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How much does Entresto cost per month?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on April 16, 2024.

Official answer


If you are paying cash, the cost for Entresto is around $730 per month for 60 tablets, but most people do not pay this price. If you have commercial insurance, you may be able to get up to a 90 day supply of Entresto for $10 using a copay card.

This price is based on using the discount card which is accepted at most U.S. pharmacies.

If you have Medicare Part D, most people pay less than $50 a month for their Entresto prescription. Prescription costs will vary by state and plan.

When you first start treatment, your may be eligible for a 30-day free trial (up to 60 tablets) to see if Entresto is the right medication for you. This offer is available to all U.S. patients regardless of insurance coverage.

The manufacturer Novartis provides a cost calculator tool on their website to estimate the cost of Entresto based on your insurance plan. To speak to representative, call 1-888-368-7378, M-F, 8AM to 8PM ET.

Learn more: Visit the Entresto Price Guide for costs, coupon and patient assistance programs.

What is Entresto used for?

Entresto tablet or Entresto Sprinkle are oral heart medications that contains two blood pressure-lowering medications: sacubitril and valsartan. Entresto relaxes blood vessels, improves blood flow, and reduces stress on the heart. It is approved to treat:

  • adults with long-lasting (chronic) heart failure to help reduce the risk of death and hospitalization. These medicines work better when the heart cannot pump a normal amount of blood to the body (a left ventricular ejection fraction (LVEF) below normal).
  • certain children one year of age and older who have heart failure that leads to symptoms.

It helps to improve your heart’s ability to pump blood to the body. Entresto is usually given together with other heart medications or in place of other heart medicines.

The most common side effects with Entresto include low blood pressure, high potassium, cough, dizziness, and kidney problems (kidney failure).

Entresto Sprinkle oral pellets, a new dosage form approved in April 2024, does not have pricing information available yet.

Related: Can Entresto be cut in half or split?

How do I afford Entresto?

Entresto was approved in 2015, does not have a generic option yet, and can be expensive. In addition to insurance coverage, there are programs and support from Novartis, the manufacturer, that can help you save each year.

How much is the cash price for Entresto?

If you are paying cash, the list price of Entresto is $734 per month for 60 tablets. This price can vary based on online coupon discounts, where you are located, and which pharmacy you visit. Check with your pharmacist for more information.

If your doctor recommends Entresto treatment for you, the manufacturer can usually supply a free month trial of medicine for you. Be sure to ask about this at your appointment or contact Novartis, the manufacturer, if you have a prescription.

Related questions

Will my insurance pay for Entresto?

If you have commercial insurance (for example: from your employer or through the marketplace), you may be able to get up to a 90-day supply of Entresto for $10 using a copay card supplied by Novartis.

Eligible commercially / privately insured patients can receive a 30-, 60-, or 90-day supply of Entresto for no more than a $10 co-pay at participating pharmacies.

  • You can get your $10 copay card from the Novartis website. It has a combined annual limit up to $4,100. After that, you will be responsible for any costs once your $4,100 limit is reached per calendar year.
  • Give your copay card to the pharmacist when you fill your prescription.
  • Copay cards are valid for one year and renew automatically.

In addition, Entresto has preferred coverage status for 83% of patients who have commercial and private insurance.

Call your prescription insurance company and ask about coverage for Entresto and if they accept the copay card. This offer is not valid under Medicare, Medicaid, or any other federal or state program. You can sign up for the copay card on the Novartis website.

Does Medicare cover Entresto?

If you have Medicare Part D, Entresto has preferred coverage for more than 95% of people with Medicare. Entresto is available at the lowest brand copay for more than 99% of people with Medicare Part D (usually less than $50).

In addition, people with Medicare Part D can access a free 30-day trial of Entresto (maximum 60 tablets) at the beginning of treatment using an offer from the manufacturer.

There is a tool on the Entresto website that Medicare patients can use to determine or compare their cost based on plan coverage. Use the "Check My Medicare Coverage Tool" to estimate your cost based on your plan, found on the Entresto website.

I don’t fall under any of these plans

If you need financial assistance, and have limited or no prescription coverage, call the Novartis Patient Assistance Foundation, an independent nonprofit organization at 1-800-277-2254 to get further information on financial assistance for Entresto.

Bottom Line

  • There are many options you can access to afford Entresto. The cash list price is roughly $734 per month, but most people do not pay this price.
  • Novartis, the manufacturer of Entresto, offers a variety of programs to provide financial assistance to patients, including a $10 copay card for patients with commercial insurance. Most Medicare plans also cover Entresto for the lowest brand name copay.
  • For your first month of treatment, your doctor or the manufacturer may be able to provide a free sample to make sure Entresto is right for you. This offer is available to any U.S. patient, regardless of insurance coverage.
  • Contact Novartis at 1-800-245-5356 if you have further questions about financial assistance for Entresto.

This is not all the information you need to know about Entresto for safe and effective use and does not take the place of your doctor's directions. Review the full Entresto product information and discuss this medicine with your doctor or other health care provider.


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