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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Loratadine-D 24 Hour, Claritin-D, Bromfed DM, Sudafed Congestion, Sudafed 12-Hour, Mucinex D, Actifed, SudoGest, Zyrtec-D, Loratadine-D 12 Hour, Show all 1042 »Virtussin DAC, Aprodine, Allegra-D 24 Hour, Resperal-DM, Cheratussin DAC, Advil Cold and Sinus, Vanacof, AllerClear D-24 Hour, Entex, Zyrtec-D 12 Hour, Allegra-D 12 Hour, Bromaline, Sudafed 24-Hour, Dimetapp DM, Tusnel, Robitussin Cold Cough and Flu, Wal-Zyr D, Disophrol, Vicks Nyquil D Cold and Flu Nighttime Relief, Unifed, Robitussin Allergy & Cough, Conex, Phenylhistine DH Expectorant, Zephrex, Robitussin Cough & Cold D, Advil Allergy Sinus, Sinarest, Decongest II, Bromfenex, Qdall, Duomine, Dristan Sinus, Stahist AD, Bromphenex DM, Hycofenix, Silfedrine, Suphedrine, Sudafed Children's Nasal Decongestant, Aleve-D Sinus & Cold, Bromadine-DM, Pseudoephedrine Plus, Suclor, Chlorafed, Afrinol, Robitussin Severe Congestion, Allpanto-S, SudoGest 12 Hour, Coldamine, Pseudovent, Hista-Vent PSE, Sinufed, Carbic-D, Rescon, Claritin-D 24 Hour, Disobrom, Exall-D, Triaminic-D Multi-Symptom Cold, Singlet, SuTan, Triacin C, Allegra-D 12 Hour Allergy & Congestion, Drixoral Sinus, Guaifenesin DAC Liquid, Triacin, Drexophed SR, Stahist, Allergy Relief D, Bromophed-DX, Brotapp-DM, Anamine, Carbofed DM Syrup, All Day Allergy-D, 12 Hour Allergy-D, Histade, Histussin D, Touro CC, Capmist DM, PanMist DM, Bromph DM, Lodrane 24D, Anamine TD, Benylin Multi-Symptom, Defen-LA, Hi Tex PSE, Mucus D, Guaitab, Medent, Nomuc-PE, Clofera, Phenylhistine DH, Hydro-Tussin CBX, Carbodec, Pannaz, Pannaz S, Children's Nyquil, CPM-PSE DM Drops, Mucus Relief D, Isophen-DF, Histex SR, Chlor-Trimeton Decongestant, Histade CR, Lodrane, Brofed, Lodrane 12D, Dimetapp Elixir, Brotapp, Biodec DM, Relcof PSE, Lortuss DM, Histinex PV, Zutripro, Decongestant Cold Formula, Pedia Relief Infant, Hydrocof-HC, Chlo Tuss, Clarinex-D 24 Hour, M-End DMX, Severe Cold Multi-Symptom, Daytime Cold, Efidac, Atridine, Sinadrin Plus, Neo AC, Polyhist NC, Atrofed, Nexafed, Nucodine, Drixoral Decongestant Non-Drowsy, Clarinex-D 12 Hour, Alka-Seltzer Cold and Sinus, Ornex, Sudogest Sinus Maximum Strength, Children's Dimetapp Decongestant Infant, Cenafed, Benadryl Severe Allergy & Sinus Headache, Genaphed, Alka-Seltzer Plus Flu/Body, Aphedrid, Chlor-Trimeton Nasal Decongestant, Lortuss EX, Tylenol Cold, Trinalin Repetabs, Claritin-D 12 Hour, Semprex-D, Actifed Cold and Sinus, Leader Allergy Relief D-24, Dixaphedrine, Dexophed, Cold Medicine Plus, Duraflu, Kolephrin, Uni-Cof Expectorant, Desihist SA, Balminil DM + Decongestant, SudaTex-DM, Desgen DM (with pseudoephedrine), Benylin DM-D, Vicks 44D, Drixoral Cough & Congestion Liquid Caps, Viravan-PDM, P-Tuss DM, Acticon, Allegra-D 24 Hour Allergy & Congestion, Deka, Pediatex TDM, Hydro-Tussin EXP, Lortuss LQ, Benaphen Plus, Tekral, Respa SA, Buckley's DM Decongestant, DiHydro-GP, Benadryl Allergy Sinus, Benadryl Children's Allergy And Sinus, Tavist NightTime Allergy, Actifed Allergy Day/Night, Dexatrex D, Welltuss EXP, Pancof EXP, Tussin Pediatric Cold and Cough, AllerDur, Entuss-D JR, Codafed, Vanacon, Su-Tuss HD Elixir, Tussafin Liquid, Hytussin Expectorant, Codar D, Zodryl DEC, Codafed Pediatric, Suttar-2, Suttar SF, Nucofed, Novagest with Codeine, Codahistine Expectorant, Gua PC, Dihistine, Guaifen DAC, Nucochem, Nuco-Tuss