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Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Loratadine-D 24 Hour, Bromfed DM, Sudafed Congestion, Claritin-D, Mucinex D, Zyrtec-D, Tusnel, Loratadine-D 12 Hour, SudoGest, Advil Cold and Sinus, Show all 1043 »Resperal-DM, Allegra-D 12 Hour, Sudafed 12-Hour, Actifed, Conex, Claritin-D 24 Hour, Allerest Maximum Strength, Aprodine, Tylenol Cold, Robitussin Allergy & Cough, Virtussin DAC, Sinarest, Despec DM, Vicks Nyquil D Cold and Flu Nighttime Relief, Suphedrine, Zyrtec-D 12 Hour, Aleve-D Sinus & Cold, Guaifen DAC, Allegra-D 24 Hour, Cheratussin DAC, Singlet, Vanacof, Drixoral Cold and Allergy, Maxifed, Zutripro, AllerClear D-24 Hour, Duraflu, Capmist DM, Deltuss DMX, Anaplex, Childrens Tylenol Cold Plus Cough, Entex, nasofed, Silfedrine, Efidac, Deconamine, Chlo Tuss, Chlor-Trimeton Allergy Decongestant, Dimetapp DM, Carbic-D, Allergy D-12, Sudafed 24-Hour, Dristan Sinus, Bromfed PD, PanMist DM, Stahist, Lortuss DM, Bromph DM, Bromaline DM, Nexafed Sinus Pressure + Pain, Bromphenex DM, Dimetapp Elixir, Dimacol, Bromaline, Viravan-PDM, Corzall Plus, Brometane DX, Hydron PCS, Dimetane DX, Chlorafed HS Timecelles, Corzall, Xiral SR, Motrin IB Sinus, Children's Nyquil, Dicel DM, Esocor P, Claritin-D 12 Hour, Allergy Relief D12, Suclor, Genaphed, Kidcare Cough and Cold, Lodrane, Ridafed, Cetiri D, Tussafin Liquid, Flutabs, Hycofenix, Tylenol Severe Cold & Flu Night Time, Allercon, Genac, Atrogen, Allerfrin, Wal-Zyr D, All Day Allergy-D, Allegra-D 24 Hour Allergy & Congestion, Chlor-Trimeton Nasal Decongestant, Cold Medicine Plus, Simplet, Mucinex D Maximum Strength, Tussin PE, Respaire-120 SR, Fenex-PSE, Entex T, Allpanto-S, Nalex Expectorant, Biotussin DAC, Dixaphedrine, Contac Cold, Alka-Seltzer Plus Flu/Body, Disobrom, Duomine, Deka, Vicks Dayquil Daytime Cold/Flu (old formulation), Stahist AD, Clarinex-D 12 Hour, Disophrol, Lortuss LQ, Tusnel Pediatric, Touro CC-LD, Relacon-DM NR, Despec Drops, Pseudo Cough, Vanacon, Su-Tuss HD Elixir, Z-Cof DM(obs), Spantuss HD, Medtuss HD, Relasin DM, Z-Cof DM, Ambi 40 /400 /20, Ambifed-G DM, Coldmist DM, Tekral, Profen II DM, Hytussin Expectorant, Protuss DM, Med-RX DM, Tussafed-LA, Touro CC, Robitussin Cough & Cold D, Profen Forte DM, Benadryl Allergy Sinus, ExeFen-DMX, Respa SA, Profen II DM Liquid, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Maxifed DMX, Altarussin CF, Liquicough DM, Pseudo Max DMX, Z-Cof 12DM, Vanex Expectorant, Decongestant Cold Formula, Tussadur-HD, Tussin Pediatric Cold and Cough, Balminil DM + Decongestant, Benylin DM-D, Pedia Relief Infant, Pediatex TDM, Decotuss-HD, Drixoral Cough & Congestion Liquid Caps, Welltuss EXP, Entuss-D JR, Pancof EXP, Hydro-Tussin EXP, Uni-Cof Expectorant, DiHydro-GP, Allegra-D 12 Hour Allergy & Congestion, Vicks 44D, Buckley's DM Decongestant, Trikof-D, Deconamine CX, Pseudo DM GG, SudaTex-DM, KG-Tuss HD, Hydrotussin HD, Entuss-D, Poly-Tussin XP, Desgen DM (with pseudoephedrine), SRC Expectorant, Dexatrex D, Tussgen Expectorant, Benaphen Plus, Benadryl Children's Allergy And Sinus, Tavist NightTime Allergy, Actifed Allergy Day/Night, Detussin Expectorant, Tussend Expectorant, P-Tuss DM, Benylin Multi-Symptom, Mardrops-DX, Tussin Cough and Cold, Trifed C, Nucofed, EndaCof-DC, Notuss-DC, KG-Fed, Cycofed, Nucodine, Neo AC, Polyhist NC, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Pseudodine C, Zodryl