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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Loratadine-D 24 Hour, Claritin-D, Sudafed Congestion, Mucinex D, Zyrtec-D, Vicks Dayquil Daytime Cold/Flu, Vicks Nyquil D Cold and Flu Nighttime Relief, Allegra-D 24 Hour, Aprodine, Show all 1040 »SudoGest, Sudafed 12-Hour, Allegra-D 12 Hour, Virtussin DAC, Loratadine-D 12 Hour, Entex, Actifed, Semprex-D, Claritin-D 24 Hour, Vanacof, Dimetapp Elixir, Tylenol Cold, Brotapp-DM, Alka-Seltzer Cold and Sinus, Resperal-DM, Conex, Advil Allergy Sinus, Sinarest, Duraflu, Nexafed, Advil Cold and Sinus, Suphedrine, Brotapp, Wal-Zyr D, Cetiri D, Cheratussin DAC, Deconamine, Aleve-D Sinus & Cold, Orlenta, Duomine, Decongestant Cold Formula, Tusnel, Robitussin-DAC, Panatuss PED, Robitussin Allergy & Cough, M-END, Dimetane DX, BromTann/DM Tann/PSE Tann, Bromaline, Zyrtec-D 12 Hour, Mucus D, Rondamine, Capmist DM, Theraflu (pseudoephedrine) Daytime Severe Cold, Alka-Seltzer Plus Flu/Body, Mucinex D Maximum Strength, Stahist, Phenapap, Contac Cold, Advil Cold and Sinus Liqui-Gels, CPM-PSE DM Drops, Stahist AD, Zutripro, Chlo Tuss, Robitussin Cold Cough and Flu, Afrinol, Sudafed 24-Hour, Guaifenesin DAC Liquid, Tylenol Cold Severe Congestion Daytime, Allerfrin, Coldcough Syrup, Actedril, Pseudovent, Bromph HD, Anaplex HD, Mintex, CP-Tannic, Allerest Maximum Strength, ExeFen-DMX, Pseudoephedrine Plus, Shellcap, Q-Tapp, Lodrane, Rescon, Bromphenex DM, Andehist DM NR Syrup, Dimetapp DM, Comtrex Acute Head Cold, Singlet, Codimal, Bromaline DM, Carbofed DM Syrup, Cold Medicine Plus, Poly-Vent DM, Hexafed, Polaramine Expectorant, Bromph DM, Robitussin Cough & Cold D, Vicks 44D, All Day Allergy-D, Guaifenex PSE 120, GP 500, Sinufed, Respaire-30, Profen Forte, Tusnel Pediatric Drops, Desal II, Versacaps, Codehist DH, Phenylhistine DH, Phenylhistine DH Expectorant, Vanatab DX, Congestac, Panatuss PED Drops, Genac, Hycofenix, Exall-D, DuraHist, Sinadrin Plus, Fedahist, Tanafed, Kronofed-A, Rinade-BID, Hydrocof-HC, Hydron PCS, Maldec, Hydrotussin HD, Pannaz, Pancof, Notuss, Benaphen Plus, Cophene No 2, Pseubrom, Cenafed, Children's Dimetapp Decongestant Infant, Sinus & Cold D, Seudotabs, Sudafed Children's Nasal Decongestant, Day Relief Cold and Flu, Guaifen DAC, Neo AC, Silfedrine, Clarinex-D 12 Hour, 12 Hour Cold, Polyhist NC, Theraflu Flu, Cold and Cough Powder, Trifed C, Benadryl Cold, Deka, M-End DMX, Respivent-D, Pseudoephedrine Sinus, Contact Cold and Sore Throat, Ritifed, Allercon, Ed A-Hist PSE, M-End WC, Abatuss DMX, 12 Hour Decongestant, Clarinex-D 24 Hour, Alavert D-12 Hour Allergy and Sinus, Clear-Atadine-D, Claritin-D 12 Hour, Dristan Cold Maximum Strength, AllerClear D-24 Hour, Triacin, DiHydro-GP, Viravan-PDM, Pediatex TDM, Triafed & Codeine, Pancof EXP, Welltuss EXP, Relasin DM, Benylin Multi-Symptom, Hydro-Tussin EXP, Uni-Cof Expectorant, Pedia Relief Infant, Allerfrin with Codeine, Triacin C, Pseudodine C, Dexatrex D, Pseudo DM GG, Pseudo Max DMX, SudaTex-DM, Trikof-D, Z-Cof 12DM, Liquicough DM, Maxifed DMX, Trisofed, Desgen DM (with pseudoephedrine), P-Tuss DM, Drixoral Cough & Congestion Liquid Caps, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Buckley's DM