Skip to Content

User Reviews for Entresto to treat Heart Failure

Entresto has an average rating of 4.7 out of 10 from a total of 118 ratings for the treatment of Heart Failure. 36% of those users who reviewed Entresto reported a positive effect, while 53% reported a negative effect.

Entresto Rating Summary

4.7/10 average rating

118 ratings from 124 user reviews.

Compare all 143 medications used in the treatment of Heart Failure.


Reviews for Entresto

Steve · Taken for less than 1 month April 8, 2021

“I've always been extremely active to the tune of 90 minutes of exercise a day even after suffering a heart attack while riding my trail bike at age 58 four years ago. Genetics was blamed for the cause. My LV Ejection fraction was not compromised at that time. However, last year I suffered a collapsed lung and pneumonia. During my 10 day hospital stay I experienced Heart Failure and an LVEF of 35%. I was told it became much better and I was released from the hospital. Over the last year I have become very tired and things became much more difficult. I had an Echocardiogram a few weeks ago and now my LVEF fraction is 31%. Yikes! My cardiologist prescribed Entresto 50 mg. and one other blood pressure drug Spron.......? I want to thank the makers of Entresto very much! I know it does not cure my underlying heath issues, but it certainly helps improve my energy level and quality of life. Thank you! Steve”

9 / 10
Michael2011 · Taken for less than 1 month March 17, 2021

“Only been taking it for three weeks my blood pressure has gone a bit low but heart rate is stable but feel tired a lot of the time. Waiting for 24hr heart monitor to see what is going on so going to stick with it until had heart monitor.”

6 / 10
captain · Taken for 6 months to 1 year March 6, 2021

“9 months ago at the age of 64, I was diagnosed with CHF with an ejection fraction of 15%. I take Entresto 97-103 mg and Carvedilol 25 mg and after 6 months my EF climbed to 60%. Yes, initially there were side effects, but they have all left. I am very grateful for these medicines.”

10 / 10

Frequently asked questions

Inpain · Taken for 1 to 6 months February 27, 2021

“Started on low dose of 24mg/26mg had bad lower back and side pain this pain eased after a week and heart doctor upped my medication to 49/51mg twice a day I have bad left chest wall pain and bad muscle pain on the left side of my icd defibilator. I am going to go back on to the 24/26mg as I don't get as much pain I walk for 6o minutes every day with no problems I hope my ef goes from 20 up to 50 or 60 in a year. I will wait and see. I will pray for each and every one of us that we get well and a cure is found for heart failure”

6 / 10
HisLovingWife September 2, 2019

“My husband went in for his latest check up at the end of March. His EF was holding steady at 29% after being diagnosed with heart failure in 2013. Rhythm was great. Doctor suggested he try Entresto. So 2 days later, after he stopped his ACE inhibitor, he started taking Entresto. 4 days after that he said he felt his heart beating weird. It wasn’t aFIB like he’s had before. So we scheduled another appointment with his doctor. He didn’t make it. Passed away on April 11th. He was fine and stable until taking this medication, now he is gone. I dig around with the help of my friend, who is a nurse, and I find this study they did on Entresto, where it shows a small amount of patients experienced something called a Ventricular Arrhythmic Storm, which causes sudden cardiac death. No mention of this anywhere in the side effects nor did our doctor tell us to keep an eye out for such things. Fair warning to those taking it.”

1 / 10
S! · Taken for 6 months to 1 year November 12, 2019

“I was diagnosed with Dilated Cardiomyopathy in July 2018, I was 43 years old and had been fit and healthy prior to this. My EF was between 15-20 and I was so ill I felt like my life was near to the end. With two young children I have never been so scared or felt so terrible in all of my life. It took a long time to get my diagnosis and my Cardiologist believes it was probably a virus that created the problem. I started on Entresto soon after my diagnosis and approximately 6 months later I went for another echo. I knew I felt better but I was shocked at my results. My heart had returned to within normal dimensions and my EF was 60. I think even my Cardiologist was surprised at how well I had done. I do however make sure I do lots of cardiovascular exercise and I have made changes to my diet for the better. I feel like a new woman and despite being worried about taking medication long term, I am so very grateful for Entresto. It's been my miracle drug.”

10 / 10
Wife of Entresto patient February 8, 2021

“The first day of starting enestro my husband did not feel good and continued to feel worse every day. After taking for a week and a half he started having confusion and shortness of breath along with severe combativeness. He literally went crazy chasing me and my 5 year old son trying to attack us like we were strangers and punched my vehicle window causing it to shatter. He never remembered any of the incidents. After 2 days of craziness I finally got the nerve to take him to the ER and he tried to jump out of my truck while driving down the road. He had severe depression and this was not his norm at all. The ER found nothing wrong and suggested that he follow up with his doctor. We came home and after talking about it we decided that it may be the enestro causing the craziness so he did not take it the next morning. Since stopping the enestro he feels better and is completely back to normal with no craziness.”

