Skip to Content

Pseudoephedrine use while Breastfeeding

Drugs containing Pseudoephedrine: Bromfed DM, Sudafed Congestion, Claritin-D, Mucinex D, Zyrtec-D, SudoGest, Aprodine, Sudafed 12-Hour, Advil Cold and Sinus, Allegra-D 12 Hour, Show all 1048 »Allegra-D 24 Hour, Sinarest, Actifed, Claritin-D 24 Hour, Robitussin Allergy & Cough, Vicks Nyquil D Cold and Flu Nighttime Relief, Coldcough Syrup, Zyrtec-D 12 Hour, Allergy Relief D 24 Hour, Allerfrin, Virtussin DAC, Tusnel, Entex PSE, Entex, Suphedrine, Tylenol Cold, Despec DM, Duomine, Conex, Nucodine, Duraflu, Resperal-DM, Tanafed DMX, Sudogest Cold & Allergy, Sudafed 24-Hour, Vicks Dayquil Daytime Cold/Flu (old formulation), Vanacof, Loratadine-D 24 Hour, SudoGest Sinus & Allergy, Orlenta, Tanafed, Clorfed, AllerClear D-24 Hour, Vicks 44M Pediatric, Rescon, Contact Cold and Sore Throat, Ru-Tuss, Stahist, Nucofed Pediatric Expectorant, Aleve-D Sinus & Cold, Benadryl Severe Allergy & Sinus Headache, Wal-Zyr D, Childrens Tylenol Cold Plus Cough, Bromaline, Sudafed Children's Nasal Decongestant, Maldec, Drixoral Decongestant Non-Drowsy, Comtrex Acute Head Cold, Ed A-Hist PSE, Dimetane DX, Semprex-D, Advil Allergy Sinus, Lodrane D, Pediatex TDM, Children's Nyquil, Rondamine DM, Dimetapp Elixir, Benadryl Allergy Sinus, Claritin-D 12 Hour, Capmist DM, Alavert D-12 Hour Allergy and Sinus, Sinus Relief, Robitussin Cough & Cold D, Lortuss DM, Histacol BD Drops, Pseudo Cough, Brometane DX, Z-Cof 12DM, Liquituss HD, Pancof HC, AlleRx Dose Pack, Brexin LA, Duralex, Advil Cold and Sinus Liqui-Gels, Respi-Tann Pd, ScopoHist, Y-Tuss, Loratadine-D 12 Hour, Coldamine, Pseudoephedrine Sinus, Sinus & Cold D, Sudogest Sinus Maximum Strength, Allerest No Drowsiness, Panatuss PED, Dexaphen SA, Acticon, Severe Cold Multi-Symptom, Alka-Seltzer Plus Flu/Body, Cold Medicine Plus, Stahist AD, Nucodine Pediatric, Clarinex-D 24 Hour, Sinutab Ex-Strength, Allegra-D 12 Hour Allergy & Congestion, Clofera, Poly-Vent, Vanex Expectorant, Tylenol Severe Cold & Flu Night Time, Nucochem Expectorant, Dixaphedrine, Pseudatex, Pediatex-D, Nexafed Nasal Decongestant, Silfedrine, Suphedrin, Afrinol, Profen Forte, Efidac, Benadryl Cold, 12 Hour Decongestant, Entex T, Dynex, Defen-LA, Zymine-D, Medtuss HD, Spantuss HD, Vanacon, Despec Drops, Hydrotussin HD, Touro CC-LD, Tusnel Pediatric, Relasin DM, Relacon-DM NR, Ambifed-G DM, Z-Cof DM(obs), KG-Tuss HD, ExeFen-DMX, Altarussin CF, Touro CC, Daytime Liquicap, Multi Symptom Cough and Cold, Tussin Cough and Cold, Tussafin Liquid, Protuss DM, Su-Tuss HD Elixir, Med-RX DM, Tussafed-LA, Profen Forte DM, Coldmist DM, Profen II DM, Ambi 40 /400 /20, Profen II DM Liquid, ExeClear-DM, S-Pak DM, Ru-Tuss DM, Aldex GS DM, Relacon-DM, Z-Cof DM, Tussgen Expectorant, Liquicough DM, Benadryl Children's Allergy And Sinus, Benylin DM-D, Allegra-D 24 Hour Allergy & Congestion, Lortuss LQ, Benaphen Plus, Tekral, Pedia Relief Infant, Viravan-PDM, Respa SA, Tavist NightTime Allergy, Tussin Pediatric Cold and Cough, DiHydro-GP, Uni-Cof Expectorant, Actifed Allergy Day/Night, Hydro-Tussin EXP, Benylin Multi-Symptom, Tusnel-DM Pediatric Drops, Pancof EXP, Welltuss EXP, Balminil DM + Decongestant, Decongestant Cold Formula, Maxifed DMX, SudaTex-DM, Trikof-D, Pseudo DM GG, Entuss-D, Poly-Tussin XP, Deconamine CX, Nalex Expectorant, SRC Expectorant, Pseudo Max DMX, Desgen DM (with pseudoephedrine), Vicks 44D, P-Tuss DM, Dexatrex D, Buckley's DM Decongestant, Drixoral Cough & Congestion Liquid Caps, Detussin Expectorant, Tussend Expectorant, Tussadur-HD, Decotuss-HD, Entuss-D JR, Medent DM, Entex Pac, Tusnel Ped-C, Trifed C, Nucofed, EndaCof-DC, Notuss-DC, KG-Fed, Cycofed, Neo AC, Polyhist NC, Triacin C, Allerfrin with Codeine, Triafed & Codeine, Pseudodine