syn-Rx DM, Ambi 60/580/30, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Ambenyl-D, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Guaifenex DM RX, Touro CC, Suda-Tussin DM, Pseudogest-DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Sudal 60/500, Demibid II, Stamoist E, Kolephrin, Allerx-D, Comtrex Allergy Sinus Night and Day, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain, Aleve-D Sinus & Headache, Quadra-Hist D Pediatric, Quadra-Hist D, Comtrex Allergy Sinus Maximum Strength, Tylenol Allergy Sinus, Allerest Sinus, Codimal, Amdry-D, Comtrex Allergy Sinus, Tricom, Comtrex Nighttime Flu Therapy, Comtrex Sinus and Nasal, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Theracaps Multi-Symptom Cough & Cold Reliever, Co-Apap, Contac Cold and Flu Maximum Strength, Comtrex Cold and Flu Maximum Strength Liquid, Comtrex Cold and Flu Maximum Strength Tablet, Extendryl PSE, AlleRx Dose Pack (AM Dose), ElixSure Congestion, Maxiflu CD, Zymine HC, Maxiflu CDX, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Advil Cold and Sinus Liqui-Gels, Advil Children's Cold, Tavist Allergy/Sinus/Headache, Sudatrate, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, Sinutab Maximum Strength Caplets, Triaminicin, Sinarest Extra Strength, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Allerest Headache Strength, Nexafed Nasal Decongestant, Children's Dimetapp Decongestant Infant, Detussin, Ridifed, Allerphed, Triofed, Aphedrid, A-Phedrin, Actedril, Atridine, Atrofed, Atrogen, Hista-Tabs, LA Nasal Decongestant, Tri-Sudo, Triafed, Triphed, Vi-Sudo, Triptifed, Actagen, Altafed, Biofed-PE, Histafed, Triacin, Ritifed, Pseudocot-T, Zymine DXR, Triposed, Allercon, Novafed, Sudodrin, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Sudafed Children's Nasal Decongestant, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Elixsure Decongestant, Pediatex TD, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, Viravan-P, Seldane-D, Comtrex Day and Night, Theraflu Flu, Cold and Cough Powder, Hist-PSE, Ed A-Hist PSE, Allerfrim, Zymine-D, Histussin D, Liquituss HD, V-Dec-M, Tusscidin PE, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tussin PE, Pseudo-G/PSI, Sinufed, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Tusnel Pediatric Drops, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Uni Tussin PE, Zaptec PSE, Ami-Tex PSE, Med-RX, Defen-LA, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Tylenol Allergy Complete NightTime, Guiadrine II, Iosal II, Respa-1st, Guiatex II, Guiadrine II SR, Desal II, Iotex PSE, Deco-D, Tenar PSE, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Hi Tex PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Humibid GC, Nasabid SR, SymTan, Ambi 80/780, Despec-SR, Guaifenex PSE 85, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., Mucus Relief D, Ambi 60/1000, Ambi 60/580, Protuss-D, Touro LA-LD, Procof D, Tussafin, Tussgen, P-V-Tussin, Hytussin, Iotussin D Liquid, Histinex D, Entuss-D Liquid, H-C Tussive D, ColdCough HCM, Pancof HC, Aldex GS, Pseudatex, Panmist LA, We Mist LA, Panmist JR, H 9600 SR, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, SudaTex-G, Guaifenex PSE 80, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Ambifed-G, Drexophed SR, Tylenol Sinus Day/Night Convenience Pack, Benadryl Severe Allergy & Sinus Headache, Coldec-TR, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Mooredec, Palgic-D, Andec-TR, Dura-Ron, Ex-Dec-TR, Andehist, Coldec D, Hydro-Tussin CBX, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, Pediatex 12D, Biohist LA, Mar-cof BP, PSE Allergy DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, Cordron-12 DM, Uni-Hist DM Pediatric Syrup, Pediatex 12 DM, Tri-Vent HC, Histex HC, Mintex HC, Pannaz S, Pseudox M, Pannaz, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Bromhist-DM, AccuHist DM Pediatric Syrup, Mesehist WC, M-End WC, Cydec-DM Drops, Creomulsion Pediatric, Ryna-C, Codahistine-DH Elixir, Neotuss D, Semprex-D, Actifed Cold and Sinus, Sinutab Maximum Strength, Sinarest Sinus, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Kidcare Cough and Cold, Novadyne DH, Rescon-DM, Tanafed-DM, C-Phed DM, Atuss-12 DM, Dicel DM, Atuss DS, Maxichlor PSE DM, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Co-Histine DH, Codehist DH, SymPak II, Vanatab DX, Allergy D-12, KS Aller-Tec D-12, Zyrtec-D 12 