1 / 10

More FAQ

bstacia2000 September 25, 2019

“I was diagnosed with congestive heart failure in 08/2018, (class 4 stage) found out after I had heart attack. I was also diagnosed with high blood pressure,I was 57 at that time, I started taking entresto in 10/2018, went for check up of heart in Feb 2019, results can back with no signs of heart failure, my EF was at 33% when diagnosed, its now back to normal between 60-65% I did change my diet completely, I no longer add salt, also check labels for hidden sodium (it is everywhere!) I exercise 30-45 mins. daily, and eat mainly a plant based diet with chicken breast and fish a few days a week. I give the glory to God first, my family for helping me along the way, and to a caring , cardiologist! Not sure if Entresto helped much but I have not had any side effect , and I was told by emergency room staff that my condition looked "grim" I also take coq10 it gives me added energy.(also, was able to stop taking 2 prescription meds.)”

8 / 10
Mkswinark · Taken for 6 months to 1 year March 13, 2020

“I was given Entresto when they said my EF was 30-35. Had to fight with the insurance to get them to cover it. Was told by cardiologist it was a miracle drug and would add years to my life. The first few months were ok but my blood pressure kept getting lower and lower. Was told by cardiologist not to take morning dose if the upper number was under 100. That was all the time. I was dizzy all the time, falling constantly. Started having chest pains and episodes of confusion. Went to cardiologist, was told they didn’t know what was wrong. My husband was having to help me walk everywhere we went. Was so tired, I couldn’t do housework, laundry or anything. Made the decision on my own to stop taking the Entresto. Within a week, I was a completely different person. Energy level is up, dizziness is gone, quality of life has returned. Entresto was one of the worst experiences of my life. Changing cardiologist. Entresto was a nightmare for me.”

1 / 10
ABC123 · Taken for 1 to 2 years December 17, 2019

“My heart function has gone from 10% up to 25%. I feel better and have noticed an increase in my energy. Entresto is my only option other than to have a mechanical heart. I feel blessed to have the doctors I have and for this medication. I have been on this medication for over a year. As far as side effects, I have only noticed an increase in my irritability. My kidneys are fine as of my last test. I don't think I would have made it much longer with only 10% heart function. This medicine has given me more time and a better quality of life.”

9 / 10
Chris · Taken for less than 1 month October 17, 2019

“I'm a 31 yr old female, diagnosed with CHF. I've only been taking Entresto for about 2 weeks now; but I've noticed a huge change with my breathing (going up 2 flights of stairs would almost kill me, now I can walk up them & have no issues at all), my energy alone I can tell has increased a lot!! & the best thing is I no longer have sleepless nights due to shortness of breathe.. I CAN LAY FLAT =D Yes, I'm still kind of "new" to this medicine; but so far so good. All I know is that I'm not miserable, weak, & hurting with chest pains anymore. The energy spike happened within a couple days of being on it too. The only side effect I have noticed though is itching; which I will take over the pain any day! - All my praise to God, & thanks to my Clinic for helping me through all this, & providing me with Entresto.”

9 / 10
N.U.F.C. November 27, 2019

“This drug Entresto had me shattered, tired beyond belief I also suffered my left leg collapsing. I suffered this problem for approx. 6months before I got taken off it. (It may have been a coincidence) however this problem got worse while on this drug. I now have excruciating pains throughout my whole leg I have seen my G.P's, muscular skeletal pain specialists & orthopaedic practitioner and no one can come up with a diagnosis. The pains are so excruciating I can't walk when taking Entresto. I was so tired I would fall asleep as soon as I sat down. And that was on the low dose of 49mg I kept being told it was a fantastic drug which had had it's trials cut short because it was so good. However this doesn't seem to be the case looking at the reviews. If anyone has similar problems to myself I would be glad to hear it as I am at my wits end and I feel it is putting a strain on me trying to cope with the Pain. My G.P. has just put me on Tramadol for the pain. However I am reluctant to take it”

1 / 10
Goldie32 February 9, 2020

“My father was diagnosed with CHF in 2003. In 2018 March his cardiologist introduced Entresto; my Dad who is usually wary of trying out new things was initially sceptical and I understand that his doctor was trying to promote Entresto to my Dad for quite some time. I am not sure of the exact conversation between the doctor and my Dad but he ended up taking Entresto and what followed was pure nightmare for him and us, his family. Dad’s energy levels plummeted and he developed renal issues not previously experienced. We took him off Entresto and the doctors gave him other medications which he had never taken before and then he took Entresto again when his conditions were slowly improving and alas one thing led to another with my Dad eventually passing away in June 2018. I am glad that Entresto is helping some people here and for the rest of you who have just started using it and experiencing adverse effects not previously experienced please do listen to your body and stop if need be.”