C, Zodryl DEC, Clarinex-D 12 Hour, Deka, M-End DMX, Drexophed SR, Desihist SA, Dexophed, Disobrom, Disophrol, 12 Hour Cold, Drixomed, Drixoral Cold and Allergy, Codar D, Guaifenesin DAC, Tannate DMP-DEX, Phenylhistine Expectorant, KG-Fed Expectorant, Nucodine Expectorant, Deconsal C Expectorant, Guaiatussin DAC, Guiatuss DAC, Mytussin DAC, Guiatussin DAC, Cycofed Pediatric Expectorant, KG-Fed Pediatric Expectorant, Tussar SF, Biotussin DAC, Cheratussin DAC, Coditussin DAC, Nuco-Tuss Expectorant, Nucochem, Guaifen DAC, Dihistine, Gua PC, Codahistine Expectorant, Novagest with Codeine, Suttar SF, Codafed, Suttar-2, Codafed Pediatric, Pharmadrine, C-Phed DPD Tann, Pseudogest-DM, Novahistine DM Expectorant with Decongestant, Sudafed Cough, Sudafed Cough Syrup, Balminil DM + Decongestant + Expectorant, TL-Dex DM, Ambi 600/1000/30, Benylin DM-D-E, Ambi 80/780/40, Calmylin 4, Ambi 60/580/30, Ambifed DM, Tenar DM, Z-COF 12, Maxifed DM, Donatussin DM Syrup, Anatuss DM, Ambenyl-D, Dimacol, Novahistine DMX, Ru-Tuss Expectorant, Rhinosyn-X, Dorcol Childrens Cough, Syn-Rx DM, Guaifenex DM RX, Suda-Tussin DM, PanMist DM, Mardrops-DX, DuraTan Forte, Histatab D, Bromatan Plus, Dur-Tann Forte, TanDur DM, SuTan-DM, Tannate PD-DM, Deltuss DMX, Abatuss DMX, TanaCof DM, Polaramine Expectorant, D-Hist D, DuraHist D, Duotan PD, Robitussin CF, Tanafed DP, AllerDur, SuTan, Deltuss DP, Hexafed, Nalfrx, Z-Cof 8DM, Drituss HD, Entre-Cough, Poly-Vent DM, Medent-DMI, Hytussin Expectorant, Versacaps, Hydro-Tuss XP, Motrin Sinus Headache, H-C Tussive D, ColdCough HCM, SymTan, Detussin, Histussin D, Zymine HC, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Motrin Cold and Flu, Motrin Childrens Cold, Advil Children's Cold, Histinex D, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Sudatrate, AlleRx Dose Pack (AM Dose), Amdry-D, Extendryl PSE, Respivent-D, Allerx-D, Sudafed 12 Hour Pressure+Pain, Aleve-D Sinus & Headache, Entuss-D Liquid, Iotussin D Liquid, Quadra-Hist D, Ru-Tuss Jr., Levall G, Guaifenex PSE 80, Medent, Touro LA-LD, Aldex GS, Despec-SR, Guaifenex PSE 85, Poly-Vent, Jr., Nomuc-PE, Maxifed-G, Maxifed, Pseudo GG TR, ExeFen, Hytussin, Mucus Relief D, Ambi 60/1000, Ambi 60/580, Ambi 80/780, Mucinex D Maximum Strength, Aquatab D Dose Pack, Protuss-D, Procof D, Rezira, Tussafin, Tussgen, P-V-Tussin, Quadra-Hist D Pediatric, nasofed, Pseudovent 400, Triphed, Allerphed, Triofed, Aphedrid, A-Phedrin, Actedril, Atridine, Atrofed, Atrogen, Hista-Tabs, LA Nasal Decongestant, Ridifed, Tri-Sudo, Vi-Sudo, Triafed, Triptifed, Actagen, Altafed, Biofed-PE, Histafed, Triacin, Ritifed, Actacin, Trisofed, Pseudocot-T, Zymine DXR, Trip-PSE, Triposed, Genac, ElixSure Congestion, Decofed, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Chlor-Trimeton Nasal Decongestant, Zephrex-D, Decofed Liquid, Kid Kare Drops, Allercon, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Contac Cold, SudoGest 12 Hour, 12 Hour Nasal Decongestant, Viravan-P, Seldane-D, Hist-PSE, Allerfrim, Pediatex TD, Ambifed-G, Pseudo Max, Dynex HD, Guiadrine II, Pseudocot-G, Nasatab LA, Eudal SR, Sudal 60/500, Tuss-LA, Stamoist E, V-Dec-M, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Iosal II, Guaivent PD, Respa-1st, Guiatex II, Ambifed, Guiadrine II SR, Decongest II, Desal II, Deco-D, Tenar PSE, GP 500, Guaifed-PSE, Abletex-PSE, Guiadrine PSE 120, Guaibid D Pediatric, Nuco-Tuss Pediatric Expectorant, Guaifenex PSE 120, Guaimax-D, Entex HC, Pseudatex HC, Hycofenix, Nalex CR, Mardrops-EX, Zephrex LA, Congestac, Zephrex, Pan-Mist LA, Poly-Vent IR, Medent-LDI, Despec-Tab, Anatuss LA, Sinufed Timecelles, Touro LA, Fenex-PSE, Nalex, Syn-Rx, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Guai-Vent/PSE, Hi Tex PSE, Sudal