Expectorant, Phenylhistine Expectorant, Biotussin DAC, Spantuss HD, Medtuss HD, Pseudo DM GG, Tussgen Expectorant, Pseudodine C, Trifed C, Decotuss-HD, Vanex Expectorant, Tussadur-HD, Tussend Expectorant, Triafed & Codeine, Allerfrin with Codeine, Detussin Expectorant, Cycofed, KG-Tuss HD, SRC Expectorant, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, KG-Fed, Notuss-DC, Entuss-D, EndaCof-DC, Hydrotussin HD, Pseudo Max DMX, Despec Drops, Trikof-D, Ambifed DM, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Dur-Tann Forte, Ambi 600/1000/30, Benylin DM-D-E, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Drituss HD, Sudafed Cough, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Ambenyl-D, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Sudafed Cough Syrup, Maxifed DM, Syn-Rx DM, TanaCof DM, Hexafed, Nalfrx, Tanafed DP, Duotan PD, Histatab D, DuraHist D, D-Hist D, Polaramine Expectorant, Tanafed DMX, Abatuss DMX, Mardrops-DX, Deltuss DMX, Tannate PD-DM, SuTan-DM, TanDur DM, Z-Cof 8DM, Entex Pac, Entre-Cough, Poly-Vent DM, Medent-DMI, Dorcol Childrens Cough, Guaifenex DM RX, Z-Cof 12DM, Tusnel Pediatric, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Coldmist DM, Altarussin CF, 12 Hour Cold, Z-Cof DM(obs), Ambifed-G DM, Touro CC-LD, ExeClear-DM, Relacon-DM NR, Deltuss DP, Despec DM, Pseudo Cough, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Liquicough DM, Maxifed DMX, S-Pak DM, Profen II DM Liquid, Suda-Tussin DM, Drixoral Cold and Allergy, Pseudogest-DM, Tusnel Ped-C, Bromatan Plus, Tusnel-DM Pediatric Drops, Medent DM, DuraTan Forte, C-Phed DPD Tann, Tannate DMP-DEX, Pharmadrine, Drixomed, ExeFen-DMX, Dexaphen SA, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Protuss DM, Med-RX DM, Tussafed-LA, Profen Forte DM, Profen II DM, Tenar DM, G-Phed- PD, Hydro-Tuss XP, Motrin Sinus Headache, H-C Tussive D, ColdCough HCM, Pancof HC, SymTan, Liquituss HD, Detussin, Zymine HC, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Advil Cold and Sinus Liqui-Gels, Histinex D, Advil Children's Cold, Clear-Atadine-D, Alavert D-12 Hour Allergy and Sinus, Allergy Relief D12, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Entuss-D Liquid, Iotussin D Liquid, Sinus & Cold D, Pseudo GG TR, Levall G, Guaifenex PSE 80, Pseudatex, Touro LA-LD, Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Maxifed-G, Maxifed, Ru-Tuss Jr., Hytussin, ExeFen, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Mucinex D Maximum Strength, Aquatab D Dose Pack, Protuss-D, Procof D, Rezira, Tussafin, Tussgen, P-V-Tussin, Allerx-D, Sudafed 12 Hour Pressure+Pain, Pseudovent 400, Triphed, Triafed, Triposed, Allerphed, Triofed, A-Phedrin, Actedril, Atrogen, Hista-Tabs, LA Nasal Decongestant, Ridifed, Tri-Sudo, Vi-Sudo, Allercon, Triptifed, Actagen, Allerfrin, Altafed, Biofed-PE, Histafed, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Genac, Pediatex TD, Aleve-D Sinus & Headache, Decofed Liquid, Quadra-Hist D Pediatric, Quadra-Hist D, nasofed, Suphedrin, ElixSure Congestion, Allermed, Novafed, Ridafed, Seudotabs, Sudrine, Superfed, Decofed, Zymine-D, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Contac Cold, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Ed A-Hist PSE, Allerfrim, Ambifed-G, Pseudo Max, Dynex HD, D-Feda II, Guaivent PD, Guaibid D Pediatric, Pseudocot-G, Nasatab LA, Eudal SR, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, Guaifenex