Entresto and Chest Pain: What Users Say

• Mks...
• Taken for 6 months to 1 year
• March 13, 2020

For Heart Failure "I was given Entresto when they said my EF was 30-35. Had to fight with the insurance to get them to cover it. Was told by cardiologist it was a miracle drug and would add years to my life. The first few months were okay but my blood pressure kept getting lower and lower. Was told by cardiologist not to take morning dose if the upper number was under 100. That was all the time. I was dizzy all the time, falling constantly. Started having chest pains and episodes of confusion. Went to cardiologist, was told they didn’t know what was wrong. My husband was having to help me walk everywhere we went. Was so tired, I couldn’t do housework, laundry, or anything. Made the decision on my own to stop taking Entresto. Within a week, I was a completely different person. Energy level is up, dizziness is gone, quality of life has returned. Entresto was one of the worst experiences of my life. Changing cardiologist. Entresto was a nightmare for me."

• Inp...
• Taken for 1 to 6 months
• February 27, 2021

For Heart Failure "Started on low dose of 24mg/26mg, had bad lower back and side pain. This pain eased after a week and heart doctor upped my medication to 49/51mg twice a day. I have bad left chest wall pain and bad muscle pain on the left side of my ICD defibrillator. I am going to go back on to the 24/26mg as I don't get as much pain. I walk for 60 minutes every day with no problems. I hope my EF goes from 20 up to 50 or 60 in a year. I will wait and see. I will pray for each and every one of us that we get well and a cure is found for heart failure."

• Bad...
• Taken for 1 to 6 months
• August 25, 2020

For Heart Failure "I'm 34 years old. The doctor claimed my heart was weak because of non-compaction, and my ejection fraction was at 30 percent from an echo. He told me to take Entresto. I was taking it for 6 months, then they sent me to take an MRI. The MRI showed the ejection fraction was 38%. All of a sudden, my body started to reject Entresto. My feet and hands started to tingle, I was extremely dizzy, I was having chest pain under my pec muscle, and one night I was breathing funny, and I thought my life was finishing. I was like, is this it? The next morning, I tried to contact my doctor's office, and they claimed that's normal. So I took it upon my own, and stopped taking the pills for a while. I want my ejection fraction to increase."

• Pai...
• Taken for 1 to 6 months
• May 2, 2022

For Heart Failure "I started taking this about 2 months ago and was told to give this a shot in hopes of raising my EF. It was at 29 or close to it, and if it worked, it could raise it back to 40-50%. That if it didn't work, I would need a pacemaker. Over the weekend, I started getting chest pains, but they would come and go, so I chalked them up to indigestion. It was really bad last night, though, but has been fine today until just a few minutes ago. I'm on 24-26 mg twice a day and will not be taking this evening's pill and calling the cardiologist in the morning. I have felt exhausted no matter if I had a great night's sleep or hardly any, and doing simple tasks gives that chest pressure pain too."

• Pai...
• Taken for 1 to 6 months
• May 2, 2022

For Heart Failure "I started taking this about 2 months ago and was told to give this a shot in hopes of raising my EF. It was at 29 or close to it, and if it worked, it could raise it back to 40-50%. That if it didn't work, I would need a pacemaker. Over the weekend, I started getting chest pains, but they would come and go, so I chalked them up to indigestion. It was really bad last night, though, but has been fine today until just a few minutes ago. I'm on 24-26 mg twice a day and will not be taking this evening's pill and calling the cardiologist in the morning. I have felt exhausted no matter if I had a great night's sleep or hardly any, and doing simple tasks gives that chest pressure pain too."

• emi...
• Taken for 1 to 6 months
• October 18, 2020

For Heart Failure "Wanted to try Entresto due to the information I read about it helping heart patients avoid hospitalizations and generally suffer fewer cardiac events. I began on the lowest dose and the first day, I felt some improvement. Then, after a short period of taking it, I stepped up to the middle dose and felt terrible. Stopped the middle dose and went back to the lowest dose. Felt better but still felt something was wrong. Chest pain, no energy, just knew this was not good. I also have normally very low blood pressure and didn't need anything lowering it even more. My cardiologist took me off it, and now I am back taking Altace instead and feeling almost back to normal. Glad it helps some people. I found it to be a drug to avoid, especially if you already have low blood pressure."

• Rya...
• Taken for less than 1 month
• January 6, 2021

For Heart Failure "I was told about this medicine when I found out my EF was 22. I had an echo performed two weeks before starting and was at an EF of 30. Started Entresto two weeks ago on the lowest dose. First side effect I got was heavy phlegm and chest tightness. I have paralyzed vocal cords, so this was not good. Second, was breathing, I felt as if I had to force myself to breathe. Third, lower back pain. Fourth, arrhythmias, including bigeminy, which I only had once. Anxiety, snapping at my wife, panic attacks, and severe chest pain from my rib cage and pectorals. This may be a miracle drug for some, but not for me."