1 / 10
Becca · Taken for 1 to 6 months December 8, 2019

“Diagnosed this Fall with stage 4 CHF at 41. I have dilated cardiomyopathy, most likely from an infection. My EF was 10-15% and I was sent to a transplant specialist. After taking Entresto and Metoprolol for two months, my EF is already at 35%! I’m very tired, but I work a full time job. One of the 2 meds is giving me headaches, but I have had zero other symptoms. Seems like a miracle drug at this point...the cost is crazy, but that seems like the way it is with drugs these days.”

10 / 10
Disappointed · Taken for less than 1 month December 9, 2019

“Cardiologist highly recommended this. Wonderful stuff! I lasted 10 day before I had to stop taking it. Terrible muscle and ligament pain. Got worse daily. When I couldn’t get out of bed on my own, I called it quits. Been off of it for two days and am almost back to normal. Be wary of this med and don’t try to push through the side effects.”

1 / 10
Badheartwilliebrown · Taken for 1 to 6 months August 25, 2020

“Im 34 years old. The doctor claimed my heart was weak because of non compaction and my ejection fraction was at 30 percent from echo . He told me to take entreso. I was taking it for 6 months, then they sent me to take a MRI. The MRI showed the ejection fraction was 38%. All of a sudden my body started to reject entreso. My feet and hand started to tingle, I was extremely dizzy, I was having chest pain under my pec muscle and one night I was breathing funny and I thought my life was finishing. I was like is this is it? The next morning I tried to contact my doctor office and they claim thats normal. So I took on my own, and stopped taking the pills for a while. I want my ejection fraction to increase. ”

4 / 10
Oscar June 3, 2020

“So my EF was 17 when my cardiologist put me on Entresto and it went down to 13 with in 1month l had to call 911 twice before my cardiologist took me back off it for critical shortness of breath and critical low blood pressure. I also experienced mental fogginess blurred vision and back pain while l was on Entresto. So my cardiologist put me back on Ramiphril and my EF went back up to 17 and l feel much better.”

1 / 10
Maria · Taken for 1 to 6 months August 14, 2019

“Started with an ejection fraction of 20 percent and after being on Entresto for 3 months it is now at 55 percent! I feel so much better, more energy, and my kidney function improved. I had always gone to another doctor and not one of my primary care doctors or cardiologist, and they told me about Entresto. After being admitted to Hospital for CHF, their cardiologist put me on Entresto and it has been a life saver! Cost a little more, but like anything else, if you want something bad enough you find a way to pay for it. I’m happy to have a life now.”

10 / 10
Francis November 21, 2019

“My husband was diagnosed with CHF since 2013, has been on Coreg, lasix and lisinopril since. His cardiologist suggested he start on Entresto 1/2 pill twice a day to start. He ended up in the ER after taking the third dose! low BP 83/54, weak, disorientated, almost delirious, very sleepy, had chills and feeling very cold. His BUN and CREATININE went up unlike he’s ever had. It was extremely scary! I almost called an ambulance because I had never seen him this way, not until he started this medicine. I read all the negative reviews before starting but still went for it. I feel bad that we did and we are now waiting for the cardiologist office to open in order to get him in to re-evaluate. Be extra careful and please keep a very close eye on your loved one and if you see anything out of the ordinary for them, act immediately and get help. Very stressful situation. Be careful with this medicine.”

1 / 10
Tedd · Taken for 1 to 6 months September 19, 2019

“My father died 4 months after beginning of treatment with Entresto. He was going worse and worse every single day till the fatal end. I am so sorry that he didn't stop the treatment from the beginning but the doctors made such a good advertisement " new medicine with excellent results, it can make miracles...bla bla"”

1 / 10
jhfrommd · Taken for 1 to 2 years February 11, 2020

“For me Entresto has been a miracle medicine. Have been on the middle dose for over a year. I am able to do just about every kind of physical activity with ease. I have had no significant side effects. I do not feel like I have HF and hope to have a new test to see whether my ejection fraction has increased from 25%. OK, so it seems that it does not work for everyone, but for many it is really incredible. I take Lasix everyday and have lost over 50 pounds by following a very low carb diet. I also do a high level exercise regime almost every day for 25 minutes. In the past five months I gone on five foreign trips that involved considerable activity.”

