Generic Name: cyclobenzaprine (SYE-kloe-BEN-za-preen)
Brand Name: Flexeril
Cyclobenzaprine is used for:
Treating muscle spasms caused by painful muscle conditions. It should be used along with rest and physical therapy. It may also be used for other conditions as determined by your doctor.
Cyclobenzaprine is a muscle relaxant. It works in parts of the brain and nervous system to help reduce muscle spasms.
Do NOT use cyclobenzaprine if:
- you are allergic to any ingredient in cyclobenzaprine
- you have an overactive thyroid, moderate to severe liver problems, or certain heart problems (eg, irregular heartbeat, congestive heart failure, heart block, conduction problems), or if you have recently had a heart attack
- you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine, rasagiline) in the last 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using cyclobenzaprine:
Some medical conditions may interact with cyclobenzaprine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of liver problems, heart problems, cerebral palsy, brain or spinal cord disease, or stroke
- if you have a history of glaucoma, increased pressure in the eye, or trouble urinating
Some MEDICINES MAY INTERACT with cyclobenzaprine. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Bupropion, MAOIs (eg, phenelzine, rasagiline), meperidine, serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, venlafaxine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), tramadol, tricyclic antidepressants (eg, amitriptyline), or verapamil because the risk of certain severe side effects called serotonin syndrome may be increased
- Anticholinergics (eg, methscopolamine, benztropine), barbiturates (eg, phenobarbital), cimetidine, fluconazole, fluvoxamine, mibefradil, or phenothiazines (eg, chlorpromazine) because they may increase the risk of cyclobenzaprine's side effects
- Guanethidine or guanfacine because their effectiveness may be decreased by cyclobenzaprine
This may not be a complete list of all interactions that may occur. Ask your health care provider if cyclobenzaprine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use cyclobenzaprine:
Use cyclobenzaprine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take cyclobenzaprine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Do not suddenly stop taking cyclobenzaprine without checking with your doctor.
- If you miss a dose of cyclobenzaprine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use cyclobenzaprine.
Important safety information:
- Cyclobenzaprine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use cyclobenzaprine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Talk with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are take cyclobenzaprine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Do NOT take more than the recommended dose or use for longer than 2 to 3 weeks without checking with your doctor.
- If your symptoms (eg, pain, tenderness, decreased range of motion) do not get better within 2 to 3 weeks or if they get worse, contact your doctor.
- Do not become overheated in hot weather or while you are being active; heatstroke may occur.
- If you experience dry mouth, use sugarless candy or gum, or melt bits of ice in your mouth. If dry mouth continues for more than 2 weeks, contact your dentist or doctor.
- Serotonin syndrome is a possibly fatal syndrome that can be caused by cyclobenzaprine. Your risk may be greater if you take cyclobenzaprine with certain other medicines (eg, "triptans," MAOIs, SSRIs). Symptoms may include agitation, confusion, hallucinations, coma, fever, fast or irregular heartbeat, tremor, excessive sweating, nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
- Use cyclobenzaprine with extreme caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, hallucinations, and fast or irregular heartbeat.
- Cyclobenzaprine should be used with extreme caution in CHILDREN younger than 15 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using cyclobenzaprine while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use cyclobenzaprine, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of cyclobenzaprine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; drowsiness; dry mouth; fatigue; nausea; nervousness; stomach pain or upset.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; confusion; fainting; fast or irregular heartbeat; mental or mood changes; numbness of an arm or a leg; one-sided weakness; seizures; sudden severe stomach pain; severe dizziness or vomiting; speech or vision problems; trouble urinating; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; chest pain; coma; confusion; fast or irregular heartbeat; loss of coordination; hallucinations; seizures; severe drowsiness, dizziness, or headache; slurred speech; tremor; vomiting.Proper storage of cyclobenzaprine:
Store cyclobenzaprine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep cyclobenzaprine out of the reach of children and away from pets.
- If you have any questions about cyclobenzaprine, please talk with your doctor, pharmacist, or other health care provider.
- Cyclobenzaprine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take cyclobenzaprine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cyclobenzaprine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cyclobenzaprine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using cyclobenzaprine.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: skeletal muscle relaxants