Decongestant, Z-Cof DM, Actacin, Ambi 40 /400 /20, Benylin DM-D, Tekral, Codar D, Nucofed, Zodryl DEC, Codafed Pediatric, Vanacon, Spantuss HD, Medtuss HD, Poly-Tussin XP, EndaCof-DC, Entuss-D, KG-Tuss HD, Su-Tuss HD Elixir, Tussafin Liquid, Hytussin Expectorant, Drituss HD, Dihistine, Hydro-Tuss XP, Gua PC, Codahistine Expectorant, Suttar-2, Codafed, Suttar SF, Novagest with Codeine, Deconamine CX, Nalex Expectorant, Pseudo Cough, Lortuss LQ, Childrens Tylenol Cold Plus Cough, Genacol Maximum Strength, Respa SA, Benadryl Allergy Sinus, Actifed Allergy Day/Night, Tavist NightTime Allergy, Benadryl Children's Allergy And Sinus, Cycofed, Allegra-D 12 Hour Allergy & Congestion, Allegra-D 24 Hour Allergy & Congestion, Detussin Expectorant, Tussgen Expectorant, Notuss-DC, SRC Expectorant, Tussend Expectorant, Tussadur-HD, KG-Fed, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Nucodine, Relacon-DM, Entex Pac, Entre-Cough, Medent-DMI, Mardrops-DX, Z-Cof 8DM, Disobrom, Lortuss DM, Dexaphen SA, Acticon, Disophrol, Maxifed DM, PanMist DM, Ambi 600/1000/30, Benylin DM-D-E, Ambi 80/780/40, Calmylin 4, Desihist SA, Dexophed, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Nalfrx, Deltuss DP, TanDur DM, SuTan-DM, Tannate PD-DM, Deltuss DMX, Dur-Tann Forte, Bromatan Plus, DuraTan Forte, C-Phed DPD Tann, Tannate DMP-DEX, Dixaphedrine, TanaCof DM, Tanafed DMX, Duotan PD, Tanafed DP, AllerDur, SuTan, Drixomed, Drixoral Cold and Allergy, Pharmadrine, D-Hist D, DuraHist D, Histatab D, Ambi 60/580/30, Ambifed DM, Tripohist D, Zymine DXR, Pseudocot-T, Profen II DM Liquid, Profen II DM, Profen Forte DM, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, ExeClear-DM, S-Pak DM, Tusnel Pediatric, Touro CC-LD, Relacon-DM NR, Despec Drops, Ambifed-G DM, Z-Cof DM(obs), Ru-Tuss DM, Aldex GS DM, Coldmist DM, Altarussin CF, Tussin Cough and Cold, Multi Symptom Cough and Cold, Trip-PSE, Ambenyl-D, Dimacol, Novahistine DMX, Drexophed SR, Anatuss DM, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Ru-Tuss Expectorant, Rhinosyn-X, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, Pseudogest-DM, Suda-Tussin DM, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Despec DM, Entex T, Tussafin, Rezira, Tussgen, P-V-Tussin, Iotussin D Liquid, Hytussin, Procof D, Protuss-D, Ambi 60/1000, Mucus Relief D, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, Histinex D, Entuss-D Liquid, Hista-Tabs, Zymine HC, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Histussin D, Detussin, ColdCough HCM, H-C Tussive D, Pancof HC, SymTan, Liquituss HD, ExeFen, Ru-Tuss Jr., Levall G, Ambifed-G, Guaifenex PSE 80, Medent, Pseudatex, Pseudovent 400, Pseudo Max, Pseudo GG, Panmist-S, Coldmist LA, Coldmist Jr, Sudal SR, Touro LA-LD, Triphed, Maxifed-G, Nomuc-PE, Maxifed, LA Nasal Decongestant, Pseudo GG TR, Poly-Vent, Jr., Poly-Vent, Ridifed, Tri-Sudo, Aldex GS, Despec-SR, Guaifenex PSE 85, Motrin Cold and Flu, Motrin Childrens Cold, Genaphed, Novafed, Ridafed, Sudrine, Superfed, Allermed, ElixSure Congestion, Allerfrim, Zymine-D, nasofed, Hist-PSE, Suphedrin, Chlor-Trimeton Nasal Decongestant, Decofed Liquid, SudoGest 12 Hour, Drixoral Decongestant Non-Drowsy, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Unifed, Elixsure