Entresto and Weakness: What Users Say

• pau...
• Taken for 1 to 6 months
• July 7, 2021

For Heart Failure "Started Entresto in May and the side effects are bad, very low blood pressure, dizzy, weak, vomiting, diarrhea. I stopped taking and went back to old heart medication. Listen to your body, I thought I was going to end up in the emergency room."

• Eno...
• Taken for 6 months to 1 year
• July 22, 2018

For Heart Failure "I was put on Entresto for approximately 6 months. This drug was a nightmare for me. Started on the recommended starting dose (med dose) in the beginning. Blood pressure and pulse rate went seriously low, and my doctor ignored these symptoms. I told him I was dizzy, weak, and felt worse than being on conventional heart failure drugs. So what does he do? He tells me to double the dose. I started taking the maximum dose. In short, it damn near killed me!! Pulse rate went as low as 30 then spiked to over 140. Blood pressure was 90/60. I had a blackout, and my life vest went into treatment mode. I ended up in the hospital emergency and was admitted to the hospital. They took me off Entresto and began treatment with conventional heart failure drugs. Doing better now but still weak. If anybody is reading this, look for supplements for heart failure. They have helped more than ever, such as CoQ10, Garlic, Krill Oil, Magnesium, L-Arginine, Taurine, D-Ribose, and L-Citrulline DL-Malate 2:1."

• Fra...
• November 21, 2019

For Heart Failure "My husband was diagnosed with CHF since 2013, has been on Coreg, Lasix, and Lisinopril since. His cardiologist suggested he start on Entresto, half a pill twice a day to start. He ended up in the ER after taking the third dose! Low BP 83/54, weak, disoriented, almost delirious, very sleepy, had chills, and feeling very cold. His BUN and creatinine went up unlike he’s ever had. It was extremely scary! I almost called an ambulance because I had never seen him this way, not until he started this medicine. I read all the negative reviews before starting but still went for it. I feel bad that we did, and we are now waiting for the cardiologist's office to open in order to get him in for re-evaluation. Be extra careful and please keep a very close eye on your loved one, and if you see anything out of the ordinary for them, act immediately and get help. A very stressful situation. Be careful with this medicine."

• A N...
• Taken for 1 to 6 months
• May 3, 2023

For Heart Failure "After a few weeks of taking the lowest dose, my dad started feeling weak, he could not breathe, and he could not walk anymore. The doctor kept saying to take Entresto because it is a miracle drug and that he just had low iron in his blood. Well, we went to another cardiologist, and my dad was full of fluids with almost an edema in his lungs! Plus, his EF got worse. Please be careful with this drug, it is not good for old people, they are too delicate, it can even kill you."

• wal...
• Taken for 1 to 6 months
• May 1, 2019

For Heart Failure "I have congestive heart failure (ejection fraction around 27%) after a massive attack back in Nov 2013. My cardiologist switched me from Ramipril to Entresto on Feb. 1st, 2019, and within a couple of weeks of starting, I experienced swelling & severe calf muscle pain, muscle weakness in my legs, waking up in the night with ice-cold toes & feet. My lower legs felt 'hard' and swollen but not like when I retained fluids, much more painful. I had a significant (& scary) increase in my blood pressure readings. I experienced overall body weakness, feeling like crap, dizziness, and a 'spacey' feeling. Entresto made me feel much worse than I had ever felt since my 'event' in 2013. I stopped taking it and went back to my old medication, feeling back to my 'normal' within a week. Three months later now and still recovering from the damage/pain to my calf muscles. What a nightmare Entresto was, it was truly awful for me."

• wal...
• Taken for 1 to 6 months
• May 1, 2019

For Heart Failure "I have congestive heart failure (ejection fraction around 27%) after a massive attack back in Nov 2013. My cardiologist switched me from Ramipril to Entresto on Feb. 1st, 2019, and within a couple of weeks of starting, I experienced swelling & severe calf muscle pain, muscle weakness in my legs, waking up in the night with ice-cold toes & feet. My lower legs felt 'hard' and swollen but not like when I retained fluids, much more painful. I had a significant (& scary) increase in my blood pressure readings. I experienced overall body weakness, feeling like crap, dizziness, and a 'spacey' feeling. Entresto made me feel much worse than I had ever felt since my 'event' in 2013. I stopped taking it and went back to my old medication, feeling back to my 'normal' within a week. Three months later now and still recovering from the damage/pain to my calf muscles. What a nightmare Entresto was, it was truly awful for me."

• Mar...
• Taken for 6 months to 1 year
• January 9, 2022

For Heart Failure "My team did not know how Entresto worked, they knew I might get GERD and that I might get low potassium. They did prescribe me potassium, and I got weaker. The last two times I had to go to their office in a wheelchair, I had trouble breathing, so they added Isosorbide. At no time did they think high dose Entresto was a problem, but when I was in there, I was not able to breathe well or walk. I realized when symptoms started it was the Entresto. I refused the drug. Next time, I was able to walk 18 hours later, but it took 110 days to have no more Entresto-caused side effect symptoms."

