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Angiotensin receptor blockers and neprilysin inhibitors

What are Angiotensin receptor blockers and neprilysin inhibitors?

Angiotensin receptor blockers with neprilysin inhibitors is a combination medicine that contains both an angiotensin receptor blocker and a neprilysin inhibitor.

How they work

Angiotensin receptor blockers (ARBs) inhibit the activation of angiotensin II receptor which causes vasodilation, a reduction of aldosterone production and reduced vasopressin release which results in a reduction in blood pressure.

Neprilysin inhibition causes an increase in levels of natriuretic peptides which is important in maintaining fluid and sodium balance through natriuresis, diuresis and vasodilation which reduces blood pressure and assists heart failure.

What they treat

The combination of angiotensin receptor blockers and neprilysin inhibitors are used to reduce risk of complications of heart failure with reduced ejection fraction.

List of Angiotensin receptor blockers and neprilysin inhibitors:

View by  Brand | Generic
Drug Name Reviews Avg. Ratings
Entresto (Pro)
Generic name: sacubitril / valsartan
116 reviews
4.7
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

See Also

Medical conditions associated with angiotensin receptor blockers and neprilysin inhibitors: