How does Repatha work?
Repatha (evolocumab) is a monoclonal antibody that works by inhibiting PCSK9 (proprotein convertase subtilisin kexin type 9). PCSK9 is a protein found in the liver that plays a key role in plasma cholesterol metabolism.
Repatha is used to prevent heart attacks, strokes and the need for coronary revascularization in those with existing cardiovascular disease. It is also used to reduce low-density lipoprotein (LDL) or ‘bad’ cholesterol in certain people with hyperlipidemia or hypercholesterolemia.
Repatha works differently from statins, which are another class of drugs used to treat high cholesterol.
What is Repatha’s mechanism of action?
Repatha is administered via a subcutaneous injection under the skin. Once administered it binds to PCSK9 and prevents the circulating PCSK9 from binding to LDL receptors. This increases the amount of LDL receptors available to clear the ‘bad’ LDL cholesterol from the blood.
Without Repatha’s binding action, PCSK9 would be free to bind to the LDL receptors. This leads to the breakdown of the receptors, after which they are recycled back to the surface of liver cells and are no longer available to clear the LDL cholesterol.
References
- Peterson AS, Fong LG, Young SG. PCSK9 function and physiology. J Lipid Res. 2008;49(6):1152-1156. doi:10.1194/jlr.E800008-JLR200.
- Food and Drug Administration. Repatha. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125522s022lbl.pdf. [Accessed February 15, 2021].
- Page MM, Watts GF. PCSK9 inhibitors - mechanisms of action. Aust Prescr. 2016;39(5):164-167. doi:10.18773/austprescr.2016.060.
Read next
Why was Repatha Pushtronex discontinued and replaced?
Repatha Pushtronex was discontinued in order to uphold Amgen’s standards for patient experience and care. It was not discontinued because of safety or efficacy concerns. Continue reading
Are there any dangers of taking Repatha?
A serious danger of taking Repatha (evolocumab) includes a possibly life-threatening allergic reaction. Also tell your doctor if you are allergic to rubber or latex. Other side effects, which could be serious in some people, include high blood sugar levels (diabetes), respiratory tract infections, urinary tract infections (UTI), high blood pressure, and influenza (flu). Continue reading
Praluent vs Repatha: What's the difference?
The differences between Repatha (evolocumab) and Praluent (alirocumab) are their active ingredients, number of treatment indications, dosage forms available and number of strengths available in syringe and pens forms. Continue reading
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Drug information
- Repatha Information for Consumers
- Repatha prescribing info & package insert (for Health Professionals)
- Side Effects of Repatha (detailed)
- Repatha user reviews (715)
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