SR, Profen II, Robitussin Severe Congestion, Uni Tussin PE, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent, Pseudovent Ped, Guaifenex GP, ExeFen-IR, Durasal II, Sudafed Non Drying Sinus, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, SudaTex-G, Coldmist, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sinutab Non Drying, S-Pack, Guiatex PSE, Mastussin PE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Mucus D, Zaptec PSE, Ru-Tuss DE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mytussin PE, Altarussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Degen II, Robafen PE, Guaivent (Ethex), Respaire-30, Tusnel Pediatric Drops, Cycofed Expectorant, Cordron-DM, Nucochem Pediatric Expectorant, Bromfed PD, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Lodrane, LoHist PSB, Brofed, Bromfed SR, M-END, Bidhist-D, Lodrane 12D, Rynex PSE, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Touro A&H, Shellcap, Allent, Drocon-CS, J-Cof DHC, Lodrane LD, PSE Brom DM, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Bromadine-DM, Anaplex DM, Bromphenex DM, Brotapp-DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, Bromaline DM, Sildec DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Shellcap PD, Nalfed PD, Dallergy DM, Tussafed, Re-Tann, Carb Pseudo-Tan, Respi-Tann, Corzall, Allres Pd, Allres D, Pseudacarb, Zotex-D, Corzall Plus, Andehist DM NR, Carbodex DM Drops, Dynatuss, Biodec DM, J-TanD PD, Maldec-DM, Cydec-DM Syrup, Dura-Ron DM, Cydec-DM Drops, Carbaxef-DM, Carbofed DM Drops, Decahist-DM, Pediatex-DM, Cordron-DM NR, Pseudo Carb DM, Mintex DM, PSE Carbinoxamine DM, PSE Carb DM Drops, Exall-D, LoHist-12D, Respahist, Touro Allergy, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Andehist NR Syrup, LoHist-PD, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brotapp, Brovex SR, Dimaphen, Lodrane 24D, Myphetane DX, Neo DM Syrup, Carboxine 12 DM, Multi-Symptom Nighttime, Tavist Allergy/Sinus/Headache, Maxiflu CD, Maxiflu CDX, Drixoral Cold/Flu, Complete Sinus Relief, Sinadrin Plus, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Contac Day and Night Cold and Flu, All-Nite Cold, NyCair, Allergy Sinus Maximum Strength, All-Nite Multi-Symptom Cold/Flu Relief, Robitussin Cold Cough and Flu, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Flutabs, Maxiflu DM, Tusnel-A, Theraflu Flu Cold & Cough, Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Actifed Cold & Sinus, Sinutab Maximum Strength Caplets, Day Relief Cold and Flu, Triaminic Flu, Cough & Fever, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Theraflu Flu & Cough, Allpanto-S, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Comtrex Sinus and Nasal, Triaminicin, Comtrex Nighttime Flu Therapy, Singlet, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Non-Drowsy Super Strength Contac Complete, Tylenol Cold Non-Drowsy Gelcaps, Bromdex D, Uni-Hist DM Pediatric Syrup, Actifed Cold and Sinus, Ursinus, Respa-AR, Sta-D, Trinalin Repetabs, Atuss DA, Dicel CD, SymPak II, M-End WC, Mar-cof BP, Rydex, Mesehist WC, AccuHist DM Pediatric Syrup, Sinarest Sinus, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Dimetapp DM, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Sinutab Maximum Strength, Nexafed Sinus Pressure + Pain, Daytime Cold and Flu Relief, Suphedrin Sinus, Daytime Non-Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Daytime Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Actifed Sinus Day and Night, Tylenol Sinus NightTime, Tylenol Sinus Day/Night Convenience Pack, Tylenol Sinus Severe Congestion Daytime, Sudafed Triple Action, Sinus Maximum Strength, Ornex Maximum Strength, Phenapap, Benadryl Allergy Sinus Headache, Tavist Sinus, Ornex, Sinutab