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Medications for High Cholesterol, Familial Homozygous

Other names: Familial Hypercholesterolemia, Homozygous; Homozygous Familial Hypercholesterolemia; Homozygous FH; Hypercholesterolemia, Familial Homozygous

About High Cholesterol, Familial Homozygous:  High cholesterol is the presence of high levels of cholesterol in the blood. Familial means that is passed down through families and is a genetic disorder. The altered gene that causes familial high cholesterol is located on chromosome number 19. It contains the information for a protein called LDL receptor that is responsible to clear up LDL from the blood stream. Rarely, a person inherits the gene mutation from both parents, making them genetically homozygous. Individuals who are homozygous have a severe form of hypercholesterolemia, with heart attack and death often occurring before age 30.

Drugs Used to Treat High Cholesterol, Familial Homozygous

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
atorvastatin X N 3 reviews
3.0

Generic name: atorvastatin systemic

Brand name:  Lipitor

Drug class: statins

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Crestor X N 1 review
8.0

Generic name: rosuvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

simvastatin X N Add review
3.0

Generic name: simvastatin systemic

Brand names:  Zocor, FloLipid

Drug class: statins

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Lipitor X N 2 reviews
4.0

Generic name: atorvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

rosuvastatin X N 1 review
8.0

Generic name: rosuvastatin systemic

Brand name:  Crestor

Drug class: statins

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Vytorin X N Add review
8.0

Generic name: ezetimibe / simvastatin systemic

Drug class: antihyperlipidemic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Zocor X N Add review
3.0

Generic name: simvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Juxtapid X N X Add review Rate

Generic name: lomitapide systemic

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

ezetimibe / simvastatin X N Add review
8.0

Generic name: ezetimibe / simvastatin systemic

Brand name:  Vytorin

Drug class: antihyperlipidemic combinations

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Kynamro B N X Add review Rate

Generic name: mipomersen systemic

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Repatha N 6 reviews
7.0

Generic name: evolocumab systemic

Drug class: PCSK9 inhibitors

For consumers: dosage, side effects

For professionals: AHFS DI Monograph, Prescribing Information

lomitapide X N X Add review Rate

Generic name: lomitapide systemic

Brand name:  Juxtapid

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

evolocumab N 6 reviews
7.0

Generic name: evolocumab systemic

Brand names:  Repatha, Repatha Pushtronex, Repatha SureClick

Drug class: PCSK9 inhibitors

For consumers: dosage,

For professionals: A-Z Drug Facts, AHFS DI Monograph

mipomersen B N X Add review Rate

Generic name: mipomersen systemic

Brand name:  Kynamro

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

Praluent N 3 reviews
5.0

Generic name: alirocumab systemic

Drug class: PCSK9 inhibitors

For consumers: dosage, side effects

For professionals: AHFS DI Monograph, Prescribing Information

alirocumab N 3 reviews
5.0

Generic name: alirocumab systemic

Brand name:  Praluent

Drug class: PCSK9 inhibitors

For consumers: dosage,

For professionals: A-Z Drug Facts, AHFS DI Monograph

FloLipid X N Add review Rate

Generic name: simvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Repatha Pushtronex N Add review Rate

Generic name: evolocumab systemic

Drug class: PCSK9 inhibitors

For consumers: dosage, side effects

Repatha SureClick N Add review Rate

Generic name: evolocumab systemic

Drug class: PCSK9 inhibitors

For consumers: dosage,

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Learn more about High Cholesterol, Familial Homozygous

Drugs.com Health Center

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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