DEC, Clarinex-D 24 Hour, M-End DMX, Drexophed SR, Desihist SA, Dexophed, Acticon, 12 Hour Cold, Dexaphen SA, Drixomed, Pharmadrine, Tannate DMP-DEX, Codar D, Codafed Pediatric, DuraTan Forte, Cycofed Pediatric Expectorant, Nucochem Expectorant, Nuco-Tuss Pediatric Expectorant, Nucodine Pediatric, Cycofed Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Guiatussin DAC, KG-Fed Pediatric Expectorant, Suttar-2, Nucofed Pediatric Expectorant, Tussar SF, Phenylhistine Expectorant, Nuco-Tuss Expectorant, Nucochem, Dihistine, Gua PC, Codahistine Expectorant, Guaifenesin DAC Liquid, Novagest with Codeine, Suttar SF, Codafed, C-Phed DPD Tann, Bromatan Plus, Multi Symptom Cough and Cold, Ambenyl-D, Ambi 600/1000/30, Benylin DM-D-E, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Ambifed DM, Tenar DM, Novahistine DM Expectorant with Decongestant, Z-COF 12, Donatussin DM Syrup, Anatuss DM, Novahistine DMX, Balminil DM + Decongestant + Expectorant, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, Pseudogest-DM, Tusnel Ped-C, Tusnel-DM Pediatric Drops, Medent DM, Daytime Liquicap, TL-Dex DM, Sudafed Cough Syrup, Dur-Tann Forte, Tanafed DP, TanDur DM, SuTan-DM, Tannate PD-DM, Abatuss DMX, TanaCof DM, Tanafed DMX, Polaramine Expectorant, D-Hist D, DuraHist D, Histatab D, Duotan PD, AllerDur, Sudafed Cough, SuTan, Deltuss DP, Rescon, Hexafed, Nalfrx, Z-Cof 8DM, Entex Pac, Entre-Cough, Poly-Vent DM, Medent-DMI, Hydro-Tuss XP, Maxifed DM, Drituss HD, Versacaps, Dynex HD, Clear-Atadine-D, Pancof HC, SymTan, Liquituss HD, Detussin, Histussin D, Zymine HC, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Advil Cold and Sinus Liqui-Gels, Advil Children's Cold, Alavert D-12 Hour Allergy and Sinus, H-C Tussive D, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Allerx-D, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain, Aleve-D Sinus & Headache, ColdCough HCM, Entuss-D Liquid, Quadra-Hist D, ExeFen, Medent, Pseudatex, Touro LA-LD, Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Pseudo GG TR, Ru-Tuss Jr., Mucus Relief D, Histinex D, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Aquatab D Dose Pack, Protuss-D, Procof D, Rezira, Tussafin, Tussgen, P-V-Tussin, Hytussin, Iotussin D Liquid, Quadra-Hist D Pediatric, Nexafed Nasal Decongestant, Levall G, Triphed, Triposed, Allerphed, Triofed, Aphedrid, A-Phedrin, Actedril, Atridine, Atrofed, Hista-Tabs, LA Nasal Decongestant, Ridifed, Tri-Sudo, Vi-Sudo, Pediatex TD, Triptifed, Actagen, Altafed, Biofed-PE, Histafed, Triacin, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Triafed, Zymine-D, Suphedrin, Decofed, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Sudafed Children's Nasal Decongestant, Decofed Liquid, Kid Kare Drops, Allerfrim, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Ed A-Hist PSE, Guaifenex PSE 80, Ambifed-G, Entex HC, Guiatex II, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Respa-1st, Ambifed, Nasatab LA, Guiadrine II SR, Defen-LA, Decongest II, Desal II, Deco-D, Tenar PSE, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Eudal SR, Pseudocot-G, Guiatex PSE, Anatuss LA, Pseudatex HC, Entex PSE, Nalex CR, Mardrops-EX, Zephrex LA, Congestac, Zephrex, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Despec-Tab, Guaimax-D, Touro LA, Guaibid D Pediatric, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Novadyne Expectorant, Guaivent PD, Hi Tex PSE, Guai Sudo, Pseudovent 400, Miraphen