PSE 60, Sinufed Timecelles, Demibid II, Guiadrine II, Iosal II, Respa-1st, Guiatex II, Ambifed, Guiadrine II SR, Desal II, Deco-D, Tenar PSE, GP 500, Guaifed-PSE, Versacaps, Nucofed Pediatric Expectorant, Guiadrine PSE 120, Despec-Tab, Entex HC, Pseudatex HC, Carbodex DM Drops, Entex PSE, Nalex CR, Mardrops-EX, Zephrex LA, Congestac, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Entex T, Nalex Jr, Guaimax-D, Anatuss LA, Touro LA, Fenex-PSE, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Abletex-PSE, Guai-Vent/PSE, Sudal SR, Profen Forte, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Durasal II, Sinutab Non Drying, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, SudaTex-G, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Uni Tussin PE, Sudafed Non Drying Sinus, Guaifenex PSE 120, Mastussin PE, Guiatex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, Biotuss PE, Guiatuss PE, Mytussin PE, S-Pack, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Respaire-30, Tusnel Pediatric Drops, Altarussin PE, Tussar SF, Comtrex Acute Head Cold, KG-Fed Pediatric Expectorant, Bidhist-D, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, LoHist PSB, Bromfed PD, Bromfed SR, Rynex PSE, M-END, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Drocon-CS, J-Cof DHC, Respahist, PSE Brom DM, Dallergy DM, Dimetane DX, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Brometane DX, Anaplex DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, Bromaline DM, Sildec DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Nalfed PD, Iofed PD, Bromdex D, Cydec-DM Drops, Allres D, Pseudacarb, Zotex-D, Corzall Plus, Andehist DM NR, Cordron-DM, Dynatuss, Tussafed, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Carbaxef-DM, Corzall, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Carboxine DM, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Allres Pd, Respi-Tann, Ultrabrom PD, Q-Tapp, Pseubrom-PD, Bromfenex PD, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Bromhist Pediatric Drops, Carb Pseudo-Tan, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, Dimaphen, LoHist-PD, LoHist-12D, J-TanD PD, Re-Tann, Respi-Tann Pd, Neo DM Syrup, BromTann/DM Tann/PSE Tann, Pediatex 12 DM, NyCair, Tavist Allergy/Sinus/Headache, Maxiflu CD, Maxiflu CDX, Drixoral Cold/Flu, Complete Sinus Relief, Drixoral Allergy Sinus, Drixoral Cold and Flu, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, All-Nite Multi-Symptom Cold/Flu Relief, Allergy Sinus Maximum Strength, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Flutabs, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Vicks Dayquil Daytime Cold/Flu (old formulation), Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Actifed Cold & Sinus, Sinutab Maximum Strength Caplets, Contact Cold and Sore Throat, Triaminic Flu, Cough & Fever, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Childrens Tylenol Cold Plus Cough, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Comtrex Sinus and Nasal, Triaminicin, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Allerest Sinus, Tylenol Allergy Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Non-Drowsy Super Strength Contac Complete, Day Relief Cold and Flu, Anaplex DMX, Rydex, Nexafed Sinus Pressure + Pain, Pseudoephedrine Sinus, Sinarest Sinus, Sinutab Maximum Strength, Ursinus, Ru-Tuss, Respa-AR, Sta-D, Dicel CD, SymPak II, M-End