Decongestant, Decofed, Efidac, Kid Kare Drops, Myfedrine, Sudodrin, Pediatex TD, Triafed, Aphedrid, A-Phedrin, Triofed, Allergy Relief D12, Leader Allergy Relief D-24, Atridine, Atrofed, Advil Children's Cold, Motrin Sinus Headache, Comtrex Cold and Flu Maximum Strength Tablet, Cough Formula M Multi-Symptom, Atrogen, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Aleve-D Sinus & Headache, Sudafed 12 Hour Pressure+Pain, Quadra-Hist D Pediatric, Quadra-Hist D, Comtrex Day and Night, Triposed, Allerphed, AlleRx Dose Pack (AM Dose), Sudatrate, Amdry-D, Extendryl PSE, Allerx-D, We Mist II LA, Drituss GP, Pseudocot-G, Nucochem, Nasatab LA, Eudal SR, Sudal 60/500, Guaibid D Pediatric, Guaivent PD, Guaifed, Guaibid D, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Tuss-LA, Stamoist E, Respa-1st, Iosal II, Guiatex II, Ambifed, Guiadrine II SR, Guiadrine II, Demibid II, Duratuss GP (old formulation), V-Dec-M, Deconsal LA, D-Feda II, Guaifenex PSE 60, Respaire-120 SR, G-Phed, Vi-Sudo, Triptifed, Entex PSE, Nalex CR, Mardrops-EX, Actagen, Altafed, Pseudatex HC, Entex HC, Comtrex Cold and Flu Maximum Strength Liquid, Histafed, Biofed-PE, Zephrex LA, Zephrex, Nalex, Fenex-PSE, Syn-Rx, Respaire-60 SR, Nasabid, Touro LA, Anatuss LA, Poly-Vent IR, Pan-Mist LA, Medent-LDI, Despec-Tab, Guaimax-D, Defen-LA, Decongest II, Humibid GC, Uni Tussin PE, Med-RX, Nasabid SR, Panmist LA, Robitussin Severe Congestion, Sinutab Non Drying, Guaivent (Ethex), Robafen PE, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Panmist JR, H 9600 SR, Guiatex II SR, Guiadrine PSE, We Mist LA, SudaTex-G, Coldmist, Miraphen PSE, Durasal II, Guaifenex GP, Pseudovent Ped, Dynex, ExeFen-IR, Profen II, Degen II, Venbid TR, Guai Sudo, Guiatex PSE, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Hi Tex PSE, Guai-Vent/PSE, Tenar PSE, Deco-D, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Pseudo-G/PSI, Zaptec PSE, Robichem PE, Q-Tussin PE, T-Tussin PE, Tusscidin PE, Tussin PE, Mytussin PE, Mastussin PE, Guaifenex RX, Ru-Tuss DE, Guaitab, Biotuss PE, Guiatuss PE, Dynex HD, Z-Tuss E, B-Vex PD, BroveX PSB, Bromhist Pediatric, Endafed, Allent, Touro A&H, BroveX PD, BroveX PSE, Bidhist-D, Bromfed SR, Lodrane 12D, Rynex PSE, Lodrane D, Shellcap PD, Lodrane LD, M-Hist TD, Histex SR, Ultrabrom, Iofed, Nalfed, Lodrane Liquid, Bromfenex PD, Bromfenex, Respahist, Nalfed PD, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfed PD, Brofed, Q-Tapp DM, Pediahist DM Drops, Uni-Hist PDX Drops, Allanhist PDX Drops, Brom Tann, Histacol BD Drops, Bromhist-DM Drops, Bromplex DM, Bromtapp-DM, Anaplex DM, Bromaxefed DM RF Syrup, PSE Brom DM, Uni-Hist DM Pediatric Drops, ProHist DM, P-Hist DM Drops, Brovex HC, Endacof HC, SymTan A, J-Tan D HC, LoHist PSB, Bromcomp HC, Visvex, Sildec DM, Carbodex DM Syrup, J-Cof DHC, Drocon-CS, Bromplex HD, Touro Allergy, Andehist NR Syrup, Decahist-DM, Carbofed DM Drops, Pediatex-DM, Cordron-DM NR, Mintex DM, Pseudo Carb DM, Carbaxef-DM, Cydec-DM Drops, Rondamine DM, Biodec DM, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Mintex HC, Histex HC, Pannaz S, Pseudox M, Biohist LA, Nacon, Tri-Vent HC, Pediatex 12 DM, Carboxine 12 DM, Carboxine