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Medications for High Cholesterol, Familial Homozygous

Other names: Familial Hypercholesterolemia, Homozygous; Homozygous Familial Hypercholesterolemia; Homozygous FH; Hypercholesterolemia, Familial Homozygous

About High Cholesterol, Familial Homozygous

High cholesterol is the presence of high levels of cholesterol in the blood. Familial means that is passed down through families and is a genetic disorder. The altered gene that causes familial high cholesterol is located on chromosome number 19. It contains the information for a protein called LDL receptor that is responsible to clear up LDL from the blood stream. Rarely, a person inherits the gene mutation from both parents, making them genetically homozygous. Individuals who are homozygous have a severe form of hypercholesterolemia, with heart attack and death often occurring before age 30.

Drugs used to treat High Cholesterol, Familial Homozygous

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
atorvastatin 3.3 3 reviews
Rx X N X

Generic name: atorvastatin systemic

Brand name:  Lipitor

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Crestor 10 1 review
Rx X N X

Generic name: rosuvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

simvastatin Rate Add review
Rx X N X

Generic name: simvastatin systemic

Brand names:  Zocor, FloLipid

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Lipitor 4.5 2 reviews
Rx X N X

Generic name: atorvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Repatha 7.0 22 reviews
Rx N

Generic name: evolocumab systemic

Drug class: PCSK9 inhibitors

For consumers: dosage, side effects

For professionals: Prescribing Information

rosuvastatin 5.5 2 reviews
Rx X N X

Generic name: rosuvastatin systemic

Brand names:  Crestor, Ezallor

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

evolocumab 7.0 22 reviews
Rx N

Generic name: evolocumab systemic

Brand name:  Repatha

Drug class: PCSK9 inhibitors

For consumers: dosage, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Vytorin Rate Add review
Rx X N X

Generic name: ezetimibe / simvastatin systemic

Drug class: antihyperlipidemic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Zocor Rate Add review
Rx X N X

Generic name: simvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Juxtapid Rate Add review
Rx X N X

Generic name: lomitapide systemic

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage, interactions, side effects

ezetimibe / simvastatin Rate Add review
Rx X N X

Generic name: ezetimibe / simvastatin systemic

Brand name:  Vytorin

Drug class: antihyperlipidemic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

lomitapide Rate Add review
Rx X N X

Generic name: lomitapide systemic

Brand name:  Juxtapid

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Ezallor 1.0 1 review
Rx X N X

Generic name: rosuvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

FloLipid Rate Add review
Rx X N X

Generic name: simvastatin systemic

Drug class: statins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

evinacumab Rate Add review
Rx N

Generic name: evinacumab systemic

Brand name:  Evkeeza

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage,

Evkeeza Rate Add review
Rx N

Generic name: evinacumab systemic

Drug class: miscellaneous antihyperlipidemic agents

For consumers: dosage,

For professionals: Prescribing Information

Roszet Rate Add review
Rx U

Generic name: ezetimibe / rosuvastatin systemic

For consumers:

Learn more about High Cholesterol, Familial Homozygous

Drugs.com Health Center

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

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