Maximum Strength Non Drowsy, Bayer Select Sinus Pain Formula, Ephed Plus, Dristan Cold Non-Drowsy, Contac Sinus, Sine-Off Maximum Strength, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, Genapap Sinus, Suphedrin Plus, Carboxine DM, Carb PSE 12 DM, Novadyne Expectorant, Kronofed-A, Codimal-LA, Kronofed-A-Jr, Dura-Tap/PD, Fedahist Timecaps, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Rinade-BID, Suphenamine-SR, Isophen-DF, ND Clear, Fedahist, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Rescon-Ed, Pseudochlor, Cophene No 2, Anaplex, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Clorfed II, Chlorafed HS Timecelles, Histalet, Chlorafed, AllePak, Advil Children's Allergy Sinus, DryMax, DuraHist, Xiral SR, RelCof DN PSE, Dallergy PSE, Relcof PSE, Mescolor, Hista-Vent PSE, PCM-LA, Amdry-C, Time-Hist QD, Rhinaclear, Duratuss DA, Allergy DN, Pseudo CM TR, Allergy AM-PM Dose Pack, VisRx Dose Pack, Histatab, Histade CR, Chlor-Trimeton Decongestant, Duotan, Durafed, Biohist LA (old formulation), Deconamine, Deconamine SR, Novafed A, Curaler, Histafed LA, Atuss HD, Maxifed-G CD, M-End Max D, Dristan Cold Maximum Strength, Lortuss EX, Tusnel C, Z-Tuss E, Tricode GF, Ambifed CD, Ambifed CDX, Ambifed-G CD, Ambifed-G CDX, Maxifed CD, Maxifed CDX, Maxifed-G CDX, Qdall, Robitussin-DAC, Ryna-CX, Medent C, Novahistine Expectorant, Nucofed Expectorant, Tussar-2, Deproist with Codeine, Co-Histine Expectorant, Decohistine Expectorant, Dihistine Expectorant with Codeine, Dihistine Expectorant, Phenhist Expectorant, Halotussin DAC, Dynahist ER, Pseudoephedrine Plus, Chlor-Trimeton Allergy Decongestant, CP-Tannic, Aller-Chlor Decongestant, Sudogest Plus, Neutrahist Drops, Ryna Liquid, Genaphed Plus, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Allerest Maximum Strength, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Dynahist-ER Pediatric, Histade, Triaminic Softchews Cold and Allergy, Mintex, Suclor, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Dicel, Sudal-12 Tannate, SudaHist, AccuHist Drops (old formulation), LoHist-D, Atuss HS, Cordron-HC NR, PSE Allergy DM, 12 Hour Allergy-D, Cordron-D, Cordron-D NR, Cordron-12 D, Pseudo Carb, Carboxine-D, PSE Allergy, Mintex PSE, Palgic DS, Allergy D-12, KS Aller-Tec D-12, Up and Up All Day Allergy Relief D, All Day Allergy-D, Allergy Relief D, Hydro-Tussin CBX, Cetiri D, Biclora-D, Chlo Tuss, Panatuss PED Drops, Vanacof DX, Vanatab DX, Certuss-D, Rondec-D, Ninjacof-D, Poly-Tussin D, Notuss-NXD, Statuss Green, NasOpen, Carboxine-PSE, Andehist, Tricode AR, Carbodec, Cordron-12 DM, Pediatex 12 DM, Tri-Vent HC, Histex HC, Mintex HC, Pannaz S, Pseudox M, Nacon, Pannaz, Biohist LA, Coldec D, Coldec, Pediatex 12D, Coldec-TR, Carboxine 12D, Carbiset, Cydec, Palgic-DC, Andec, Mooredec, Rondamine, Cardec-S, Palgic-D, Andec-TR, Carbic-D, Dura-Ron, Ex-Dec-TR, Dihistine DH, Zodryl DAC, Cordron-HC, Histinex PV, Pedia Relief Cough-Cold, Pancof, Tricof, Hydro-Tussin DHC, Dihydro-CP, Uni-Cof, Z-Tuss 2, Lemohist Plus, Zutripro, Notuss-Forte, Notuss, Detuss, JayCof-HC, Duotan DM, Pediatex HC, Tussend, Welltuss HC, Hexatussin, Hyphed, Tussin-V, Q-V Tussin, A-G Tussin, KG-Tussin, P-V-Tussin Syrup, Hydrotuss HC, Hydron PCS, Hydrocof-HC, T-Tanna DM, Allres DS, Phenylhistine DH, Rescon-DM, Decohistine DH, Codehist DH, Phenylhistine DH Expectorant, Novadyne DH, Co-Histine DH, Ryna-C, Codahistine-DH Elixir, Neotuss D, Rhinosyn-DM, Creomulsion Cough/Cold/Allergy, Creomulsion Pediatric, Kidcare Cough and Cold, Tanafed-DM, Triaminic-D Multi-Symptom Cold, C-Phed DM, M-End DM, Atuss-12 DM, Dicel DM, Atuss DS, Entre-S, Maxichlor PSE DM, Kidkare Cough/Cold, Neutrahist PDX Drops, AccuHist PDX Drops, CPM-PSE DM Drops, Esocor P, Mesehist DM, Tripohist D

