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Entresto Side Effects

Generic Name: sacubitril / valsartan

Note: This page contains information about the side effects of sacubitril / valsartan. Some of the dosage forms included on this document may not apply to the brand name Entresto.

In Summary

Common side effects of Entresto include: hyperkalemia, hypotension, and increased serum creatinine. Other side effects include: acute renal failure, and renal failure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to sacubitril / valsartan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by sacubitril / valsartan. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking sacubitril / valsartan:

More common:
  • Abdominal or stomach pain
  • blurred vision
  • confusion
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • irregular heartbeat
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
Less common:
  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • swelling of the face, fingers, or lower legs
  • weight gain
Rare
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Minor Side Effects

Some of the side effects that can occur with sacubitril / valsartan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Cough
  • dizziness

For Healthcare Professionals

Applies to sacubitril / valsartan: oral tablet

General

The most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.[Ref]

Cardiovascular

Very common (10% or more): Hypotension (18%)
Common (1% to 10%): Orthostasis[Ref]

Metabolic

Very common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)[Ref]

Renal

Very common (10% or more): Serum creatinine increased greater than 50% (16%)
Common (1% to 10%): Renal failure/acute renal failure[Ref]

Respiratory

Common (1% to 10%): Cough[Ref]

Nervous system

Common (1% to 10%): Dizziness[Ref]

Dermatologic

Uncommon (0.1% to 1%): Angioedema[Ref]

The incidence of angioedema was 2.4% in Black patients.[Ref]

Hematologic

Common (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%[Ref]

Other

Common (1% to 10%): Falls[Ref]

References

1. "Product Information. Entresto (sacubitril-valsartan)." Novartis Pharmaceuticals, East Hanover, NJ.

Not all side effects for Entresto may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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