• Rob...
• Taken for less than 1 month
• October 21, 2021

For Heart Failure "After a severe heart failure in 2017, my husband was in a coma for 5 days. He was taken out of the coma, had a defib implant, HEF (heart ejection fraction) at 18%, and was discharged with metoprolol and Enalapril. Six months later, he is building a shed and feeling rejuvenated. The doctor changed Enalapril to Entresto, a new miracle drug for people with low HEF. This easygoing, laughing, funny man changed to a dizzy, weak-legged, extremely fatigued, despondent, depressed man. No energy, no stamina, no taste for food, can't bend over to put on shoes and socks, feeling like he is going to fall, up for a couple of hours, then needs to sleep for 4 hours, pulse in the 80s+, BP got as low as 63/41. Very low BP reading. Called the hospital, after a telephone conference due to COVID, advised to stop Entresto. Amazing, he feels back to his usual optimistic self, looking forward to a new grandchild, which he was thinking 'prepare for the time of death' planning! This drug might work for some, but not for 51% of people."

• Dev...
• July 25, 2018

For Heart Failure "My father is dead. My dad was 87 and did have a weak heart, but he had been riding his bike a few miles a day. This awful drug does not have a lot of data on older people. He was put on this drug in September of 2017. My mother kept questioning the med because she saw him getting weaker, and the doctor continued to say it was good. By March, he was so weak that they begged the doctor to get him off. He finally came off, but the damage was done. He died a little over 3 months after. Get your loved one off this med."

• Pur...
• Taken for 6 months to 1 year
• March 24, 2023

For Heart Failure "In February 2022, my husband had congestive heart failure with an EF of 10%. His cardiologist put him on Entresto 24-26 mg along with carvedilol 12.5 mg 2x daily. Within a couple of days, he was complaining about having trouble walking. This went on for months but was getting worse. The pain would start at the top of his feet, sharp stabbing pain, and travel up both legs until it would stop him dead in his tracks. He had to have follow-up tests, and his EF rate is now 60-65%. His cardiologist stopped his Lasix for about a week to see if that was causing the leg pain, but no. Then he stopped the rosuvastatin 40 mg for a week; still no. The pain was getting worse, and he was getting fatigued. He was also becoming weak. My husband had bloodwork, and his potassium was high. The doctor immediately stopped the Entresto. I would not recommend Entresto. It seems to cause more harm than good."

• Pur...
• Taken for 6 months to 1 year
• March 24, 2023

For Heart Failure "In February 2022, my husband had congestive heart failure with an EF of 10%. His cardiologist put him on Entresto 24-26 mg along with carvedilol 12.5 mg 2x daily. Within a couple of days, he was complaining about having trouble walking. This went on for months but was getting worse. The pain would start at the top of his feet, sharp stabbing pain, and travel up both legs until it would stop him dead in his tracks. He had to have follow-up tests, and his EF rate is now 60-65%. His cardiologist stopped his Lasix for about a week to see if that was causing the leg pain, but no. Then he stopped the rosuvastatin 40 mg for a week; still no. The pain was getting worse, and he was getting fatigued. He was also becoming weak. My husband had bloodwork, and his potassium was high. The doctor immediately stopped the Entresto. I would not recommend Entresto. It seems to cause more harm than good."

• Fra...
• April 21, 2019

For Heart Failure "My 97-year-old mother has been on Entresto, and it has her so weak and gasping for air. She is itching and being very warm. I am taking her off of the Entresto. I don't believe this drug is good for elderly patients. As of today, I'm taking her off this drug. I will let her cardiologist know. She is on other blood pressure meds and on a diuretic."

• Mic...
• October 14, 2017

For Heart Failure "My 89-year-old father was taking this med for a few weeks. He was weak (we had to pull him out of bed or out of his chair, he walked with a walker, was confused, just totally not him). He happened to have a urinary infection about the same time, so we blamed that. Finally, a week later, infection gone -- and he was still so weak. Hospitalized one day, many tests, and nothing found. Started to take half the dose of Entresto, per his cardiologist (we asked since that was the only thing different at this point)... in five days, back to normal. No walker, no need to help him get up, alert and living again! P.S. His primary care doctor said he doesn't prescribe Entresto... it's two powerful drugs. He isn't the cardio guy, but... beware!"

• Bec...
• Taken for 1 to 6 months
• December 27, 2017

For Heart Failure "I don't see any improvement with Entresto. I actually think I'm worse, with weakness and dizziness in addition to arrhythmias. Also, I have more joint pain and have had more frequent angina."