Medically reviewed by Drugs.com. Last updated on Jan 4, 2021.

Pseudoephedrine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Drug Levels

Maternal Levels. A single oral dose of 60 mg of pseudoephedrine in 3 women resulted in peak milk levels of less than 1 mg/L 1 hour after the dose.[2] Other authors used data from this study to calculate the amount excreted in milk to be 5.5% of the weight-adjusted maternal dosage.[3]

After a 60 mg oral dose of immediate-release pseudoephedrine, peak milk levels averaging 698 mcg/L occurred 1.7 hours after the dose and half-life in milk was 5.5 hours. A fully breast-fed infant would receive a dose of 4.3% (range 2.2 to 6.7%) of the maternal weight-adjusted dose.[3]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Mothers reported irritability was reported in 20% of infants exposed to pseudoephedrine in one study of breastfeeding mothers.[4]

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, pseudoephedrine was reported to cause adverse reactions in 4 infants, primarily agitation.[5]

Effects on Lactation and Breastmilk

After a single dose of pseudoephedrine 60 mg orally in 8 nursing mothers, there was a mean 24% decrease in milk production over the following 24 hours. No change in blood flow to the breast was detected that could explain the decreased milk production; there was a 13.5% decrease in serum prolactin after pseudoephedrine, but this change did not achieve statistical significance. Oxytocin levels were not measured.[3]

Alternate Drugs to Consider

Oxymetazoline

References

1.
Johnson HM, Eglash A, Mitchell KB, et al. ABM Clinical Protocol #32: Management of hyperlactation. Breastfeed Med. 2020;15:129–34. [PubMed: 32031417]
2.
Findlay JW, Butz RF, Sailstad JM, et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol. 1984;18:901–6. [PMC free article: PMC1463694] [PubMed: 6529531]
3.
Aljazaf K, Hale TW, Ilett KF, et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003;56:18–24. [PMC free article: PMC1884328] [PubMed: 12848771]
4.
Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393–9. [PubMed: 8498418]
5.
Soussan C, Gouraud A, Portolan G, et al. Drug-induced adverse reactions via breastfeeding: A descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014;70:1361–6. [PubMed: 25183382]

Substance Identification

Substance Name

Pseudoephedrine

CAS Registry Number

90-82-4

Drug Class

Breast Feeding

Lactation

Adrenergic Agents

Adrenergic Alpha-Agonists

Central Nervous System Stimulants

Sympathomimetics

Vasoconstrictor Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.