Hour, Up and Up All Day Allergy Relief D, 12 Hour Allergy-D, Biclora-D, Dicel CD, Trinalin Repetabs, Panatuss PED Drops, Panatuss PED, Vanacof DX, Certuss-D, Decohistine DH, Clofera, Poly-Tussin D, Notuss-NXD, Statuss Green, Sta-D, Respa-AR, Ru-Tuss, Ursinus, Dihistine DH, Tricode AR, Zodryl DAC, Carbaxef-DM, Dura-Ron DM, Triaminic-D Multi-Symptom Cold, Anaplex DMX, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Neo DM Syrup, Bromdex D, BromTann/DM Tann/PSE Tann, BroveX PSB DM, Anaplex HD, PBM Allergy, BroveX PSE DM, BroveX PSE DM Tablets, PediaHist DM, LoHist PSB, Bromfed PD, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, BroveX PSE, Bromplex HD, Drocon-CS, BroveX PSB, Bromplex DM, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Anaplex DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Dallergy DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, J-Cof DHC, BroveX PD, B-Vex PD, Cydec-DM Syrup, Carb Pseudo-Tan, Bromhist-NR, Brovex SR, Lodrane 24D, LoHist-PD, LoHist-12D, J-TanD PD, Exall-D, AccuHist DM Pediatric Drops, Re-Tann, Respi-Tann Pd, Respi-Tann, Unit-Hist Drops, Allres Pd, Allres D, Pseudacarb, Zotex-D, Corzall Plus, EndaCof PD Drops, Carbodex DM Drops, Cordron-DM, Dynatuss, Biodec DM, Maldec-DM, Di-Bromm, Unit-Tex 10/120 ER, Bromhist Pediatric, Histex SR, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, M-Hist TD, AccuHist Pediatric, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, Mesehist DM, Allres DS, Actifed Sinus Day and Night, Ambifed CDX, Bayer Select Sinus Pain Formula, Sinutab Maximum Strength Non Drowsy, Tavist Sinus, Benadryl Allergy Sinus Headache, Sudogest Sinus Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Tricode GF, Ambifed CD, Ambifed-G CD, M-End Max D, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Tussar-2, Deproist with Codeine, Dristan Cold Maximum Strength, Dynahist ER, Decohistine Expectorant, Re2+30, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Suclor, Sudal-12, Qdall, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Triaminic Softchews Cold and Allergy, Pseudoephedrine Plus, Co-Histine Expectorant, Dihistine Expectorant with Codeine, Genaphed Plus, Neo AC, Suttar-2, Codafed Pediatric, Zodryl DEC, Allerest No Drowsiness, Suphedrin Sinus, Codar D, Nucofed, EndaCof-DC, Notuss-DC, KG-Fed, Polyhist NC, Suttar SF, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Trifed C, Pseudodine C, Sinus Maximum Strength, Deka, Sudafed Triple Action, Tylenol Sinus Severe Congestion Daytime, Bromanate DX Cough, Tylenol Sinus NightTime, Codafed, Novagest with Codeine, Dihistine Expectorant, Guaiatussin DAC, Phenhist Expectorant, Halotussin DAC, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guiatuss DAC, Codahistine Expectorant, Mytussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Biotussin DAC, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Nucochem, Dihistine, Gua PC, SudoGest Sinus & Allergy, Sudogest Cold & Allergy, Duotan DM, Xiral SR, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Atuss HS, Advil Allergy Sinus, Advil Children's Allergy Sinus, AlleRx Dose Pack, DryMax, DuraHist, RelCof DN PSE, Hydrotuss HC, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Allergy DN, Pseudo CM TR, Hydron PCS, P-V-Tussin Syrup, ScopoHist, Notuss-Forte, T-Tanna DM, Pedia Relief Cough-Cold, Nexafed Sinus Pressure + Pain, Phenapap, Pancof, Tricof, Hydro-Tussin DHC, Uni-Cof, Z-Tuss 2, Suphedrin Plus, Genapap Sinus, Notuss, KG-Tussin, Detuss, Histinex PV, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, Coldamine, Allergy AM-PM Dose Pack, Ryna Liquid, Pseudochlor, Pseudocot-C, Rinade-BID, Suphenamine-SR, Isophen-DF, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Cophene No 2, D-Amine-SR, Anaplex, Anamine, Klerist-D, Fedahist Gyrocaps, Clorfed II, Curaler, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Deconomed SR, Colfed-A, VisRx Dose Pack, Durafed, Histatab, Tylenol Sinus Maximum Strength, Sinutab Regular Strength, Sine-Off Maximum Strength, Contac Sinus, Dristan Cold Non-Drowsy, Alka-Seltzer Cold and Sinus, Ephed Plus, Histade CR, Chlor-Trimeton Decongestant, Duotan, Biohist LA (old formulation), Chlorphedrin SR, Deconamine SR, Duratuss DA, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Tripohist D

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20170110

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