Drug interactions between gabapentin and metronidazole
Interactions between your drugs
- Gabapentin is in the drug class gamma-aminobutyric acid analogs.
- Gabapentin is used to treat the following conditions:
- Alcohol Withdrawal
- Benign Essential Tremor
- Bipolar Disorder
- Burning Mouth Syndrome
- Cluster-Tic Syndrome
- Diabetic Peripheral Neuropathy
- Hot Flashes
- Lhermitte's Sign
- Nausea/Vomiting, Chemotherapy Induced
- Neuropathic Pain
- Occipital Neuralgia
- Periodic Limb Movement Disorder
- Peripheral Neuropathy
- Postherpetic Neuralgia
- Postmenopausal Symptoms
- Pudendal Neuralgia
- Reflex Sympathetic Dystrophy Syndrome
- Restless Legs Syndrome
- Small Fiber Neuropathy
- Transverse Myelitis
- Trigeminal Neuralgia
- Metronidazole is a member of the following drug classes: amebicides, miscellaneous antibiotics.
- Metronidazole is used to treat the following conditions:
- Aspiration Pneumonia
- Bacterial Infection
- Bacterial Vaginitis
- Balantidium coli
- Bone infection
- Clostridial Infection
- Crohn's Disease, Acute
- Crohn's Disease, Maintenance
- Deep Neck Infection
- Dental Abscess
- Dientamoeba fragilis
- Helicobacter Pylori Infection
- Intraabdominal Infection
- Joint Infection
- Lemierre's Syndrome
- Nongonococcal Urethritis
- Pelvic Inflammatory Disease
- Pseudomembranous Colitis
- Skin or Soft Tissue Infection
- STD Prophylaxis
- Surgical Prophylaxis
Drug and food interactions
Applies to: metronidazole
Consumer information for this interaction is not currently available.
CONTRAINDICATED: Use of alcohol or products containing alcohol during nitroimidazole therapy may result in a disulfiram-like reaction in some patients. There have been a few case reports involving metronidazole, although data overall are not convincing. The presumed mechanism is inhibition of aldehyde dehydrogenase (ALDH) by metronidazole in a manner similar to disulfiram. Following ingestion of alcohol, inhibition of ALDH results in increased concentrations of acetaldehyde, the accumulation of which can produce an unpleasant physiologic response referred to as the 'disulfiram reaction'. Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmia, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death. However, some investigators have questioned the disulfiram-like properties of metronidazole. One study found neither elevations in blood acetaldehyde nor objective or subjective signs of a disulfiram-like reaction to ethanol in six subjects treated with metronidazole (200 mg three times a day for 5 days) compared to six subjects who received placebo.
MANAGEMENT: Because clear evidence is lacking concerning the safety of ethanol use during nitroimidazole therapy, patients should be apprised of the potential for interaction. Consumption of alcoholic beverages and products containing propylene glycol is specifically contraindicated during and for at least 3 days after completion of metronidazole and benznidazole therapy according to their product labeling.
Applies to: gabapentin
Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Do not use more than the recommended dose of gabapentin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.