10 / 10
Dash · Taken for less than 1 month December 17, 2019

“New Cardiologist, CHF since aggressive chemotherapy for Hodgkin's Lymphoma ten years ago my body chemistry changed. Taken all the ACE inhibitors, everyone of them made me horribly ill, Bisoprolol in combo with med I can't remember ended me up in emerg with a pulse of 30bpm. I told my new Cardiologist I was stopping all cardiac meds as I was no use to anyone as I couldn't function, He jumped up and down like a mexican jumping bean telling me I will drop dead of a stroke if I don't take this Entresto. So I'm on week two of only two pills a day and am back on the couch with not enough energy to cook for myself. Lost my appetite, can't think straight, dizzy, and have given up on living. I mean why. Quality of life is most important for me even if it going to be cut short. My last ECG's are normally irregular, I have a defib implant and the amount of incidents have been triple fold since on this med. I have no faith in big money pharmacologists. They are only out for the money.”

1 / 10
JJ · Taken for 1 to 2 years May 7, 2019

“Began taking Entresto Oct. 2017 for CHF and my heart function has greatly improved. Nevertheless, I can attest to the fact that weight gain is a definite side affect. Within the first month I gained 11 pounds and within the first year I gained 38 pounds. Follow-up appointments and conversations with my cardiologist only resulted in him not acknowledging the fact of this apparent side affect and proceeding to tell me that, “This weight gain is definitely not a side affect and I should join Weight Watchers.” I’ve now been taking Entresto for 19 months along with exercising and eating healthy foods, this medication is still producing weight gain. No matter how strongly the doctor denies weight gain as a side affect, the truth of the matter is that, “weight gain is a definitely a proven side affect.””

8 / 10
Rudy · Taken for less than 1 month January 18, 2021

“I'm going on 61 years old and have had heart failure since I was 42. Struggling with diabetes also since 2019. I was put on entresto 2020 felt terrible. It put me back years, I asked to try it again 2021 Felt terrible no energy bloating tried it for 6 weeks. I'm glad I'm off it now as it never worked for me.”

1 / 10
Rain maker October 12, 2019

“Dr took me off Losarten (cozaar) and put me on entresto 3 days ago. Feel like I have been in a car wreck and haven’t slept for two nights. Felt so much better when I was just on toprol XL and lasix. Arrangements being made for bivetricular pacer so hoping that will help. Not sure if I can or want to tolerate entresto. 79 year old male with 40 EF, or was before entresto. 5 bypasses 30 years ago and several stents and two mild heart attacks since. Know I wont live forever, but want to maintain as much life quality as possible.”

1 / 10
Ava · Taken for 1 to 6 months August 20, 2019

“My dad was on this medication for 3 months, he literally had all of its side effects : weight loss, high potassium, kidney failure , dizziness, blurred vision and on top of it ended up in the hospital due to abnormal labs and poor kidney function where they took him off of that medication. His kidneys are getting worse and worse when they were functioning well prior to taking Entresto! I advise everybody to really watch it’s side effects and ask for your doctor for other medications out there but this one. Please don’t take this one , it’s too risky .”

1 / 10
Linda giving God the glory · Taken for 1 to 6 months June 4, 2019

“One day when I was out and about I met a young lady and all of a sudden she just started talking to me about her condition and it was almost the same as mine. We both had leaky valves and very low ejection fraction. Mine was at least 20-25%. She told me to try entresto, she said it's been working for her. So to make long story short I took her advice and asked my doctor to take me off losartan and let's try entresto. It improved my breathing immediately but after a month of taking it , I started getting all of these side effects like itching, headaches, joint stiffness, coughing etc. Finally some of the side effects did get better . I started the entresto at the beginning of February. Today is June 4th I just got an echo done today and my E F is now 45- 50%. I give god the glory for this drug called entresto and for the angel he sent my way to advise me to take it”

10 / 10
Boss · Taken for 1 to 2 years August 30, 2020

“I was on Isosorbide with a cheap copay. The doctor switched me to Entresto with a high copay. At first the ProNTBNP numbers looked good. They have been steadily climbing. The doctor seems satisfied if my number goes into the 1,000s. Novartis the maker has been found giving kickbacks to doctors. Seems the doctors have a financial interest keeping you on the expensive drug. He hinted my EF would go up with it. So far it hasn't.”

3 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Learn more about Heart Failure

IBM Watson Micromedex

Symptom checker

Symptoms and treatments

Mayo Clinic Reference