DM, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, Tussafed, Dynatuss, Brovex SR, Bromhist-NR, Dimaphen, Lodrane 24D, LoHist-12D, LoHist-PD, Di-Bromm, Unit-Hist Drops, Sildec, Bromaxefed RF Syrup, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, J-TanD PD, Re-Tann, Corzall Plus, Zotex-D, Andehist DM NR, Carbodex DM Drops, Cordron-DM, Pseudacarb, Allres D, Carb Pseudo-Tan, Respi-Tann Pd, Respi-Tann, Corzall, Allres Pd, Bromadine-DM, Brometane DX, Theraflu Max-D Severe Cold & Flu, Balminil Cough and Flu Sugar Free, Flutabs, Maxiflu DM, Allpanto-S, Tusnel-A, Phlemgesic, All-Nite Multi-Symptom Cold/Flu Relief, All-Nite Cold, Co-Apap, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, NyCair, Theraflu Flu Cold & Cough, Comtrex Non-Drowsy, Contac Day and Night Allergy, Daytime Cold, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Benadryl Severe Allergy & Sinus Headache, Severe Cold Multi-Symptom, Daytime Non-Drowsy, Day Time Multi Symptom, Contac Severe Cold and Flu Non Drowsy, Non-Drowsy Super Strength Contac Complete, Tylenol Cold Non-Drowsy Gelcaps, Daytime Cold and Flu Relief, Contac Day and Night Cold and Flu, Hexaflu, Allerest Sinus, Kolephrin, Tylenol Allergy Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Night and Day, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus, Tricom, Triaminic Flu, Cough & Fever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Allerest Headache Strength, Sinarest Extra Strength, Complete Sinus Relief, Drixoral Cold/Flu, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Maxiflu CDX, Maxiflu CD, Sinutab Maximum Strength Caplets, Triaminicin, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Tavist Allergy/Sinus/Headache, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Theraflu Flu & Cough, AccuHist DM Pediatric Drops, EndaCof PD Drops, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, SymPak II, Dicel CD, Mar-cof BP, Rydex, Mesehist WC, PediaHist DM, BroveX PSE DM Tablets, Bromanate DX Cough, Myphetane DX, Bromatane DX, Myphetane DX Cough, Liquiphed DM, Bromophed-DX, Dallergy DM, Neo DM Syrup, PBM Allergy, BroveX PSE DM, BroveX PSB DM, Anaplex DMX, Bromdex D, Trinalin Repetabs, Sta-D, Tavist Sinus, Benadryl Allergy Sinus Headache, Ornex, Sinutab Maximum Strength Non Drowsy, Ephed Plus, Bayer Select Sinus Pain Formula, Sudogest Sinus Maximum Strength, Allerest No Drowsiness, Sudafed Triple Action, Tylenol Sinus Severe Congestion Daytime, Sinus Maximum Strength, Suphedrin Sinus, Ornex Maximum Strength, Sinus Relief, Dristan Cold Non-Drowsy, Actifed Cold and Sinus, Sinutab Maximum Strength, Ursinus, Ru-Tuss, Respa-AR, Sinarest Sinus, Suphedrin Plus, Sine-Off Maximum Strength, Contac Sinus, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, Genapap Sinus, Coldec D, Coldec, Fedahist Gyrocaps, Codimal-LA Half, Clorfed II, Curaler, Histafed LA, Chlorafed, Klerist-D, Anamine, Brexin LA, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Anaplex, Chlor-Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Atrohist Pediatric Capsule, Suphedrine Plus, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Histade, Dynahist-ER Pediatric, Hayfebrol Liquid, SudoGest Sinus & Allergy, Neutrahist Drops, Sudogest