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How long do Repatha side effects last?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Sep 19, 2023.

Official answer


Clinical trials for Repatha do not detail how long the side effects of Repatha last, therefore it is hard to find accurate information about this.

Often side effects last the length of time the medication stays in the body and side effects decrease as the amount of medication decreases in your body.

How long a medication stays in the body depends on its half-life. Repatha’s half-life ranges between 11 and 17 days, depending on personal variation.

So once you have had your last dose then in 11 to 17 days half of the medications will have been removed from your body, and then after another 11 to 17 days there will only be 25% medication left in your body, and so on.

For a lot of medications the time for most of the medication to be removed from your body is 5.5 half-lives. For Repatha this would range from:

  • 11 days X 5.5 = 60.5 days
  • 17 days X 5.5 = 93.5 day

Therefore most of the medication will be removed from your body between 60.5 days and 93.5 days (approximately 2 to 3 months) which is when you would hope to be side effect free.


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