WC, Mar-cof BP, Mesehist WC, Suphedrin Plus, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Phenapap, Genapap Sinus, Tylenol Cold Non-Drowsy Gelcaps, Sinus Maximum Strength, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Benadryl Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Suphedrin Sinus, Tylenol Sinus Maximum Strength, Ornex Maximum Strength, Allerest No Drowsiness, Benadryl Allergy Sinus Headache, Tavist Sinus, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Sinus Relief, Dristan Cold Non-Drowsy, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Cordron-12 DM, Tri-Vent HC, Cycofed Pediatric Expectorant, Codimal-LA Half, Suphenamine-SR, Kronofed-A, ND Clear, Chlordrine SR, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Klerist-D, Fedahist Gyrocaps, Duralex, Clorfed II, Curaler, Histafed LA, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Rinade-BID, Pseudocot-C, Atrohist Pediatric Capsule, Duratuss DA, Allergy DN, Pseudo CM TR, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Duotan, Durafed, Biohist LA (old formulation), Deconamine, Deconamine SR, Novafed A, Clorfed, Deconomed SR, Histalet, Fedahist, Tanafed, Chlorafed HS Timecelles, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Suphedrine Plus, Allerest Maximum Strength, AllePak, Halotussin DAC, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Novadyne Expectorant, Maxifed-G CD, Nucochem Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Guiatussin DAC, Maxifed-G CDX, Maxifed CDX, Chlor-Trimeton Allergy Decongestant SR, SudaHist, Tavist-DA, Dynahist-ER Pediatric, CP-Tannic, Mintex, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, AccuHist Drops (old formulation), Maxifed CD, LoHist-D, Triaminic Softchews Cold and Allergy, Dynahist ER, M-End Max D, Dristan Cold Maximum Strength, Tusnel C, Z-Tuss E, Tricode GF, Ambifed CD, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Rhinaclear, Time-Hist QD, Histex HC, Poly-Tussin D, Mintex PSE, Palgic DS, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, Cetiri D, Biclora-D, Panatuss PED Drops, Panatuss PED, Vanacof DX, Vanatab DX, Certuss-D, Notuss-NXD, Carboxine-D, Statuss Green, NasOpen, Dihistine DH, Tricode AR, Zodryl DAC, Decohistine DH, Codehist DH, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Neotuss D, PSE Allergy, Pseudo Carb, Vicks 44M Pediatric, Mooredec, Mintex HC, Pseudox M, Nacon, Biohist LA, Coldec D, Coldec, Pediatex 12D, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Rondamine, Cordron-12 D, Cardec-S, Maldec, Palgic-D, Andec-TR, Dura-Ron, Ex-Dec-TR, Coldec-TR, Andehist, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Rhinosyn-DM, Creomulsion Cough/Cold/Allergy, Amdry-C, Hydron PCS, JayCof-HC, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Cordron-HC, Notuss, Cordron-HC NR, Atuss HD, Atuss HS, Advil Children's Allergy Sinus, AlleRx Dose Pack, DryMax, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Mescolor, PCM-LA, Detuss, Notuss-Forte, Creomulsion Pediatric, AccuHist PDX Drops, Kidcare Cough and Cold, Rescon-DM, Tanafed-DM, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, Esocor P, Lemohist Plus, Mesehist DM, Allres DS, Duotan DM, T-Tanna DM, Pedia Relief Cough-Cold, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Coldcough Syrup, Z-Tuss 2, Tripohist D

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20170110

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