• Rya...
• Taken for less than 1 month
• January 6, 2021

For Heart Failure "I was told about this medicine when I found out my EF was 22. I had an echo performed two weeks before starting and was at an EF of 30. Started Entresto two weeks ago on the lowest dose. First side effect I got was heavy phlegm and chest tightness. I have paralyzed vocal cords, so this was not good. Second, was breathing, I felt as if I had to force myself to breathe. Third, lower back pain. Fourth, arrhythmias, including bigeminy, which I only had once. Anxiety, snapping at my wife, panic attacks, and severe chest pain from my rib cage and pectorals. This may be a miracle drug for some, but not for me."

• Nik...
• May 17, 2018

For Heart Failure "Before we started going to this new cardiologist, my husband was stabilized. We were not only hiking for 3 hours, but mountain biking over 2 hours a day. This new physician said it would be 'better' for him and gave him a 2-week trial pack. The moment he started the dosing regimen, he turned into what I call a 'Different Person.' He became highly irritable, with mood swings, and that was only the 1/2 dose for 3 days. When he took the full dose, everything started to break loose. He couldn't go more than 1/4 hour on the mountain bike due to chest tightness. And yesterday, we walked for only 10 minutes, and he had severe chest pain to the point of almost having to go to the ER. His usual dose of beta blocker and 3 doses over a period of an hour of DE (Diatomaceous Earth) brought the blood pressure down from 186/133 to 113/65. I knew it was the Entresto from start to finish, and trust me on this one. We're finished, not only with the new cardiologist but Entresto as well."

• Nik...
• May 17, 2018

For Heart Failure "Before we started going to this new cardiologist, my husband was stabilized. We were not only hiking for 3 hours, but mountain biking over 2 hours a day. This new physician said it would be 'better' for him and gave him a 2-week trial pack. The moment he started the dosing regimen, he turned into what I call a 'Different Person.' He became highly irritable, with mood swings, and that was only the 1/2 dose for 3 days. When he took the full dose, everything started to break loose. He couldn't go more than 1/4 hour on the mountain bike due to chest tightness. And yesterday, we walked for only 10 minutes, and he had severe chest pain to the point of almost having to go to the ER. His usual dose of beta blocker and 3 doses over a period of an hour of DE (Diatomaceous Earth) brought the blood pressure down from 186/133 to 113/65. I knew it was the Entresto from start to finish, and trust me on this one. We're finished, not only with the new cardiologist but Entresto as well."

• Dgf...
• Taken for 1 to 6 months
• December 10, 2021

For Heart Failure "Suddenly, one evening I couldn’t breathe, went to the ER and was diagnosed with CHF, dilated cardiomyopathy, pulmonary edema, and pneumonia. A 2D echo showed LVEF of 30-35% and I was started on a low dose of Entresto and have felt worse since being on it, with symptoms of chest pain, shortness of breath, increased PVCs, hypotension, dizziness, numbness and tingling in the entire body, with feelings of doom. After revisiting the ER two more times and one more hospital admission and still feeling worse, I realized after having taken Entresto for 3 months that my horrible symptoms began when I started taking Entresto. I stopped taking Entresto four days ago and am actually beginning to feel better, more normal. Know that Entresto is a great new drug for treating heart failure, but unfortunately I could not tolerate it ... the side effects outweighed the benefits for me."

• P09...
• January 5, 2021

For Heart Failure "I was diagnosed with heart failure three years ago at age 34 and prescribed Entresto for the past two years when my EF was 15. The first year was rough taking the medication as I was constantly tired and lethargic. After about a year, I feel more energy walking and am not in a tired and dizzy state that I was for a year prior. However, if I ever miss a dose, I notice that I immediately, within a day or two, start feeling chest tightness, shortness of breath, and ankle tingling. I am on the lowest dose along with Carvedilol and have resisted any raised dosages. I feel okay with it as long as the regimen is kept. Last EF was 29, so there is some improvement."

• Mir...
• Taken for less than 1 month
• July 13, 2021

For Heart Failure "52 yr old male, 10 years ago had a massive heart attack. Over the years, I have neglected my meds to my detriment. Rushed to the hospital 10 days ago. Findings: LVSD, borderline EF 35-40. There was talk of a defibrillator required urgently. Was put on Entresto 24 mg/26 mg, been taking twice daily since July 5, 2021. I feel much better, but I do have chest tightness at times and can still feel my heart pumping. So far, so good. I hope it works for me. Good luck, everyone. London, July 14, 2021."

• Me...
• Taken for less than 1 month
• January 8, 2018

For Heart Failure "I have felt better when tachycardia is decreased, but I have tingling in my hands and feet, as well as some mild chest pain and altered nervous state."