PSE, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent, Pseudovent Ped, Guaifenex GP, Dynex, ExeFen-IR, Profen II, Profen Forte, Durasal II, Guiadrine PSE, Humibid GC, Guiatex II SR, We Mist LA, SudaTex-G, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Med-RX, Uni Tussin PE, Guaipax PSE, Q-Tussin PE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Mucus D, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Robichem PE, Robitussin Severe Congestion, T-Tussin PE, Tusscidin PE, Sinufed, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Respaire-30, Tusnel Pediatric Drops, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Sinutab Non Drying, Nucochem Pediatric Expectorant, Cordron-DM, Halotussin DAC, LoHist PSB, J-Cof DHC, M-END, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Brofed, Carbodex DM Syrup, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Sildec DM, P-Hist DM Drops, Allent, Brotapp-DM, BromTann/DM Tann/PSE Tann, Bromdex D, Neo DM Syrup, Dallergy DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Bromadine-DM, Anaplex DM, Andehist DM NR Syrup, ProHist DM, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, Shellcap, Shellcap PD, BroveX PSB DM, Comtrex Acute Head Cold, J-TanD PD, Exall-D, Re-Tann, Respi-Tann Pd, Carb Pseudo-Tan, Respi-Tann, Allres Pd, Allres D, Pseudacarb, Zotex-D, Andehist DM NR, Carbodex DM Drops, Dynatuss, LoHist-PD, Tussafed, Biodec DM, Rondamine DM, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, LoHist-12D, Lodrane 24D, Lodrane LD, Lodrane Liquid, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Nalfed, Dimaphen, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brotapp, Brovex SR, Anaplex DMX, PBM Allergy, PSE Carbinoxamine DM, All-Nite Multi-Symptom Cold/Flu Relief, Maxiflu CDX, Drixoral Cold/Flu, Complete Sinus Relief, Sinadrin Plus, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, Multi-Symptom Nighttime, NyCair, Robitussin Cold Cough and Flu, Tavist Allergy/Sinus/Headache, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Contact Cold and Sore Throat, Day Relief Cold and Flu, Maxiflu CD, Actifed Cold & Sinus, Daytime Cold and Flu Relief, Comtrex Sinus and Nasal, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Triaminic Flu, Cough & Fever, Comtrex Nighttime Flu Therapy, Allergy Sinus Maximum Strength, Tricom, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Tylenol Cold Non-Drowsy Gelcaps, Daytime Non-Drowsy, BroveX PSE DM, Dicel CD, Suphedrin Plus, Phenapap, Pseudoephedrine Sinus, Sinarest Sinus, Sinutab Maximum Strength, Actifed Cold and Sinus, Semprex-D, Ursinus, Ru-Tuss, Respa-AR, Sta-D, Trinalin Repetabs, SymPak II, Tylenol Sinus Maximum Strength, M-End WC, Mar-cof BP, Rydex, Mesehist WC, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, Genapap Sinus, Sinutab Regular Strength, Theraflu (pseudoephedrine) Daytime Severe Cold, Sinus Maximum Strength, Severe Cold Multi-Symptom, Daytime Cold, Benadryl Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Suphedrin Sinus, Sine-Off Maximum Strength, Ornex Maximum Strength, Allerest No Drowsiness, Sudogest Sinus Maximum Strength, Benadryl Allergy Sinus Headache, Tavist Sinus, Ornex, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Alka-Seltzer Cold and Sinus, Sinus Relief, Dristan Cold Non-Drowsy, Contac Sinus, Mintex DM, PSE Carb DM Drops, Phenhist Expectorant, Suphenamine-SR, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Isophen-DF, Fedahist, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Pseudochlor, Cophene No 2, Anamine, Klerist-D, Tanafed, Histalet, Fedahist Gyrocaps, Allergy DN, DryMax, DuraHist, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, AllePak, Rhinaclear, Pseudo CM TR, Clorfed, Coldamine, ScopoHist, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Deconamine SR, Novafed A, Duratuss DA, Codimal-LA Half, Clorfed II, Advil Children's Allergy Sinus, Maxifed CD, Qdall, Dynahist ER, M-End Max D, Dristan Cold Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Tricode GF, Ambifed CD, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Maxifed CDX, Triaminic Softchews Cold and Allergy, Maxifed-G CD, Maxifed-G CDX, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Pseudoephedrine Plus, LoHist-D, Curaler, Chlor-Trimeton Allergy Decongestant SR, Chlorafed, Histafed LA, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Sudogest Cold & Allergy, Genaphed Plus, SudoGest Sinus & Allergy, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Tavist-DA, AccuHist Drops (old formulation), Dynahist-ER Pediatric, CP-Tannic, Histade, Mintex, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AlleRx Dose Pack, Advil Allergy Sinus, Carboxine DM, KS Aller-Tec D-12, Andehist, Hydro-Tussin CBX, Carboxine-PSE, Cordron-D, Pediatex-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, Up and Up All Day Allergy Relief D, Ex-Dec-TR, 12 Hour Allergy-D, Allergy Relief D, Biclora-D, Panatuss PED Drops, Panatuss PED, Vanacof DX, Vanatab DX, Certuss-D, Clofera, Poly-Tussin D, Notuss-NXD, Statuss Green, NasOpen, Coldec-TR, Dura-Ron, Tricode AR, Biohist LA, Carboxine 12 DM, Carb PSE 12 DM, PSE Allergy DM, Cordron-12 DM, Pediatex 12 DM, Tri-Vent HC, Histex HC, Mintex HC, Pannaz S, Pseudox M, Nacon, Pannaz, Coldec D, Andec-TR, Coldec, Carbodec, Pediatex 12D, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Mooredec, Rondamine, Cardec-S, Maldec, Palgic-D, Dihistine DH, Zodryl DAC, Atuss HS, Pediatex HC, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Coldcough Syrup, Z-Tuss 2, Lemohist Plus, Notuss-Forte, Notuss, Detuss, Histinex PV, JayCof-HC, Tussend, Pedia Relief Cough-Cold, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydrocof-HC, Cordron-HC, Cordron-HC NR, Atuss HD, Pancof, T-Tanna DM, Phenylhistine DH, Rescon-DM, Decohistine DH, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Neotuss D, Rhinosyn-DM, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Tanafed-DM, Duotan DM, C-Phed DM, M-End DM, Atuss-12 DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Mesehist DM, Triaminic-D Multi-Symptom Cold, Allres DS, Tripohist D

Medically reviewed on Jan 10, 2017

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1. Eglash A. Treatment of maternal hypergalactia. Breastfeed Med. 2014;9:423-5. PMID: 25361472

2. Findlay JW, Butz RF et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901-6. PMID: 6529531

3. Aljazaf K, Hale TW et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18-24. PMID: 12848771

4. Ito S, Blajchman A et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

5. Soussan C, Gouraud A, Portolan G et al. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361-6. PMID: 25183382

Pseudoephedrine Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

231

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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