Plus, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, Time-Hist, Anamine TD, Novafed A, Deconamine SR, Duratuss DA, Clorfed, Chlorafed HS Timecelles, Histalet, Biohist LA (old formulation), Durafed, Histatab, VisRx Dose Pack, Histade CR, Chlor-Trimeton Decongestant, Duotan, Codimal-LA, Kronofed-A-Jr, Suphenamine-SR, Duralex, Isophen-DF, ND Clear, Chlordrine SR, Pseudocot-C, Deconomed SR, Fedahist Timecaps, Dura-Tap/PD, Chlorphedrin SR, Colfed-A, D-Amine-SR, Suclor, Re2+30, Halotussin DAC, Phenhist Expectorant, Novadyne Expectorant, Nucochem Pediatric Expectorant, Nuco-Tuss Pediatric Expectorant, Nucochem Expectorant, Dihistine Expectorant, Dihistine Expectorant with Codeine, Tussar-2, Nucofed Expectorant, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Pediatric Expectorant, Cycofed Pediatric Expectorant, Nucofed Pediatric Expectorant, Tussar SF, Phenylhistine Expectorant, Biotussin DAC, Guiatussin DAC, Mytussin DAC, Nucodine Expectorant, KG-Fed Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Novahistine Expectorant, Medent C, AccuHist Drops (old formulation), SudaHist, LoHist-D, Triaminic Softchews Cold and Allergy, Dynahist ER, Qdall, Sudal-12 Tannate, Dicel, Pediox Chewable, Sudal-12, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, M-End Max D, Lortuss EX, Maxifed CDX, Maxifed CD, Maxifed-G CD, Maxifed-G CDX, Ryna-CX, Ambifed-G CDX, Ambifed-G CD, Theracaps Multi-Symptom Cough & Cold Reliever, Tusnel C, Tricode GF, Ambifed CD, Ambifed CDX, Allergy AM-PM Dose Pack, ScopoHist, Poly-Tussin D, Clofera, Notuss-NXD, Statuss Green, Dihistine DH, NasOpen, Certuss-D, Vanacof DX, Up and Up All Day Allergy Relief D, KS Aller-Tec D-12, 12 Hour Allergy-D, Allergy Relief D, Biclora-D, Tricode AR, Zodryl DAC, Creomulsion Cough/Cold/Allergy, Vicks 44M Pediatric, Creomulsion Pediatric, Kidcare Cough and Cold, Rescon-DM, Children's Nyquil, Rhinosyn-DM, Neotuss D, Novadyne DH, Decohistine DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Allergy D-12, Contac Cold and Flu Maximum Strength, Cardec-S, Mooredec, Palgic-D, Andec-TR, Dura-Ron, Carbic-D, Andec, Palgic-DC, Pediatex 12D, Carbodec, Carboxine 12D, Carbiset, Cydec, Ex-Dec-TR, Coldec-TR, Carboxine-D, Pseudo Carb, PSE Allergy, Mintex PSE, Palgic DS, Cordron-12 D, Cordron-D NR, Hydro-Tussin CBX, Andehist, Carboxine-PSE, Cordron-D, Pediatex-D, Tanafed-DM, C-Phed DM, Cordron-HC NR, Cordron-HC, Atuss HD, Atuss HS, AlleRx Dose Pack, Advil Children's Allergy Sinus, Hydrotuss HC, P-V-Tussin Syrup, Tussin-V, Hyphed, Q-V Tussin, A-G Tussin, KG-Tussin, DryMax, Xiral SR, AllePak, Time-Hist QD, Rhinaclear, Allergy DN, Coldamine, Pseudo CM TR, Amdry-C, PCM-LA, Dallergy PSE, RelCof DN PSE, Relcof PSE, Mescolor, Hista-Vent PSE, Hexatussin, Welltuss HC, AccuHist PDX Drops, Neutrahist PDX Drops, Esocor P, Mesehist DM, Allres DS, Triaminic-D Multi-Symptom Cold, Kidkare Cough/Cold, Maxichlor PSE DM, Atuss-12 DM, M-End DM, Dicel DM, Atuss DS, Entre-S, Duotan DM, T-Tanna DM, Histinex PV, Detuss, JayCof-HC, Pediatex HC, Tussend, Notuss-Forte, Lemohist Plus, Hydro-Tussin DHC, Tricof, Dihydro-CP, Uni-Cof, Z-Tuss 2, Nuco-Tuss Expectorant

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Last Revision Date

20170110

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