Evolocumab Side Effects
Applies to evolocumab: parenteral solution for injection.
Side effects include:
Adverse effects (reported in >5% of adults with primary hyperlipidemia): Nasopharyngitis, upper respiratory tract infection, influenza, back pain, injection site reactions (e.g., erythema, pain, bruising).
Adverse effects (reported in >5% of adults with established cardiovascular disease): Diabetes mellitus, nasopharyngitis, upper respiratory tract infection.
For Healthcare Professionals
Applies to evolocumab: subcutaneous solution.
General
The more commonly reported adverse reactions have included nasopharyngitis, upper respiratory tract infection, back pain, and injection site reactions.
Hypersensitivity
Common (1% to 10%): Hypersensitivity reactions (including rash, eczema, erythema, urticaria)
Postmarketing reports: Angioedema[Ref]
Cardiovascular
Common (1% to 10%): Hypertension[Ref]
Gastrointestinal
Common (1% to 10%): Diarrhea, gastroenteritis, nausea (1.8%)[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection[Ref]
Local
Common (1% to 10%): Injection site reaction (including erythema, pain, bruising)[Ref]
Musculoskeletal
Common (1% to 10%): Back pain, myalgia, musculoskeletal pain, arthralgia (1.8%)[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Neurocognitive events (0.2%)[Ref]
Other
Common (1% to 10%): Influenza, fatigue (1.6%)
Uncommon (0.1% to 1%): Contusion[Ref]
Respiratory
Common (1% to 10%): Influenza, fatigue (1.6%)
Uncommon (0.1% to 1%): Contusion[Ref]
Immunologic
Rare (less than 0.1%): Development anti-drug antibody
Postmarketing reports: Influenza-like illness[Ref]
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More about evolocumab
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- Reviews (561)
- Dosage information
- During pregnancy
- Drug class: PCSK9 inhibitors
- Breastfeeding
Patient resources
Other brands
Professional resources
Related treatment guides
References
1. Product Information. Repatha (evolocumab). Amgen USA. 2015.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.